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1. 发明申请

WO9927916A3 METHOD FOR PRODUCING SOLID DOSING FORMS 审中-公开
标题翻译：生产固体剂型的方法
公开(公告)号：WO9927916A3
公开(公告)日：1999-08-12
申请号：PCT/EP9807716
申请日：1998-11-30
申请人： BASF AG , KOTHRADE STEPHAN , MEFFERT HELMUT , BERNDL GUNTHER , ERNST ANDREAS , SANNER AXEL
发明人： KOTHRADE STEPHAN , MEFFERT HELMUT , BERNDL GUNTHER , ERNST ANDREAS , SANNER AXEL
IPC分类号： A61K47/32 , A23K20/10 , A23K40/10 , A23K40/20 , A23L27/00 , A23L33/10 , A61K9/16 , A61K9/20 , A61K9/22 , A61K31/277 , A61K31/421
CPC分类号： A61K31/421 , A23K20/10 , A23K40/10 , A23K40/20 , A23K40/25 , A23L27/74 , A23L33/10 , A23V2002/00 , A61K9/2027 , A61K9/2095 , A61K31/277 , A23V2200/21 , A23V2250/30 , A23V2250/51088 , A23V2250/5118
摘要： The invention relates to a method for producing solid dosing forms by mixing at least one polymeric binding agent, at least one active substance, and optional common additives while producing a plastic mixture and during shaping, whereby a copolymer from a N-vinyl lactam and from an copolymerizable monomer with a hydrophobic radical is used as a polymeric binding agent. Dosing forms which slowly release the active substance are obtained in a simple and economical manner.
摘要翻译：本发明涉及一种用于通过将至少一种聚合物粘合剂，至少一种活性成分，并在适当的常规添加剂，以形成塑料混合物制备固体剂型，和成形，使用如聚合物粘合剂的N-乙烯基内酰胺的共聚物和可共聚的单体与疏水性残留物一起使用。以简单和廉价的方式，获得缓慢释放活性成分的剂型。

2. 发明专利

CA2253695A1 THE PRODUCTION OF SOLID DOSAGE FORMS 未知
公开(公告)号：CA2253695A1
公开(公告)日：1999-06-01
申请号：CA2253695
申请日：1998-11-30
申请人： BERNDL GUNTHER , SANNER AXEL , KOTHRADE STEPHAN , ERNST ANDREAS
发明人： BERNDL GUNTHER , SANNER AXEL , KOTHRADE STEPHAN , ERNST ANDREAS
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K47/32 , A61K47/34 , A01N25/10 , A23K1/16 , A23L1/03 , A61K7/46
摘要： Solid dosage forms are produced by mixing at least one polymeric binder, at least one active ingredient and, where appropriate, conventional additives, to form a plastic mixture, by using a homo- or copolymer of N-vinylcaprolactam as polymeric binder. It is possible in this way to produce solid dosage forms with rapid release of the active ingredient in a simple and low-cost manner.

3. 发明专利

CA2253700A1 THE PRODUCTION OF SOLID DOSAGE FORMS 未知
公开(公告)号：CA2253700A1
公开(公告)日：1999-06-01
申请号：CA2253700
申请日：1998-11-30
申请人： ERNST ANDREAS , SANNER AXEL , KOTHRADE STEPHAN
发明人： ERNST ANDREAS , SANNER AXEL , KOTHRADE STEPHAN
IPC分类号： A01N25/14 , A23K20/10 , A23K40/10 , A23K40/20 , A23L27/00 , A23L33/10 , A61K9/20 , A61K31/167 , A61K31/277 , A61K47/32 , A61K47/34 , A01N25/10 , A23K1/16 , A23L1/30
摘要： Solid dosage forms are produced by mixing and melting at least one polymeric binder, where appropriate at least one active ingredient and, where appropriate, conventional additives, extruding the mixture and shaping, wherein homo- and/or copolymers of 2-substituted oxazolines are used as polymeric binder.

4. 发明专利

CA2316060C UNDERWATER PELLETIZING OF ACTIVE-COMPOUND-CONTAINING MELTS 未知
公开(公告)号：CA2316060C
公开(公告)日：2009-05-19
申请号：CA2316060
申请日：2000-08-16
申请人： KESSLER THOMAS , BERNDL GUNTHER , ERNST ANDREAS
发明人： KESSLER THOMAS , BERNDL GUNTHER , ERNST ANDREAS
IPC分类号： A61K9/16 , A01N25/10 , A01N25/12 , A23K40/10 , A23K40/20 , A23L33/15 , A23L33/155 , A23P1/02 , A61J3/00 , A61J3/06 , A61K9/19 , A61K47/32 , B01J2/20 , B29B9/06 , C08J3/205
摘要： A process for producing pellets comprising biologically active substances in which the biologically active substances are homogeneously dispersed in a matrix based on at least one thermoplastic polymer, which polymer has in aqueous medium a pH-dependent solubility, by homogeneous mixing of the starting materials in the melt and subsequent extrusion and shaping, which comprises the shaping being performed in a cooling medium in which the pellets are not soluble or dispersible.

5. 发明专利

CA2316060A1 UNDERWATER PELLETIZING OF ACTIVE-COMPOUND-CONTAINING MELTS 未知
公开(公告)号：CA2316060A1
公开(公告)日：2001-03-10
申请号：CA2316060
申请日：2000-08-16
申请人： KESSLER THOMAS , BERNDL GUNTHER , ERNST ANDREAS
发明人： KESSLER THOMAS , BERNDL GUNTHER , ERNST ANDREAS
IPC分类号： A01N25/10 , A01N25/12 , A23K40/10 , A23K40/20 , A23L33/15 , A23L33/155 , A23P1/02 , A61J3/00 , A61K9/16 , A61K9/19 , A61K47/32 , B01J2/20 , B29B9/06 , C08J3/205 , A61K9/20 , A61J3/06 , A23P1/12
摘要： A process for producing pellets comprising biologically active substances in which the biologically active substances are homogeneously dispersed in a matrix based on at least one thermoplastic polymer, which polymer has in aqueous medium a pH-dependent solubility, by homogeneous mixing of the starting materials in the melt and subsequent extrusion and shaping, which comprises the shaping being performed in a cooling medium in which the pellets are not soluble or dispersible.

6. 发明申请

WO2012020289A3 SPECIFIC ACTIVE SITE INHIBITORS OF ENZYMES OR SUBSTRATE BINDING PARTNERS AND METHODS OF PRODUCING SAME 审中-公开
标题翻译：酶或底物结合的特定活性位点抑制剂及其生产方法
公开(公告)号：WO2012020289A3
公开(公告)日：2012-05-18
申请号：PCT/IB2011001663
申请日：2011-06-08
申请人： UNIV TORONTO , SIDHU SACHDEV , BEATTY LINDA , ERNST ANDREAS
发明人： SIDHU SACHDEV , BEATTY LINDA , ERNST ANDREAS
IPC分类号： C07K14/47
CPC分类号： C07K14/435 , A61K38/17 , C07K14/47
摘要： The present disclosure provides a method of producing enzyme- specific inhibitors or substrate binding partners comprising: identifying active site residues of the substrate in the enzyme substrate complex or in substrate binding partner-substrate complex; randomizing the active site residues to produce a combinatorial library of substrate variants; and selecting substrate variants that inhibit enzyme activity or bind substrate as substrate-specific binding partners. The present disclosure also provides ubiquitin enzyme specific inhibitors and ubiquitin variants that bind ubiquitin interaction motifs.
摘要翻译：本公开提供了生产酶特异性抑制剂或底物结合配偶体的方法，包括：鉴定酶底物复合物或底物结合配偶体 - 底物复合物中底物的活性位点残基; 使活性位点残基随机化以产生底物变体的组合文库; 并选择抑制酶活性或结合底物作为底物特异性结合配偶体的底物变体。本公开还提供了结合遍在蛋白相互作用基序的遍在蛋白酶特异性抑制剂和泛素变体。

7. 发明申请

WO2004041617A3 CARGO SECURING DEVICE 审中-公开
标题翻译：货物安全装置
公开(公告)号：WO2004041617A3
公开(公告)日：2004-07-29
申请号：PCT/EP0312247
申请日：2003-11-03
申请人： BOMBARDIER TRANSP GMBH , ERNST ANDREAS , METZE HANS-JURGEN , WIELOCH BERTRAM , NICOLIN DR JOHANNES
发明人： ERNST ANDREAS , METZE HANS-JURGEN , WIELOCH BERTRAM , NICOLIN DR JOHANNES
IPC分类号： B60P7/08 , B61D45/00
CPC分类号： B61D45/001 , B60P7/0892
摘要： A cargo securing device (2) adapted to resist shifting of a load (30) located on a cargo surface (1), comprises a securing member having a first face (19) for contacting the load and a second face (24) for contacting the cargo surface. The securing member is provided with a latch (10) engageable in the cargo surface whereby a force exerted by the load on the first face is transmitted through the latch to the cargo surface to prevent shifting of the load. The cargo securing device is provided with a load release mechanism adapted to release the force on the latch to facilitate its disengagement from the cargo surface. The device may be provided with a flexible anchor (8) by which the securing member may be slid along a slot in the cargo surface. It is particularly adapted for securing loads against shifting during rail transport.
摘要翻译：适于阻止位于货物表面（1）上的载荷（30）的移动的货物固定装置（2）包括一个固定构件，该固定构件具有用于接触该载荷的第一面（19）和用于接触的第二面（24）货物表面。固定构件设置有可接合在货物表面中的闩锁（10），由此由第一面上的负载施加的力通过闩锁传递到货物表面以防止载荷的移动。货物固定装置设置有适于将力释放在闩锁上以便于其从货物表面脱离的卸载机构。该装置可以设置有柔性锚固件（8），固定构件可以沿着货物表面中的狭槽滑动。它特别适用于在铁路运输期间确保负载抵抗换挡。

8. 发明申请

WO2011039184A2 METHOD AND DEVICE FOR MANAGING OBJECT VIEW DATA IN AN OBJECT DATABASE 审中-公开
标题翻译：用于管理对象数据库中的对象视图数据的方法和设备
公开(公告)号：WO2011039184A2
公开(公告)日：2011-04-07
申请号：PCT/EP2010064356
申请日：2010-09-28
申请人： FRAUNHOFER GES FORSCHUNG , ERNST ANDREAS , RUF TOBIAS , KUEBLBECK CHRISTIAN
发明人： ERNST ANDREAS , RUF TOBIAS , KUEBLBECK CHRISTIAN
IPC分类号： G06K9/62
CPC分类号： G06K9/00295 , G06K9/6255
摘要： A method for managing object view data in an object database comprises detecting a view of an object in an image and comparing view data of the detected view to object view data of object views of objects in an object database on the basis of a comparison criterion. The method further comprises storing the view data of the detected view together with time information in the object database as new object view data when the comparison shows that the detected view does not correspond to any object view in the object database, or changing time information of existing object view data of an object view in the object database when the comparison shows that the detected view corresponds to the object view. The method further comprises managing the object view data in the object database on the basis of the time information of the object view data.
摘要翻译：一种用于在对象数据库管理对象视图的数据的方法包括：检测图像中的对象的视图和视图通过基于比较标准的在对象数据库中的对象的对象视图的对象视图数据捕获的视图的数据进行比较。此外，该方法包括存储连同时间信息在对象数据库作为新的对象视图的数据中获取的视图的视图数据，当所述比较指示对应于在对象数据库中没有对象视图所获取的视图，或从在对象视图的现有对象视图数据变更的时间的信息对象数据库如果比较显示捕获的视图对应于对象视图。另外，该方法包括基于对象视图数据的时间信息来管理对象数据库中的对象视图数据。

9. 发明申请

WO2008102019A3 USE OF WATER-DISPERSIBLE CAROTINOID NANOPARTICLES AS TASTE MODULATORS, TASTE MODULATORS CONTAINING WATER-DISPERSIBLE CAROTINOID NANOPARTICLES, AND METHOD FOR TASTE MODULATION 审中-公开
标题翻译：使用水分散性类胡萝卜素纳米粒子口味调节剂，口感调节剂含有水分散性类胡萝卜素纳米粒子和方法味道调制
公开(公告)号：WO2008102019A3
公开(公告)日：2009-05-22
申请号：PCT/EP2008052273
申请日：2008-02-25
申请人： BASF SE , MATUSCHEK MARKUS , ERNST ANDREAS , KOEPSEL CHRISTIAN , JAGER MARTIN B , KLEBER ALICE , KROHN MICHAEL , ZINKE HOLGER
发明人： MATUSCHEK MARKUS , ERNST ANDREAS , KOEPSEL CHRISTIAN , JAGER MARTIN B , KLEBER ALICE , KROHN MICHAEL , ZINKE HOLGER
IPC分类号： A23L1/22 , A23L1/275
CPC分类号： A23L2/56 , A23L2/58 , A23L2/60 , A23L5/44 , A23L5/47 , A23L27/204 , A23L27/30 , A23L27/86 , A23P10/30 , A23V2002/00 , A23V2200/25 , A23V2200/16 , A23V2200/132 , A23V2200/044 , A23V2200/224 , A23V2250/211 , A23V2250/213 , A23V2250/242
摘要： The invention relates to the use of at least one type of water-dispersible carotinoid nanoparticles as taste modulators in material compositions; to a method for taste modulation of material compositions, according to which at least one type of water-dispersible carotinoid nanoparticles is added to material compositions; and to taste modulators for material compositions, containing (A) at least one type of water-dispersible carotinoid nanoparticles, and (B) at least one azo compound containing at least one azo group.
摘要翻译：至少一种类型的水可分散的类胡萝卜素纳米颗粒作为在材料组合物中的味道调节剂的用途; 一种用于物质的组合物，其中至少一种类型的水可分散的类胡萝卜素纳米颗粒添加物质的组合物的味道的调制方法; 以及味道调节剂对材料的组合物，其包含至少（A）在一种类型的水可分散的类胡萝卜素纳米粒子和（B）至少一种偶氮化合物包含至少一个偶氮基团。

10. 发明申请

WO2004012696A8 RETINOID-CONTAINING PREPARATIONS 审中-公开
标题翻译：类视黄醇含筹备工作
公开(公告)号：WO2004012696A8
公开(公告)日：2005-01-20
申请号：PCT/EP0307700
申请日：2003-07-16
申请人： BASF AG , JENTZSCH AXEL , HABICH ANDREAS , KOEPSEL CHRISTIAN , ERNST ANDREAS
发明人： JENTZSCH AXEL , HABICH ANDREAS , KOEPSEL CHRISTIAN , ERNST ANDREAS
IPC分类号： A23L33/15 , A23L33/155 , A61K8/67 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61K7/48 , A61K7/02 , A61K7/42
CPC分类号： A61Q19/00 , A61K8/671 , A61K8/676 , A61K8/678 , A61K2800/522 , A61K2800/59 , A61Q1/02 , A61Q17/04
摘要： Disclosed are preparations containing at least one retinoid, at least one water-soluble antioxidant, and at least one oil-soluble antioxidant. The invention is characterized by the fact that the preparations contain at least 1 part by weight of one or several water-soluble antioxidants and 0.1 to 100 parts by weight of one or several oil-soluble antioxidants per part by weight of retinoid, the content of one or several water-soluble antioxidants ranging between 0.05 and 0.8 percent by weight relative to the total quantity of the preparations.
摘要翻译：含有至少一种类维生素A，至少一种水溶性抗氧化剂和至少一种油溶性的抗氧化剂，按重量计的一种或多种油溶性抗氧化剂，其中的特征在于，在每部分中的制剂重量的类视黄醇存在至少1重量份的一种或多种水溶性的抗氧化剂和0.1〜100份的制剂在0.05的范围内的一种或多种水溶性的抗氧化剂的含量以0.8重量％，基于所述制剂的总量。

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