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1. 发明申请

WO2009150099A1 SCORING CATHETER FOR TREATING DISEASED HEART VALVES 审中-公开
标题翻译：用于治疗疾病心脏瓣膜的分拣器
公开(公告)号：WO2009150099A1
公开(公告)日：2009-12-17
申请号：PCT/EP2009/056893
申请日：2009-06-04
申请人： BAVARIA MEDIZIN TECHNOLOGIE GMBH , GRANADA, Juan, F. , SAUERTEIG, Knut
发明人： GRANADA, Juan, F. , SAUERTEIG, Knut
IPC分类号： A61B17/3207
CPC分类号： A61B17/320725 , A61B2017/22098
摘要： The present invention provides a valvuloplasty catheter which has a scoring element at its distal part to score stenotic, calcified heart valves in radial direction and to make the single valve flaps/leaflets work again. In addition to this, the device could comprise an attached balloon to post-dilate the valve after the scoring procedure. To reduce a future recalcification, the scoring element and/or the balloon have a pharmacologic coating on their outer surface.
摘要翻译：本发明提供一种瓣膜成形术导管，其在其远端具有刻痕元件，以在径向方向上分割狭窄的钙化心脏瓣膜，并使单瓣瓣/小叶再次起作用。除此之外，装置可以包括附着的气囊，以在评分程序之后对瓣膜进行后扩张。为了减少未来的再钙化，评分元件和/或气球在其外表面上具有药理涂层。

2. 发明授权

EP2293726B1 SCORING CATHETER FOR TREATING DISEASED HEART VALVES 有权
标题翻译：刻划导管用于治疗ILL心脏瓣膜
公开(公告)号：EP2293726B1
公开(公告)日：2012-06-20
申请号：EP09761662.7
申请日：2009-06-04
申请人： Bavaria Medizin Technologie GmbH
发明人： GRANADA, Juan, F. , SAUERTEIG, Knut
IPC分类号： A61B17/3207
CPC分类号： A61B17/320725 , A61B2017/22098
摘要： The present invention provides a valvuloplasty catheter which has a scoring element at its distal part to score stenotic, calcified heart valves in radial direction and to make the single valve flaps/leaflets work again. In addition to this, the device could comprise an attached balloon to post-dilate the valve after the scoring procedure. To reduce a future recalcification, the scoring element and/or the balloon have a pharmacologic coating on their outer surface.

3. 发明公开

EP2293726A1 SCORING CATHETER FOR TREATING DISEASED HEART VALVES 有权
标题翻译：刻划导管用于治疗ILL心脏瓣膜
公开(公告)号：EP2293726A1
公开(公告)日：2011-03-16
申请号：EP09761662.7
申请日：2009-06-04
申请人： Bavaria Medizin Technologie GmbH
发明人： GRANADA, Juan, F. , SAUERTEIG, Knut
IPC分类号： A61B17/3207
CPC分类号： A61B17/320725 , A61B2017/22098
摘要： The present invention provides a valvuloplasty catheter which has a scoring element at its distal part to score stenotic, calcified heart valves in radial direction and to make the single valve flaps/leaflets work again. In addition to this, the device could comprise an attached balloon to post-dilate the valve after the scoring procedure. To reduce a future recalcification, the scoring element and/or the balloon have a pharmacologic coating on their outer surface.

4. 发明公开

EP3265029A1 TAVI ANCHORING ASSIST DEVICE 有权
标题翻译： TAVI锚定辅助装置
公开(公告)号：EP3265029A1
公开(公告)日：2018-01-10
申请号：EP16711930.4
申请日：2016-03-04
申请人： Boston Scientific Scimed Inc. , Granada, Juan, F.
发明人： GRANADA, Juan, F. , FOLAN, Martyn, G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2436 , A61F2/2439 , A61F2230/0054 , A61F2250/0003 , A61F2250/0037 , A61F2250/006 , A61F2250/0069
摘要： An implant system may include a delivery sheath having an actuator mechanism, an anchoring assistance device including an expandable scaffold including a mid-body section, a cusp interface section, and a crown end arrangement, and a replacement heart valve implant. The cusp interface section includes a plurality of loop portions arranged at radial intervals about the expandable scaffold. Each loop portion is circumferentially spaced apart from another loop portion by a region having a deployment ring, the region being configured to span a commissure of the aortic valve and extending distally a shorter distance from the distal end than the loop portions. An elongate deployment member is configured to releasably engage with the deployment rings to actuate the expandable scaffold from a delivery configuration to a deployed configuration. The replacement heart valve implant is configured to be at least partially disposed within the expandable scaffold in the deployed configuration.

5. 发明申请

WO2007112064A2 CONFORMABLE VASCULAR PROSTHESIS DELIVERY SYSTEM 审中-公开
标题翻译：一致的血管PROSTHESIS传递系统
公开(公告)号：WO2007112064A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/007371
申请日：2007-03-23
申请人： PRESCIENT MEDICAL INC , GRANADA, Juan, F. , FURNISH, Simon, M.
发明人： GRANADA, Juan, F. , FURNISH, Simon, M.
IPC分类号： A61F2/84
CPC分类号： A61F2/958 , A61M25/0119
摘要： Novel approaches for a conformable vascular prosthesis delivery system are provided which overcome the limitations of existing high pressure balloons for delivering intravascular prostheses to the site of high-risk plaques. One embodiment involves a short balloon segment which is inflated at one end of the prosthesis and then pulled to traverse the length of the prosthesis, dilating the surrounding prosthesis and securing it to the vessel wall as it traverses the length of the prosthesis. The short balloon segment causes less local trauma to the vessel relative to a full length balloon. Another embodiment involves use of a self-expandable mesh to expand the surrounding prosthesis and secure it to the vessel wall. The self expandable mesh is less traumatic than a typical angioplasty balloon because of the lower radial forces applied and the relatively higher transverse flexibility of the mesh.
摘要翻译：提供了适用于血管假体输送系统的新方法，其克服了用于将血管内假体递送到高风险斑块位置的现有高压气囊的局限性。一个实施例涉及一种短气囊段，其在假体的一端处被充气，然后被拉动以穿过假体的长度，扩张周围的假体并且当其穿过假体的长度时将其固定到血管壁。短气囊段相对于全长气囊对血管造成更少的局部创伤。另一个实施例涉及使用自扩张网来扩展周围假体并将其固定到血管壁。由于施加较小的径向力和网格的相对较高的横向柔韧性，自膨胀网格比典型的血管成形术球囊创伤小。

6. 发明申请

WO2007112025A3 COMPOSITE VASCULAR PROSTHESIS 审中-公开
公开(公告)号：WO2007112025A3
公开(公告)日：2007-10-04
申请号：PCT/US2007/007299
申请日：2007-03-23
申请人： PRESCIENT MEDICAL INC , GRANADA, Juan, F. , FURNISH, Simon, M.
发明人： GRANADA, Juan, F. , FURNISH, Simon, M.
IPC分类号： A61F2/06
摘要： A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents.

7. 发明申请

WO2007143173A2 ATHEROGENIC COMPOSITIONS AND ANIMAL MODELS OF VASCULAR LESIONS 审中-公开
标题翻译：血管成分的组成和动物模型
公开(公告)号：WO2007143173A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/013075
申请日：2007-06-01
申请人： THE METHODIST HOSPITAL RESEARCH INSTITUTE , GRANADA, Juan, F.
发明人： GRANADA, Juan, F.
CPC分类号： A61K31/56
摘要： Disclosed are atherogenic compositions and methods for inducing atherosclerotic vascular lesions in mammalian animal models for studying atherosclerosis and the processes of disease involving the vascular accumulation of vulnerable plaque. Also disclosed are methods for using these animals to model atherosclerotic lesion formation and the resulting cardiovascular diseases in humans.
摘要翻译：公开了在哺乳动物模型中诱导动脉粥样硬化血管病变的动脉粥样硬化组合物和方法，用于研究动脉粥样硬化和涉及易损斑块血管积累的疾病过程。还公开了使用这些动物来模拟动脉粥样硬化病变形成和人类产生的心血管疾病的方法。

8. 发明申请

WO2004028589A3 APPARATUS AND METHOD FOR DELIVERY OF MITOMYCIN THROUGH AN ELUTING BIOCOMPATIBLE IMPLANTABLE MEDICAL DEVICE 审中-公开
公开(公告)号：WO2004028589A3
公开(公告)日：2004-04-08
申请号：PCT/US2003/030613
申请日：2003-09-26
申请人： ENDOVASCULAR DEVICES, INC. , GRANADA, Juan, F. , FURNISH, Simon, M.
发明人： GRANADA, Juan, F. , FURNISH, Simon, M.
IPC分类号： A61F2/06
摘要： The present invention is an apparatus and a method for delivery of mitomycin through an eluting biocompatible implantable medical device (99). A biocompatible drug release matrix comprises a biocompatible drug release matrix and a drug (55) incorporated into the biocompatible drug release matrix. The drug (55) has antibiotic and anti-proliferative properties and is an analogue related to the quinone-containing alkylating agents of a mitomycin family. The drug (55) is initially released from the biocompatible drug release matrix at a faster rate followed by a release at a slower rate. The drug (55) release rate maintains tissue level concentrations of the drug (55) for at least two weeks after implantation of the medical device (99). The present invention provides a coating for a vascular prosthesis that elutes the drug (55) at a controlled rate to inhibit proliferation of smooth muscle cells causing restenosis.

9. 发明申请

WO2016144796A1 TAVI ANCHORING ASSIST DEVICE 审中-公开
标题翻译： TAVI锚固辅助装置
公开(公告)号：WO2016144796A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/020992
申请日：2016-03-04
申请人： BOSTON SCIENTIFIC SCIMED, INC. , GRANADA, Juan, F.
发明人： GRANADA, Juan, F. , FOLAN, Martyn, G.
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2436 , A61F2/2439 , A61F2230/0054 , A61F2250/0003 , A61F2250/0037 , A61F2250/006 , A61F2250/0069
摘要： An implant system may include a delivery sheath having an actuator mechanism, an anchoring assistance device including an expandable scaffold including a mid-body (114) section, a cusp interface section (116), and a crown end arrangement(118), and a replacement heart valve implant. The cusp interface section includes a plurality of loop portions (134) arranged at radial intervals about the expandable scaffold. Each loop portion is circumferentially spaced apart from another loop portion by a region (133) having a deployment ring (134), the region being configured to span a commissure of the aortic valve and extending distally a shorter distance from the distal end than the loop portions. An elongate deployment member is configured to releasably engage with the deployment rings to actuate the expandable scaffold from a delivery configuration to a deployed configuration. The replacement heart valve implant is configured to be at least partially disposed within the expandable scaffold in the deployed configuration.
摘要翻译：植入系统可以包括具有致动器机构的输送护套，包括可扩展支架的锚定辅助装置，所述支架包括中体部（114）部分，尖部接合部分（116）和冠部端部布置（118），以及更换心脏瓣膜植入物。尖端界面部分包括围绕可膨胀支架以径向间隔布置的多个环部分（134）。每个环部分通过具有展开环（134）的区域（133）在周向上与另一个环部分间隔开，该区域构造成跨越主动脉瓣的连接并且远离远端远离环路延伸较短的距离部分。细长展开构件构造成可释放地与展开环接合，以将可扩展支架从输送构型驱动到展开构型。置换心脏瓣膜植入物构造成在展开构型中至少部分地设置在可扩展支架内。

10. 发明申请

WO2012127309A1 DISK-BASED VALVE APPARATUS AND METHOD FOR THE TREATMENT OF VALVE DYSFUNCTION 审中-公开
标题翻译：基于盘的阀装置和用于治疗瓣膜功能障碍的方法
公开(公告)号：WO2012127309A1
公开(公告)日：2012-09-27
申请号：PCT/IB2012/000563
申请日：2012-03-21
申请人： ONTORFANO, Matteo , CHIEFFO, Alaide , GRANADA, Juan, F.
发明人： ONTORFANO, Matteo , CHIEFFO, Alaide , GRANADA, Juan, F.
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2418 , A61F2/2445 , A61F2230/005 , A61F2230/0058 , A61F2230/0065 , A61F2230/0078 , A61F2250/0039
摘要： The present invention comprises a novel and safer mechanism of deployment using a self- positioning, self-centering, and self-anchoring method. To embody the present invention, a disk-based valve apparatus allowing the repositioning and retrieval of the implantable valve while working on a dysfunctional valve structure is disclosed. The disk-based valve apparatus may comprise one or more disks, either proximal or distal, a valve-housing component and a valve component. The one or more disks may be either proximal or distal, may be either connected to each other or disconnected from each other and may either be symmetrical or have different shapes and dimensions. The disk-based valve apparatus may be self anchoring, such as anchored by pressure from the one or more disk, or may be anchored using any anchoring.
摘要翻译：本发明包括使用自定位，自居中和自锚定方法的新颖且更安全的部署机制。为了实现本发明，公开了一种基于盘的阀装置，其允许在工作在不正常的阀结构上时对植入式阀进行重新定位和取回。基于盘的阀装置可以包括一个或多个近侧或远侧的盘，阀壳体部件和阀部件。一个或多个盘可以是近端的或远端的，可以彼此连接或彼此断开连接并且可以是对称的或具有不同的形状和尺寸。基于盘的阀装置可以是自锚固的，例如通过来自一个或多个盘的压力锚定，或者可以使用任何锚定锚固。

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