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1. 发明申请

WO2014182631A1 TREATMENT OF ALZHEIMER'S DISEASE SUBPOPULATIONS WITH POOLED IMMUNOGLOBULIN G 审中-公开
标题翻译：治疗阿尔茨海默病患者血液中游离脂肪酸G
公开(公告)号：WO2014182631A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/036848
申请日：2014-05-05
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
发明人： GELMONT, David, M. , SINGER, Julia , FRITSCH, Sandor , SCHWARZ, Hans-Peter
IPC分类号： A61K39/00
CPC分类号： C07K16/18 , A61K38/47 , A61K39/39516 , A61K2039/505 , C07K16/06 , C07K16/065 , G01N33/6896
摘要： The present invention provides, among other aspects, methods for the treatment of Alzheimer's disease in a subject in need thereof, the method including administration of a therapeutically effective amount of a pooled human immunoglobulin G (IgG) composition to a subject with moderately severe Alzheimer's disease, a subject carrying an ApoE4 allele, or both, where the amount of pooled human IgG is from 300 mg/kg to 800 mg/kg body weight of the subject per two week period, and where the amount is administered in one or more doses during the two week period after initiation of a therapeutic regimen. Also provided, are methods for selecting a treatment regimen for a subject with Alzheimer's disease, including diagnosing the severity of the Alzheimer's disease, determining if the subject carries an APOE4 allele, or both, and assigning a treatment regimen including administration of pooled human immunoglobulin G and/or an anti-beta amyloid monoclonal antibody.
摘要翻译：除其他方面外，本发明还提供了在有需要的受试者中治疗阿尔茨海默氏病的方法，所述方法包括将治疗有效量的合并的人免疫球蛋白G（IgG）组合物给予具有中等严重阿尔茨海默病的受试者，携带ApoE4等位基因或两者的受试者，其中合并的人IgG的量为每两周一次的受试者体重为300mg / kg至800mg / kg，并且其中以一个或多个剂量在开始治疗方案后的两周期间。还提供了用于选择阿尔茨海默氏病患者的治疗方案的方法，包括诊断阿尔茨海默氏病的严重程度，确定受试者是否携带APOE4等位基因，或两者，以及分配治疗方案，包括给予合并的人免疫球蛋白G 和/或抗β淀粉样蛋白单克隆抗体。

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