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1. 发明申请

WO2008016652A2 BLOOD VESSEL IMAGING AND USES THEREFOR 审中-公开
标题翻译：血管成像及其使用
公开(公告)号：WO2008016652A2
公开(公告)日：2008-02-07
申请号：PCT/US2007017197
申请日：2007-07-30
申请人： BIO TREE SYSTEMS INC , HEYMACH JOHN , NAUMOV GEORGE , KANG KONGBIN , BRAUNER RAUL A
发明人： HEYMACH JOHN , NAUMOV GEORGE , KANG KONGBIN , BRAUNER RAUL A
IPC分类号： A61B6/00
CPC分类号： A61B6/032 , A61B6/037 , A61B6/508
摘要： Methods are disclosed for analyzing representations of one or more structures in the body of a subject (e.g., a human subject or other animal subject) to glean information about the health of the subject or to evaluate the subject's response to a therapy or other condition. Aspects of the invention relate to obtaining structural information from casts (e.g., vascular casts from animal models) and using the information as a reference for evaluating structures in the body of a subject. Methods are disclosed for diagnosing, staging, grading, and monitoring diseases. Methods also are disclosed for targeting treatments, monitoring the effectiveness of therapies, and/or screening or validating therapies based analyzing structures (e.g., vascular structures) in a subject and comparing them to reference structures observed in casts obtained from models (e.g., animal models) of related diseases or conditions.
摘要翻译：公开了用于分析受试者（例如，人类受试者或其他动物受试者）体内的一种或多种结构的表现以收集关于受试者健康的信息或评估受试者对治疗或其他状况的反应的方法。本发明的方面涉及从铸件（例如，来自动物模型的血管形态）获得结构信息，并且使用该信息作为评估受试者体内的结构的参考。公开了用于诊断，分期，分级和监测疾病的方法。公开了用于靶向治疗，监测疗法的有效性和/或筛选或验证基于对象的分析结构（例如，血管结构）的治疗方法并将其与从模型（例如动物模型）获得的模型中观察到的参考结构进行比较的方法）相关疾病或病症。

2. 发明申请

WO2009088963A3 METHODS OF OBTAINING GEOMETRY FROM IMAGES 审中-公开
标题翻译：从图像中获取几何的方法
公开(公告)号：WO2009088963A3
公开(公告)日：2009-09-11
申请号：PCT/US2009000008
申请日：2009-01-02
申请人： BIO TREE SYSTEMS INC , KANG KONGBIN , BRAUNER RAUL A , WU YANCHUN , CRUZ JOAO
发明人： KANG KONGBIN , BRAUNER RAUL A , WU YANCHUN , CRUZ JOAO
IPC分类号： G06T17/00 , A61B5/00 , A61B6/00
CPC分类号： G06T7/0012 , A61B5/055 , A61B6/504 , A61B6/508 , A61B2576/02 , G06K9/6215 , G06T7/20 , G06T7/60 , G06T7/74 , G06T15/08 , G06T2207/10028 , G06T2207/10072 , G06T2207/10116 , G06T2207/20004 , G06T2207/30101
摘要： In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature.
摘要翻译：在一个方面，提供一种使用适于响应于至少一个特征的匹配滤波器来检测至少一个血管的至少一个图像中的至少与血管相关联的特征的方法。所述方法包括对所述至少一个图像中的选定体素应用比例检测滤波器以确定每个所选择的体素处的匹配滤波器的比例，确定每个所选择的体素处的匹配滤波器的取向，其中确定取向通过使用在每个所选择的体素中确定的比例来辅助，在每个所选择的体素处以每个所选择的体素应用匹配滤波器，并且在每个所选择的体素处确定取向以在每个所选择的体素处获得滤波器响应，以及分析每个所选择的体素处的过滤器响应，以确定相应的体素是否对应于所述至少一个特征。

3. 发明申请

WO2008002648A2 BINNED MICRO-VESSEL DENSITY METHODS AND APPARATUS 审中-公开
标题翻译： BINNED微压容器密度方法和装置
公开(公告)号：WO2008002648A2
公开(公告)日：2008-01-03
申请号：PCT/US2007015048
申请日：2007-06-28
申请人： BIO TREE SYSTEMS INC , KIMIA BENJAMIN , BRAUNER RAUL A , HEYMACH JOHN , FUNARO JESSE
发明人： KIMIA BENJAMIN , BRAUNER RAUL A , HEYMACH JOHN , FUNARO JESSE
CPC分类号： G06T7/0012 , G06T7/44 , G06T7/62 , G06T2207/10116 , G06T2207/30024 , G06T2207/30101
摘要： In one aspect, a method of obtaining micro-vessel density (MVD) measurements from an image of biological vasculature containing a plurality of vessels is provided. The method comprises acts of analyzing a region of interest of the image for each of a plurality of bins, each of the plurality of bins associated with a predetermined range of vessel sizes, the act of analyzing the region of interest including determining which of the plurality of bins that portions of any vessel subject matter identified in the region of interest belong based on a size associated with the respective portions of the vessel subject matter, and associating each portion of the vessel subject matter with the corresponding one of the plurality of bins to which the portion belongs, and computing at least one measurement for each of the plurality of bins, the at least one measurement related to the MVD of the portions of vessel subject matter associated with the respective bin.
摘要翻译：在一个方面，提供了从包含多个血管的生物脉管系统的图像获得微血管密度（MVD）测量结果的方法。该方法包括以下动作：针对多个仓中的每一个分析图像的感兴趣区域，多个仓中的每一个与预定范围的血管大小相关联，分析感兴趣区的动作包括确定多个仓中的哪一个根据与所述容器主题的相应部分相关联的大小，并且将所述容器主题的每个部分与所述多个容器中的相应一个相关联，来识别在所述感兴趣区域中识别的任何容器主题的部分以及为所述多个仓中的每一个计算至少一个测量结果，所述至少一个测量结果涉及与相应仓相关联的血管主体部分的MVD。

4. 发明申请

WO2010101660A3 VASCULAR ANALYSIS METHODS AND APPARATUS 审中-公开
标题翻译：血管分析方法和装置
公开(公告)号：WO2010101660A3
公开(公告)日：2011-01-13
申请号：PCT/US2010000696
申请日：2010-03-06
申请人： BIO TREE SYTEMS INC , KANG KONGBIN , BRAUNER RAUL A , WU YANCHUN , CRUZ JOAO
发明人： KANG KONGBIN , BRAUNER RAUL A , WU YANCHUN , CRUZ JOAO
IPC分类号： A61B6/00 , G06T17/00
CPC分类号： G06T7/0016 , A61B6/508 , G06T7/11 , G06T7/13 , G06T7/149 , G06T7/155 , G06T2207/10072 , G06T2207/20021 , G06T2207/20036 , G06T2207/20112 , G06T2207/30101 , G06T2207/30172
摘要： According to some aspects, a method of identifying a boundary of a portion of a vasculature is provided, the vasculature comprising a geometric representation of a plurality of vessels. The method comprises logically dividing the geometric representation into a plurality of regions, determining at least one feature within each of the plurality of regions, and defining the boundary of the portion of the vasculature based, at least in part, on the at least one feature determined within each of the plurality of regions, wherein the boundary forms a volume defining a separation between inside and outside of the portion of the vasculature. According to some aspects, a method of performing vascular analysis using a geometric representation of a plurality of vessels of the vasculature is provided. The method comprises computing a boundary of a portion of the vasculature based on the geometric representation, logically dividing the geometric representation within the boundary into a plurality of regions, and analyzing at least one feature for each of the plurality of regions within the boundary.
摘要翻译：根据一些方面，提供了一种识别脉管系统的一部分的边界的方法，所述脉管系统包括多个血管的几何表示。所述方法包括将所述几何表示逻辑地划分成多个区域，确定所述多个区域中的每一个区域内的至少一个特征，以及至少部分地基于所述至少一个特征限定所述脉管系统的所述部分的边界在所述多个区域的每一个内确定，其中所述边界形成限定所述脉管系统部分的内部和外部之间的间隔的体积。根据一些方面，提供使用脉管系统的多个血管的几何表示进行血管分析的方法。所述方法包括基于所述几何表示计算所述脉管系统的一部分的边界，将所述边界内的几何表示逻辑地划分为多个区域，以及分析所述边界内的所述多个区域中的每一个的至少一个特征。

5. 发明专利

CA2938077A1 METHODS AND SYSTEM FOR LINKING GEOMETRY OBTAINED FROM IMAGES 未知
公开(公告)号：CA2938077A1
公开(公告)日：2014-09-18
申请号：CA2938077
申请日：2014-03-14
申请人： BIO-TREE SYSTEMS INC
发明人： KANG KONGBIN , WU YANCHUN , BRAUNER RAUL A
IPC分类号： A61B5/02
摘要： Techniques for linking geometry extracted from one or more medical images, the geometry including a plurality of geometric objects each having parameter values including at least one value for location and at least one value for direction/orientation, the plurality of geometric objects comprising a target geometric object and at least two candidate geometric objects, the techniques include: (A) comparing parameter values of the target geometric object with parameter values of the at least two candidate geometric objects, (B) selecting one of the at least two candidate geometric objects to link to the target geometric object based, at least in part, on the comparison; and (C) linking the target geometric object with the selected candidate geometric object.

6. 发明专利

CA2748854A1 METHODS OF OBTAINING GEOMETRY FROM IMAGES 未知
公开(公告)号：CA2748854A1
公开(公告)日：2009-07-16
申请号：CA2748854
申请日：2009-01-02
申请人： BIO TREE SYSTEMS INC
发明人： KANG KONGBIN , BRAUNER RAUL A , WU YANCHUN , CRUZ JOAO
IPC分类号： G06T17/00 , A61B5/00 , A61B6/00
摘要： In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature.

7. 发明专利

CA2694166A1 BLOOD VESSEL IMAGING AND USES THEREFOR 未知
公开(公告)号：CA2694166A1
公开(公告)日：2008-02-07
申请号：CA2694166
申请日：2007-07-30
申请人： BIO TREE SYSTEMS INC
发明人： HEYMACH JOHN , NAUMOV GEORGE , KANG KONGBIN , BRAUNER RAUL A
IPC分类号： A61B6/00
摘要： Methods are disclosed for analyzing representations of one or more structures in the body of a subject (e.g., a human subject or other animal subject) to glean information about the health of the subject or to evaluate the subject's response to a therapy or other condition. Aspects of the invention relate to obtaining structural information from casts (e.g., vascular casts from animal models) and using the information as a reference for evaluating structures in the body of a subject. Methods are disclosed for diagnosing, staging, grading, and monitoring diseases. Methods also are disclosed for targeting treatments, monitoring the effectiveness of therapies, and/or screening or validating therapies based analyzing structures (e.g., vascular structures) in a subject and comparing them to reference structures observed in casts obtained from models (e.g., animal models) of related diseases or conditions.

8. 发明专利

CA2692270A1 BINNED MICRO-VESSEL DENSITY METHODS AND APPARATUS 未知
公开(公告)号：CA2692270A1
公开(公告)日：2008-01-03
申请号：CA2692270
申请日：2007-06-28
申请人： BIO TREE SYSTEMS INC
发明人： KIMIA BENJAMIN , FUNARO JESSE , HEYMACH JOHN , BRAUNER RAUL A
IPC分类号： G06T7/00
摘要： In one aspect, a method of obtaining micro-vessel density (MVD) measureme nts from an image of biological vasculature containing a plurality of vessel s is provided. The method comprises acts of analyzing a region of interest o f the image for each of a plurality of bins, each of the plurality of bins a ssociated with a predetermined range of vessel sizes, the act of analyzing t he region of interest including determining which of the plurality of bins t hat portions of any vessel subject matter identified in the region of intere st belong based on a size associated with the respective portions of the ves sel subject matter, and associating each portion of the vessel subject matte r with the corresponding one of the plurality of bins to which the portion b elongs, and computing at least one measurement for each of the plurality of bins, the at least one measurement related to the MVD of the portions of ves sel subject matter associated with the respective bin.

9. 发明专利

CA3058610A1 METHODS OF OBTAINING 3D RETINAL BLOOD VESSEL GEOMETRY FROM OPTICAL COHERENT TOMOGRAPHY IMAGES AND METHODS OF ANALYZING SAME 未知
公开(公告)号：CA3058610A1
公开(公告)日：2017-10-05
申请号：CA3058610
申请日：2017-03-30
申请人： BIO TREE SYSTEMS INC
发明人： KANG KONGBIN , WU YANCHUN , BRAUNER RAUL A
IPC分类号： A61B3/10 , A61B3/12 , A61B3/14 , A61B5/00 , G06K9/00 , G06T7/00
摘要： Embodiments relate to extracting blood vessel geometry from one or more optical coherent tomography (OCT) images for use in analyzing biological structures for diagnostic and therapeutic applications for diseases that can be detected by vascular changes in the retina. An OCT image refers generally to one or more images of any dimension obtained using any one or combination of OCT techniques. Some embodiments include a method of identifying a region of interest of a retina from a plurality of retinal blood vessels in at least one optical coherence tomography (OCT) image of at least a portion of the retina. Some embodiments include a method of distinguishing between a plurality of retinal layers from vessel morphology information of retinal blood vessels in at least one optical coherence tomography (OCT) image of at least a portion of the retina.

10. 发明专利

AT553457T 未知
公开(公告)号：AT553457T
公开(公告)日：2012-04-15
申请号：AT07796551
申请日：2007-06-28
申请人： BIO TREE SYSTEMS INC
发明人： KIMIA BENJAMIN , BRAUNER RAUL A , HEYMACH JOHN , FUNARO JESSE
IPC分类号： G06T7/00
摘要： In one aspect, a method of obtaining micro-vessel density (MVD) measurements from an image of biological vasculature containing a plurality of vessels is provided. The method comprises acts of analyzing a region of interest of the image for each of a plurality of bins, each of the plurality of bins associated with a predetermined range of vessel sizes, the act of analyzing the region of interest including determining which of the plurality of bins that portions of any vessel subject matter identified in the region of interest belong based on a size associated with the respective portions of the vessel subject matter, and associating each portion of the vessel subject matter with the corresponding one of the plurality of bins to which the portion belongs, and computing at least one measurement for each of the plurality of bins, the at least one measurement related to the MVD of the portions of vessel subject matter associated with the respective bin.

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