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1. 发明申请

WO1997043237A1 SUBSITUTE 4-ARYLBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：作为基质金属蛋白酶抑制剂的4-ARYLBUTYRIC酸衍生物
公开(公告)号：WO1997043237A1
公开(公告)日：1997-11-20
申请号：PCT/US1997007951
申请日：1997-05-12
申请人： BAYER CORPORATION , KLUENDER, Harold, C., E. , DIXON, Brian, R. , BRITTELLI, David, R.
发明人： BAYER CORPORATION
IPC分类号： C07C59/84
CPC分类号： C07D209/48 , C07C59/84 , C07C59/90 , C07D237/32 , C07D253/04
摘要： Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have generalized formula (I) wherein R represents C6-C12 alkyl; C5-C12 alkoxy; C5-C12 alkylthio; a polyether of formula R O(C2H4O)a- in which a is 1 or 2 and R is C1-C5 alkyl, phenyl, or benzyl; and substituted alkynyl of formula R (CH2)b-CC-; in which b is 1-10 and R is H-, HO-, or R O- in which R is C1-C3 alkyl, phenyl, or benzyl. The alkyl, phenyl, and benzyl portions of R may bear at least one pharmaceutically-acceptable substituent. The subscript n is 2-4. R represents phenyl; imidoyl of 4-12 carbon atoms; (3H)-benzo-1,2,3-triazin-4-on-3-yl; N-saccharinyl; (2H)-phthalazin-1-on-2-yl; 2-benzoxazolin-2-on-3-yl; 5,5-dimethyloxazolidine-2,4-dion-3-yl; and thiazolidine-2,4-dion-3-yl; with the phenyl and benzo portions of R permissibly bearing at least one pharmaceutically-acceptable substituent. Pharmaceutically acceptable salts of these materials are also included.
摘要翻译：基质金属蛋白酶抑制剂，含有它们的药物组合物，以及使用它们治疗各种生理条件的方法。本发明的化合物具有通式（I），其中R 1表示C 6 -C 12烷基; C5-C12烷氧基; C5-C12烷硫基; 式R 2 O（C 2 H 4 O）a - 的聚醚，其中a为1或2，R 2为C 1 -C 5烷基，苯基或苄基; 和取代的式R 3（CH 2）b-CC-的炔基; 其中b为1-10，R 3为H，HO-或R 4 O-，其中R 4为C 1 -C 3烷基，苯基或苄基。 R 1的烷基，苯基和苄基部分可以具有至少一个药学上可接受的取代基。下标n为2-4。 R 5表示苯基; 4-12个碳原子的亚氨基; （3H） - 苯并-1,2,3-三嗪-4-上-3-基; 的N- saccharinyl; （2H）-2,3-二氮杂萘-1-酮-2-基; 2-苯并恶唑啉-2-酮-3-基; 5,5-二甲基唑烷-2,4-二酮-3-基; 和噻唑烷-2,4-二酮-3-基; 其中R 5的苯基和苯并部分允许具有至少一个药学上可接受的取代基。也包括这些材料的药学上可接受的盐。

2. 发明申请

WO1997043239A1 INHIBITION OF MATRIX METALLOPROTEASES BY 2-SUBSTITUTED-4-(4-SUBSTITUTEDPHENYL)-4-OXOBUTYRIC ACIDS 审中-公开
标题翻译：通过取代的二异丁基氧化物抑制基质金属
公开(公告)号：WO1997043239A1
公开(公告)日：1997-11-20
申请号：PCT/US1997007976
申请日：1997-05-12
申请人： BAYER CORPORATION , VAN ZANDT, Michael, C. , BRITTELLI, David, R. , DIXON, Brian, R.
发明人： BAYER CORPORATION
IPC分类号： C07C59/90
CPC分类号： C07D263/44 , C07C59/90 , C07D237/32 , C07D243/24 , C07D253/04 , C07D263/58 , C07D275/04 , C07D277/34
摘要： Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have generalized formula (1) wherein r is 0-2, T is selected from (a) and (b) and R is a mono- or bi-heterocyclic structure. These compounds are useful for inhibiting matrix metalloproteases and, therefore, combating conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis of degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from athrosclerotic plaque rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.
摘要翻译：提出了基质金属蛋白酶抑制化合物，其药物组合物和使用这些化合物的疾病治疗方法。本发明的化合物具有通式（1），其中r为0-2，T选自（a）和（b），R 40为单或双杂环结构。这些化合物可用于抑制基质金属蛋白酶，因此可用于抗MMP的作用，例如骨关节炎，类风湿性关节炎，脓毒性关节炎，牙周病，角膜溃疡，蛋白尿，动脉瘤性主动脉疾病，疏水性表皮松解症，大疱疹，导致炎症的病症反应，由MMP活性介导的骨质减少，下颌关节疾病，神经系统脱髓鞘疾病，创伤性关节损伤后退行性软骨损失的肿瘤转移，以及来自动脉粥样硬化斑块破裂的冠状动脉血栓形成。本发明还提供了用于治疗这些病症的药物组合物和方法。

3. 发明申请

WO1997043238A1 SUBSTITUTED OXOBUTYRIC ACIDS AS MATRIX METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：作为基质金属蛋白酶抑制剂的取代的氧代酸
公开(公告)号：WO1997043238A1
公开(公告)日：1997-11-20
申请号：PCT/US1997007975
申请日：1997-05-12
申请人： BAYER CORPORATION , DIXON, Brian, R. , CHEN, Jinshan , VAN ZANDT, Michael , BRITTELLI, David, R.
发明人： BAYER CORPORATION
IPC分类号： C07C59/90
CPC分类号： C07D209/48 , C07C59/90 , C07D253/08
摘要： The present invention provides pharmaceutical compositions and methods for treating certain conditions comprising administering an amount of a compound or composition of the invention which is effective to inhibit the activity of at least one matrix metalloprotease, resulting in achievement of the desired effect. The compounds of the present invention are either of generalized formula (I) wherein y is 0, 2, or 3, r is 0-6, Z is (CH2)7 or (CH2)e-C6H4-(CH2)f, wherein e is 0-1 and f is 1-6, and R is -H, -Cl, -OMe or (a), (b) wherein n is 0-4, R is C2H5, allyl, benzyl, and R is (c) wherein t is 0-1, x is 0-4, and R is one of the following: halide, alkyl of 1-6 carbons, OR, NR2, NO2 (R = H or alkyl of 1-6 carbons). These compounds are useful for inhibiting matrix metalloproteases and, therefore, combating conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from atherosclerotic plaque rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.
摘要翻译：本发明提供用于治疗某些病症的药物组合物和方法，包括给予一定量的有效抑制至少一种基质金属蛋白酶活性的本发明化合物或组合物，从而达到预期的效果。本发明的化合物是通式（I），其中y是0,2或3，r是0-6，Z是（CH 2）7或（CH 2）e -C 6 H 4 - （CH 2）f，其中 e为0-1且f为1-6，R 15为-H，-Cl，-OMe或（a），（b）其中n为0-4，R 17为C 2 H 5，烯丙基，苄基，R 16是（c）其中t是0-1，x是0-4，R 4是以下之一：卤素，1-6个碳的烷基，OR，NR 2，NO 2（ R = H或1-6个碳的烷基）。这些化合物可用于抑制基质金属蛋白酶，因此可用于抗MMP的作用，例如骨关节炎，类风湿性关节炎，脓毒性关节炎，牙周病，角膜溃疡，蛋白尿，动脉瘤性主动脉疾病，疏水性表皮松解症，大疱疹，导致炎症的病症反应，由MMP活性介导的骨质减少，颞下颌关节病，神经系统脱髓鞘疾病，创伤性关节损伤后的肿瘤转移或退行性软骨损失以及来自动脉粥样硬化斑块破裂的冠状动脉血栓形成。本发明还提供了用于治疗这些病症的药物组合物和方法。

4. 发明申请

WO1997043245A1 INHIBITION OF MATRIX METALLOPROTEASES BY ACETYLENE CONTAINING COMPOUNDS 审中-公开
标题翻译：含乙烯基化合物对基质金属微球的抑制作用
公开(公告)号：WO1997043245A1
公开(公告)日：1997-11-20
申请号：PCT/US1997007921
申请日：1997-05-12
申请人： BAYER CORPORATION , DIXON, Brian, R. , CHEN, Jinshan
发明人： BAYER CORPORATION
IPC分类号： C07C229/34
CPC分类号： C07D209/48 , C07C59/90 , C07C229/34
摘要： Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have the generalized formula (I) where R is selected from the group comprising: HOCH2, MeOCH2, (n-Pr)2NCH2, CH3CO2CH2, EtOCO2CH2, HO(CH2)2, CH3CO2(CH2)2, HO2C(CH2)2, OHC(CH2)3, HO(CH2)4, Ph, 3-HO-Ph, and PhCH2OCH2; and R is (a) or (b). These compounds are useful for inhibiting matrix metalloproteases and, therefore, combating conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from athrosclerotic plate rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.
摘要翻译：提出了基质金属蛋白酶抑制化合物，其药物组合物和使用这些化合物的疾病治疗方法。本发明的化合物具有通式（I），其中R 15选自HOCH 2，MeOCH 2，（n-Pr）2 NCH 2，CH 3 CO 2 CH 2，EtOCO 2 CH 2，HO（CH 2）2，CH 3 CO 2（CH 2）2 ，HO2C（CH2）2，OHC（CH2）3，HO（CH2）4，Ph，3-HO-Ph和PhCH2OCH2; R 16为（a）或（b）。这些化合物可用于抑制基质金属蛋白酶，因此可用于抗MMP的作用，例如骨关节炎，类风湿性关节炎，脓毒性关节炎，牙周病，角膜溃疡，蛋白尿，动脉瘤性主动脉疾病，疏水性表皮松解症，大疱疹，导致炎症的病症反应，MMP活性介导的骨质减少，颞下颌关节疾病，神经系统脱髓鞘疾病，创伤性关节损伤后的肿瘤转移或退行性软骨损失，以及来自冠状动脉板破裂的冠状动脉血栓形成。本发明还提供了用于治疗这些病症的药物组合物和方法。

5. 发明申请

WO1998004528A2 SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS 审中-公开
标题翻译：作为抗高血压药物，抗高血压药物和抗高血压药物的替代吡啶和二苯醚
公开(公告)号：WO1998004528A2
公开(公告)日：1998-02-05
申请号：PCT/US1997013248
申请日：1997-07-29
申请人： BAYER CORPORATION , BAYER AKTIENGESELLSCHAFT
发明人： BAYER CORPORATION , BAYER AKTIENGESELLSCHAFT , SCHMIDT, Gunter , ANGERBAUER, Rolf , BRANDES, Arndt , MULLER-GLIEMANN, Matthias , BISCHOFF, Hilmar , SCHMIDT, Delf , WOHLFEIL, Stefan , SCHOEN, William, R. , LADOUCEUR, Gaetan, H. , COOK, James, H., II , LEASE, Timothy, G. , WOLANIN, Donald, J. , KRAMSS, Richard, H. , HERTZOG, Donald, L. , OSTERHOUT, Martin, H.
IPC分类号： C07D213/20
CPC分类号： C07D213/30 , C07D213/32 , C07D213/34 , C07D213/38 , C07D213/50 , C07D213/55 , C07D213/64 , C07D213/70 , C07D213/74 , C07D213/80 , C07D215/14 , C07D221/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D411/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D487/04 , C07F7/1804
摘要： Substituted pyridines of formula (IA) are produced by reaction of suitably substituted pyridylaldehydes with Grignard or Witting reagents, and the resulting products are appropriately reduced. The pyridines of formula (IA) are suitable as active compounds in pharmaceutical products, particularly in pharmaceutical products for the inhibition of cholesterol ester transfer proteins. 3-Heteroalkyl-aryl-substituted pyridines of formula (IB) are produced from pyridines which are correspondingly protected at the hydroxy group and correspondingly substituted. The compounds of formula (IB) according to the invention are suitable as active compounds in pharmaceutical products, particularly pharmaceutical products for the treatment of hyperlipoproteinemia. Substituted pyridines and benzenes of formula (IC) are produced by procedures disclosed herein, and are useful as active ingredients in pharmaceutical products, particularly pharmaceutical products for inhibition of the glucagon receptor, leading to treatment of glucagon-mediated conditions such as diabetes.
摘要翻译：式（IA）的取代的吡啶通过适当取代的吡啶基醛与格氏试剂或Witting试剂的反应制备，所得产物适当地还原。式（IA）的吡啶适合作为药物产品中的活性化合物，特别是用于抑制胆固醇酯转移蛋白的药物。式（IB）的3-杂芳烷基 - 芳基取代的吡啶由吡啶制备，其相应地被羟基保护并相应地被取代。根据本发明的式（IB）化合物适合作为药物产品中的活性化合物，特别是用于治疗高脂蛋白血症的药物。通过本文公开的方法制备式（IC）的取代的吡啶和苯，并且可用作药物产品中的活性成分，特别是用于抑制胰高血糖素受体的药物产品，导致治疗胰高血糖素介导的病症如糖尿病。

6. 发明申请

WO1997001764A1 APPARATUS FOR ORIENTING AND LOADING COMPACT MEDICAMENTS 审中-公开
标题翻译：用于定向和加载紧急药物的装置
公开(公告)号：WO1997001764A1
公开(公告)日：1997-01-16
申请号：PCT/US1995008101
申请日：1995-06-27
申请人： BAYER CORPORATION
发明人： BAYER CORPORATION , REVELLE, David, J. , PASTECKI, Peter, A. , REITER, Thomas, C.
IPC分类号： G01N35/04
CPC分类号： A61J3/005 , B65G47/1492 , B65G2201/027
摘要： An apparatus (10) for orienting and loading solid compact medicaments, such as solid compact medicaments (A), into a carrier device (C) comprises a feeder (12) having a plurality of elongated first channels (20) through which the solid compact medicaments travel with an acute angle relative to a predetermined orientation of the carrier device (C). An orienting member (32) cooperating with the feeder (12) reorients the solid compact medicaments to the predetermined orientation as they exit the feeder (12). In an alternative embodiment, a pitch changing means (42) in fluid communications with the orienting means (32) provides for final orientation of the solid compact medicaments prior to loading in the carrier device (C).
摘要翻译：用于将固体致密药物（例如固体致密药物（A））定向和装载到载体装置（C）中的装置（10）包括具有多个细长的第一通道（20）的进料器（12），固体致密体药物相对于载体装置（C）的预定方向以锐角行进。与进料器（12）配合的取向件（32）在出口给料器（12）时将固体紧凑型药物重新定向至预定取向。在替代实施例中，与定向装置（32）流体连通的间距改变装置（42）在装载到载体装置（C）之前提供固体紧凑型药物的最终取向。

7. 发明申请

WO1996009317A1 CLONING OF AN INSULIN-DEPENDENT MEMBRANE AMINOPEPTIDASE FROM GLUT-4 VESICLES 审中-公开
标题翻译：从GLUT-4 VESICLES克隆胰岛素依赖性膜蛋白酶
公开(公告)号：WO1996009317A1
公开(公告)日：1996-03-28
申请号：PCT/US1995011902
申请日：1995-09-19
申请人： BAYER CORPORATION
发明人： BAYER CORPORATION , KNOWLES, William, J. , GURALSKI, Donna , LETSINGER, John, T. , HAIGH, Wallace , HART, John, T. , CLAIRMONT, Kevin, B.
IPC分类号： C07H21/04
CPC分类号： G01N33/573 , C07K16/40 , C12N9/48 , C12Q1/37 , G01N2333/8103
摘要： An aminopeptidase which cleaves insulin has been purified from GLUT-4-containing vesicles and cloned. The peptidase has a measured mass of approximately 165 kD, but is 110 kD in its deglycosylated state. It has a predicted mass of 117,239 Daltons based on the amino acid sequence predicted from the cDNA of the figure (SEQ ID NOs: 15 and 16). It includes peptides having the amino acid sequences Phe-Ala-Ala-Thr-Gln-Phe-Glu-Pro-Leu-Ala-Ala (SEQ ID NO: 1) and Ile-Leu-Gln-Asn-Gln-Ile-Gln-Gln-Gln-Thr-Arg-Thr-Asp-Glu-Gly-Xaa-Pro-Xaa-Met (SEQ ID NO: 2), and binds with antibodies produced against the peptide identified as (SEQ ID NO: 1). Modulators of the activity of the aminopeptidase and a method for treating syndromes of insulin resistance, including diabetes, by administration of such a modulator are also claimed.
摘要翻译：切割胰岛素的氨基肽酶已从含GLUT-4的囊泡中纯化并克隆。肽酶具有约165kD的测量质量，但其脱糖基化状态为110kD。基于从图中的cDNA预测的氨基酸序列（SEQ ID NO：15和16），其具有117,239道尔顿的预测质量。它包括具有氨基酸序列Phe-Ala-Ala-Thr-Gln-Phe-Glu-Pro-Leu-Ala-Ala（SEQ ID NO：1）和Ile-Leu-Gln-Asn-Gln-Ile-Gln -Gln-Gln-Thr-Arg-Thr-Asp-Glu-Gly-Xaa-Pro-Xaa-Met（SEQ ID NO：2），并与针对鉴定为（SEQ ID NO：1）的肽产生的抗体结合。还要求保护氨基肽酶活性的调节剂和通过施用这种调节剂治疗胰岛素抵抗综合征（包括糖尿病）的方法。

8. 发明申请

WO1998029359A1 A PROCESS FOR THE PRODUCTION OF POLYUREA ENCAPSULATED FERTILIZER PARTICLES AND THE ENCAPSULATED FERTILIZER PARTICLES PRODUCED BY THIS PROCESS 审中-公开
标题翻译：生产聚氨酯增效肥料的方法和本工艺生产的包埋肥料颗粒
公开(公告)号：WO1998029359A1
公开(公告)日：1998-07-09
申请号：PCT/US1997023111
申请日：1997-12-11
申请人： BAYER CORPORATION
发明人： BAYER CORPORATION , MARKUSCH, Peter, H. , CLINE, Robert, L.
IPC分类号： C05G03/00
CPC分类号： C08G18/5024 , C05G3/0029
摘要： This invention relates to a process for the production of polyurea encapsulated fertilizer particles. These are produced by applying an isocyanate-reactive component which contains at least two amine groups to fertilizer particles to form amine coated particles, and applying a polyisocyanate component to the amine coated particles to form polyurea coated particles. Theses steps may optionally be repeated in successive order. The resultant polyurea encapsulated fertilizer particles contain from about 0.5 to 15 % by weight of polyurea, based on the total weight of the encapsulated fertilizer particles. Instead of using an amine group containing isocyanate-reactive component, water can be applied first.
摘要翻译：本发明涉及一种生产聚脲包封肥料颗粒的方法。这些是通过将含有至少两个胺基的异氰酸酯反应性组分施用于肥料颗粒以形成胺包被的颗粒并将多异氰酸酯组分施加到胺涂覆的颗粒上以形成聚脲涂覆的颗粒来制备的。这些步骤可以可选地以连续的顺序重复。基于所包封的肥料颗粒的总重量，所得聚脲包封的肥料颗粒含有约0.5至15重量％的聚脲。代替使用含有异氰酸酯反应性组分的胺基，可以首先施加水。

9. 发明申请

WO1997043247A1 INHIBITION OF MATRIX METALLOPROTEASES BY SUBSTITUTED PHENETHYL COMPOUNDS 审中-公开
标题翻译：通过取代的苯乙烯化合物抑制基质金属
公开(公告)号：WO1997043247A1
公开(公告)日：1997-11-20
申请号：PCT/US1997007919
申请日：1997-05-12
申请人： BAYER CORPORATION , WOLANIN, Donald, J.
发明人： BAYER CORPORATION
IPC分类号： C07C235/84
CPC分类号： C07D295/192 , C07C17/16 , C07C45/46 , C07C59/88 , C07C69/738 , C07C235/84 , C07C25/02 , C07C49/813
摘要： Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have generalized formula (I), wherein R is a substituted phenylethyl moiety. These compounds are useful for inhibiting matrix metalloproteases and, therefore, combatting conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempero mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from athrosclerotic plaque rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.
摘要翻译：提出了基质金属蛋白酶抑制化合物，其药物组合物和使用这些化合物的疾病治疗方法。本发明的化合物具有通式（I），其中R 25是取代的苯乙基部分。这些化合物可用于抑制基质金属蛋白酶，因此可用于促进MMP的作用，如骨关节炎，类风湿性关节炎，脓毒性关节炎，牙周病，角膜溃疡，蛋白尿，动脉瘤性主动脉疾病，疏水性表皮松解症，大疱疹，导致炎症的病症反应，MMP活性介导的骨质减少，颞下颌关节疾病，神经系统脱髓鞘疾病，创伤性关节损伤后的肿瘤转移或退行性软骨损失，以及来自动脉粥样硬化斑块破裂的冠状动脉血栓形成。本发明还提供了用于治疗这些病症的药物组合物和方法。

10. 发明申请

WO1996020972A2 A PROCESS FOR THE REMOVAL OF A pH-BASIC MATERIAL FROM A POLYETHER POLYOL 审中-公开
标题翻译：从聚醚多元醇中去除pH基本材料的方法
公开(公告)号：WO1996020972A2
公开(公告)日：1996-07-11
申请号：PCT/US1995016244
申请日：1995-12-08
申请人： BAYER CORPORATION
发明人： BAYER CORPORATION , KRATZ, Mark, R. , YEATER, Robert, P. , BALISTER, David, A. , TIRPAK, Robin, E. , NEWMAN, Lewis, S. , STEITLE, Richard, B. , SOLOMON, Mark, S. , TIMM, Ronald, B.
IPC分类号： C08G65/30
CPC分类号： C08G65/30
摘要： A process for removing a pH-basic material from a polyether polyol polymerizate in which a polymerizate containing polyether and an alkaline material is combined with water and, if the difference between the specific gravity of the poymerizate and water is less than 0.1, an inorganic salt at a temperature and under conditions such that an emulsion forms. No organic solvent is required. The emulsion is heated to a temperature of from about 90 to about 150 DEG C. The heated emulsion is then passed through a coalescing medium at a rate such that the residence time is sufficient to separate the emulsion into an aqueous phase containing the pH-basic material and an organic phase containing a polyether polyol which is substantially free of pH-basic material.
摘要翻译：从聚醚多元醇聚合物中除去含有聚醚和碱性物质的聚合物的pH-碱性物质与水混合的方法，如果所述聚合物与水的比重之差小于0.1，则无机盐在温度和条件下使得形成乳液。不需要有机溶剂。将乳液加热至约90至约150℃的温度。然后将加热的乳液以一定的速率通过聚结介质，使得停留时间足以将乳液分离成含有pH-碱性的水相材料和含有基本上不含pH-碱性材料的聚醚多元醇的有机相。

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