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1. 发明申请

WO2015114294A1 FIELD PATHOGEN IDENTIFICATION 审中-公开
标题翻译：现场病毒鉴定
公开(公告)号：WO2015114294A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/000027
申请日：2015-01-28
申请人： BG RESEARCH LTD
发明人： NAZARETH, Nelson , EDGE, David , TYLER, Adam
IPC分类号： B01L7/00 , B01L9/06 , G01N21/64 , B01L3/00
CPC分类号： B01L7/52 , B01L3/502753 , B01L3/50851 , B01L9/06 , B01L9/523 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/082 , B01L2200/147 , B01L2300/0654 , B01L2300/0672 , B01L2300/0681 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2400/0421 , C12Q1/6818 , C12Q1/686 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N35/0099 , G01N35/028 , G01N2021/6417 , G01N2021/6439 , G01N2021/6484 , G01N2035/00326 , G01N2035/00396 , G01N2201/068
摘要： A process for the identification of genetic material in a biological liquid sample and comprising the steps of injecting into a reaction vessel containing freeze dried PCR reagents and labelled primers sufficient pure water to liquify the reagents and primers; injecting the biological liquid sample into the reaction vessel; subjecting the reaction vessel contents to a cell disruption process, in the said reaction vessel; conducting pathogen specific polymerase chain reaction (PCR) on the contents of the reaction vessel; and monitoring the PCR and determining therefrom the presence of a specific genetic material. A device for performing the process comprises a heat reduction module (HRM); a peltier cell (TEC) the base plate whereof is contiguous with the HRM; a reaction vessel receiving heat transfer sleeve contiguous with a working face of the TEC; retention means for holding a reaction vessel in the sleeve; and means for driving the TEC.
摘要翻译：一种用于鉴定生物液体样品中的遗传物质的方法，包括以下步骤：将含有冷冻干燥的PCR试剂的反应容器和标记的引物注入足够的纯水以液化试剂和引物; 将生物液体样品注入反应容器中; 在反应容器中对反应容器内容物进行细胞破碎处理; 对病原体特异性聚合酶链反应（PCR）进行反应器内容物的测定; 并监测PCR并从中确定特定遗传物质的存在。一种用于执行该过程的装置包括一个减热模块（HRM）; 一个珀耳帖细胞（TEC），其底板与HRM相邻; 接收与TEC的工作面相邻的传热套筒的反应容器; 用于将反应容器保持在套筒中的保持装置; 以及驾驶TEC的手段。

2. 发明申请

WO2007138302A1 PERFORMANCE ISSUES IN USE OF VESSELS FOR BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：用于生物应用的船舶的性能问题
公开(公告)号：WO2007138302A1
公开(公告)日：2007-12-06
申请号：PCT/GB2007/001977
申请日：2007-05-29
申请人： BG RESEARCH LTD
发明人： WARD, David , EDGE, David , NAZARETH, Nelson
IPC分类号： B01L3/00 , G01N21/63
CPC分类号： G01N21/0332 , B01L3/5082 , B01L3/50851 , B01L2200/147 , B01L2300/042 , B01L2300/0654 , B01L2300/0663 , B01L2300/0829 , B01L2300/0887 , B01L2300/16 , B01L2300/1822 , B01L2300/1827 , G01N21/253 , G01N21/6452 , G01N2021/0382 , G01N2201/1211
摘要： A reaction vessel (10a) for containing a sample during a chemical, biological or biochemical process carried out therein and comprising a heating layer (13) formed of an electrically conductive material whereby an electric current passed therethrough generates heat, and a lining (17) thereto comprising an electrically insulative, thermally conductive material, and apparatus and process employing such vessels.
摘要翻译：一种用于在其中进行的化学，生物或生物化学过程中容纳样品的反应容器（10a），包括由导电材料形成的加热层（13），由此通过的电流产生热量，衬里（17）其包括电绝缘导热材料，以及使用这种容器的装置和方法。

3. 发明申请

WO2020025947A1 METHODS AND COMPOSITIONS TO DETECT MICROBES AND VIRAL PARTICLES 审中-公开
公开(公告)号：WO2020025947A1
公开(公告)日：2020-02-06
申请号：PCT/GB2019/052133
申请日：2019-07-30
申请人： BG RESEARCH LTD
发明人： NAZARETH, Nelson , EDGE, David , TYLER, Adam
IPC分类号： C12Q1/6806 , C12Q1/6848 , C12Q1/686
摘要： The present invention relates to rapid, safe and accurate methods of preparing samples that comprise microbial or viral nucleic acids for amplification and which can be used to detect the presence of highly pathogenic viruses such as Ebola. The methods involve heating the sample in the presence of a reagent that comprises a solvent and a detergent. Reagents and compositions are also provided.

4. 发明申请

WO2011157989A2 CELL DISRUPTION 审中-公开
标题翻译：细胞破坏
公开(公告)号：WO2011157989A2
公开(公告)日：2011-12-22
申请号：PCT/GB2011/000898
申请日：2011-06-15
申请人： BG RESEARCH LTD. , NAZARETH, Nelson , EDGE, David , WARD, David
发明人： NAZARETH, Nelson , EDGE, David , WARD, David
IPC分类号： C12N1/06
CPC分类号： C12N15/1003 , B01L3/5029 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/10 , B01L2200/141 , B01L2200/147 , B01L2300/044 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , C12N1/066 , C12N1/08 , F25B21/04
摘要： A process for the disruption of a biological cell comprising freezing, boiling or perhaps alternately freezing and boiling the material containing the biological cell using a thermoelectric cell a base face whereof is contiguous with a heat sink/source held at a substantially constant temperature and a working face. Apparatus for carrying out the disruption process comprises a peltier cell a base face of which is flexibly attached to a heat sink arranged to be kept at a constant temperature of around 50°C and a working face of which is contiguous with a reaction vessel or a reaction vessel holder. Reversal of the voltage in the peltier cell enables the working face alternately to reach below freezing and above boiling temperatures, and/or with use of a resistive wire on the vessel holder for heating with the TEC used purely for cooling The peltier cell base face is constructed of materials which tend to inhibit disintegration of the peltier cell brought about by expansion and contraction under heat.
摘要翻译：一种用于破坏生物细胞的方法，包括使用热电池冷冻，沸腾或者可能交替地冷冻和沸腾含有生物细胞的材料，其基面与保持在基本上恒定的温度的热沉/源连接，并且工作面对。用于进行破碎处理的装置包括一个珀耳帖细胞，其基面灵活地连接到散热器，该散热器被设置成保持在约50℃的恒定温度，其工作面与反应容器或反应容器在皮肤细胞中的电压反转使得工作面交替地达到低于冰点和沸点以上的温度，和/或使用电阻丝在容器保持器上用于纯化用于冷却的TEC加热珀耳帖细胞基面是由倾向于抑制由加热引起的膨胀和收缩引起的珀耳帖细胞崩解的材料构成。

5. 发明申请

WO2008107683A3 THERMAL CYCLING APPARATUS AND PROCESS 审中-公开
公开(公告)号：WO2008107683A3
公开(公告)日：2008-09-12
申请号：PCT/GB2008/000775
申请日：2008-03-06
申请人： BG RESEARCH LTD , WARD, David , NAZARETH, Nelson
发明人： WARD, David , NAZARETH, Nelson
IPC分类号： B01L7/00
摘要： A thermal cycling apparatus and process wherein at least one reaction vessel (14) is associated with a thermo-electric cooler (TEC) device (12), such as a peltier cell, arranged to provide both heating and cooling of the reaction vessel. One side of the TEC is associated with the said at least one reaction vessel (14) and the other side is arranged in use to be maintained at a temperature intermediate the highest temperature and the lowest temperature used in the thermal cycling operation. Electric current is supplied to the TEC in one direction whereby the said one side becomes- hotter than the said other side and then in the other direction whereby the said one side becomes cooler than the said other side.

6. 发明申请

WO2022195289A2 AN APPARATUS AND ASSOCIATED METHODS FOR THERMAL CYCLING 审中-公开
公开(公告)号：WO2022195289A2
公开(公告)日：2022-09-22
申请号：PCT/GB2022/050686
申请日：2022-03-18
申请人： BG RESEARCH LTD
发明人： NAZARETH, Nelson
IPC分类号： B01L3/00 , B01L7/00 , G01N35/00 , B65D17/00 , B04B15/02 , B01L2300/044 , B01L2300/0809 , B01L2300/1822 , B01L2400/0409 , B01L7/52 , G01N2035/00346
摘要： An apparatus comprising: first and second Peltier devices arranged in substantial opposition to one another; and a thermally conducting chamber defined substantially between the first and second Peltier devices and configured to enclose a reaction vessel during use to facilitate a transfer of heat between the reaction vessel and the Peltier devices.

7. 发明申请

WO2019207308A3 METHODS 审中-公开
公开(公告)号：WO2019207308A3
公开(公告)日：2019-10-31
申请号：PCT/GB2019/051156
申请日：2019-04-25
申请人： BG RESEARCH LTD
发明人： NAZARETH, Nelson , EDGE, David , TYLER, Adam , SADLER, Matthew
IPC分类号： B01L3/00 , C12Q1/686 , B01L7/00
摘要： The present invention relates to bio-secure means for the detection of pathogens and provides a bio-secure reaction vessel and methods of preparing a sample for PCR-based pathogen detection. The reaction vessel comprises a reaction chamber portion (1); a cap holder portion (2); and a cap (3). Two points of security, such as two O-ring seals (9, 10), are provided between the cap (3) and the reaction chamber portion (1). A first seal (9) may be located at a top of the cap holder portion (2) and a second seal (10) may be located at a base of the cap (10).

8. 发明申请

WO2015114296A1 APPARATUS AND METHOD FOR THERMOCYCLIC BIOCHEMICAL OPERATIONS 审中-公开
标题翻译：用于热生物化学操作的装置和方法
公开(公告)号：WO2015114296A1
公开(公告)日：2015-08-06
申请号：PCT/GB2015/000029
申请日：2015-01-28
申请人： BG RESEARCH LTD
发明人： NAZARETH, Nelson , EDGE, David , TYLER, Adam
IPC分类号： G01N21/64 , B01L3/00 , B01L7/00 , C12Q1/68
CPC分类号： B01L7/52 , B01L3/502753 , B01L3/50851 , B01L9/06 , B01L9/523 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2200/082 , B01L2200/147 , B01L2300/0654 , B01L2300/0672 , B01L2300/0681 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2300/185 , B01L2400/0421 , C12Q1/6818 , C12Q1/686 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N35/0099 , G01N35/028 , G01N2021/6417 , G01N2021/6439 , G01N2021/6484 , G01N2035/00326 , G01N2035/00396 , G01N2201/068
摘要： Process and apparatus for the optimisation of DNA detection and comprising: charging a plurality of reaction vessels with reagents and primers suspected of being suitable for the particular sample, in various quantities; placing in each reaction vessel a sample of the target DNA; subjecting each vessel concurrently to PCR; simultaneously observing optically the whole PCR process in each reaction vessel.
摘要翻译：用于优化DNA检测的方法和装置，包括：以多种量装入多个反应容器，试剂和引物被认为适合特定样品; 在每个反应容器中放置目标DNA的样品; 每个血管同时进行PCR; 同时在每个反应容器中光学地观察整个PCR过程。

9. 发明申请

WO2012063011A2 HEATING AND COOLING LOW VOLUME BIOLOGICAL REACTION VESSELS 审中-公开
标题翻译：加热和冷却低体积生物反应容器
公开(公告)号：WO2012063011A2
公开(公告)日：2012-05-18
申请号：PCT/GB2011/001565
申请日：2011-11-08
申请人： BG RESEARCH LTD , NAZARETH, Nelson , DRISCOLL, Antony , EDGE, David
发明人： NAZARETH, Nelson , DRISCOLL, Antony , EDGE, David
IPC分类号： B01L7/00
CPC分类号： F25B21/02 , B01L7/52 , B01L9/06 , B01L2300/0627 , B01L2300/0832 , B01L2300/1822 , B01L2300/1827 , B01L2300/1894 , B65D81/38
摘要： A vessel cup assembly for receiving a chemical and/or biological reaction process vessel containing reactants and processing the reaction therein and comprising: a reaction vessel receiving portion; a heater portion; and a cooling portion; and wherein the assembly is of integral construction.
摘要翻译：一种用于接收含有反应物并在其中处理反应的化学和/或生物反应处理容器的容器杯组件，包括：反应容器接收部分; 加热器部分; 和冷却部分; 并且其中所述组件是整体结构。

10. 发明申请

WO2010010361A1 IMPROVEMENTS IN REACTOR APPARATUS 审中-公开
标题翻译：反应器装置的改进
公开(公告)号：WO2010010361A1
公开(公告)日：2010-01-28
申请号：PCT/GB2009/001838
申请日：2009-07-23
申请人： BG RESEARCH LTD , WARD, David , NAZARETH, Nelson
发明人： WARD, David , NAZARETH, Nelson
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2300/1827 , B01L2300/185 , B01L2300/1883
摘要： Apparatus for effecting a chemical or biological reaction comprising: a heat removal module comprising a thermally conductive material having therein a channel adapted for the flow of a coolant liquid, a heating element mounted upon the HRM; and a layer of thermally insulative material between the HRM and the heater, the thermally insulative material having the property of restricting heat loss from the heating element into the HRM while the heating element is in heating mode while permitting heat transfer therethrough when the heating element is not in heating mode.
摘要翻译：用于实现化学或生物反应的装置，包括：散热模块，其包括导热材料，其中具有适于冷却剂液体流动的通道，安装在所述HRM上的加热元件; 以及在HRM和加热器之间的绝热材料层，该热绝缘材料具有在加热元件处于加热模式时限制从加热元件到HRM的热损失的特性，同时当加热元件为不在加热模式。

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