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1. 发明申请

WO2010030602A1 DEVICE TO INDICATE PRIMING OF AN INFUSION LINE 审中-公开
标题翻译：用于显示输注线的预处理的装置
公开(公告)号：WO2010030602A1
公开(公告)日：2010-03-18
申请号：PCT/US2009/056231
申请日：2009-09-08
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , STERNBERG, Shmuel , DESAI, Siddharth, B. , BLACK, Larry , PAULEY, Robin, G.
发明人： STERNBERG, Shmuel , DESAI, Siddharth, B. , BLACK, Larry , PAULEY, Robin, G.
IPC分类号： A61M5/38 , A61M39/20
CPC分类号： G01D7/005 , A61M5/141 , A61M5/3146 , A61M5/385 , A61M39/10 , A61M39/20 , A61M2005/1402 , A61M2005/3125 , A61M2039/205 , A61M2205/331 , A61M2205/7536
摘要： A priming indicator for a fluid infusion system includes a luer cap (20) or other component of the infusion system having an indicator surface (22) covered by a membrane (24). The membrane exhibits a first visual characteristic, such as being opaque, when dry and exhibits a second characteristic, such as becoming less opaque, when wet. Once the membrane becomes wet, indicia on the surface, which may be provided on a rod at least partially covered by the membrane, becomes visible, thereby indicating an intravenous tube to which the luer cap is secured has been primed or is nearly primed. The indicator may alternately be employed at an upstream end of an infusion set, such as at the port of a medical bag providing a supply of fluid, to indicate a low level of fluid in the medical bag.
摘要翻译：用于流体输注系统的起动指示器包括输注系统的路厄帽（20）或其他部件，其具有由膜（24）覆盖的指示器表面（22）。当膜干燥时，膜呈现第一视觉特征，例如不透明的，并且当湿时呈现第二特性，例如变得不透明。一旦膜变湿，可以设置在至少部分地被膜覆盖的杆上的表面上的标记变得可见，从而指示固定有鲁尔帽的静脉内管已被引发或几乎被引发。可以在输液器的上游端（例如在提供流体供应的医疗袋的端口处）使用指示器，以指示医疗袋中的低水平的流体。

2. 发明申请

WO2003078023A1 COMPOUND REMOVAL DEVICE 审中-公开
标题翻译：化合物去除装置
公开(公告)号：WO2003078023A1
公开(公告)日：2003-09-25
申请号：PCT/US2003/006922
申请日：2003-03-06
申请人： BAXTER INTERNATIONAL INC. , STERNBERG, Shmuel , PAULEY, Robin, G.
发明人： STERNBERG, Shmuel , PAULEY, Robin, G.
IPC分类号： B01D29/00
CPC分类号： B01J20/28026 , A61J1/10 , A61J1/1468 , A61J1/1487 , A61M1/0218 , A61M1/3679 , A61M1/3683 , A61M1/3686 , B01D15/00 , B01J20/26 , B01J20/261 , B01J20/28033 , B01J20/2805 , B01J20/321 , B01J20/3223 , B01J20/324 , B01J20/327 , B01J20/3276 , B01J20/3282
摘要： Devices for removing compounds from a biological fluid are disclosed. The devices (20) include sorbent beads (22) applied to an adhesive-surface (26, 28) of support (24). The devices (20) may be used in "batch-type" or "flow-through" systems.
摘要翻译：公开了从生物流体中除去化合物的装置。装置（20）包括施加到支撑件（24）的粘合剂表面（26,28）上的吸附剂珠粒（22）。装置（20）可以用于“分批式”或“流通”系统。

3. 发明公开

EP2367584A1 DEVICE TO INDICATE PRIMING OF AN INFUSION LINE 失效转让
标题翻译：装置用于显示输液软管的预填充状态
公开(公告)号：EP2367584A1
公开(公告)日：2011-09-28
申请号：EP09792320.5
申请日：2009-09-08
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： STERNBERG, Shmuel , DESAI, Siddharth, B. , BLACK, Larry , PAULEY, Robin, G.
IPC分类号： A61M5/38 , A61M39/20
CPC分类号： G01D7/005 , A61M5/141 , A61M5/3146 , A61M5/385 , A61M39/10 , A61M39/20 , A61M2005/1402 , A61M2005/3125 , A61M2039/205 , A61M2205/331 , A61M2205/7536
摘要： A priming indicator for a fluid infusion system includes a luer cap (20) or other component of the infusion system having an indicator surface (22) covered by a membrane (24). The membrane exhibits a first visual characteristic, such as being opaque, when dry and exhibits a second characteristic, such as becoming less opaque, when wet. Once the membrane becomes wet, indicia on the surface, which may be provided on a rod at least partially covered by the membrane, becomes visible, thereby indicating an intravenous tube to which the luer cap is secured has been primed or is nearly primed. The indicator may alternately be employed at an upstream end of an infusion set, such as at the port of a medical bag providing a supply of fluid, to indicate a low level of fluid in the medical bag.

4. 发明申请

WO1996036296A1 MULTIPLE LAYER, FORMED-IN-PLACE IMMUNOISOLATION MEMBRANE STRUCTURES FOR IMPLANTATION OF CELLS IN HOST TISSUE 审中-公开
标题翻译：多层，形成的免疫组织膜结构，用于植入宿主细胞中的细胞
公开(公告)号：WO1996036296A1
公开(公告)日：1996-11-21
申请号：PCT/US1996006826
申请日：1996-05-13
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , PAULEY, Robin, G. , McLARTY, Donna, L. , KHARE, Atul, R. , STERNBERG, Shmuel , BOGGS, Daniel, R. , NEUENFELDT, Steven , JONES, Mark , BRAUKER, James, H. , MARTINSON, Laura, A.
IPC分类号： A61F02/02
CPC分类号： A61K9/0024 , A61F2/022 , A61L27/38
摘要： A permeable structure (16) forms a chamber (12) to hold living cells (14). The structure includes a first permeable region (18) surrounding at least a portion of the chamber (12) having a confirmation that, when implanted is host tissue, substantially blocks penetration of host cells into the chamber (12) while permitting solute transport. The structure (16) also includes a second permeable region (20) overlaying the first permeable region (18) having a confirmation that, when implanted in host tissue, forms a permeable interface with host tissue that permits solute transport. A third permeable region (22) is located between the first (18) and second (20) permeable regions. The third region (22) comprises a solution of polymer material formed in place between the first (18) and second (20) permeable regions. The third permeable region (22) bonds the first (18) and second (20) permeable regions together. The third permeable region (22) also has a confirmation that, when implanted in host tissue, permits solute transport between the first (18) and second (20) permeable regions together, providing a robust, laminated structure that resists delamination during implantation caused by cellular infiltration into discontinuous spaces between the first (18) and second (20) regions. The third, formed-in-place region (22) can also have a confirmation providing an immunoisolation effect. Furthermore, the permeability of the third, formed-in-place membrane (22) is sufficient high that it does not adversely effect the permability value desired for the overall multiple layer structure (16).
摘要翻译：可渗透结构（16）形成容纳活细胞（14）的腔室（12）。该结构包括围绕腔室（12）的至少一部分的第一可渗透区域（18），其确认当植入的是宿主组织时，基本上阻止宿主细胞渗入腔室（12），同时允许溶质运输。结构（16）还包括覆盖第一可渗透区域（18）的第二可渗透区域（20），其确认当植入宿主组织时，与允许溶质运输的宿主组织形成可渗透界面。第三可渗透区域（22）位于第一（18）和第二（20）可渗透区域之间。第三区域（22）包括在第一（18）和第二（20）可渗透区域之间形成的聚合物材料溶液。第三可渗透区域（22）将第一（18）和第二（20）可渗透区域结合在一起。第三渗透区域（22）还确认，当植入到宿主组织中时，允许第一（18）和第二（20）可渗透区域之间的溶质传输在一起，提供坚固的层压结构，其抵抗植入期间的分层，由细胞浸润到第一（18）和第二（20）区域之间的不连续空间。第三个就地区域（22）也可以具有提供免疫隔离效果的确认。此外，第三就地形成膜（22）的渗透性足够高，使得其不会对整个多层结构（16）所期望的渗透性值产生不利影响。

5. 发明申请

WO1994020603A1 RECTIFYING DIALYZER, BIOREACTOR AND MEMBRANE 审中-公开
标题翻译：修复DIALYZER，生物反应器和膜
公开(公告)号：WO1994020603A1
公开(公告)日：1994-09-15
申请号：PCT/US1994002126
申请日：1994-02-28
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , OFSTHUN, Norma, J. , HENDERSON, Lee, W. , BROWN, Richard, I. , PAULEY, Robin, G.
IPC分类号： C12M03/06
CPC分类号： B01D61/243 , B01D61/14 , B01D69/02 , B01D69/08 , C12M29/16
摘要： The invention provides dual-skinned membrane useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have skins of polymer on the opposite sides with differing permeability to solutes and sieving coefficient characteristics. The skin on each side have pores that are invisible at 10,000 times magnification, the microporous structure between said skins contains pores capable of retaining solutes in a molecular weight range of about 5000 to 200,000 in an increased concentration between the interior and the exterior skins. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties.
摘要翻译：本发明提供双皮肤膜，其可用作单向或整流膜，其减少透析中溶质分子的反过滤，并改善膜生物反应器中的营养供应和产物回收。膜是双面聚合材料，优选为中空纤维的形式。膜在相对侧具有聚合物的表面，对溶质和筛分系数特性具有不同的渗透性。每侧的皮肤具有在10,000倍放大率下不可见的孔，所述表皮之间的微孔结构包含能够在内部和外部皮肤之间以更高浓度保持在约5000至200,000的分子量范围内的溶质的孔。通过使用中空纤维膜束作为具有整流性质的透析装置形成改进的透析装置。

6. 发明申请

WO1990011812A1 GAS SEPARATING AND VENTING FILTER AND METHOD OF MAKING SAME 审中-公开
标题翻译：气体分离和通风过滤器及其制造方法
公开(公告)号：WO1990011812A1
公开(公告)日：1990-10-18
申请号：PCT/US1990001820
申请日：1990-04-04
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , SCHMEISER, William, C. , KULLE, Lee, K. , LAL, Birendra, K. , PAULEY, Robin, G.
IPC分类号： B01D19/00
CPC分类号： A61M5/38 , A61M5/165 , A61M2005/1655 , B01D19/0031 , B01D63/021 , B01D63/024 , B01D63/04 , B01D2313/16 , B01D2319/06
摘要： Disclosed is gas separating and venting filter (10) including a housing (8) having walls (18) defining an interior chamber (12) with a fluid inlet (32), a liquid outlet (30), and a gas outlet (28) from the interior chamber. Within the chamber are a plurality of hollow microporous fibers of a hydrophilic nature (34), with the interior of the fibers being in communication with the liquid outlet. Furthermore, there are a plurality of microporous hollow fibers of a hydrophobic nature (36) disposed within the interior chamber, with the interior of the hollow fibers being in communication with the gas outlet.
摘要翻译：公开了一种气体分离和排气过滤器（10），其包括具有限定具有流体入口（32），液体出口（30）和气体出口（28）的内部室（12）的壁（18）的壳体（8）从室内。腔室内是多个具有亲水性质的空心微孔纤维（34），纤维的内部与液体出口连通。此外，存在设置在内部室内的多个疏水性微孔中空纤维（36），中空纤维的内部与气体出口连通。

7. 发明申请

WO1993014186A1 RECTIFYING DIALYZER, MEMBRANE AND PROCESS 审中-公开
标题翻译：修复DIALYZER，膜和工艺
公开(公告)号：WO1993014186A1
公开(公告)日：1993-07-22
申请号：PCT/US1993000132
申请日：1993-01-08
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , OFSTHUN, Norma, J. , HENDERSON, Lee, W. , BROWN, Richard, I. , PAULEY, Robin, G.
IPC分类号： C12M03/06
CPC分类号： B01D61/147 , B01D61/243 , B01D69/02 , B01D69/08 , C12M29/16
摘要： The invention provides dual-skinned membranes useful as one way or rectifying membranes which reduce back filtration of solute molecules in dialysis and which improve nutrient supply and product recovery in membrane bioreactors. The membranes are dual-skinned polymeric materials preferably in the form of hollow fibers. The membranes have skins of polymer on the opposite sides with differing porosity or sieving coefficient characteristics. The membranes are formed by extruding a polymer dissolved in a solvent while contacting at least one surface with a non-solvent which is miscible with the solvent. The other surface is contacted with a non-solvent. The two non-solvents are either different from each other or one of the non-solvents contains a soluble additive which changes the porosity of the skin formed on the dissolved extruded polymer. Improved dialysis devices are formed by using bundles of the hollow fiber membranes as a dialysis means having rectifying properties. Improved bioreactors are formed by using bundles of hollow fiber membranes as a growth vessel having rectifying properties.

8. 发明公开

EP1094883A1 APPARATUS, MEMBRANES AND METHODS FOR REMOVING ORGANIC COMPOUNDS FROM A BIOLOGICAL FLUID 审中-公开
标题翻译：设备，膜和方法去除有机物成分从生物流体
公开(公告)号：EP1094883A1
公开(公告)日：2001-05-02
申请号：EP99931936.1
申请日：1999-06-25
申请人： BAXTER INTERNATIONAL INC. , Cerus Corporation
发明人： BOGGS, Daniel, R. , HEI, Derek, J. , STERNBERG, Schmuel , PAULEY, Robin, G. , MCLARTY, Donna, L.
IPC分类号： B01D61/00
CPC分类号： B01D69/148 , A61M1/02 , A61M1/3686 , B01D63/087 , B01D63/14 , B01D65/022 , B01D67/0009 , B01D67/0086 , B01D69/02 , B01D69/10 , B01D69/147 , B01D71/16 , B01D71/30 , B01D71/34 , B01D71/54 , B01D2321/346 , B01D2323/42 , B01D2325/38
摘要： A membrane (10) and a method for making a membrane (10) are disclosed. The membrane (10) includes a polymeric matrix (16) and a particulate material immobilized within the matrix (16). The membrane (10) may include a support (18) within the core of the mebrane (10) and may further include a skin (19). The membrane (10) may find particular application in methods and apparatus for removing organic compounds from a biological fluid as part of a pathogen inactivation treatment.

9. 发明公开

EP1487559A1 COMPOUND REMOVAL DEVICE 审中-公开
标题翻译： VORRICHTUNG ZUR ENTFERNUNG VON VERBINDUNGEN
公开(公告)号：EP1487559A1
公开(公告)日：2004-12-22
申请号：EP03711447.7
申请日：2003-03-06
申请人： BAXTER INTERNATIONAL INC.
发明人： STERNBERG, Shmuel , PAULEY, Robin, G.
IPC分类号： B01D29/00 , B01D39/00 , B01D15/00
CPC分类号： B01J20/28026 , A61J1/10 , A61J1/1468 , A61J1/1487 , A61M1/0218 , A61M1/3679 , A61M1/3683 , A61M1/3686 , B01D15/00 , B01J20/26 , B01J20/261 , B01J20/28033 , B01J20/2805 , B01J20/321 , B01J20/3223 , B01J20/324 , B01J20/327 , B01J20/3276 , B01J20/3282
摘要： Devices for removing compounds from a biological fluid are disclosed. The devices (20) include sorbent beads (22) applied to an adhesive-surface (26, 28) of support (24). The devices (20) may be used in 'batch-type' or 'flow-through' systems.
摘要翻译：公开了从生物流体中除去化合物的装置。装置（20）包括施加到支撑件（24）的粘合剂表面（26,28）上的吸附剂珠（22）。装置（20）可以用于“分批式”或“流通”系统。

10. 发明授权

EP0576659B1 MEMBRANE, RECTIFYING DIALYZER, BIOREACTOR AND THE RELEVANT USE THEREOF 失效
标题翻译： REED，REKTIFIKATIONSDIALYSATOR，生物反应器及其应用
公开(公告)号：EP0576659B1
公开(公告)日：2001-05-16
申请号：EP93903007.8
申请日：1993-01-08
申请人： BAXTER INTERNATIONAL INC.
发明人： OFSTHUN, Norma, J. , HENDERSON, Lee, W. , BROWN, Richard, I. , PAULEY, Robin, G.
IPC分类号： C12M3/06 , B01D63/08 , A61M1/18
CPC分类号： B01D61/147 , B01D61/243 , B01D69/02 , B01D69/08 , C12M29/16

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