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    • 4. 发明申请
    • BREATHABLE FILMS WITH MICROBIAL BARRIER PROPERTIES
    • 具有微生物屏障特性的透气膜
    • WO2018057869A1
    • 2018-03-29
    • PCT/US2017/052927
    • 2017-09-22
    • BECTON, DICKINSON AND COMPANY
    • ZHANG, JianbinHERMEL-DAVIDOCK, TheresaCOUGHLIN, Edward Bryan
    • C08J5/18A61L15/00
    • Films for medical devices and/or packaging include polyethylene-poly(ethylene oxide) amphiphilic graft copolymers (PE- g -PEO) in their base polymer formulations of polyethylene and poly(ethylene oxide). The films may be treated to include a nitric-oxide releasing agent incorporated into the PE- g -PEO. Also, microbial agents for inclusion in medical devices are provided, which comprise: an olefin-poly(ethylene oxide) amphiphilic graft copolymer, wherein a portion of the poly(ethylene oxide) comprises end groups converted to a nitric oxide-releasing agent. The amphiphilic graft copolymer of the microbial agents may comprise a polyethylene-poly(ethylene oxide) amphiphilic graft copolymer (PE- g -PEO), a polypropylene-poly(ethylene oxide) amphiphilic graft copolymer (PP- g -PEO), or mixtures thereof.
    • 用于医疗装置和/或包装的薄膜包括聚乙烯 - 聚(环氧乙烷)两亲性接枝共聚物(PE-g-PEO)在其聚乙烯和聚 (环氧乙烷)。 该膜可以被处理成包括并入PE-g-PEO中的一氧化氮释放剂。 此外,提供了用于包含在医疗装置中的微生物剂,其包含:烯烃 - 聚(环氧乙烷)两亲接枝共聚物,其中一部分聚(环氧乙烷)包含转化为一氧化氮释放剂的端基。 微生物剂的两亲性接枝共聚物可包含聚乙烯 - 聚(环氧乙烷)两亲接枝共聚物(PE-g -PEO),聚丙烯 - 聚(环氧乙烷)两亲接枝共聚物(PP- g-PEO)或其混合物。