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1. 发明申请

WO2009120566A1 IMPROVED TOPICAL OPHTHALMIC COMPOSITIONS 审中-公开
标题翻译：改进的局部眼科组合物
公开(公告)号：WO2009120566A1
公开(公告)日：2009-10-01
申请号：PCT/US2009/037619
申请日：2009-03-19
申请人： BAUSCH & LOMB INCORPORATED , CIOLKOWSKI, Mary, Lee , HUANG, Yan , COFFEY, Martin, J.
发明人： CIOLKOWSKI, Mary, Lee , HUANG, Yan , COFFEY, Martin, J.
IPC分类号： A61K9/00 , A61K9/08 , A61K9/10 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/44
CPC分类号： A61K9/0048 , A61K9/08 , A61K9/10 , A61K31/437 , A61K31/4709 , A61K31/496 , A61K31/498 , A61K31/55 , A61K31/56 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/186 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/44
摘要： An multifunctional ophthalmic composition includes a nonionic oxygen- containing polymer and a surfactant. The composition can be used to treat or control ophthalmic diseases, conditions, or disorders. The composition can be a drug delivery vehicle for medicaments having low solubility in water.
摘要翻译：多功能眼用组合物包括非离子含氧聚合物和表面活性剂。该组合物可用于治疗或控制眼科疾病，病症或病症。该组合物可以是在水中溶解度低的药物的药物递送载体。

2. 发明申请

WO2009058585A2 NON-AQUEOUS WATER-MISCIBLE MATERIALS AS VEHICLES FOR DRUG DELIVERY 审中-公开
标题翻译：不含水的不可思议的材料作为药物输送的车辆
公开(公告)号：WO2009058585A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/080267
申请日：2008-10-17
申请人： BAUSCH & LOMB INCORPORATED , ROHRS, Brian, R. , COFFEY, Martin, J.
发明人： ROHRS, Brian, R. , COFFEY, Martin, J.
IPC分类号： A61K9/00 , A61K47/10 , A61K47/40 , A61K47/44 , A61K31/00
CPC分类号： A61K9/0048 , A61K9/0051 , A61K31/47 , A61K31/55 , A61K47/10 , A61K47/40 , A61K47/44
摘要： A pharmaceutical composition includes at least one pharmaceutical component having a low aqueous solubility and at least one non-aqueous water-miscible material. Such a pharmaceutical composition is useful in providing a therapeutically meaningful amount of such pharmaceutical component at a target tissue. The pharmaceutical composition is particularly suitable for administration to or into an ocular environment to treat or control an ocular disease, disorder, or condition.
摘要翻译：药物组合物包含至少一种具有低水溶性的药物组分和至少一种非水性水混溶性材料。这样的药物组合物可用于在目标组织处提供治疗上有意义的量的此类药物成分。药物组合物特别适合于施用于或进入眼部环境以治疗或控制眼部疾病，病症或病症。

3. 发明申请

WO2011162951A1 COMPOSITIONS AND METHODS FOR ENHANCING REDUCTION OF SPORE-FORMING MICROORGANISM 审中-公开
标题翻译：用于增强形成微生物的组合物和方法
公开(公告)号：WO2011162951A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/039567
申请日：2011-06-08
申请人： BAUSCH & LOMB INCORPORATED , COFFEY, Martin, J. , SHAWER, Mohannad
发明人： COFFEY, Martin, J. , SHAWER, Mohannad
IPC分类号： A61K9/00 , A61K47/26 , A01G1/00 , A61G1/00 , A61K31/00 , C11D3/00
CPC分类号： A61K9/0048 , A61K31/00 , A61K31/7004 , A61K31/7016 , A61K47/26 , A61K2300/00
摘要： A pharmaceutical formulation comprises a pharmaceutically acceptable preservative and a material selected from the group consisting of D-glucose, sucrose, maltose, D-mannose, trehalose, glutamic acid, mixtures thereof, and combinations thereof, wherein the formulation has enhanced preservative efficacy against spore- forming microorganisms. The formulation can further comprise boric acid and/or phosphate. A method for enhancing the preservative efficacy of a pharmaceutical formulation against spore-forming microorganisms, comprising adding a pharmaceutically acceptable preservative, and a material selected from the group consisting of D-glucose, sucrose, maltose, D-mannose, trehalose, glutamic acid, mixtures thereof, and combinations thereof, to the pharmaceutical formulation. The formulation optionally includes an active agent for treating or controlling a disease or disorder of the eye. The formulation may be used to treat, clean, disinfect, store, wet, or rewet contact lenses.
摘要翻译：药物制剂包含药学上可接受的防腐剂和选自D-葡萄糖，蔗糖，麦芽糖，D-甘露糖，海藻糖，谷氨酸，其混合物及其组合的材料，其中所述制剂对孢子具有增强的防腐功效 - 形成微生物。制剂还可以包含硼酸和/或磷酸盐。一种用于增强药物制剂对孢子形成微生物的防腐功效的方法，包括加入药学上可接受的防腐剂和选自D-葡萄糖，蔗糖，麦芽糖，D-甘露糖，海藻糖，谷氨酸，它们的混合物，及其组合。制剂任选地包括用于治疗或控制眼睛疾病或病症的活性剂。该制剂可用于治疗，清洁，消毒，储存，湿润或再湿润隐形眼镜。

4. 发明申请

WO2009061607A2 WATER-IMMISCIBLE MATERIALS AS VEHICLES FOR DRUG DELIVERY 审中-公开
标题翻译：作为用于药物递送的车辆的易燃材料
公开(公告)号：WO2009061607A2
公开(公告)日：2009-05-14
申请号：PCT/US2008/080665
申请日：2008-10-22
申请人： BAUSCH & LOMB INCORPORATED , ROHRS, Brian, R. , COFFEY, Martin, J.
发明人： ROHRS, Brian, R. , COFFEY, Martin, J.
IPC分类号： A61K9/08 , A61K9/10 , A61K9/107 , A61K47/10 , A61K47/14 , A61K47/34 , A61K47/44 , A61K31/55 , A61K31/4709
CPC分类号： A61K9/0019 , A61K9/0048 , A61K31/4709 , A61K31/55 , A61K47/14 , A61K47/44
摘要： A pharmaceutical composition includes at least one pharmaceutical component and at least one water-immiscible material. The pharmaceutical component is more soluble in the water-immiscible material than in water. The pharmaceutical composition is suitable for ocular administration.
摘要翻译：药物组合物包括至少一种药物组分和至少一种与水不混溶的材料。药物组分在水中与水不混溶的材料更易溶。药物组合物适用于眼部给药。

5. 发明申请

WO2013043387A1 OPHTHALMIC GEL COMPOSITIONS 审中-公开
标题翻译：眼底胶组合物
公开(公告)号：WO2013043387A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/054100
申请日：2012-09-07
申请人： BAUSCH & LOMB INCORPORATED , COFFEY, Martin, J.
发明人： COFFEY, Martin, J.
IPC分类号： A61K9/00 , A61K9/10 , A61K31/56 , A61K47/02 , A61K47/32
CPC分类号： A61K47/44 , A61K9/0048 , A61K31/56 , A61K47/24 , A61K47/32
摘要： A suspension comprising an ophthalmic active that has a solubility in water at 25° C and a pH of 7 of less than 0.1 times the concentration of the active in mg/mL in the suspension, the ophthalmic active suspended in a formulation vehicle. The formulation vehicle comprises a lightly cross-linked carboxy-containing polymer and a concentration of ionic salt components to provide the suspension with a calculated ionic strength of less than 0.1. The suspension has the following rheological properties, G' > G" and a suspension yield value of greater than 1 Pa. Also, upon addition of 30 inL of the suspension to a volume of 6 mL to 12 mL of simulated tear fluid, the resulting tear mixture transitions to a liquid form wherein, G" > G' and the tear mixture has a yield value of less than 0.1 Pa.
摘要翻译：一种悬液，其包含眼睛活性物质，所述眼用活性物质在水中的溶解度为25℃，pH为7，小于悬浮液中以mg / mL为单位的活性成分浓度的0.1倍，所述眼科活性剂悬浮在制剂载体中。制剂载体包含轻度交联的含羧基聚合物和离子盐组分的浓度，以提供小于0.1的计算离子强度的悬浮液。悬浮液具有以下流变性质，G'> G，悬浮液产率大于1Pa。另外，当将30μL悬浮液加入体积为6mL至12mL的模拟泪液中时，得到的撕裂混合物转变成液体形式，其中G“> G'和撕裂混合物的屈服值小于0.1Pa。

6. 发明申请

WO2014035451A1 OPHTHALMIC COMPOSITIONS WITH WAX ESTERS 审中-公开
标题翻译：眼科组合物
公开(公告)号：WO2014035451A1
公开(公告)日：2014-03-06
申请号：PCT/US2012/064791
申请日：2012-11-13
申请人： BAUSCH & LOMB INCORPORATED
发明人： COFFEY, Martin, J.
IPC分类号： A61K9/00 , A61K9/10 , A61K31/202 , A61K47/02 , A61K47/32 , A61K31/21
CPC分类号： A61K31/202 , A61K9/0048 , A61K9/10 , A61K31/201 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/44 , A61K2300/00
摘要： A suspension comprising a mixture of wax esters suspended in a formulation vehicle. The formulation vehicle comprises a lightly cross-linked carboxy-containing polymer and a concentration of ionic salt components to provide the suspension with a calculated ionic strength of less than 0.1. The suspension has the following rheological properties, (T > G" and a suspension yield value of greater than 1 Pa. Also, upon addition of 30 mL of the suspension to a volume of 6 mL to 12 mL of simulated tear fluid, the resulting tear mixture transitions to a liquid form wherein, G" > G' and the tear mixture has a yield value of less than 0. 1 Pa.
摘要翻译：包含悬浮在制剂载体中的蜡酯的混合物的悬浮液。制剂载体包含轻度交联的含羧基聚合物和离子盐组分的浓度，以提供小于0.1的计算离子强度的悬浮液。悬浮液具有以下流变性质（T> G“，悬浮液产率大于1Pa。另外，在将体积为6mL至12mL的模拟泪液的30ml悬浮液中加入，得到撕裂混合物转变成液体形式，其中G“> G'和撕裂混合物的屈服值小于0.1Pa。

7. 发明申请

WO2014035450A1 OPHTHALMIC COMPOSITIONS WITH OMEGA-3 FATTY ACIDS 审中-公开
标题翻译：含OMEGA-3脂肪酸的眼科组合物
公开(公告)号：WO2014035450A1
公开(公告)日：2014-03-06
申请号：PCT/US2012/064790
申请日：2012-11-13
申请人： BAUSCH & LOMB INCORPORATED
发明人： COFFEY, Martin, J.
IPC分类号： A61K9/00 , A61K9/10 , A61K31/202 , A61K47/02 , A61K47/32
CPC分类号： A61K31/202 , A61K9/0048 , A61K9/10 , A61K31/201 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/44 , A61K2300/00
摘要： A suspension comprising a mixture of oniega-3 fatty acids suspended in a formulation vehicle. The formulation vehicle comprises a lightly cross-linked carboxy-containing polymer and a concentration of ionic salt components to provide the suspension with a calculated ionic strength of less than 0.1. The suspension has the following rheological properties, G' > G" and a suspension yield value of greater than 1 Pa. Also, upon addition of 30 mL of the suspension to a volume of 6 mL to 12 mL of simulated tear fluid, the resulting tear mixture transitions to a liquid form wherein, G" > G' and the tear mixture has a yield value of less than 0.1 Pa.
摘要翻译：一种悬浮液，其包含悬浮在制剂载体中的脂质-3脂肪酸的混合物。制剂载体包含轻度交联的含羧基聚合物和离子盐组分的浓度，以提供小于0.1的计算离子强度的悬浮液。悬浮液具有以下流变性质，G'> G，悬浮液产率大于1Pa。此外，当将30mL悬浮液加入体积为6mL至12mL的模拟泪液中时，得到的撕裂混合物转变成液体形式，其中G“> G'和撕裂混合物的屈服值小于0.1Pa。

8. 发明公开

EP2758031A1 OPHTHALMIC GEL COMPOSITIONS 审中-公开
标题翻译： OPHTHALMISCHE GELZUSAMMENSETZUNGEN
公开(公告)号：EP2758031A1
公开(公告)日：2014-07-30
申请号：EP12772836.8
申请日：2012-09-07
申请人： Bausch & Lomb Incorporated
发明人： COFFEY, Martin, J.
IPC分类号： A61K9/00 , A61K9/10 , A61K31/56 , A61K47/02 , A61K47/32
CPC分类号： A61K47/44 , A61K9/0048 , A61K31/56 , A61K47/24 , A61K47/32
摘要： A suspension comprising an ophthalmic active that has a solubility in water at 25° C and a pH of 7 of less than 0.1 times the concentration of the active in mg/mL in the suspension, the ophthalmic active suspended in a formulation vehicle. The formulation vehicle comprises a lightly cross-linked carboxy-containing polymer and a concentration of ionic salt components to provide the suspension with a calculated ionic strength of less than 0.1. The suspension has the following rheological properties, G' > G" and a suspension yield value of greater than 1 Pa. Also, upon addition of 30 inL of the suspension to a volume of 6 mL to 12 mL of simulated tear fluid, the resulting tear mixture transitions to a liquid form wherein, G" > G' and the tear mixture has a yield value of less than 0.1 Pa.

9. 发明公开

EP2890363A1 OPHTHALMIC COMPOSITIONS WITH OMEGA-3 FATTY ACIDS 审中-公开
标题翻译：与OMEGA-3脂肪酸眼用组合物
公开(公告)号：EP2890363A1
公开(公告)日：2015-07-08
申请号：EP12794823.0
申请日：2012-11-13
申请人： Bausch & Lomb Incorporated
发明人： COFFEY, Martin, J.
IPC分类号： A61K9/00 , A61K9/10 , A61K31/202 , A61K47/02 , A61K47/32
CPC分类号： A61K31/202 , A61K9/0048 , A61K9/10 , A61K31/201 , A61K47/10 , A61K47/12 , A61K47/32 , A61K47/44 , A61K2300/00
摘要： A suspension comprising a mixture of oniega-3 fatty acids suspended in a formulation vehicle. The formulation vehicle comprises a lightly cross-linked carboxy-containing polymer and a concentration of ionic salt components to provide the suspension with a calculated ionic strength of less than 0.1. The suspension has the following rheological properties, G' > G" and a suspension yield value of greater than 1 Pa. Also, upon addition of 30 mL of the suspension to a volume of 6 mL to 12 mL of simulated tear fluid, the resulting tear mixture transitions to a liquid form wherein, G" > G' and the tear mixture has a yield value of less than 0.1 Pa.

10. 发明授权

EP2214644B1 WATER-IMMISCIBLE MATERIALS AS VEHICLES FOR DRUG DELIVERY 有权
标题翻译：水基材料为手段，-RELEASE
公开(公告)号：EP2214644B1
公开(公告)日：2013-03-20
申请号：EP08848169.2
申请日：2008-10-22
申请人： Bausch & Lomb Incorporated
发明人： ROHRS, Brian, R. , COFFEY, Martin, J.
IPC分类号： A61K9/08 , A61K9/10 , A61K9/107 , A61K47/10 , A61K47/14 , A61K47/34 , A61K47/44 , A61K31/55 , A61K31/4709 , A61K9/00
CPC分类号： A61K9/0019 , A61K9/0048 , A61K31/4709 , A61K31/55 , A61K47/14 , A61K47/44

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