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1. 发明申请

US20150037326A1 Pharmaceutical composition comprising a polymeric carrier cargo complex and an antigen 审中-公开
标题翻译：药物组合物，其包含聚合物载体载体复合物和抗原
公开(公告)号：US20150037326A1
公开(公告)日：2015-02-05
申请号：US14375392
申请日：2013-01-30
申请人： BAYER INNOVATION GMBH , CUREVAC GMBH , ICON GENETICS GMBH
发明人： John-Edward Butler-Ransohoff , Karl-Josef Kallen , Thomas Kramps , Victor Klimyuk , Franziska Jarczowski
IPC分类号： A61K47/36 , C07K16/18 , A61K39/395 , A61K39/39 , A61K39/00
CPC分类号： A61K47/36 , A61K39/0011 , A61K39/39 , A61K39/39558 , A61K47/643 , A61K47/645 , A61K47/646 , A61K2039/505 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/572 , A61K2039/585 , A61K2039/6081 , C07K16/18 , C07K16/3061 , C07K16/4208 , C07K2317/13 , C07K2317/55 , C07K2317/76 , C12N15/8258 , C12N15/87 , C12N2770/00043 , C12N2770/40043
摘要： The present invention is directed to a pharmaceutical composition including (eg for use as an adjuvant) a polymeric carrier cargo complex, comprising as a carrier a polymeric carrier formed by disulfide-crosslinked cationic components and as a cargo at least one nucleic acid (molecule) and at least one antigen associated with a tumour or cancer disease selected from; an idiotype immunoglobulin (e.g. an idiotype antibody or an idiotype B cell receptor); or at least one idiotype T cell receptor, or in each case a fragment, variant and/or derivative thereof. The inventive pharmaceutical composition allows for efficient induction of an adaptive immune response directed against the idiotype immunoglobulin or T cell receptor, particularly of a Th1-shiftet immune response. The present invention furthermore provides kits or kits of parts comprising the components of the inventive pharmaceutical composition, as well as the use of the inventive pharmaceutical composition or the inventive kit as a vaccine, particularly in the therapy of a tumour or cancer disease such as lymphoma, particularly B cell or T cell lymphoma.
摘要翻译：本发明涉及包含（例如用作佐剂）聚合物载体货物复合物的药物组合物，其包含作为载体的由二硫键交联的阳离子组分形成的聚合物载体和作为货物的至少一种核酸（分子）和与选自以下的肿瘤或癌症疾病相关的至少一种抗原; 独特型免疫球蛋白（例如独特型抗体或独特型B细胞受体）; 或至少一种独特型T细胞受体，或在每种情况下为其片段，变体和/或衍生物。本发明的药物组合物允许有效诱导针对独特型免疫球蛋白或T细胞受体，特别是Th1移位免疫应答的适应性免疫应答。本发明还提供了包含本发明药物组合物组分的试剂盒或试剂盒，以及本发明的药物组合物或本发明试剂盒作为疫苗的用途，特别是用于治疗肿瘤或癌症疾病例如淋巴瘤，特别是B细胞或T细胞淋巴瘤。

2. 发明授权

US09890391B2 RNA vector with an open reading frame, an albumin 3′-UTR, and a histone stem loop 有权
公开(公告)号：US09890391B2
公开(公告)日：2018-02-13
申请号：US14388220
申请日：2013-03-27
申请人： CureVac GmbH
发明人： Andreas Thess , Karl-Josef Kallen
IPC分类号： C12N15/00 , C12N15/85 , C12N15/67 , C12N15/88 , A61K48/00
CPC分类号： C12N15/85 , A61K48/00 , C12N15/67 , C12N15/88 , C12N2830/50
摘要： The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′UTR element comprising a nucleic acid sequence which is derived from the 3′UTR of an albumin gene or from a variant of the 3′UTR of an albumin gene. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, the invention relates to the use of a 3′UTR element comprising a nucleic acid sequence which is derived from the 3′UTR of an albumin gene or from a variant of the 3′UTR of an albumin gene for the stabilization and/or prolongation of protein expression from a nucleic acid sequence comprising such 3′UTR element.

3. 发明申请

US20150118264A1 PHARMACEUTICAL COMPOSITION COMPRISING A POLYMERIC CARRIER CARGO COMPLEX AND AT LEAST ONE PROTEIN OR PEPTIDE ANTIGEN 审中-公开
标题翻译：包含聚合物载体复合物和至少一种蛋白质或肽抗原的药物组合物
公开(公告)号：US20150118264A1
公开(公告)日：2015-04-30
申请号：US14375215
申请日：2013-01-31
申请人： CureVac GmbH
发明人： Patrick Baumhof , Thomas Kramps , Söhnke Voss , Karl-Josef Kallen , Mariola Fotin-Mleczek
IPC分类号： A61K39/39 , A61K48/00 , A61K39/35 , A61K39/00 , C12N7/00 , A61K39/145 , A61K39/29 , A61K39/12 , A61K47/48 , A61K39/205
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/12 , A61K39/145 , A61K39/205 , A61K39/29 , A61K39/35 , A61K47/645 , A61K47/646 , A61K48/0041 , A61K2039/5252 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/572 , A61K2039/575 , A61K2039/6093 , C12N7/00 , C12N2710/20034 , C12N2710/20071 , C12N2730/10134 , C12N2730/10171 , C12N2760/16134 , C12N2760/16171 , C12N2760/20134 , C12N2760/20171 , Y02A50/416
摘要： The present invention is directed to a pharmaceutical composition including (e.g. for use as an adjuvant) a polymeric carrier cargo complex, comprising as a carrier a polymeric carrier formed by disulfide-crosslinked cationic components; and as a cargo at least one nucleic acid molecule, and at least one antigen that is selected from an antigen from a pathogen associated with infectious disease; an antigen associated with allergy or allergic disease; an antigen associated with autoimmune disease; or an antigen associated with a cancer or tumour disease, or in each case a fragment, variant and/or derivative of said antigen. The pharmaceutical composition allows for efficient induction of an adaptive immune response directed against said antigen. The present invention furthermore provides kits, as well as the use of the pharmaceutical composition or the kit as a vaccine, particularly in the treatment of infectious diseases, allergies, autoimmune diseases and tumour or cancer diseases.
摘要翻译：本发明涉及包含（例如用作佐剂）聚合物载体货物复合物的药物组合物，其包含作为载体的由二硫化物交联的阳离子组分形成的聚合物载体; 以及作为货物至少一种核酸分子和至少一种选自与感染性疾病相关的病原体的抗原的抗原; 与过敏或过敏性疾病相关的抗原; 与自身免疫性疾病相关的抗原; 或与癌症或肿瘤疾病相关的抗原，或在每种情况下都是所述抗原的片段，变体和/或衍生物。药物组合物允许有效诱导针对所述抗原的适应性免疫应答。本发明还提供试剂盒，以及药物组合物或试剂盒作为疫苗的用途，特别是用于治疗感染性疾病，过敏反应，自身免疫性疾病和肿瘤或癌症疾病。

4. 发明申请

US20150184195A1 ARTIFICIAL NUCLEIC ACID MOLECULES 有权
标题翻译：人工核酸分子
公开(公告)号：US20150184195A1
公开(公告)日：2015-07-02
申请号：US14388220
申请日：2013-03-27
申请人： CureVac GmbH
发明人： Andreas Thess , Karl-Josef Kallen
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , A61K48/00 , C12N15/67 , C12N15/88 , C12N2830/50
摘要： The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′UTR element comprising a nucleic acid sequence which is derived from the 3′UTR of an albumin gene or from a variant of the 3′UTR of an albumin gene. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, the invention relates to the use of a 3′UTR element comprising a nucleic acid sequence which is derived from the 3′UTR of an albumin gene or from a variant of the 3′UTR of an albumin gene for the stabilization and/or prolongation of protein expression from a nucleic acid sequence comprising such 3′UTR element.
摘要翻译：本发明涉及包含至少一个开放阅读框和至少一个3'UTR元件的人源核酸分子，其包含衍生自白蛋白基因的3'UTR或3'UTR的变体的核酸序列的白蛋白基因。本发明还涉及这种人工核酸分子在基因治疗和/或基因疫苗接种中的用途。此外，本发明涉及包含衍生自白蛋白基因的3'UTR或白蛋白基因的3'UTR的变体的核酸序列的3'UTR元件用于稳定化和/或从包含这种3'UTR元件的核酸序列延长蛋白质表达。

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