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1. 发明申请

WO2005070037A2 AUTOMATED MEDIA OPTIMIZATION TECHNOLOGY 审中-公开
标题翻译：自动媒体优化技术
公开(公告)号：WO2005070037A2
公开(公告)日：2005-08-04
申请号：PCT/US2005/000269
申请日：2005-01-06
申请人： BECTON, DICKINSON AND COMPANY , HAALAND, Perry, D. , CHANEY, Bryce, N. , HOLDREAD, Stacy, D.
发明人： HAALAND, Perry, D. , CHANEY, Bryce, N. , HOLDREAD, Stacy, D.
IPC分类号： G01N1/28 , G01N33/48 , G01N33/50 , G01N35/10 , G06F19/00
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/5044 , G01N35/1011 , G01N2001/282
摘要： An automated system and method for identifying agents capable of eliciting a phenotypic change in a cell-type. The method includes the steps of providing a statistical design including generic factor names, factor levels and experimental runs, and utilizing a software program to generate a computer representation of the statistical design by automatically mapping the identities of the agents to the generic factor names, concentrations or amounts of the agents to the factor levels, and the locations of the receptacles to the experimental runs. The method also includes placing different mixtures of single agents, such as peptones, into receptacles in the array based on the computer representation of the statistical design, contacting the placed mixtures with cells, acquiring experimental data from the contacted cells, and utilizing a processor including an algorithm for comparing the acquired data with the statistical design to identify peptone combinations and concentrations that optimize cell culture conditions.
摘要翻译：用于鉴定能够引发细胞类型的表型变化的试剂的自动系统和方法。该方法包括以下步骤：提供包括通用因子名称，因子水平和实验运行的统计设计，并且利用软件程序通过自动将代理的身份映射到通用因子名称，浓度来生成统计设计的计算机表示或药剂的量与因子水平，以及容器的位置到实验运行。该方法还包括基于统计设计的计算机表示将单一试剂例如蛋白胨的不同混合物放入阵列中的容器中，将放置的混合物与细胞接触，从接触的细胞获取实验数据，并且利用处理器一种将获得的数据与统计设计进行比较的算法，以识别优化细胞培养条件的蛋白胨组合和浓度。

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