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1. 发明公开

EP1045829A1 VERFAHREN ZUR HERSTELLUNG VON N-(3-AMINO-4-FLUOR-PHENYL)-SULFONSÄUREAMIDEN, N-(3-AMINO-4-FLUOR-PHENYL)-CARBONSÄUREAMIDEN UND N-(3-AMINO-4-FLUOR-PHENYL)-CARBAMATEN 有权
标题翻译：用于生产N-（3-氨基-4-氟 - 苯基）-SULFONSÄUREAMIDEN，N-（3-氨基-4-氟 - 苯基）甲酰胺和N-（3-氨基-4-氟 - 苯基） - 氨基甲酸酯
公开(公告)号：EP1045829A1
公开(公告)日：2000-10-25
申请号：EP98966672.2
申请日：1998-12-24
申请人： BAYER AG
发明人： HUPPERTS, Achim , LANTZSCH, Reinhard
IPC分类号： C07C231/02 , C07C233/43 , C07C235/56 , C07C269/04 , C07C271/28 , C07C303/38 , C07C311/08
CPC分类号： C07C231/02 , C07C269/04 , C07C303/38 , C07C311/08 , C07C233/80 , C07C235/56 , C07C271/26
摘要： The invention relates to a method for producing N-(3-amino-4-fluorophenyl)- sulphonamides, N-(3-amino-4-fluorophenyl) carboxylic acid amides and N-(3-amino-4-fluorophenyl) carbamates of general formula (I), wherein A stands for SO2, CO or CO2 and R stands for optionally substituted alkyl or aryl, whereby 1-fluoro-2,4 diamino-benzol of formula (II) with sulphonyl chlorides, carboxylic acid chlorides or chloroformic acid esters of general formula (III), wherein A and R have the meaning cited above, is made to react with an acid acceptor and in the presence of a diluting agent at temperatures ranging between -20 °C and +100 °C.

2. 发明公开

EP1030848A1 VERFAHREN ZUR HERSTELLUNG VON TRIAZOLINTHION-DERIVATEN 有权转让
公开(公告)号：EP1030848A1
公开(公告)日：2000-08-30
申请号：EP98951467.4
申请日：1998-09-25
申请人： BAYER AG
发明人： JAUTELAT, Manfred , HUPPERTS, Achim , LANTZSCH, Reinhard
IPC分类号： C07D249/12 , C07C337/06
CPC分类号： C07D249/12 , C07C337/06
摘要： The invention relates to a novel method for producing triazolinthion derivatives of formula (I) in which R?1 and R2¿ have the meanings given in the description. To this end, a) Hydrazine derivatives of formula (II) or addition salts thereof are reacted with an inorganic or organic acid with thiocyanate of formula (III) Y-SCN in which Y represents sodium, potassium or ammonium, said reaction is carried out in the presence of a diluting agent and optionally in the presence of a catalyst; b) the formed thiosemicarbazide derivatives of formula (IV) are reacted with formic acid optionally in the presence of a catalyst and optionally in the presence of a diluting agent. The thiosemicarbazide derivatives of formula (IV) are novel.
摘要翻译：本发明涉及一种制备式（I）三唑啉酮衍生物的新方法，其中R 1和R 2具有在说明书中给出的含义。为此，a）式（II）的肼衍生物或其加成盐与无机酸或有机酸与其中Y代表钠，钾或铵的式（III）Y-SCN的硫氰酸酯反应，所述反应进行在稀释剂存在下并任选在催化剂存在下进行; b）将所形成的式（IV）的氨基硫脲衍生物与甲酸任选在催化剂存在下并任选在稀释剂存在下反应。式（IV）的氨基硫脲衍生物是新颖的。

3. 发明授权

EP0994849B1 VERFAHREN ZUR HERSTELLUNG VON 2,4,5-TRIFLUOR-BENZONITRIL 失效
标题翻译：用于生产2,4,5-三氟苯甲腈
公开(公告)号：EP0994849B1
公开(公告)日：2002-09-04
申请号：EP98932174.0
申请日：1998-06-18
申请人： BAYER AG
发明人： HUPPERTS, Achim , LANTZSCH, Reinhard
IPC分类号： C07C253/00 , C07C255/50
CPC分类号： C07C253/00 , C07C255/50
摘要： The invention relates to a method for the production of 2,4,5-trifluorobenzonitrile of formula (I), comprising the following steps: A) reacting 2,4,5-trifluoroaniline of formula (II) with a nitrosation agent in the presence of a diluent, and B) reacting the product of step A) with an alkaline metal cyanide in the presence of a transition metal compound, an acid scavenger and a diluent.

4. 发明公开

EP1003718A1 VERFAHREN ZUR HERSTELLUNG VON N-(5-AMINO-2-CYANO-4-FLUOR-PHENYL)-SULFONAMIDEN UND NEUE ZWISCHENPRODUKTE 失效
标题翻译： VERFAHREN ZUR HERSTELLUNG VON N-（5-氨基-2-氰基-4-氟 - 苯基） - 磺酰胺和NED ZWISCHENPRODUKTE
公开(公告)号：EP1003718A1
公开(公告)日：2000-05-31
申请号：EP98940212.8
申请日：1998-07-13
申请人： BAYER AG
发明人： HUPPERTS, Achim , DREWES, Mark, Wilhelm , ERDMAN, David , LANTZSCH, Reinhard
IPC分类号： C07C303/38 , C07C303/40 , C07C211/52 , C07C311/08 , C07C311/48
CPC分类号： C07C311/08 , C07C255/58 , C07C303/38 , C07C303/40 , C07C311/48
摘要： The invention relates to a method for producing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides. In a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonic acid halogenides in the presence of an acid acceptor and a diluting agent at temperatures between 0 °C and 150 °C. In a second step, the N-(2-cyano-4,5-difluoro-phenyl)-sulphonamide and/or N-(2-cyano-4,5-difluoro-phenyl)-sulphonamides are reacted, either in the pure state or mixed, with ammonia in the presence of a diluting agent at temperatures between 100 °C and 200 °C. The invention also relates to new intermediate products of this method.
摘要翻译：本发明涉及生产N-（5-氨基-2-氰基-4-氟 - 苯基） - 磺酰胺的方法。在第一步中，2-氨基-4,5-二氟 - 苯甲腈与磺酸卤化物在酸受体和稀释剂存在下在0℃至150℃之间的温度下反应。在第二步中，将N-（2-氰基-4,5-二氟 - 苯基） - 磺酰胺和/或N-（2-氰基-4,5-二氟 - 苯基） - 磺酰胺以纯在稀释剂存在下，在100℃和200℃之间的温度下与氨一起混合或混合。本发明还涉及该方法的新的中间产物。

5. 发明公开

EP0994849A1 VERFAHREN ZUR HERSTELLUNG VON 2,4,5-TRIFLUOR-BENZONITRIL 失效
标题翻译：用于生产2,4,5-三氟苯甲腈
公开(公告)号：EP0994849A1
公开(公告)日：2000-04-26
申请号：EP98932174.0
申请日：1998-06-18
申请人： BAYER AG
发明人： HUPPERTS, Achim , LANTZSCH, Reinhard
IPC分类号： C07C253/00 , C07C255/50
CPC分类号： C07C253/00 , C07C255/50
摘要： The invention relates to a method for the production of 2,4,5-trifluorobenzonitrile of formula (I), comprising the following steps: A) reacting 2,4,5-trifluoroaniline of formula (II) with a nitrosation agent in the presence of a diluent, and B) reacting the product of step A) with an alkaline metal cyanide in the presence of a transition metal compound, an acid scavenger and a diluent.

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