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1. 发明专利

DE69818044T2 未知
公开(公告)号：DE69818044T2
公开(公告)日：2004-07-15
申请号：DE69818044
申请日：1998-05-29
申请人： BAYER AG
发明人： JIANG QINGPING , XI JUN , NATRAJAN ANAND , SHARPE DAVID , BAUMANN MARCUS , HILFIKER ROLF , SCHMIDT ERIKA , SENN PAUL , THOMMEN FRITZ , WALDNER ADRIAN , ALDER ALEX , LAW SAY-JONG
IPC分类号： C09B11/04 , C09B15/00 , C09K11/07 , G01N33/533 , G01N33/542 , G01N33/58
摘要： A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emission wavelengths of acridinium or benzacridinium esters in order to further reduce or eliminate the emission spectral overlap between the parent polysubstituted aryl Acridinium Esters (DMAE) and Benzacridinium Esters (LEAE) is disclosed. The ETC's retain the unique desired properties of acridinium or benzacridinium compounds including complete light emission in very short period of time, monophasic emission spectrum, simplicity of triggering mechanism, ability of labeling the biological molecules of interest to form a tracer, and good stability. Additionally, the range of the emission spectrum of an acridinium or benzacridinium compound can now be shifted at will and at longer leap through the choice of a luminophore as the integral part of an ETC molecule. Disclosed are chemiluminescent labeled conjugates comprising an acridinium or benzacridinium moiety covalently attached to a luminophore via a spacer, said moiety further conjugated to a biological molecule of interest, wherein said spacer is of an appropriate length to allow the excited species generated from said moiety to transfer energy efficiently to said luminophore, resulting in the emission of light in the spectral region of said luminophore. Also disclosed are binding assays using said conjugates, test kits comprising said conjugates and methods of preparing the conjugates.

2. 发明专利

DE69818044D1 未知
公开(公告)号：DE69818044D1
公开(公告)日：2003-10-16
申请号：DE69818044
申请日：1998-05-29
申请人： BAYER AG
发明人： JIANG QINGPING , XI JUN , NATRAJAN ANAND , SHARPE DAVID , BAUMANN MARCUS , HILFIKER ROLF , SCHMIDT ERIKA , SENN PAUL , THOMMEN FRITZ , WALDNER ADRIAN , ALDER ALEX , LAW SAY-JONG
IPC分类号： C09B11/04 , C09B15/00 , C09K11/07 , G01N33/533 , G01N33/542 , G01N33/58
摘要： A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emission wavelengths of acridinium or benzacridinium esters in order to further reduce or eliminate the emission spectral overlap between the parent polysubstituted aryl Acridinium Esters (DMAE) and Benzacridinium Esters (LEAE) is disclosed. The ETC's retain the unique desired properties of acridinium or benzacridinium compounds including complete light emission in very short period of time, monophasic emission spectrum, simplicity of triggering mechanism, ability of labeling the biological molecules of interest to form a tracer, and good stability. Additionally, the range of the emission spectrum of an acridinium or benzacridinium compound can now be shifted at will and at longer leap through the choice of a luminophore as the integral part of an ETC molecule. Disclosed are chemiluminescent labeled conjugates comprising an acridinium or benzacridinium moiety covalently attached to a luminophore via a spacer, said moiety further conjugated to a biological molecule of interest, wherein said spacer is of an appropriate length to allow the excited species generated from said moiety to transfer energy efficiently to said luminophore, resulting in the emission of light in the spectral region of said luminophore. Also disclosed are binding assays using said conjugates, test kits comprising said conjugates and methods of preparing the conjugates.

3. 发明专利

AT249628T 未知
公开(公告)号：AT249628T
公开(公告)日：2003-09-15
申请号：AT98920688
申请日：1998-05-29
申请人： BAYER AG
发明人： JIANG QINGPING , XI JUN , NATRAJAN ANAND , SHARPE DAVID , BAUMANN MARCUS , HILFIKER ROLF , SCHMIDT ERIKA , SENN PAUL , THOMMEN FRITZ , WALDNER ADRIAN , ALDER ALEX , LAW SAY-JONG
IPC分类号： C09B11/04 , C09B15/00 , C09K11/07 , G01N33/533 , G01N33/542 , G01N33/58
摘要： A new class of chemiluminescent acridinium or benzacridinium compounds is disclosed by virtue of forming an intramolecular energy transfer conjugate (ETC) between the acridinium or benzacridinium compound and a luminophore. A method of extending the emission wavelengths of acridinium or benzacridinium esters in order to further reduce or eliminate the emission spectral overlap between the parent polysubstituted aryl Acridinium Esters (DMAE) and Benzacridinium Esters (LEAE) is disclosed. The ETC's retain the unique desired properties of acridinium or benzacridinium compounds including complete light emission in very short period of time, monophasic emission spectrum, simplicity of triggering mechanism, ability of labeling the biological molecules of interest to form a tracer, and good stability. Additionally, the range of the emission spectrum of an acridinium or benzacridinium compound can now be shifted at will and at longer leap through the choice of a luminophore as the integral part of an ETC molecule. Disclosed are chemiluminescent labeled conjugates comprising an acridinium or benzacridinium moiety covalently attached to a luminophore via a spacer, said moiety further conjugated to a biological molecule of interest, wherein said spacer is of an appropriate length to allow the excited species generated from said moiety to transfer energy efficiently to said luminophore, resulting in the emission of light in the spectral region of said luminophore. Also disclosed are binding assays using said conjugates, test kits comprising said conjugates and methods of preparing the conjugates.

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