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1. 发明申请

WO02071067A9 ASSAY SYSTEM FOR SIMULTANEOUS DETECTION AND MEASUREMENT OF MULTIPLE MODIFIED CELLULAR PROTEINS 审中-公开
标题翻译：用于同时检测和测量多种改良的细胞蛋白的测定系统
公开(公告)号：WO02071067A9
公开(公告)日：2004-01-29
申请号：PCT/US0207130
申请日：2002-03-06
申请人： BIO RAD LABORATORIES , NGUYEN QUAN , SONG YONG
发明人： NGUYEN QUAN , SONG YONG
IPC分类号： G01N21/64 , G01N21/78 , G01N33/53 , G01N33/543 , G01N33/545 , G01N33/552 , G01N33/68
CPC分类号： G01N33/6842 , G01N33/6803 , G01N33/6854 , Y10S435/973
摘要： A method and kit for simultaneous detection and/or determination of a plurality of modified proteins in a sample. The method comprises: a) contacting the sample under mild protein denaturation conditions with a plurality of first antibodies capable of binding to a specific target protein, the first antibodies being immobilized on solid support material, each first antibody being differentiable from others by a differentiation parameter, whereby the first antibodies bind to respective target proteins present in the sample; b) removing unbound materials from the locus of the first antibodies; c) contacting the materials from step (b) with one or more second antibodies, each of which is specific to a class or subclass of modified proteins or with a plurality of second antibodies, each of which is specific to a modified protein, so as to bind the second antibody or antibodies to modified proteins in the sample; and d) detecting and/or determining a plurality of modified proteins in the sample.
摘要翻译：用于同时检测和/或测定样品中多种修饰蛋白质的方法和试剂盒。该方法包括：a）将温和蛋白质变性条件下的样品与能够结合特异性靶蛋白的多个第一抗体接触，将第一抗体固定在固体支持材料上，每个第一抗体通过分化参数与其它抗体不同，其中第一抗体结合存在于样品中的各个靶蛋白质; b）从第一抗体的位点去除未结合的物质; c）使来自步骤（b）的材料与一种或多种第二抗体接触，每种抗体对修饰蛋白质的一类或亚类具有特异性，或者具有多种第二抗体，每种抗体对于修饰的蛋白质是特异性的，因此将第二抗体或抗体与样品中的修饰蛋白结合; 和d）检测和/或确定样品中的多种修饰的蛋白质。

2. 发明申请

WO02059617A3 STANDARD DILUENT FOR MULTIPLEX ASSAYS 审中-公开
标题翻译：多重测定标准稀释液
公开(公告)号：WO02059617A3
公开(公告)日：2003-08-21
申请号：PCT/US0148252
申请日：2001-12-13
申请人： BIO RAD LABORATORIES , NGUYEN QUAN , ZHANG AIGUO
发明人： NGUYEN QUAN , ZHANG AIGUO
IPC分类号： G01N33/50 , B01J20/281 , G01N30/88 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/96 , G01N33/531
CPC分类号： G01N33/54393 , G01N33/6863 , G01N33/96 , G01N2496/00
摘要： The present invention provides standard diluents for use in multiplex assays comprising a biological fluid that normally includes two or more different target analytes but that is substantially free of the two or more different target analytes, as well as kits and methods relating to the standard diluent. The standard diluents of the invention provide an accurate and reliable means to calibrate the amount of multiple target analytes in a single assay.
摘要翻译：本发明提供用于多重测定的标准稀释剂，其包含通常包含两种或更多种不同目标分析物但基本上不含两种或多种不同目标分析物的生物流体，以及与标准稀释剂相关的试剂盒和方法。本发明的标准稀释剂提供了在单次测定中校准多种靶分析物的量的精确和可靠的手段。

3. 发明专利

AU2002351265A1 BLOCK FOR MAINTENANCE, CALIBRATION AND VALIDATION OF AUTOMATED MULTIPLEX ANALYTICAL SYSTEMS 未知
公开(公告)号：AU2002351265A1
公开(公告)日：2003-06-23
申请号：AU2002351265
申请日：2002-12-05
申请人： BIO RAD LABORATORIES
发明人： NGUYEN QUAN , DAVIS DIANA
IPC分类号： B01L99/00 , G01N35/10 , G01N21/66 , G01N35/00
摘要： Various functions for maintenance, calibration and validation of an automated instrument that is capable of performing multiple simultaneous assays using fluorescence detection and microscopic beads as a solid phase are provided by a single block that is inserted into the instrument in place of a sample plate. The block contains several different sets of wells, all appropriately labeled, for the retention of various liquids and bead suspensions, including different sets for the different functions.

4. 发明专利

CA2382565A1 AUTOMATIC ALIGNMENT SYSTEM FOR COUPLING MULTIPLE LIGHT SOURCES 未知
公开(公告)号：CA2382565A1
公开(公告)日：2001-03-08
申请号：CA2382565
申请日：2000-08-31
申请人： BIO RAD LABORATORIES
发明人： ANDREWS TIMOTHY , NGUYEN QUAN , YETSO STEPHEN C
IPC分类号： G02B6/35 , G02B26/02
摘要： A system for coupling up one or more light sources to one or more destinatio ns is provided. Under the present invention, the transmission efficiency from a light source to a destination is optimized regularly on an automatic basis b y monitoring the intensity of the light transmitted. In a preferred embodiment , the system includes a source fiberoptic cable for bundling up light emitted from a multitude of light sources, a destination fiberoptic cable for receiving light transmitted from the source fiberoptic cable, a motorized positioning stage for aligning the source and the destination fiberoptic cables, and a feedback servo control for adjusting the motorized positioning stage to accurately align the source and the destination fiberoptic cables based on the intensity of the light transmitted by the source fiberoptic cable. In operation, the intensity of the light transmitted by the source fiberoptic cable is detected by the feedback servo control. Based on the intensity reading, the feedback servo control selectively directs the motorized positioning stage to align the source and the destination fiberopt ic cables in an optimal position to improve transmission efficiency.

5. 发明专利

CA2439404A1 ASSAY SYSTEM FOR SIMULTANEOUS DETECTION AND MEASUREMENT OF MULTIPLE MODIFIED CELLULAR PROTEINS 未知
公开(公告)号：CA2439404A1
公开(公告)日：2002-09-12
申请号：CA2439404
申请日：2002-03-06
申请人： BIO RAD LABORATORIES
发明人： SONG YONG , NGUYEN QUAN
IPC分类号： G01N21/64 , G01N21/78 , G01N33/53 , G01N33/543 , G01N33/545 , G01N33/552 , G01N33/68
摘要： A method and kit for simultaneous detection and/or determination of a plurality of modified proteins in a sample. The method comprises: a) contacting the sample under mild protein denaturation conditions with a plurality of first antibodies capable of binding to a specific target protei n, the first antibodies being immobilized on solid support material, each first antibody being differentiable from others by a differentiation parameter, whereby the first antibodies bind to respective target proteins present in t he sample; b) removing unbound materials from the locus of the first antibodies ; c) contacting the materials from step (b) with one or more second antibodies , each of which is specific to a class or subclass of modified proteins or wit h a plurality of second antibodies, each of which is specific to a modified protein, so as to bind the second antibody or antibodies to modified protein s in the sample; and d) detecting and/or determining a plurality of modified proteins in the sample.

6. 发明专利

CA2431201A1 STANDARD DILUENT FOR MULTIPLEX ASSAYS 未知
公开(公告)号：CA2431201A1
公开(公告)日：2002-08-01
申请号：CA2431201
申请日：2001-12-13
申请人： BIO RAD LABORATORIES
发明人： ZHANG AIGUO , NGUYEN QUAN
IPC分类号： G01N33/50 , B01J20/281 , G01N30/88 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/96
摘要： The present invention provides standard diluents for use in multiplex assays comprising a biological fluid that normally includes two or more different target analytes but that is substantially free of the two or more different target analytes, as well as kits and methods relating to the standard diluen t. The standard diluents of the invention provide an accurate and reliable mean s to calibrate the amount of multiple target analytes in a single assay.

7. 发明专利

AU6608500A Automated landmarking for two-dimensional electrophoresis 未知
公开(公告)号：AU6608500A
公开(公告)日：2001-02-13
申请号：AU6608500
申请日：2000-07-25
申请人： BIO RAD LABORATORIES
发明人： NGUYEN QUAN , RANDALL JON , DAVIS DIANA
IPC分类号： G01N27/447 , G01N33/68

8. 发明专利

CA2437753A1 MULTIPLEX PROTEIN INTERACTION DETERMINATIONS USING GLUTATHIONE-GST BINDING 未知
公开(公告)号：CA2437753A1
公开(公告)日：2002-09-26
申请号：CA2437753
申请日：2002-02-14
申请人： BIO RAD LABORATORIES
发明人： SONG YONG , NGUYEN QUAN
IPC分类号： G01N33/50 , C12Q1/48 , G01N21/78 , G01N33/15 , G01N33/53 , G01N33/543 , G01N33/58 , G01N33/536 , C07H21/02 , C07H21/04 , C12N15/00 , C12Q1/68
摘要： Fusion proteins in which glutathione S-transferase (GST) is a fusion partner are used as an immobilized binding member in screening procedures or other multi-analyte test procedures based on protein interaction. In such procedures, a particular protein is selected from a group of candidate proteins on the basis of the binding affinity of that protein for a target protein, with either the candidate proteins or the target protein being a fusion partner with GST and the GST portion of the fusion partner having bee n immobilized on glutathione-coated particles by the binding of GST to glutathione. The particles themselves are classifiable by different values o f a differentiation parameter that permits them to be distinguished by flow cytometry, and the procedure is conducted in a manner that associates the individual candidate proteins with individual classes of the particles. When a binding interaction occurs between a candidate protein and the target protei n, the particles on which the interaction has occurred are readily distinguishe d by flow cytometry and correlated with the candidate protein that exhibited t he binding.

9. 发明专利

AU7109900A Automatic alignment system for coupling multiple light sources 未知
公开(公告)号：AU7109900A
公开(公告)日：2001-03-26
申请号：AU7109900
申请日：2000-08-31
申请人： BIO RAD LABORATORIES
发明人： YETSO STEPHEN C , NGUYEN QUAN , ANDREWS TIMOTHY
IPC分类号： G02B6/35 , G02B26/02

10. 发明申请

WO0116639A9 AUTOMATIC ALIGNMENT SYSTEM FOR COUPLING MULTIPLE LIGHT SOURCES 审中-公开
标题翻译：用于耦合多光源的自动对准系统
公开(公告)号：WO0116639A9
公开(公告)日：2002-09-12
申请号：PCT/US0024247
申请日：2000-08-31
申请人： BIO RAD LABORATORIES
发明人： YETSO STEPHEN C , NGUYEN QUAN , ANDREWS TIMOTHY
IPC分类号： G02B6/35 , G02B26/02
CPC分类号： G02B6/3588 , G02B6/3502 , G02B6/3558
摘要： A system for coupling up one or more light sources to one or more destinations is provided. Under the present invention, the transmission efficiency from a light source to a destination is optimized regularly on an automatic basis by monitoring the intensity of the light transmitted. In a preferred embodiment, the system includes a source fiberoptic cable for bundling up light emitted from a multitude of light sources, a destination fiberoptic cable for receiving light transmitted from the source fiberoptic cable, a motorized positioning stage for aligning the source and the destination fiberoptic cables, and a feedback servo control for adjusting the motorized positioning stage to accurately align the source and the destination fiberoptic cables based on the intensity of the light transmitted by the source fiberoptic cable. In operation, the intensity of the light transmitted by the source fiberoptic cable is detected by the feedback servo control. Based on the intensity reading, the feedback servo control selectively directs the motorized positioning stage to align the source and the destination fiberoptic cables in an optimal position to improve transmission efficiency.
摘要翻译：提供了用于将一个或多个光源耦合到一个或多个目的地的系统。在本发明的基础上，通过监视发射光的强度，自动地优化从光源到目的地的传输效率。在优选实施例中，系统包括用于捆扎从多个光源发射的光的源光纤光缆，用于接收从光纤光缆传输的光的目的光纤电缆，用于对准源和目的地光纤的电动定位台电缆和反馈伺服控制器，用于调整电动定位平台，以根据源光纤电缆传输的光强度精确对准源和目标光纤电缆。在操作中，由光纤光缆传输的光的强度由反馈伺服控制来检测。基于强度读数，反馈伺服控制选择性地引导电动定位台将源和目的地光纤电缆对准在最佳位置以提高传输效率。

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