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1. 发明授权

EP1948133B1 ARGATROBAN FORMULATION COMPRISING AN ACID AS SOLUBILIZER 有权
标题翻译：用酸溶液的经纪人ARGATROBANFORMULIERUNG
公开(公告)号：EP1948133B1
公开(公告)日：2011-06-29
申请号：EP06802424.9
申请日：2006-08-28
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation) , Baxter Healthcare S.A.
发明人： OWOO, George , BURGOS, Richard A.
IPC分类号： A61K9/08
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/47 , A61K31/4709 , A61K47/02 , A61K47/12
摘要： An aqueous, stable, sterile pharmaceutical composition of the thrombin inhibitor argatroban in a solution containing an acid to solubilize the argatroban, substantially free from dehydrated alcohol is described, as well as method for its preparation.

2. 发明公开

EP1948133A2 ARGATROBAN FORMULATION COMPRISING AN ACID AS SOLUBILIZER 有权
标题翻译：用酸溶液的经纪人ARGATROBANFORMULIERUNG
公开(公告)号：EP1948133A2
公开(公告)日：2008-07-30
申请号：EP06802424.9
申请日：2006-08-28
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation) , Baxter Healthcare SA
发明人： OWOO, George , BURGOS, Richard A.
IPC分类号： A61K9/08
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/47 , A61K31/4709 , A61K47/02 , A61K47/12
摘要： An aqueous, stable, sterile pharmaceutical composition of the thrombin inhibitor argatroban in a solution containing an acid to solubilize the argatroban, substantially free from dehydrated alcohol is described, as well as method for its preparation.

3. 发明申请

WO2008143682A1 COLORED ESMOLOL CONCENTRATE 审中-公开
标题翻译：有色ESMOLOL浓缩液
公开(公告)号：WO2008143682A1
公开(公告)日：2008-11-27
申请号：PCT/US2007/075069
申请日：2007-08-02
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth E
发明人： TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth E
IPC分类号： A61K47/22 , A61K9/00
CPC分类号： A61K31/24 , A61K9/0019
摘要： A concentrated esmolol formulation is provided that is distinguishable from a diluted form of the concentrated esmolol formulation. The concentrated esmolol formulation can include from about 25 to about 1000 mg/ml of esmolol hydrochloride, a buffering agent and a color additive. Any number of color additives may be included such as indocyanine green, phenopheylene, hemoglobin, cyanocobalamine, patent blue, and indigo carmine vitamin B2 and naturally occurring vitamins and minerals. Also, a medical product is provided that includes a colored concentrated esmolol housed in a container, and a package housing the container and instructions. Additionally a method of allowing easy identification of a concentrated esmolol formulation is provided. The method includes providing a colored concentrated esmolol formulation that has from about 25 to about 1000 mg/ml of esmolol and a color additive.
摘要翻译：提供浓缩艾司洛尔制剂，其与浓缩艾司洛尔制剂的稀释形式区分开。浓缩的艾司洛尔制剂可以包括约25至约1000mg / ml的盐酸艾司洛尔，缓冲剂和颜色添加剂。可以包括任何数量的着色添加剂，例如吲哚菁绿，苯乙烯，血红蛋白，氰钴胺，专利蓝和靛蓝胭脂红维生素B2以及天然存在的维生素和矿物质。此外，提供了一种医疗产品，其包括容纳在容器中的着色浓缩艾司洛尔，以及容纳容器和指令的包装。另外，提供了容易鉴定浓缩艾司洛尔制剂的方法。该方法包括提供具有约25至约1000mg / ml艾司洛尔和着色添加剂的着色浓缩艾司洛尔制剂。

4. 发明申请

WO2008153582A1 CONCENTRATE ESMOLOL 审中-公开
标题翻译：浓缩ESMOLOL
公开(公告)号：WO2008153582A1
公开(公告)日：2008-12-18
申请号：PCT/US2007/074325
申请日：2007-07-25
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth E
发明人： TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth E
IPC分类号： A61K9/00 , A61K47/12 , A61K31/215 , A61K31/24
CPC分类号： A61K31/216 , A61K9/0019 , A61K31/195 , A61K31/215 , A61K31/24 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/26
摘要： A concentrate esmolol formulation is provided that is safer than current concentrate (e.g., 250 mg/ml) esmolol compositions. The concentrate esmolol formulation can include from about 40-60 mg/ml of esmolol hydrochloride. The concentrate esmolol composition allows a practitioner the flexibility of choosing a bolus volume for direct injection to a patient or, optionally, to use the composition to make a customized, diluted composition of esmolol. Methods of the present invention provide for the reduction of potential adverse health consequences resulting in the improper dosing of prior art concentrate compositions of esmolol. Also, a medical product is provided that includes a concentrate esmolol housed in a container, and a package housing the container and instructions.
摘要翻译：提供比当前浓缩物（例如250mg / ml）艾司洛尔组合物更安全的浓缩艾司洛尔制剂。浓缩艾司洛尔制剂可以包括约40-60mg / ml的盐酸艾司洛尔。浓缩艾司洛尔组合物允许从业者灵活地选择推注体积以直接注射给患者，或者任选地使用组合物制备定制的，稀释的艾司洛尔组合物。本发明的方法提供减少潜在的不利健康后果，导致不适当地给予艾司洛尔浓缩组合物的现有技术。此外，提供了包括容纳在容器中的浓缩物艾司洛尔的医疗产品和容纳容器的包装和说明书。

5. 发明申请

WO2008147715A2 MULTI-DOSE CONCENTRATE ESMOLOL WITH BENZYL ALCOHOL 审中-公开
标题翻译：多元醇浓缩醇与苯甲醇
公开(公告)号：WO2008147715A2
公开(公告)日：2008-12-04
申请号：PCT/US2008/063755
申请日：2008-05-15
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth, E.
发明人： TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth, E.
IPC分类号： A61K9/08 , A61K31/215
CPC分类号： A61K31/24 , A61K9/0019 , A61K47/10 , A61K47/12
摘要： Disclosed are concentrate esmolol injection essentially free from other related esters of esmolol and diluted esmolol compositions. The concentrate esmolol formulation includes from about 25-1000 mg/ml of esmolol and about 1-25 % w/v of benzyl alcohol and the combination thereof. The compositions can also be used as multi-dose compositions. The present invention also discloses diluted, ready-to-use compositions of esmolol prepared by dilution of the present invention concentrates. Also disclosed are methods of making and using the ready-to-use compositions of the present invention.
摘要翻译：公开了基本上不含艾司洛尔和稀释艾司洛尔组合物的其它相关酯的浓缩艾司洛尔注射液。浓缩艾司洛尔制剂包括约25-1000mg / ml的艾司洛尔和约1-25％w / v的苄醇及其组合。组合物也可以用作多剂量组合物。本发明还公开了通过稀释本发明浓缩物制备的稀释的即用型艾司洛尔组合物。还公开了制备和使用本发明的即用组合物的方法。

6. 发明申请

WO2007027565A2 ARGATROBAN FORMULATION 审中-公开
标题翻译： ARGATROBAN公式
公开(公告)号：WO2007027565A2
公开(公告)日：2007-03-08
申请号：PCT/US2006/033432
申请日：2006-08-28
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , OWOO, George , BURGOS, Richard A.
发明人： OWOO, George , BURGOS, Richard A.
CPC分类号： A61K9/0019 , A61K9/08 , A61K31/47 , A61K31/4709 , A61K47/02 , A61K47/12
摘要： An aqueous, stable, sterile pharmaceutical composition of the thrombin inhibitor argatroban in a solution containing an acid to solubilize the argatroban, substantially free from dehydrated alcohol is described, as well as method for its preparation.
摘要翻译：描述了一种含有稳定，无菌的凝血酶抑制剂阿加曲班的药物组合物，其含有基本上不含脱水醇的阿卡曲潘溶解酸的溶液，以及其制备方法。

7. 发明公开

EP2162154A1 COLORED ESMOLOL CONCENTRATE 失效
标题翻译：有色艾司洛尔精矿
公开(公告)号：EP2162154A1
公开(公告)日：2010-03-17
申请号：EP07813699.1
申请日：2007-08-02
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth E
IPC分类号： A61K47/22 , A61K9/00
CPC分类号： A61K31/24 , A61K9/0019
摘要： A concentrated esmolol formulation is provided that is distinguishable from a diluted form of the concentrated esmolol formulation. The concentrated esmolol formulation can include from about 25 to about 1000 mg/ml of esmolol hydrochloride, a buffering agent and a color additive. Any number of color additives may be included such as indocyanine green, phenopheylene, hemoglobin, cyanocobalamine, patent blue, and indigo carmine vitamin B2 and naturally occurring vitamins and minerals. Also, a medical product is provided that includes a colored concentrated esmolol housed in a container, and a package housing the container and instructions. Additionally a method of allowing easy identification of a concentrated esmolol formulation is provided. The method includes providing a colored concentrated esmolol formulation that has from about 25 to about 1000 mg/ml of esmolol and a color additive.

8. 发明公开

EP2164463A1 CONCENTRATE ESMOLOL 审中-公开
标题翻译：艾司洛尔精矿
公开(公告)号：EP2164463A1
公开(公告)日：2010-03-24
申请号：EP07840511.5
申请日：2007-07-25
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth E
IPC分类号： A61K9/00 , A61K47/12 , A61K31/215 , A61K31/24
CPC分类号： A61K31/216 , A61K9/0019 , A61K31/195 , A61K31/215 , A61K31/24 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/26
摘要： A concentrate esmolol formulation is provided that is safer than current concentrate (e.g., 250 mg/ml) esmolol compositions. The concentrate esmolol formulation can include from about 40-60 mg/ml of esmolol hydrochloride. The concentrate esmolol composition allows a practitioner the flexibility of choosing a bolus volume for direct injection to a patient or, optionally, to use the composition to make a customized, diluted composition of esmolol. Methods of the present invention provide for the reduction of potential adverse health consequences resulting in the improper dosing of prior art concentrate compositions of esmolol. Also, a medical product is provided that includes a concentrate esmolol housed in a container, and a package housing the container and instructions.

9. 发明授权

EP2162154B1 COLORED ESMOLOL CONCENTRATE 失效
标题翻译：有色艾司洛尔精矿
公开(公告)号：EP2162154B1
公开(公告)日：2011-06-15
申请号：EP07813699.1
申请日：2007-08-02
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth E
IPC分类号： A61K47/22 , A61K9/00
CPC分类号： A61K31/24 , A61K9/0019
摘要： A concentrated esmolol formulation is provided that is distinguishable from a diluted form of the concentrated esmolol formulation. The concentrated esmolol formulation can include from about 25 to about 1000 mg/ml of esmolol hydrochloride, a buffering agent and a color additive. Any number of color additives may be included such as indocyanine green, phenopheylene, hemoglobin, cyanocobalamine, patent blue, and indigo carmine vitamin B2 and naturally occurring vitamins and minerals. Also, a medical product is provided that includes a colored concentrated esmolol housed in a container, and a package housing the container and instructions. Additionally a method of allowing easy identification of a concentrated esmolol formulation is provided. The method includes providing a colored concentrated esmolol formulation that has from about 25 to about 1000 mg/ml of esmolol and a color additive.

10. 发明公开

EP2164464A2 MULTI-DOSE CONCENTRATE ESMOLOL WITH BENZYL ALCOHOL 审中-公开
标题翻译：与苄多剂量艾司洛尔精矿
公开(公告)号：EP2164464A2
公开(公告)日：2010-03-24
申请号：EP08755579.3
申请日：2008-05-15
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： TIWARI, Deepak , OWOO, George , NAYAK, Rekha , BURHOP, Kenneth, E.
IPC分类号： A61K9/00
CPC分类号： A61K31/24 , A61K9/0019 , A61K47/10 , A61K47/12
摘要： Disclosed are concentrate esmolol injection essentially free from other related esters of esmolol and diluted esmolol compositions. The concentrate esmolol formulation includes from about 25-1000 mg/ml of esmolol and about 1-25 % w/v of benzyl alcohol and the combination thereof. The compositions can also be used as multi-dose compositions. The present invention also discloses diluted, ready-to-use compositions of esmolol prepared by dilution of the present invention concentrates. Also disclosed are methods of making and using the ready-to-use compositions of the present invention.

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