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    • 7. 发明专利
    • ES2128583T3
    • 1999-05-16
    • ES94928281
    • 1994-10-01
    • BEIERSDORF AG
    • GOHLA SVENMULLER ANJANIELSEN JENS
    • A61K8/06A61K9/113A61K8/20A61K8/34A61K8/36A61K8/37A61K8/39A61K8/73A61K8/86A61K8/89A61K8/92A61K8/97A61Q19/00B01J13/00C09K23/34C09K23/42A61K7/00
    • PCT No. PCT/DE94/01157 Sec. 371 Date Jun. 17, 1996 Sec. 102(e) Date Jun. 17, 1996 PCT Filed Oct. 1, 1994 PCT Pub. No. WO95/17155 PCT Pub. Date Jun. 29, 1995Multiple emulsions of the W/O/W type having a continuous external aqueous phase, an oily phase dispersed therein and a second (internal) aqueous phase dispersed in this oily phase, comprising (a) at least one emulsifier whose lipophilicity increases with increasing temperature and the hydrophilicity of which increases with decreasing temperature, the emulsifier or emulsifiers changing from an HLB value 10 in the temperature range of 40 DEG -90 DEG C., the HLB value of the emulsifier or emulsifiers at room temperature being between 11 and 18, the emulsifier not being completely soluble in the oily phase when the oily phase is combined with the aqueous phase, (b) an oily phase, the base constituent(s) being physiologically tolerated oils, fats and waxes having a "required HLB value" (RHLB) of 10-20, and/or a polarity (determined in surface tension units), individually or in combination, of less than 30 mN/m, (c) an external and an internal aqueous phase, the aqueous phases comprising 0.1-5% by weight of organic and/or inorganic electrolytes with mono-, di- or trivalent cations, (e) optionally further auxiliaries and/or additives to stabilize the multiple emulsion droplets, after in situ formation thereof, and (f) optionally other bases, auxiliaries, additives and/or active compounds customary in cosmetics or medical galenics.