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1. 发明专利

ZA200203983B Method for production of 1.3-disubstituted 2-nitroguanidines. 未知
公开(公告)号：ZA200203983B
公开(公告)日：2003-07-30
申请号：ZA200203983
申请日：2002-05-20
申请人： BAYER AG
发明人： LAAK KAI VAN , SIRGES WOLFRAM , WOLLWEBER DETLEF
IPC分类号： C07D277/20 , C07D213/61 , C07D251/08 , C07D277/32 , C07D307/14 , C07D307/34 , C07D
摘要： The present invention relates to a process for the preparation of compounds of the formula (I)by reacting compounds of the formula (II)in whichHet, R1, R2 and R4 are as defined in the description,with anhydrous hydrogen chloride or compounds which generate hydrogen chloride.

2. 发明专利

AU2371401A Method for producing n-methyl-n'-nitroguanidine 未知
公开(公告)号：AU2371401A
公开(公告)日：2001-07-24
申请号：AU2371401
申请日：2001-01-03
申请人： BAYER AG
发明人： LAAK KAI VAN , SIRGES WOLFRAM
IPC分类号： C07C277/08 , C07C279/36
摘要： The present invention relates to a novel process for the preparation of N-methyl-N'-nitroguanidine by reacting nitroguanidine with aqueous methylamine solution buffered by the addition of inorganic or organic acids.

3. 发明专利

DE10000891A1 未知
公开(公告)号：DE10000891A1
公开(公告)日：2001-07-19
申请号：DE10000891
申请日：2000-01-12
申请人： BAYER AG
发明人： LAAK KAI VAN , SIRGES WOLFRAM
IPC分类号： C07C277/08 , C07C279/36
摘要： The invention relates to a novel method for producing N-methyl-N'-nitroguanidine by reacting nitroguanidine with an aqueous methylamine solution that has been buffered by adding inorganic or organic acids.

4. 发明专利

NO971513A 未知
公开(公告)号：NO971513A
公开(公告)日：1997-10-06
申请号：NO971513
申请日：1997-04-03
申请人： BAYER AG
发明人： LENFERS JAN-BERND , FEY PETER , NAAB PAUL , LAAK KAI VAN
IPC分类号： C07C69/612 , C07C69/616 , C07C69/65 , C07D471/04 , C07D487/04 , A61K31/44
CPC分类号： C07D471/04 , C07C69/612 , C07C69/616 , C07C69/65 , C07D487/04

5. 发明专利

NO954885L 未知
公开(公告)号：NO954885L
公开(公告)日：1996-06-06
申请号：NO954885
申请日：1995-12-01
申请人： BAYER AG
发明人： MITTENDORF JOACHIM , FEY PETER , JUNGE BODO , KAULEN JOHANNES , LAAK KAI VAN , MEIER HEINRICH , SCHOHE-LOOP RUDOLF
IPC分类号： A61K31/4412 , A61P25/28 , C07D207/40 , C07D207/416 , C07D211/80 , C07D211/90 , C07D401/02 , C07D401/06 , C07D401/12 , C07D521/00
摘要： 2-Benzylidene-3-oxo-butyric acid malimide esters(II), enantiomerically pure aminocrotonic acid malimide esters (IIIa) and enantiomerically pure acetoacetic acid malimide esters (VI) are new. Benzylidene compounds of formula (II), enantiomerically pure aminocrotonic acid esters of formula (IIIa) and enantiomerically pure acetoacetic acid esters of formula (VI) are new. [Image] R2>phenyl substituted by 1 or 2 of halo, CN, ethynyl, OCF3, SMe, NO2, CF3, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl or 1-4C alkoxy; A : H or 1-8C alkyl; or phenyl or benzyl (both optionally substituted by 1-3 of OH, NO2, halo, CN, COOH, CF3, OCF3 or 1-6C alkoxy or by NR6>R7> or SO2R8>); R6>, R7>H, Ph or 1-5C alkyl; R8>1-4C alkyl or Ph. Independent claims are also included for: (1) the preparation of enatiomerically pure (II), (IIIa) and (VI); and (2) the preparation of diastereomeric 1,4-dihydropyridines of formula (IVa) or (IVb) by: (a) reacting enatiomerically pure (II) with aminocrotonic acid ester of formula Me-C(NH2)=CH-COOR1> (III) in a solvent, optionally in presence of base; or (b) reacting enatiomerically pure (IIIa) with benzylidene compound of formula R2>-CH=C(COMe)-COOR1> (IIa) in a solvent, optionally in presence of base. [Image] R1>1-8C alkyl (optionally substituted by 1-6C alkoxy) or 3-7C cycloalkyl.

6. 发明专利

BR0016521A 未知
公开(公告)号：BR0016521A
公开(公告)日：2002-09-24
申请号：BR0016521
申请日：2000-12-08
申请人： BAYER AG
发明人： LAAK KAI VAN , SIRGES WOLFRAM , WOLLWEBER DETLEF
IPC分类号： C07D277/20 , C07D213/61 , C07D251/08 , C07D277/32 , C07D307/14 , C07D307/34
摘要： The present invention relates to a process for the preparation of compounds of the formula (I)by reacting compounds of the formula (II)in whichHet, R1, R2 and R4 are as defined in the description,with anhydrous hydrogen chloride or compounds which generate hydrogen chloride.

7. 发明专利

NO312832B1 未知
公开(公告)号：NO312832B1
公开(公告)日：2002-07-08
申请号：NO954885
申请日：1995-12-01
申请人： BAYER AG
发明人： MITTENDORF JOACHIM , FEY PETER , JUNGE BODO , KAULEN JOHANNES , LAAK KAI VAN , MEIER HEINRICH , SCHOHE-LOOP RUDOLF
IPC分类号： A61K31/4412 , A61P25/28 , C07D207/40 , C07D207/416 , C07D211/80 , C07D211/90 , C07D401/02 , C07D401/06 , C07D401/12 , C07D521/00 , A61K31/44
摘要： 2-Benzylidene-3-oxo-butyric acid malimide esters(II), enantiomerically pure aminocrotonic acid malimide esters (IIIa) and enantiomerically pure acetoacetic acid malimide esters (VI) are new. Benzylidene compounds of formula (II), enantiomerically pure aminocrotonic acid esters of formula (IIIa) and enantiomerically pure acetoacetic acid esters of formula (VI) are new. [Image] R2>phenyl substituted by 1 or 2 of halo, CN, ethynyl, OCF3, SMe, NO2, CF3, 1-4C alkyl, 2-4C alkenyl, 2-4C alkynyl or 1-4C alkoxy; A : H or 1-8C alkyl; or phenyl or benzyl (both optionally substituted by 1-3 of OH, NO2, halo, CN, COOH, CF3, OCF3 or 1-6C alkoxy or by NR6>R7> or SO2R8>); R6>, R7>H, Ph or 1-5C alkyl; R8>1-4C alkyl or Ph. Independent claims are also included for: (1) the preparation of enatiomerically pure (II), (IIIa) and (VI); and (2) the preparation of diastereomeric 1,4-dihydropyridines of formula (IVa) or (IVb) by: (a) reacting enatiomerically pure (II) with aminocrotonic acid ester of formula Me-C(NH2)=CH-COOR1> (III) in a solvent, optionally in presence of base; or (b) reacting enatiomerically pure (IIIa) with benzylidene compound of formula R2>-CH=C(COMe)-COOR1> (IIa) in a solvent, optionally in presence of base. [Image] R1>1-8C alkyl (optionally substituted by 1-6C alkoxy) or 3-7C cycloalkyl.

8. 发明专利

NO20003784D0 未知
公开(公告)号：NO20003784D0
公开(公告)日：2000-07-24
申请号：NO20003784
申请日：2000-07-24
申请人： BAYER AG
发明人： LENFERS JAN-BERND , FEY PETER , NAAB PAUL , LAAK KAI VAN
IPC分类号： C07C69/612 , C07C69/616 , C07C69/65 , C07D471/04 , C07D487/04
摘要： Preparation of (heterocyclyl-methyl)phenylacetic acid compounds of formula (I) and its salts comprises (1) diastereoselective alkylation of a compound of formula CH3-Ar-CH2COOR6 (II) with a compound of formula T-Z (III) in an inert solvent in the presence of a base to give the compound of formula CH3-Ar-CHT(*)COOR6 (IV); (2) halogenation of (IV) to give the compound of formula R7-CH2-Ar-CHT(*)COOR6 (V); (3) reacting (V) with a compound A-H (VI) to give the compound of formula A-CH2-Ar-CHT(*)COOR6 (VII); and (4a) hydrolysis of (VII) to give (I; Q = OH), or (4b) reaction with the appropriate compound to give (I; Q = activated group). Ar = phenylene; A = a group of formula (a) or (b') (N.B., (b') is described as an aza-indole and given everywhere else as a group of formula (b); A', D, E, G, L, M = H or R; R1+R2 complete benzene, pyridine or a ring of formula (c) (all optionally substituted by mono- to tri-substituted by R); R5 = H or 1-4C alkyl; R3+R4 complete benzene, 4-8 membered cycloalkene or 4-8 membered oxocycloalkene group (all optionally mono- to tri-substituted by R); R = halo, CF3, CO2H, OH, 1-6C alkoxy, 1-6C alkoxycarbonyl or 1-6C alkyl (optionally substituted by OH or 1-4C alkoxy); T = 4-12C cycloalkyl or 1-12C alkyl; Q = OH or an activated group; OR6 = a chiral alcohol group; Z = a typical leaving group such as Br, Cl, I, mesyl, tosyl or SO2CF3, preferably I or Br; R7 = halo, such as Cl, Br or I, preferably Br. Also claimed is a method for preparing (I) by resolving (R,S) CH3-Ar-CH2COOH (X) by reaction with (R)- or (S)-phenylethylamine in an inert solvent followed by crystallisation of the resulting phenylethylammonium salt; reaction with isobutene in an inert solvent in the presence of an acid to give (XII) of formula (IV; R6 = tert. butyl); and treatment of (XII) as for (IV). The following compounds and their salts are new; (I; A = a group of formula (a1) or (b1); Q = OH or Cl); (IV; R6 = D- or L-menthyl or tert.-butyl and T is not isopropyl (sic)); (V; R6 = D- or L-menthyl or tert.-butyl R7 = Br)); and compounds described as (VII) with R6 = D- or L-menthyl and given the formula (A).

9. 发明专利

DE19853863C1 Production of oxadiazolone derivatives useful as herbicide intermediates comprises simultaneously adding a carboxylic acid hydrazide solution and phosgene to a solvent 未知
公开(公告)号：DE19853863C1
公开(公告)日：2000-03-16
申请号：DE19853863
申请日：1998-11-23
申请人： BAYER AG
发明人： LAAK KAI VAN , CASSER CARL , JAUTELAT MANFRED , NIEHOFF MICHAEL
IPC分类号： A01N43/824 , C01B32/80 , C07D271/113
摘要： Production of 5-alkyl-1,3,4-oxadiazol-2(3H)-ones (I) comprises simultaneously adding parallel streams of (a) a solution of a carboxylic acid hydrazide (II) in an organic solvent and (b) phosgene to a solvent. Production of oxadiazolones of formula (I) comprises simultaneously adding parallel streams of (a) a solution of a carboxylic acid hydrazide of formula (II) in an organic solvent and (b) phosgene to a solvent. R = alkyl.

10. 发明专利

AU5654098A Process for the racemization of substituted 4-ketocarboxylic acids 未知
公开(公告)号：AU5654098A
公开(公告)日：1998-06-29
申请号：AU5654098
申请日：1997-11-19
申请人： BAYER AG
发明人： LAAK KAI VAN , PREISS MICHAEL
IPC分类号： C07C51/353 , C07C319/20 , C07C323/56 , C07D209/48 , C07B55/00

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