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1. 发明申请

WO0076966A3 INDOLINYLAMIDE DERIVATIVES AND THE USE THEREOF AS ANTIVIRAL DRUGS 审中-公开
标题翻译： INDOLINYLAMIDDERIVATE及其作为抗病毒药物
公开(公告)号：WO0076966A3
公开(公告)日：2001-07-19
申请号：PCT/EP0005114
申请日：2000-06-05
申请人： BAYER AG , HANDKE GABRIELE , BAUMEISTER JUDITH , BENDER WOLFGANG , BETZ ULRICH , BRANDS MICHAEL , ECKENBERG PETER , FISCHER RUEDIGER , HENDRIX MARTIN , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JOERG , KLEYMANN GERALD , MAESSEN JUTTA , SCHNEIDER UDO , WEBER OLAF
发明人： HANDKE GABRIELE , BAUMEISTER JUDITH , BENDER WOLFGANG , BETZ ULRICH , BRANDS MICHAEL , ECKENBERG PETER , FISCHER RUEDIGER , HENDRIX MARTIN , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JOERG , KLEYMANN GERALD , MAESSEN JUTTA , SCHNEIDER UDO , WEBER OLAF
IPC分类号： C07D209/08 , C07D401/12 , C07D403/12 , C07D405/12 , A61K31/404 , A61P31/12
CPC分类号： C07D401/12 , C07D209/08 , C07D403/12 , C07D405/12
摘要： The invention relates to compounds of general formula (I), to a method for the production thereof and to the use of said compounds as medicaments, particularly as antiviral drugs.
摘要翻译：本发明betrifftneue通式（I）化合物，它们的制备方法以及它们作为药物的用途，尤其是作为抗病毒药物的方法。

2. 发明申请

WO03064394A8 5-RING HETEROCYCLES USED AS ANTIVIRAL AGENTS 审中-公开
标题翻译： 5-的环杂次循环使用作为抗病毒剂
公开(公告)号：WO03064394A8
公开(公告)日：2003-12-24
申请号：PCT/EP0300376
申请日：2003-01-16
申请人： BAYER AG , WUNBERG TOBIAS , BETZ ULRICH , KLEYMANN GERALD , NIKOLIC SUSANNE , REEFSCHLAEGER JUERGEN , SCHOHE-LOOP RUDOLF , ZIMMERMANN HOLGER , ZUMPE FRANZ , BENDER WOLFGANG , HENNINGER KERSTIN , HEWLETT GUY , JENSEN AXEL , KELDENICH JOERG
发明人： WUNBERG TOBIAS , BETZ ULRICH , KLEYMANN GERALD , NIKOLIC SUSANNE , REEFSCHLAEGER JUERGEN , SCHOHE-LOOP RUDOLF , ZIMMERMANN HOLGER , ZUMPE FRANZ , BENDER WOLFGANG , HENNINGER KERSTIN , HEWLETT GUY , JENSEN AXEL , KELDENICH JOERG
IPC分类号： A61K31/4152 , A61K31/4196 , A61P31/12 , C07D231/20 , C07D231/54 , C07D249/12 , A61K31/12
CPC分类号： C07D249/12 , C07D231/20 , C07D231/54
摘要： The invention relates to 5-ring heterocycles, methods for the production thereof, and the use thereof for the production of medicines used for treating or preventing diseases, particularly medicines used as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及5-环杂环，以及它们的制备方法以及它们在制备用于疾病的治疗和/或预防药物的用途，特别是用作抗病毒剂，尤其是对抗巨细胞病毒。

3. 发明申请

WO2004060860A3 METHOD FOR INHIBITING THE REPLICATION OF HERPES VIRUSES 审中-公开
标题翻译：方法INHIBITING疱疹病毒的复制
公开(公告)号：WO2004060860A3
公开(公告)日：2005-02-10
申请号：PCT/EP0314883
申请日：2003-12-24
申请人： BAYER HEALTHCARE AG , BETZ ULRICH , HEWLETT GUY , KLEYMANN GERALD , LAMPE THOMAS , LIN TSE-I , NIKOLIC SUSANNE , REEFSCHLAEGER JUERGEN , WUNBERG TOBIAS , ZIMMERMANN HOLGER , ZUMPE FRANZ , BENDER WOLFGANG , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JOERG , SCHOHE-LOOP RUDOLF
发明人： BETZ ULRICH , HEWLETT GUY , KLEYMANN GERALD , LAMPE THOMAS , LIN TSE-I , NIKOLIC SUSANNE , REEFSCHLAEGER JUERGEN , WUNBERG TOBIAS , ZIMMERMANN HOLGER , ZUMPE FRANZ , BENDER WOLFGANG , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JOERG , SCHOHE-LOOP RUDOLF
IPC分类号： A61P31/22 , C07D237/04 , G01N33/569
CPC分类号： C07C311/08 , C07C275/40 , C07D237/04 , G01N33/56994 , G01N2500/00
摘要： The invention relates to a method for inhibiting the replication of herpes viruses, to methods for identifying compounds that inhibit the replication of herpes viruses with this method, to compounds with activity directed against herpes viruses, to methods for producing these compounds, and to the use thereof for producing medicaments used in the treatment of herpes infections.
摘要翻译：本发明涉及一种抑制疱疹病毒，用于鉴定抑制疱疹病毒的复制使用这种方法的化合物，具有抗疱疹病毒活性的化合物的方法中的复制，涉及它们的制备方法以及它们用于制备药物的疱疹感染的治疗中使用的方法的方法，

4. 发明申请

WO2004015416A3 METHODS FOR THE IDENTIFICATION OF AGENTS WITH ANTI-MICROBIAL ACTION 审中-公开
标题翻译：一种用于识别物质具有抗微生物作用
公开(公告)号：WO2004015416A3
公开(公告)日：2004-05-06
申请号：PCT/EP0308145
申请日：2003-07-24
申请人： BAYER HEALTHCARE AG , KLEYMANN GERALD , WERLING HANS-OTTO
发明人： KLEYMANN GERALD , WERLING HANS-OTTO
IPC分类号： C12Q1/18 , G01N33/50 , G01N33/52
CPC分类号： C12Q1/18 , G01N33/5014
摘要： The invention relates to a novel method and the use thereof for the discovery of novel anti-microbial agents, characterised in that potential agents are simultaneously incubated with eukaryotic cells and non-viral microbes in a test composition, the viability of the eukaryotic cells is determined and subsequently those agents are selected for which the signal for the corresponding test composition is significantly larger than the mean value of the infection control at at least one concentration of the agent.
摘要翻译：本发明涉及一种新的方法和其用于新的抗微生物剂的发现，其特征在于，潜在剂的用途是在同时与真核细胞和真核细胞的活力，确定非病毒的微生物，随后这样的试剂一起温育测定中使用被选择，其中，相应的测试方法的信号大于平均感染控制所述活性成分中的至少一个的浓度的显著更大。

5. 发明专利

PL356484A1 THIAZOLYL AMIDE DERIVATIVES 未知
公开(公告)号：PL356484A1
公开(公告)日：2004-06-28
申请号：PL35648400
申请日：2000-12-12
申请人： BAYER AG
发明人： FISCHER RUDIGER , KLEYMANN GERALD , BETZ ULRICH , BAUMEISTER JUDITH , BENDER WOLFGANG , ECKENBERG PETER , HANDKE GABRIELE , HENRIX MARTIN , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JORG , SCHNEIDER UDO , WEBER OLAF
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , C07D277/20 , A61K31/5377 , A61K31/695 , A61P1/16 , A61P11/00 , A61P25/00 , A61P27/02 , A61P31/12 , A61P31/22 , C07B61/00 , C07D277/54 , C07D417/12 , C07D521/00 , C07F7/18 , C07F9/6539
摘要： The present invention relates to novel compounds, to a process for their preparation and to their use as medicaments, in particular as antiviral medicaments.

6. 发明专利

DE10222024A1 New N-substituted N'-((5-oxo-2-pyrrolidinyl)-phenyl)-(thio)ureas, are antiviral agents especially effective against human cytomegalovirus 未知
公开(公告)号：DE10222024A1
公开(公告)日：2003-11-27
申请号：DE10222024
申请日：2002-05-17
申请人： BAYER AG
发明人： WUNBERG TOBIAS , BAUMEISTER JUDITH , BETZ ULRICH , JENSEN AXEL , NIKOLIC SUSANNE , REEFSCHLAEGER JUERGEN , ZIMMERMANN HOLGER , ZUMPE FRANZ , GROSSER ROLF , KLEYMANN GERALD , BENDER WOLFGANG , HENNINGER KERSTIN , HEWLETT GUY , KELDENICH JOERG
IPC分类号： A61K31/4015 , A61P31/12 , A61P31/18 , A61P31/20 , A61P31/22 , C07D207/26
摘要： N-(Aryl or cycloalkyl)-N'-((5-oxo-2-pyrrolidinyl)-phenyl)-urea or thiourea derivatives (I) are new. Pyrrolidone derivatives of formula (I) are new. D = O or S; R1, R4 = H or alkyl (optionally substituted (os) by 1-3 of halo, OH, alkoxy, aryl, NH2 or alkylamino); R2 = 3-10C cycloalkyl or aryl (os by 1-3 of halo, OH, NO2, CN, alkoxy, COOH, alkoxycarbonyl, NH2, alkylamino, alkylaminocarbonyl or alkyl); R3, R6 = H or alkyl (os by 1-3 of F, Cl, OH, alkoxy, aryl, NH2 or alkylamino); R5 = H, halo, OH, CN, alkoxy, COOH, alkoxycarbonyl, CONH2, alkylaminocarbonyl, NH2, alkylamino or alkyl; R7 = H or alkyl (os by 1-3 of halo, OH, COOH, CONH2, alkoxy, aryl, NH2, alkylamino, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonylamino or arylcarbonylamino); or R1 + R4 or R3 + R6 = group completing a 3-6C cycloalkyl ring (os by 1-3 of halo, OH, alkyl, alkoxy, aryl, NH2 or alkylamino); Alkyl moieties have 1-6C and aryl moieties 6-10C. Provided that: (1) R1, R3, R4 and R6 are not all H; and (2) the -NHC(D)NHR2 group is not in the 4-position of the phenyl ring; An Independent claim is included for the preparation of (I).

7. 发明专利

AU8200701A Inverse thiazolyl amide derivatives 未知
公开(公告)号：AU8200701A
公开(公告)日：2002-02-18
申请号：AU8200701
申请日：2001-07-23
申请人： BAYER AG
发明人： HENDRIX MARTIN , KLEYMANN GERALD , BETZ ULRICH , BAUMEISTER JUDITH , BENDER WOLFGANG , ECKENBERG PETER , FISCHER RUDIGER , HANDKE GABRIELE , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JORG , SCHNEIDER UDO , WEBER OLAF
IPC分类号： A61P31/12 , C07D277/36 , A61K31/425

8. 发明专利

DE10038022A1 未知
公开(公告)号：DE10038022A1
公开(公告)日：2002-02-14
申请号：DE10038022
申请日：2000-08-04
申请人： BAYER AG
发明人： HENDRIX MARTIN , KLEYMANN GERALD , BETZ ULRICH , BAUMEISTER JUDITH , BENDER WOLFGANG , ECKENBERG PETER , FISCHER RUEDIGER , HANDKE GABRIELE , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JOERG , SCHNEIDER UDO , WEBER OLAF
IPC分类号： A61P31/12 , C07D277/36 , A61K31/425 , C07D417/12 , C07D417/14
摘要： The invention relates to novel compounds, namely inverse thiazolyl amide derivatives of the formula (I). The invention also relates to methods for producing said derivatives, and to their use as medicaments, especially as antiviral medicaments.

9. 发明专利

AU5973400A Method for identifying compounds with anti-herpes activity 未知
公开(公告)号：AU5973400A
公开(公告)日：2001-12-24
申请号：AU5973400
申请日：2000-06-15
申请人： BAYER AG
发明人： KLEYMANN GERALD , BETZ ULRICH , FISCHER RUDIGER , HENDRIX MARTIN , HEWLETT GUY , PEVZNER VENIAMIN
IPC分类号： C07D277/54 , C07D417/12 , G01N33/50 , G01N33/569

10. 发明专利

DE19962532A1 New 2-acylamino-5-aminosulfonyl-1,3-thiazole derivatives, useful as antiviral agents, especially for treatment or prophylaxis of herpes simplex virus infections 未知
公开(公告)号：DE19962532A1
公开(公告)日：2001-07-05
申请号：DE19962532
申请日：1999-12-23
申请人： BAYER AG
发明人： FISCHER RUEDIGER , KLEYMANN GERALD , BETZ ULRICH , BAUMEISTER JUDITH , BENDER WOLFGANG , ECKENBERG PETER , HANDKE GABRIELE , HENDRIX MARTIN , HENNINGER KERSTIN , JENSEN AXEL , KELDENICH JOERG , SCHNEIDER UDO , WEBER OLAF
IPC分类号： C07D277/54 , C07D417/12 , C07D521/00 , C07F7/18 , C07F9/6539 , A61K31/425
摘要： 2-Acylamino-5-aminosulfonyl-1,3-thiazole derivatives (I) are new. Thiazole derivatives of formula (I) and their salts are new. R1 = H, halo, alkyl, alkoxy, aminoalkyl or haloalkyl; R2, R3 = H, alkoxy, cycloalkyl or biphenylaminocarbonyl; alkyl (optionally substituted (os) by 1-3 of 3-6C cycloalkyl, alkoxy, halo, OH, NH2, trialkylsilyloxy, 3,4-methylenedioxyphenyl, tetrahydrofuran-2-yl, -N(R'2)-COOCMe3, Het1, Het2 or aryl (itself os by OH or alkoxy); -COCH(R10)-NH2; or -CH(R11)-OCOR12; or NR2R3 = 5- or 6-membered saturated heterocycle optionally containing O; R'2, R8, R9 = H or 1-4C alkyl; Het1 = optionally N-bonded 5- or 6-membered aromatic heterocycle containing 1-3 of S, N and O as heteroatom(s); Het2 = optionally N-bonded 3-8 membered saturated or unsaturated non-aromatic heterocycle containing 1-3 of S, N and O as heteroatom(s); R10 = side-chain of a naturally occurring alpha -amino acid; R11 = 1-4C alkyl; R12 = H, 1-4C alkyl or -CHR10-NH2; R4 = H, 1-6C acyl, 2-6C alkenyl or cycloalkyl; or alkyl os by (i) 1-3 of halo, OH, cycloalkyl, 1-6C acyl, alkoxy, COOH, -NHCOOCMe3, -(OCH2CH2)nOEt, OPh, aryl or NR13R14 or (ii) Het1 (optionally fused with benzo), 1-(R16)-2-pyrrolidinyl, tetrahydrofuran-2-yl, benzo-1,4-dioxan-2-yl, 2-oxo-1-pyrrolidinyl or -OCONR17R18; n = 0 or 1; R13, R14 = H, 1-6C acyl, alkyl, CONH2, mono- or dialkylaminoalkyl, mono- or dialkylaminocarbonyl, aryl or alkoxycarbonyl; or NR13R14 = 5- or 6-membered saturated heterocycle optionally containing O, S or NR15 as additionally heteroatom and os by oxo; R15 = H or 1-4C alkyl; R17, R18 = H; or alkyl or aryl (both os by 1-3 of OH, alkoxy and halo); R5, R7 = H, alkyl, halo, NH2, mono- or dialkylamino or (1-6C) alkanoylamino; R6 = phenyl, os by 1-3 Q; Q = halo, aryl (os by 1-3 Q'), alkoxy (os by 1-6 F), alkoxycarbonyl, alkylthio, OH, COOH, alkyl (os by tetrahydrofuran-2-yl), Het1 (os by 1-3 Q'), mono- or bicyclic Het2 (os by 1-3 of oxo, halo, OH, alkoxycarbonyl, alkoxycarbonylamino, alkyl, haloalkyl and hydroxyalkyl), 2-6C alkenyl, OR19, NR20R21, CONR22R23, carbazole, dibenzofuran, dibenzothiepin, xanthene or 9,10-dihydroacridine; Q' = (1-6C) alkanoyl, alkoxy, alkyl, halo, alkoxycarbonyl, NO2, haloalkyl, haloalkoxy, NH2, alkylthio, OH, COOH, CONH2, mono- or dialkylaminocarbonyl, mono- or di-(1-6C alkanoyl)-amino, alkoxycarbonylamino, alkylsulfoxy, alkylsulfonyl, trialkylsilyloxy, CN or mono- or bicyclic Het2; R19 = phenyl (os by NR24R25) or alkyl (os by 1-3 of OH or halo); R24, R25 = H, alkyl or 1-6C acyl; R20, R21 = H, CONH2, mono- or dialkylaminocarbonyl, phenyl, 1-6C acyl or alkyl (where alkyl is os by alkoxy, 1-6C acyl, phenyl or Het1; and phenyl and Het1 are os by one or more of halo and/or OH); R22, R23 = H or alkyl; and D' = halogen. alkyl moieties have 1-6C, cycloalkyl moieties 3-8C and aryl moieties 6-10C unless specified otherwise. Independent claims are included for: (i) the preparation of (I); (ii) new sulfonyl halide intermediates of formula (IV); and (iii) the use of N-(5-(aminosulfonyl)-1,3-thiazol-2-yl)-acetamide, N-(5-(aminosulfonyl)-1,3-thiazol-2-yl)-2-phenylacetamide or N-(5-(aminosulfonyl)-1,3-thiazol-2-yl)-2-(1,1'-biphenyl)-4-ylacetamide derivatives for the preparation of medicaments.

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