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1. 发明申请

WO2011066008A3 BLOOD TRANSCRIPTIONAL SIGNATURE OF ACTIVE VERSUS LATENT MYCOBACTERIUM TUBERCULOSIS INFECTION 审中-公开
标题翻译：活动性血清MYCOBACTERIUM TUBCCOSOS感染的血液转录水平
公开(公告)号：WO2011066008A3
公开(公告)日：2011-07-21
申请号：PCT/US2010046042
申请日：2010-08-19
申请人： BAYLOR RES INST , BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN , MEDICAL RES COUNCIL ON BEHALF OF THE NAT INST FOR MEDICAL RES , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： C12Q1/68 , C12N15/31 , C12R1/32 , G01N33/15
CPC分类号： C12Q1/689 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： The present invention includes methods, systems and kits for distinguishing between active and latent Mycobacterium tuberculosis infection in a patient suspected of being infected with Mycobacterium tuberculosis, the method including the steps of obtaining a patient gene expression dataset from a patient suspected of being infected with Mycobacterium tuberculosis; sorting the patient gene expression dataset into one or more gene modules associated with Mycobacterium tuberculosis infection; and comparing the patient gene expression dataset for each of the one or more gene modules to a gene expression dataset from a non-patient; wherein an increase or decrease in the totality of gene expression in the patient gene expression dataset for the one or more gene modules is indicative of active Mycobacterium tuberculosis infection.
摘要翻译：本发明包括用于区分疑似感染结核分枝杆菌的患者中的活性和潜在结核分枝杆菌感染的方法，系统和试剂盒，所述方法包括以下步骤：从疑似感染分枝杆菌的患者获得患者基因表达数据集结核; 将患者基因表达数据集分类成与结核分枝杆菌感染相关的一个或多个基因模块; 以及将所述一个或多个基因模块中的每一个的患者基因表达数据集与来自非患者的基因表达数据集进行比较; 其中所述一个或多个基因模块的患者基因表达数据集中基因表达的总和的增加或减少指示活动性结核分枝杆菌感染。

2. 发明公开

EP2300823A4 BLOOD TRANSCRIPTIONAL SIGNATURE OF MYCOBACTERIUM TUBERCULOSIS INFECTION 审中-公开
标题翻译：感染的结核分枝tuberculosum血液转录签名
公开(公告)号：EP2300823A4
公开(公告)日：2012-03-14
申请号：EP09771053
申请日：2009-06-25
申请人： BAYLOR RES INST , NAT INST FOR MEDICAL RES , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： G01N33/50 , C12Q1/00 , G01N33/53
CPC分类号： G01N33/5695 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2800/60

3. 发明专利

PE03862011A1 PATRON DE TRANSCRIPCION SANGUINEA DE LA INFECCION POR MYCOBACTERIUM TUBERCULOSIS 未知
公开(公告)号：PE03862011A1
公开(公告)日：2011-07-03
申请号：PE0011822010
申请日：2009-06-25
申请人： BAYLOR RES INST , NAT INST FOR MEDICAL RES , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： G01N33/50 , C12Q1/00 , G01N33/53
CPC分类号： G01N33/5695 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , G01N2800/60
摘要： REFERIDA A UN METODO PARA DIFERENCIAR UNA INFECCION POR MYCOBACTERIUM TUBERCULOSIS ACTIVA DE UNA LATENTE EN UN PACIENTE, QUE COMPRENDE OBTENER UN CONJUNTO DE DATOS DE EXPRESION GENICA DE UNA MUESTRA DE SANGRE ENTERA DE UN PACIENTE Y DETERMINAR LA EXPRESION DIFERENCIAL DE UNO O MAS MODULOS DE EXPRESION GENICA QUE DISTINGUEN ENTRE INDIVIDUOS INFECTADOS Y NO INFECTADOS, DONDE EL CONJUNTO DE DATOS DEMUESTRA UN CAMBIO AGREGADO EN LOS NIVELES DE POLINUCLEOTIDOS EN UNO O MAS MODULOS DE EXPRESION GENICA DE TRANSCRIPCION PARA INDIVIDUOS INFECTADOS. EL MODULO COMPRENDE UN CONJUNTO DE DATOS DE LOS GENES EN LOS MODULOS M1.2, M1.3, M1.4, M1.5, M1.8, M2.1, M2.4, M2.8, M3.1, M3.2, M3.3, M3.4, M3.6, M3.7, M3.8 O M3.9 PARA DETECTAR LA INFECCION PULMONAR ACTIVA Y PARA DETECTAR UNA INFECCION LATENTE, EL MODULO COMPRENDE UN CONJUNTO DE DATOS DE LOS GENES EN LOS MODULOS M1.5, M2.1, M2.6, M2.10, M3.2 O M3.3

4. 发明专利

PE20110386A1 PATRON DE TRANSCRIPCION SANGUINEA DE LA INFECCION POR MYCOBACTERIUM TUBERCULOSIS 未知
公开(公告)号：PE20110386A1
公开(公告)日：2011-07-03
申请号：PE2010001182
申请日：2009-06-25
申请人： BAYLOR RES INST , NAT INST FOR MEDICAL RES , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： G01N33/50 , C12Q1/00 , G01N33/53
摘要： REFERIDA A UN METODO PARA DIFERENCIAR UNA INFECCION POR MYCOBACTERIUM TUBERCULOSIS ACTIVA DE UNA LATENTE EN UN PACIENTE, QUE COMPRENDE OBTENER UN CONJUNTO DE DATOS DE EXPRESION GENICA DE UNA MUESTRA DE SANGRE ENTERA DE UN PACIENTE Y DETERMINAR LA EXPRESION DIFERENCIAL DE UNO O MAS MODULOS DE EXPRESION GENICA QUE DISTINGUEN ENTRE INDIVIDUOS INFECTADOS Y NO INFECTADOS, DONDE EL CONJUNTO DE DATOS DEMUESTRA UN CAMBIO AGREGADO EN LOS NIVELES DE POLINUCLEOTIDOS EN UNO O MAS MODULOS DE EXPRESION GENICA DE TRANSCRIPCION PARA INDIVIDUOS INFECTADOS. EL MODULO COMPRENDE UN CONJUNTO DE DATOS DE LOS GENES EN LOS MODULOS M1.2, M1.3, M1.4, M1.5, M1.8, M2.1, M2.4, M2.8, M3.1, M3.2, M3.3, M3.4, M3.6, M3.7, M3.8 O M3.9 PARA DETECTAR LA INFECCION PULMONAR ACTIVA Y PARA DETECTAR UNA INFECCION LATENTE, EL MODULO COMPRENDE UN CONJUNTO DE DATOS DE LOS GENES EN LOS MODULOS M1.5, M2.1, M2.6, M2.10, M3.2 O M3.3

5. 发明专利

CA2729000A1 BLOOD TRANSCRIPTIONAL SIGNATURE OF MYCOBACTERIUM TUBERCULOSIS INFECTION 未知
公开(公告)号：CA2729000A1
公开(公告)日：2009-12-30
申请号：CA2729000
申请日：2009-06-25
申请人： BAYLOR RES INST , IMP COLLEGE HEALTHCARE NHS TRUST , NAT INST FOR MEDICAL RES
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： G01N33/50 , C12Q1/00 , G01N33/53
摘要： The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosis, and distinguishing such patients from uninfected individuals, the method including the steps of obtaining a gene expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non- infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection.

6. 发明专利

SG182951A1 BLOOD TRANSCRIPTIONAL SIGNATURE OF MYCOBACTERIUM TUBERCULOSIS INFECTION 未知
公开(公告)号：SG182951A1
公开(公告)日：2012-08-30
申请号：SG2012039715
申请日：2009-06-25
申请人： BAYLOR RES INST , NAT INST FOR MEDICAL RES , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
摘要： OF THE INVENTIONThe present invention includes methods, systems and kits for distinguishing between active and latent mycobaCterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosk,and distinguishing such patients from uninfected individuals, the method including the steps of5 obtaining a gate expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non-infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection. 87The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosis, and distinguishing such patients from uninfected individuals, the method including the steps of obtaining a gene expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non-infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection,(Figure I)

7. 发明公开

EP2825671A4 EARLY DETECTION OF TUBERCULOSIS TREATMENT RESPONSE 审中-公开
标题翻译：肺结核治疗反应的早期检测
公开(公告)号：EP2825671A4
公开(公告)日：2015-08-26
申请号：EP13761285
申请日：2013-03-13
申请人： BAYLOR RES INST , MEDICAL RES COUNCIL , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： O'GARRA ANNE , BLOOM CHLOE , BERRY MATTHEW PAUL REDDOCH , WILKINSON ROBERT , BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , PASCUAL MARIA VIRGINIA
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/68
CPC分类号： C12Q1/6883 , A61K31/133 , A61K31/455 , A61K31/496 , A61K31/4965 , C12Q1/68 , C12Q2600/118 , C12Q2600/158 , G01N33/48 , G01N33/68 , G01N33/6893 , G01N2333/35 , G01N2800/26 , G01N2800/52

8. 发明公开

EP2519652A4 BLOOD TRANSCRIPTIONAL SIGNATURE OF ACTIVE VERSUS LATENT MYCOBACTERIUM TUBERCULOSIS INFECTION 审中-公开
标题翻译：相比递延结核分支杆菌活性转录BLOOD签名INFECTION-
公开(公告)号：EP2519652A4
公开(公告)日：2013-05-01
申请号：EP10833713
申请日：2010-08-19
申请人： BAYLOR RES INST , MEDICAL RES COUNCIL , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： C12Q1/68 , C12N15/31 , C12R1/32 , G01N33/15
CPC分类号： C12Q1/689 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158

9. 发明专利

CA2895133A1 BLOOD TRANSCRIPTIONAL SIGNATURES OF ACTIVE PULMONARY TUBERCULOSIS AND SARCOIDOSIS 未知
公开(公告)号：CA2895133A1
公开(公告)日：2014-06-19
申请号：CA2895133
申请日：2013-12-13
申请人： BAYLOR RES INST , MEDICAL RES COUNCIL , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： O'GARRA ANNE , BLOOM CHLOE , BERRY MATTHEW PAUL REDDOCH , BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , PASCUAL MARIA VIRGINIA
IPC分类号： C12Q1/68
摘要： The present invention includes a method of determining a lung disease from a patient suspected of sarcoidosis, tuberculosis, lung cancer or pneumonia comprising: obtaining a sample from whole blood of the patient suspected of sarcoidosis, tuberculosis, lung cancer or pneumonia; detecting expression of (although not exclusive) six or more disease genes, markers, or probes selected from SEQ ID NOS.: 1 to 1446, wherein increased expression of mRNA of upregulated sarcoidosis, tuberculosis, lung cancer and pneumonia markers of SEQ ID NOS.: 1 to 1446 and/or decreased expression of mRNA of downregulated sarcoidosis, tuberculosis, lung cancer or pneumonia markers of SEQ ID NOS.: 1 to 1446 relative to the expression of the mRNAs from a normal sample; and determining the lung disease based on the expression level of the six or more disease markers of SEQ ID NOS.: 1 to 1446 based on a comparison of the expression level of sarcoidosis, tuberculosis, lung cancer, and pneumonia.

10. 发明专利

CA2782211A1 BLOOD TRANSCRIPTIONAL SIGNATURE OF ACTIVE VERSUS LATENT MYCOBACTERIUM TUBERCULOSIS INFECTION 未知
公开(公告)号：CA2782211A1
公开(公告)日：2011-06-03
申请号：CA2782211
申请日：2010-08-19
申请人： BAYLOR RES INST , MEDICAL RES COUNCIL , IMP COLLEGE HEALTHCARE NHS TRUST
发明人： BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN , O'GARRA ANNE , BERRY MATTHEW , KON ONN MIN
IPC分类号： C12Q1/68 , C12N15/31 , G01N33/15
摘要： The present invention includes methods, systems and kits for distinguishing between active and latent Mycobacterium tuberculosis infection in a patient suspected of being infected with Mycobacterium tuberculosis, the method including the steps of obtaining a patient gene expression dataset from a patient suspected of being infected with Mycobacterium tuberculosis; sorting the patient gene expression dataset into one or more gene modules associated with Mycobacterium tuberculosis infection; and comparing the patient gene expression dataset for each of the one or more gene modules to a gene expression dataset from a non-patient; wherein an increase or decrease in the totality of gene expression in the patient gene expression dataset for the one or more gene modules is indicative of active Mycobacterium tuberculosis infection.

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