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1. 发明专利

JP2009292826A New sulfonate-substituted pyrazolopyridine derivative 审中-公开
标题翻译：新的磺化取代的吡唑并吡啶衍生物
公开(公告)号：JP2009292826A
公开(公告)日：2009-12-17
申请号：JP2009179293
申请日：2009-07-31
申请人： Bayer Healthcare Ag , バイエル・ヘルスケア・アクチェンゲゼルシャフトBayer HealthCare AG
发明人： STASCH JOHANNES-PETER , FEURER ACHIM , WEIGAND STEFAN , STAHL ELKE , FLUBACHER DIETMAR , ALONSO-ALIJA CRISTINA , WUNDER FRANK , LANG DIETER , DEMBOWSKY KLAUS , STRAUB ALEXANDER , PERZBORN ELISABETH
IPC分类号： C07D471/04 , A61K31/21 , A61K31/34 , A61K31/506 , A61K31/5377 , A61K33/26 , A61K45/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P15/10 , A61P25/00 , A61P29/00 , A61P43/00
CPC分类号： C07D471/04
摘要： PROBLEM TO BE SOLVED: To provide a substance for treating cardiovascular disorder, hyperpiesia, thrombo-embolic disorder or ischemic disorder, sexual dysfunction or inflammation, and for treating central nervous system disorder.
SOLUTION: This new pyrazolopyridine derivative is represented by formula (I) [wherein R
1 is formula -O-SO
2 R
3 group (R
3 is a 1-6C alkyl which may be substituted, a 3-8C cycloalkyl which may be substituted, or a phenyl which may be substituted), R
2 is H or a 1-6C alkyl-SO
2 which may be substituted].
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于治疗心血管疾病，高血压，血栓栓塞性障碍或缺血性障碍，性功能障碍或炎症以及用于治疗中枢神经系统疾病的物质。解决方案：该新的吡唑并吡啶衍生物由式（I）表示[其中R 1为式-O-SO 2 SBR 2 R 3 / 基团（R 3 SP 3是可以被取代的1-6C烷基，可以被取代的3-8C环烷基或可被取代的苯基），R“ 是H或可以被取代的1-6C烷基-SO 2 SB 。版权所有（C）2010，JPO＆INPIT

2. 发明申请

WO2006094627A2 USE OF HYDROXY TETRAHYDRO-NAPHTHALENE DERIVATIVES 审中-公开
标题翻译：使用羟基四氢萘基衍生物
公开(公告)号：WO2006094627A2
公开(公告)日：2006-09-14
申请号：PCT/EP2006001575
申请日：2006-02-22
申请人： BAYER HEALTHCARE AG , ALONSO-ALIJA CRISTINA , GUPTA JANG , HINZEN BERTHOLD
发明人： ALONSO-ALIJA CRISTINA , GUPTA JANG , HINZEN BERTHOLD
CPC分类号： A61K31/17
摘要： This invention relates to new uses of hydroxy-tetrahydro-naphthalenylurea derivatives which are described in WO 03/095420 as an active ingredient of pharmaceutical preparations for the treatment of diseases associated with VR1 activity. The new uses of the present invention are the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of respiratory diseases or disorders such as the common cold, cough, sneeze, bronchitis including acute and chronic bronchitis, bronchiolitis, rhinitis, allergic rhinitis, vasomotor rhinitis, mucositis, sinusitis, allergy, disorders associated with exogenous irritants such as tobacco smoke, smog, high levels of atmospheric SO2 and noxious gases in the workplace, and airways hyperreactivity, milk product intolerance, Loffler's pneumonia, emphysema, cystic fibrosis, bronchiectasis, pulmonary fibrosis, pneumoconiosis, collagen vascular disease, granulomatous disease, laryngitis, pharyngitis, pneumonia, pleuritis, persistent asthma and chronic asthmatic bronchitis.
摘要翻译：本发明涉及WO 03/095420中描述的羟基 - 四氢 - 萘基脲衍生物作为治疗与VR1活性有关的疾病的药物制剂的活性成分的新用途。本发明的新用途是预防和治疗与VR1活性相关的疾病，特别是用于治疗呼吸系统疾病或病症，例如感冒，咳嗽，打喷嚏，支气管炎，包括急性和慢性支气管炎，细支气管炎，鼻炎，过敏性鼻炎，血管舒缩性鼻炎，粘膜炎，鼻窦炎，变态反应，与外源性刺激物如烟草烟雾，烟雾，工作场所高水平的大气二氧化硫和有毒气体相关的疾病，气道高反应性，乳制品不耐受，霍夫勒肺炎，肺气肿，囊性纤维化，支气管扩张，肺纤维化，肺尘埃沉着病，胶原血管病，肉芽肿病，喉炎，咽炎，肺炎，胸膜炎，持续性哮喘和慢性哮喘性支气管炎。

3. 发明专利

DE50111292D1 未知
公开(公告)号：DE50111292D1
公开(公告)日：2006-11-30
申请号：DE50111292
申请日：2001-11-12
申请人： BAYER HEALTHCARE AG
发明人： STASCH JOHANNES-PETER , FEURER ACHIM , WEIGAND STEFAN , STAHL ELKE , FLUBACHER DIETMAR , ALONSO-ALIJA CRISTINA , WUNDER FRANK , LANG DIETER , DEMBOWSKY KLAUS , STRAUB ALEXANDER , PERZBORN ELISABETH
IPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61K45/00 , A61K47/16 , A61P5/24 , A61P9/00 , A61P9/10 , A61P9/12 , A61P15/00 , A61P25/00 , A61P29/00 , A61P43/00 , C07D221/00 , C07D231/00
摘要： This invention relates to compounds of the formula in which R 1 , R 2 , and R 3 are as defined in the claims, to a process for preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods of using such compounds for treatment of hypertension and sexual dysfunction.

4. 发明专利

DK1506193T3 未知
公开(公告)号：DK1506193T3
公开(公告)日：2006-10-09
申请号：DK03727359
申请日：2003-04-25
申请人： BAYER HEALTHCARE AG
发明人： ALONSO-ALIJA CRISTINA , BISCHOFF ERWIN , MUENTER KLAUS , STASCH JOHANNES-PETER , STAHL ELKE , WEIGAND STEFAN , FEURER ACHIM
IPC分类号： C07D471/04 , A61K31/506 , A61K45/06 , A61P9/00 , A61P9/02 , A61P9/10 , A61P9/12 , A61P13/00 , A61P15/00 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/16 , A61P25/24 , A61P25/28 , A61P27/06
摘要： The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.

5. 发明专利

AT330957T 未知
公开(公告)号：AT330957T
公开(公告)日：2006-07-15
申请号：AT03727359
申请日：2003-04-25
申请人： BAYER HEALTHCARE AG
发明人： ALONSO-ALIJA CRISTINA , BISCHOFF ERWIN , MUENTER KLAUS , STASCH JOHANNES-PETER , STAHL ELKE , WEIGAND STEFAN , FEURER ACHIM
IPC分类号： A61K31/506 , A61K45/06 , A61P9/00 , A61P9/02 , A61P9/10 , A61P9/12 , A61P13/00 , A61P15/00 , A61P15/10 , A61P19/10 , A61P25/00 , A61P25/16 , A61P25/24 , A61P25/28 , A61P27/06 , C07D471/04
摘要： The present invention relates to compounds which stimulate soluble guanylate cyclase, to the preparation thereof and to the use thereof as medicaments, in particular as medicaments for the treatment of cardiovascular disorders and/or sexual dysfunction.

6. 发明专利

DE60206072T2 未知
公开(公告)号：DE60206072T2
公开(公告)日：2006-07-13
申请号：DE60206072
申请日：2002-12-09
申请人： BAYER HEALTHCARE AG
发明人： ALONSO-ALIJA CRISTINA , MICHELS MARTIN , SCHIROK HARTMUT , SCHLEMMER KARL-HEINZ , DODD SARA , FITZGERALD MARY , BELL JOHN , GILL ANDREW
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/505 , A61K31/551 , A61P1/00 , A61P1/02 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/16 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/02 , A61P43/00 , C07D233/22 , C07D235/12 , C07D239/06 , C07D239/70
摘要： The present invention relates to pyridinones, processes for their preparation and their use in medicaments, especially for the treatment of COPD.

7. 发明专利

ES2252066T3 NUEVOS DERIVADOS DE ACIDOS DICARBOXILICOS CON PROPIEDADES FARMACEUTICAS. 未知
公开(公告)号：ES2252066T3
公开(公告)日：2006-05-16
申请号：ES00964067
申请日：2000-08-31
申请人： BAYER HEALTHCARE AG
发明人： ALONSO-ALIJA CRISTINA , HEIL MARKUS , FLUBACHER DIETMAR , NAAB PAUL , STASCH JOHANNES-PETER , WUNDER FRANK
IPC分类号： C07D295/08 , A61K31/194 , A61K31/196 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/426 , A61K31/44 , A61K45/00 , A61P1/16 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P43/00 , C07C63/33 , C07C63/72 , C07C63/74 , C07C65/24 , C07C65/28 , C07C69/76 , C07C69/92 , C07C69/94 , C07C217/16 , C07C217/22 , C07C229/38 , C07C229/52 , C07C233/25 , C07C235/42 , C07C275/42 , C07C317/44 , C07C323/56 , C07C323/62 , C07D211/60 , C07D213/64 , C07D213/65 , C07D231/12 , C07D233/90 , C07D261/08 , C07D263/56 , C07D263/57 , C07D271/06 , C07D277/24 , C07D295/092 , C07D295/185 , C07D295/21 , C07D307/42 , C07D333/54 , C07D333/56 , C07D241/04 , C07C317/46 , C07C235/84
摘要： Compuestos de **fórmula** en la que B significa arilo con 6 a 10 átomos de carbono, r significa 0 ó 1, V falta o significa O, NR4, NR4CONR4, NR4CO, NR4SO2, COO, CONR4 o S(O)o, en las que R4 significa, independientemente de un resto R4 adicional dado el caso presente, hidrógeno, alquilo de cadena lineal o ramificado con hasta 8 átomos de carbono, cicloalquilo con 3 a 8 átomos de carbono, arilo con 6 a 10 átomos de carbono o arilalquilo con 7 a 18 átomos de carbono, pudiendo estar sustituido el resto arilo a su vez una o varias veces con halógeno, alquilo, alcoxi con hasta 6 átomos de carbono, o significa 0, 1 ó 2, Q falta o significa alquileno de cadena lineal o ramificado, alquenodiilo de cadena lineal o ramificado o alquinodiilo de cadena lineal o ramificado con hasta 15 átomos de carbono en cada caso, que pueden contener uno o varios grupos seleccionados entre O, S(O)p, NR5, CO, OCO, S-CO, CONR5 o NR5SO2 y pueden estar sustituidos una o varias veces con halógeno, hidroxi o alcoxi con hasta 4 átomos de carbono, pudiendo estar unidos entre sí dado el caso dos átomos cualesquiera de la cadena anterior formando un anillo de tres a ocho miembros, o significa CONR5.

9. 发明专利

ES2243598T3 NUEVOS DERIVADOS DE PIRAZOLOPIRIDINA SUSTITUIDOS CON PIRIDINA. 未知
公开(公告)号：ES2243598T3
公开(公告)日：2005-12-01
申请号：ES01997489
申请日：2001-11-09
申请人： BAYER HEALTHCARE AG
发明人： STASCH JOHANNES-PETER , FEURER ACHIM , WEIGAND STEFAN , STAHL ELKE , FLUBACHER DIETMAR , ALONSO-ALIJA CRISTINA
IPC分类号： A61K31/505 , A61K31/506 , A61K45/00 , A61K45/06 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P15/00 , A61P15/10 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , A61P31/18 , A61P37/04 , A61P43/00 , C07D471/04 , A61K31/415
摘要： Compuestos de fórmula (I) en la que R1 representa 4-piridinilo o 3-piridinilo; R2 representa H, NH2 o halógeno; así como sus sales e hidratos.

10. 发明专利

ES2238592T3 IMIDAZOPIRIDINONAS COMO INHIBIDORES DE LA MAP QUINASA P38. 未知
公开(公告)号：ES2238592T3
公开(公告)日：2005-09-01
申请号：ES02758340
申请日：2002-07-15
申请人： BAYER HEALTHCARE AG
发明人： ALONSO-ALIJA CRISTINA , MICHELS MARTIN , SCHIROK HARTMUT , SCHLEMMER KARL-HEINZ , DODD SARA , FITZGERALD MARY
IPC分类号： A61K31/437 , A61P29/00 , A61P43/00 , C07D471/04
摘要： Compuestos de fórmula general (I) **(Fórmula)** en la que R1 representa hidrógeno, halógeno, alquilo C1-C6, arilo C6-C10, heteroarilo C5-C8, cicloalquilo C3-C8, alcoxi C1C6, en la que R1 puede estar opcionalmente sustituido con 1 a 3 sustituyentes R1-1, en el que R1-1 es halógeno, amino, mono o di-alquil(C1-C6)-amino, alcoxi C1-C6, R2 representa hidrógeno, halógeno, alquilo C1-C6, arilo C6-C10, heteroarilo C5-C8, cicloalquilo C3-C8, alcoxi C1C6, en la que R2 puede estar opcionalmente sustituido con 1 a 3 sustituyentes R2-1, en el que R2-1 es halógeno, amino, mono o di-alquil(C1-C6)-amino, alcoxi C1-C6, o R1 y R2 junto con los átomos de carbono a los que están unidos forman un anillo de arilo C6-C10, heteroarilo C5C8, cicloalquilo C5-C8 o heterociclilo C5-C8, en el que el anillo está opcionalmente sustituido con alquilo C1-C6, alcoxi C1-C6, halógeno, ciano, amino, mono o di-alquil(C1-C6)-amino, COR2-2, en el que R2-2 es OH, alcoxi C1-C6, ariloxi C6-C10, amino, mono o di-alquil(C1-C6)amino, R3 representa hidrógeno o alquilo C1-C6, R4 representa -COR4-1, en el que R4-1 representa arilo C6-C10 o heteroarilo, en el que R4-1 puede estar opcionalmente sustituido con 1 a 3 sustituyentes seleccionados del grupo que consiste en halógeno, amino, alquilo C1-C6, alcoxi C1-C6, mono- o di-alquil(C1-C6)-amino, trifluorometilo, ciano, nitro e hidroxi, con la condición de que el compuesto no sea la 8-benzoil-H-imidazo[1, 2-a]piridin-5-ona o la 8-benzoil1midazo[1, 2-a]-piridin-5-ona. o una de sus sales farmacéuticamente aceptable.

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