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1. 发明申请

WO2005070037A3 AUTOMATED MEDIA OPTIMIZATION TECHNOLOGY 审中-公开
标题翻译：自动化媒体优化技术
公开(公告)号：WO2005070037A3
公开(公告)日：2005-09-29
申请号：PCT/US2005000269
申请日：2005-01-06
申请人： BECTON DICKINSON CO , HAALAND PERRY D , CHANEY BRYCE N , HOLDREAD STACY D
发明人： HAALAND PERRY D , CHANEY BRYCE N , HOLDREAD STACY D
IPC分类号： G01N1/28 , G01N33/48 , G01N33/50 , G01N35/10 , G06F19/00
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/5044 , G01N35/1011 , G01N2001/282
摘要： An automated system and method for identifying agents capable of eliciting a phenotypic change in a cell-type. The method includes the steps of providing a statistical design including generic factor names, factor levels and experimental runs, and utilizing a software program to generate a computer representation of the statistical design by automatically mapping the identities of the agents to the generic factor names, concentrations or amounts of the agents to the factor levels, and the locations of the receptacles to the experimental runs. The method also includes placing different mixtures of single agents, such as peptones, into receptacles in the array based on the computer representation of the statistical design, contacting the placed mixtures with cells, acquiring experimental data from the contacted cells, and utilizing a processor including an algorithm for comparing the acquired data with the statistical design to identify peptone combinations and concentrations that optimize cell culture conditions.
摘要翻译：用于鉴定能够引发细胞型表型变化的试剂的自动化系统和方法。该方法包括以下步骤：提供包括通用因子名称，因子水平和实验运行的统计设计，以及利用软件程序通过将代理的身份自动映射到通用因子名称，浓度来生成统计设计的计算机表示或剂量到因子水平的量，以及容器到实验运行的位置。该方法还包括基于统计设计的计算机表示将单个试剂（例如胨）的不同混合物放置在阵列中的容器中，将放置的混合物与细胞接触，从接触的细胞获取实验数据，以及使用包括用于将获取的数据与统计设计进行比较以鉴定优化细胞培养条件的蛋白胨组合和浓度的算法。

2. 发明专利

CA2537997A1 METHODS OF SURFACE MODIFICATION TO ENHANCE CELL ADHESION 未知
公开(公告)号：CA2537997A1
公开(公告)日：2005-04-14
申请号：CA2537997
申请日：2004-08-26
申请人： BECTON DICKINSON CO
发明人： LIEBMANN-VINSON ANDREA , CHANEY BRYCE N
IPC分类号： C12N5/00 , C12M3/00 , C12N11/00 , C12N11/06 , C12N11/16 , G01N33/543
摘要： The current invention relates to methods of producing a surface with enhance d cell-formed surface such that at least one intermediate adhesive properties comprising treating a pre reactive group is exposed on the surface. The exposed intermediate reactive group is then reacted to create a self-assembl ed monolayer, comprising at least one reactive group. The self~-assembled monolayer is created non-mechanically. The reactive group is then coupled to at least one cell-adhesive molecule. The current invention also relates to cell culture devices comprising at least one oxygen-sensing compound and a cell-adhesive molecule.

3. 发明专利

CA2537994A1 METHODS OF SURFACE MODIFICATION OF A FLEXIBLE SUBSTRATE TO ENHANCE CELL ADHESION 未知
公开(公告)号：CA2537994A1
公开(公告)日：2005-04-14
申请号：CA2537994
申请日：2004-08-26
申请人： BECTON DICKINSON CO
发明人： LIEBMANN-VINSON ANDREA , CHANEY BRYCE N
IPC分类号： C12M3/00 , B05D1/18 , B05D3/12 , C12N5/00
摘要： The present invention provides methods of producing a surface with enhanced cell~adhesive properties comprising applying a stress to a polymeric matrix. The strained matrix is then modified by grafting a self-assembled monolayer onto the strained matrix, with the self~-assembled monolayer comprising at least one exposed functional group. At least one cell~adhesive molecule can then be coupled to the at least one exposed functional group on the self- ~assembled monolayer to produce a surface with enhanced cell-adhesive properties.

4. 发明专利

CA2553092A1 AUTOMATED MEDIA OPTIMIZATION TECHNOLOGY 未知
公开(公告)号：CA2553092A1
公开(公告)日：2005-08-04
申请号：CA2553092
申请日：2005-01-06
申请人： BECTON DICKINSON CO
发明人： CHANEY BRYCE N , HOLDREAD STACY D , HAALAND PERRY D
IPC分类号： G01N33/48 , G01N1/28 , G01N33/50 , G01N35/10 , G06F19/00
摘要： An automated system and method for identifying agents capable of eliciting a phenotypic change in a cell-type. The method includes the steps of providing a statistical design including generic factor names, factor levels and experimental runs, and utilizing a software program to generate a computer representation of the statistical design by automatically mapping the identities of the agents to the generic factor names, concentrations or amounts of the agents to the factor levels, and the locations of the receptacles to the experimental runs. The method also includes placing different mixtures of single agents, such as peptones, into receptacles in t he array based on the computer representation of the statistical design, contacting the placed mixtures with cells, acquiring experimental data from the contacted cells, and utilizing a processor including an algorithm for comparing the acquired data with the statistical design to identify peptone combinations and concentrations that optimize cell culture conditions.

5. 发明专利

AU2005206700A1 Automated media optimization technology 未知
公开(公告)号：AU2005206700A1
公开(公告)日：2005-08-04
申请号：AU2005206700
申请日：2005-01-06
申请人： BECTON DICKINSON CO
发明人： CHANEY BRYCE N , HAALAND PERRY D , HOLDREAD STACY D
IPC分类号： G06F19/00 , G01N1/28 , G01N33/48 , G01N33/50 , G01N35/10
摘要： An automated system and method for identifying agents capable of eliciting a phenotypic change in a cell-type. The method includes the steps of providing a statistical design including generic factor names, factor levels and experimental runs, and utilizing a software program to generate a computer representation of the statistical design by automatically mapping the identities of the agents to the generic factor names, concentrations or amounts of the agents to the factor levels, and the locations of the receptacles to the experimental runs. The method also includes placing different mixtures of single agents, such as peptones, into receptacles in the array based on the computer representation of the statistical design, contacting the placed mixtures with cells, acquiring experimental data from the contacted cells, and utilizing a processor including an algorithm for comparing the acquired data with the statistical design to identify peptone combinations and concentrations that optimize cell culture conditions.

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