专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009064210A2 PROCESS 审中-公开
标题翻译：处理
公开(公告)号：WO2009064210A2
公开(公告)日：2009-05-22
申请号：PCT/PT2008000048
申请日：2008-11-13
申请人： BIAL PORTELA & CA SA , BROADBELT BRIAN , BELIAEV ALEXANDER , LEARMONTH DAVID
发明人： BROADBELT BRIAN , BELIAEV ALEXANDER , LEARMONTH DAVID
IPC分类号： C07D311/74
CPC分类号： C07D311/04
摘要： Compounds of formula I, V, VI and II, and processes for their preparation, wherein R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group; and R4 is alkyl or aryl. There is also provided a process for preparing a compound of formula B from the compounds of formula V and I.
摘要翻译：式I，V，VI和II的化合物及其制备方法，其中R1，R2和R3相同或不同，表示氢，卤素，烷基，烷氧基，羟基，硝基，烷基羰基氨基，烷基氨基或二烷基氨基; R4是烷基或芳基。还提供了由式V和I化合物制备式B化合物的方法。

2. 发明申请

WO2007139413A3 POLYMORPHS OF (R) -5- (2-AMINOETHYL) -1- (6, 8-DIFLUOROCHROMAN-3-YL) -1,3- DIHYDROIMIDAZOLE-THIONE HYDROCHLORIDE 审中-公开
标题翻译：（R）-5-（2-氨基乙基）-1-（6,7,8-二氟-3-三氟甲基）-1,3-二氢吲哚-3-基氧基氯化物的聚合物
公开(公告)号：WO2007139413A3
公开(公告)日：2008-04-03
申请号：PCT/PT2007000023
申请日：2007-05-31
申请人： PORTELA & CA SA , BELIAEV ALEXANDER , LEARMONTH DAVID , SMOLENSKAYA VALERIYA
发明人： BELIAEV ALEXANDER , LEARMONTH DAVID , SMOLENSKAYA VALERIYA
IPC分类号： C07D413/04 , A61K31/352 , A61P9/02
CPC分类号： A61K31/4178 , C07D405/04
摘要： Polymorphs of (R)-5-(2-Aminoethyl)-l-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione hydrochloride and methods of their preparation.
摘要翻译：（R）-5-（2-氨基乙基）-1-（6,8-二氟色素-3-基）-1,3-二氢咪唑-2-硫酮盐酸盐的多晶型物及其制备方法。

3. 发明专利

MX2008015044A POLIMORFOS DE CLORHIDRATO DE (R)-5-(2-AMINOETIL)-1-(6,8-DIFLUOROCR OMAN-3-IL)-1,3-DIHIDROIMIDAZOL-TIONA. 未知
公开(公告)号：MX2008015044A
公开(公告)日：2008-12-10
申请号：MX2008015044
申请日：2007-05-31
申请人： BIAL PORTELA & CA SA
发明人： BELIAEV ALEXANDER , LEARMONTH DAVID , SMOLENSKAYA VALERIYA
IPC分类号： C07D413/04 , A61K31/352 , A61P9/02
摘要： Polimorfos de Clorhidrato de (R)-5-(2-Aminoetil)-1-(6,8-difluorocr oman-3-il)-1,3-dihidroimidazol-2-tiona y métodos para su preparación.

4. 发明专利

CA2648916A1 PREPARATION OF ESLICARBAZEPINE AND RELATED COMPOUNDS BY ASYMMETRIC HYDROGENATION 未知
公开(公告)号：CA2648916A1
公开(公告)日：2007-10-18
申请号：CA2648916
申请日：2007-04-11
申请人： BIAL PORTELA & CA SA
发明人： LEARMONTH DAVID , YU BING , LI WENGE
IPC分类号： C07D223/22
摘要： A process for preparing a compound of the formula IA or IB, wherein R is a!kyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkox y, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalky l represents a saturated alicyclic g.tau.oup with 3 to 6 carbon atoms; the ter m aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II, wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.

5. 发明专利

BRPI0711508A2 未知
公开(公告)号：BRPI0711508A2
公开(公告)日：2011-11-01
申请号：BRPI0711508
申请日：2007-05-31
申请人： BIAL PORTELA & CA SA
发明人： BELIAEV ALEXANDER , LEARMONTH DAVID , SMOLENSKAYA VELERIYA
IPC分类号： C07D413/04 , A61K31/352 , A61P9/02
摘要： Polymorphs of (R)-5-(2-Aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydroimidazole-2-thione hydrochloride and methods of their preparation.

6. 发明专利

AT520665T 未知
公开(公告)号：AT520665T
公开(公告)日：2011-09-15
申请号：AT06726863
申请日：2006-04-21
申请人： BIAL PORTELA & CA SA
发明人： LEARMONTH DAVID , GRASA GABRIELA , ZANOTTI-GEROSA ANTONIO
IPC分类号： C07D223/22
摘要： A process for preparing (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide or (R)-(-)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide, by reduction of oxcarbazepine in the presence of a catalyst and a hydride source is disclosed. The catalyst is prepared from a combination of [RuX 2 (L)] 2 wherein X is chlorine, bromine or iodine, and L is an aryl or aryl-aliphatic ligand, with a ligand of formula (A) or formula (B): wherein R 1 is chosen from C 1-6 alkoxy and C 1-6 alkyl, n is a number from 0 to 5, and when n is a number from 2 to 5, R 1 can be the same or different, and R 2 is alkyl, substituted alkyl, aryl, substituted aryl, alkaryl or substituted alkaryl. The hydride source is either NR 3 R 4 R 5 and formic acid, [R 3 R 4 R 5 NH][OOCH] and optionally formic acid, or [M][OOCH] x and formic acid, wherein R 3 , R 4 and R 5 are C 1-6 alkyl, M is an alkali metal or alkaline earth metal and x is 1 or 2. A pH from 6.5 to 8 is maintained during the process.

7. 发明专利

DK2004610T3 Fremstilling af eslicarbazepin og beslægtede forbindelser ved asymmetrisk hydrogenering 未知
公开(公告)号：DK2004610T3
公开(公告)日：2010-11-22
申请号：DK07747757
申请日：2007-04-11
申请人： BIAL PORTELA & CA SA
发明人： YU BING , LI WENGE , LEARMONTH DAVID
IPC分类号： C07D223/22

8. 发明专利

CA2653956A1 NEW CRYSTAL FORMS 未知
公开(公告)号：CA2653956A1
公开(公告)日：2007-12-06
申请号：CA2653956
申请日：2007-05-31
申请人： BIAL PORTELA & CA SA
发明人： BELIAEV ALEXANDER , LEARMONTH DAVID , SMOLENSKAYA VALERIYA
IPC分类号： C07D413/04 , A61K31/352 , A61P9/02
摘要： Polymorphs of (R)-5-(2-Aminoethyl)-l-(6,8-difluorochroman-3-yl)-1,3-dihyd roimidazole-2-thione hydrochloride and methods of their preparation.

9. 发明专利

CA2648916C PREPARATION OF ESLICARBAZEPINE AND RELATED COMPOUNDS BY ASYMMETRIC HYDROGENATION 未知
公开(公告)号：CA2648916C
公开(公告)日：2015-11-17
申请号：CA2648916
申请日：2007-04-11
申请人： BIAL PORTELA & CA SA
发明人： YU BING , LI WENGE , LEARMONTH DAVID
IPC分类号： C07D223/22
摘要： A process for preparing a compound of the formula IA or IB, wherein R is a!kyl, aminoalkyl, halogenalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxy, phenyl or substituted phenyl or pyridyl group; the term alkyl means carbon chain, straight or branched, containing from 1 to 18 carbon atoms; the term halogen represents fluorine, chlorine, bromine or iodine; the term cycloalkyl represents a saturated alicyclic g.tau.oup with 3 to 6 carbon atoms; the term aryl represents unsubstituted phenyl group or phenyl substituted by alkoxy, halogen or nitro group, the process comprising asymmetric hydrogenation of a compound of the formula II, wherein R has the same meanings as above, using a chiral catalyst and a source of hydrogen.

10. 发明专利

ES2441794T3 Método para la preparación de 10,11-dihidro-10-hidroxi-5H-dibenz/b,f/azepin-5-carboxamida 未知
公开(公告)号：ES2441794T3
公开(公告)日：2014-02-06
申请号：ES06700407
申请日：2006-01-13
申请人： BIAL PORTELA & CA SA
发明人： LEARMONTH DAVID , WEINGAERTNER GUENTER , KRAEMER MATTHIAS
IPC分类号： C07D223/22 , A61K31/55 , C07D491/04
摘要： Un proceso para la preparación de 10,11-dihidro-10-hidroxi-5H-dibenz/b,f/azepin-5-carboxamida (1) medianteapertura de anillo de 1a,10b-dihidro-6H-dibenz/b,f/oxireno[d]azepin-6-carboxamida (5), caracterizado por que laapertura de anillo se realiza en condiciones de presión elevada, siendo la presión de 200 kPa a 4,0 MPa.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式