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1. 发明申请

WO2009089409A8 INTRAVITREAL INJECTION SYSTEM HAVING COAXIAL CANNULAE AND USE THEREOF 审中-公开
标题翻译：具有同轴肛门的内窥镜注射系统及其使用
公开(公告)号：WO2009089409A8
公开(公告)日：2010-04-15
申请号：PCT/US2009030532
申请日：2009-01-09
申请人： BAUSCH & LOMB , VALENTI MICHAEL J , BARTELS STEPHEN PAUL , DAVIO STEPHEN R , ROTOLI FRANCESCO P , LEVY BRIAN
发明人： VALENTI MICHAEL J , BARTELS STEPHEN PAUL , DAVIO STEPHEN R , ROTOLI FRANCESCO P , LEVY BRIAN
IPC分类号： A61F9/00 , A61M5/32
CPC分类号： A61F9/0017
摘要： An ophthalmic injection system (1) having coaxial cannulae (14, 24) includes a plurality of syringe bodies (10, 20) and a plurality of cannulae, wherein a first non-flexible cannula is configured to accommodate and guide a second cannula that moves inside the first cannula and penetrates into the internal cavity of an eye globe. The first cannula is long enough to penetrate one or more outer layers of the eye globe. A syringe body is connected to the second cannula for accommodation and infusion of a pharmaceutical composition (40). A plunger (30) is inserted into an annular space of the second syringe body at its distal end for injecting the pharmaceutical composition to the surgical site.
摘要翻译：具有同轴插管（14,24）的眼科注射系统（1）包括多个注射器体（10,20）和多个插管，其中第一非柔性插管构造成容纳并引导移动的第二插管在第一套管内并穿透眼球的内腔。第一套管足够长以穿透眼球的一个或多个外层。注射器主体连接到第二套管以容纳和输注药物组合物（40）。柱塞（30）在其远端插入第二注射器主体的环形空间中，用于将药物组合物注射到手术部位。

2. 发明申请

WO2009089409A3 INTRAVITREAL INJECTION SYSTEM HAVING COAXIAL CANNULAE AND USE THEREOF 审中-公开
标题翻译：具有同轴肛门的内窥镜注射系统及其使用
公开(公告)号：WO2009089409A3
公开(公告)日：2009-10-29
申请号：PCT/US2009030532
申请日：2009-01-09
申请人： BAUSCH & LOMB , VALENTI MICHAEL J , BARTELS STEPHEN PAUL , DAVIO STEPHEN R , ROTOLI FRANCESCO P , LEVY BRIAN
发明人： VALENTI MICHAEL J , BARTELS STEPHEN PAUL , DAVIO STEPHEN R , ROTOLI FRANCESCO P , LEVY BRIAN
IPC分类号： A61F9/00 , A61M5/32
CPC分类号： A61F9/0017
摘要： An ophthalmic injection system (1) having coaxial cannulae (14, 24) includes a plurality of syringe bodies (10, 20) and a plurality of cannulae, wherein a first non-flexible cannula is configured to accommodate and guide a second cannula that moves inside the first cannula and penetrates into the internal cavity of an eye globe. The first cannula is long enough to penetrate one or more outer layers of the eye globe. A syringe body is connected to the second cannula for accommodation and infusion of a pharmaceutical composition (40). A plunger (30) is inserted into an annular space of the second syringe body at its distal end for injecting the pharmaceutical composition to the surgical site.
摘要翻译：具有同轴插管（14,24）的眼科注射系统（1）包括多个注射器体（10,20）和多个插管，其中第一非柔性插管构造成容纳并引导移动的第二插管在第一套管内并穿透眼球的内腔。第一套管足够长以穿透眼球的一个或多个外层。注射器主体连接到第二套管以容纳和输注药物组合物（40）。柱塞（30）在其远端插入第二注射器主体的环形空间中，用于将药物组合物注射到手术部位。

3. 发明申请

WO2005065644A3 DRUG DELIVERY DEVICE WITH MESH BASED SUTURE TAB 审中-公开
标题翻译：药物递送装置与基于MESH的衣柜
公开(公告)号：WO2005065644A3
公开(公告)日：2006-05-11
申请号：PCT/US2004042090
申请日：2004-12-16
申请人： BAUSCH & LOMB , WATSON DAVID , PURTELL GEORGE , LEVY BRIAN , RUSCIO DOMINIC V , KUNZLER JAY F , SCHMIDT MICHAEL M , JONASSE MATTHEW S , SALAMONE JOSEPH C
发明人： WATSON DAVID , PURTELL GEORGE , LEVY BRIAN , RUSCIO DOMINIC V , KUNZLER JAY F , SCHMIDT MICHAEL M , JONASSE MATTHEW S , SALAMONE JOSEPH C
IPC分类号： A61K9/00 , A61F2/00 , A61F9/00 , A61F9/007 , A61K9/22
CPC分类号： A61F9/0008 , A61F9/0017 , A61F2250/0068 , A61K9/0051
摘要： A drug delivery device for placement in the eye includes a drug core comprising a pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material impermeable to passage of the active agent and includes an opening for passage of the pharmaceutically agent therethrough to eye tissue. The holder includes a tab, the tab being associated with a biocompatible surgical fabric.
摘要翻译：用于放置在眼睛中的药物递送装置包括包含药物活性剂的药物核心和保持药物核心的保持器。保持器由不透过活性剂通过的材料制成，并且包括用于药剂通过其通过眼组织的开口。保持器包括突片，突片与生物相容的手术织物相关联。

4. 发明申请

WO2006122249A2 A NON-SURGICAL METHOD FOR PREVENTING OR REDUCING THE RATE OF THE PROGRESSION OF NON-PROLIFERATIVE DIABETIC RETINOPATHY AND THE TREATMENT OF OTHER OCULAR CONDITIONS 审中-公开
标题翻译：用于预防或降低非增殖性糖尿病进展速度和治疗其他症状的非手术方法
公开(公告)号：WO2006122249A2
公开(公告)日：2006-11-16
申请号：PCT/US2006018251
申请日：2006-05-10
申请人： BAUSCH & LOMB , BARTELS STEPHEN P , MCINTIRE GREGORY L , COMSTOCK TIMOTHY L , LEVY BRIAN
发明人： BARTELS STEPHEN P , MCINTIRE GREGORY L , COMSTOCK TIMOTHY L , LEVY BRIAN
CPC分类号： A61K38/484 , A61K9/0051
摘要： A non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy to the proliferative form of diabetic retinopathy comprising intravitreally administering to a patient suffering from non-proliferative diabetic retinopathy an effective amount of serine proteinase enzyme sufficient to create, without surgery, a posterior vitreal detachment to prevent or reduce the progression of proliferative diabetic retinopathy in said patient. Also disclosed is a non-surgical method of treating ocular conditions such as retinal ischemia, retinal inflammation, retinal edema tractional retinal detachment, tractional retinopathy, vitreous hemorrhage and tractional maculopathy by intravitreally administering to a patient suffering from one or more of these conditions with an effective amount of a serine proteinase enzyme to reduce or treat that particular ocular condition. Plasmin, microplasmin and miniplasmin are preferred serine proteinase enzymes and plasmin is the most preferred.
摘要翻译：一种非手术方法，用于预防或降低非增殖性糖尿病性视网膜病变进展为糖尿病性视网膜病变的增殖速率的方法，包括对患有非增殖性糖尿病性视网膜病变的患者玻璃体内施用有效量的丝氨酸蛋白酶，其足以产生，无手术，术后玻璃体脱离以预防或减少所述患者中增殖性糖尿病视网膜病变的进展。还公开了一种非手术方法，其通过对患有这些病症中的一种或多种的患者进行玻璃体腔内施用来治疗眼部疾病如视网膜缺血，视网膜炎症，视网膜水肿性视网膜脱离，牵引性视网膜病变，玻璃体出血和牵引性黄斑病变有效量的丝氨酸蛋白酶以减少或治疗该特定的眼部病症。纤溶酶，微量血浆和微型血小板是优选的丝氨酸蛋白酶，纤溶酶是最优选的。

5. 发明申请

WO2005065602A3 DRUG DELIVERY DEVICE WITH MECHANICAL LOCKING MECHANISM 审中-公开
标题翻译：具有机械锁定机构的药物递送装置
公开(公告)号：WO2005065602A3
公开(公告)日：2005-10-27
申请号：PCT/US2004042089
申请日：2004-12-16
申请人： BAUSCH & LOMB , WATSON DAVID , PURTELL GEORGE , LEVY BRIAN , RUSCIO DOMINIC V , KUNZLER JAY F , SCHMIDT MICHAEL M , JONASSE MATTHEW S , SALAMONE JOSEPH C
发明人： WATSON DAVID , PURTELL GEORGE , LEVY BRIAN , RUSCIO DOMINIC V , KUNZLER JAY F , SCHMIDT MICHAEL M , JONASSE MATTHEW S , SALAMONE JOSEPH C
IPC分类号： A61F2/00 , A61F9/00 , A61K9/00
CPC分类号： A61F9/0017 , A61K9/0051
摘要： A drug delivery device (1) for placement in the eye includes a drug core (2) comprising a pharmaceutically active agent (3), and a holder (6) that holds the drug core. The holder is made of a material impermeable to passage of the active agent and includes at least one opening (7) for passage of the pharmaceutically agent therethrough to eye tissue. The holder is mechanically secured to a suture tab (10).
摘要翻译：用于放置在眼睛中的药物输送装置（1）包括药物核心（2），其包含药物活性剂（3）和保持药物核心的保持器（6）。保持器由不透过活性剂通过的材料制成，并且包括至少一个开口（7），用于使药剂穿过其中进入眼组织。保持器机械地固定到缝合片（10）上。

6. 发明申请

WO2005063204A3 DRUG DELIVERY DEVICE WITH SUTURE RING 审中-公开
标题翻译：药物递送设备与SUTURE环
公开(公告)号：WO2005063204A3
公开(公告)日：2005-12-08
申请号：PCT/US2004042431
申请日：2004-12-16
申请人： BAUSCH & LOMB , LEVY BRIAN , WATSON DAVID , PURTELL GEORGE , RUSCIO DOMINIC V , KUNZLER JAY F , SCHMIDT MICHAEL M , JONASSE MATTHEW S , SALAMONE JOSEPH C
发明人： LEVY BRIAN , WATSON DAVID , PURTELL GEORGE , RUSCIO DOMINIC V , KUNZLER JAY F , SCHMIDT MICHAEL M , JONASSE MATTHEW S , SALAMONE JOSEPH C
IPC分类号： A61F2/00 , A61F9/00 , A61K9/00 , A61K9/22 , A61F9/007
CPC分类号： A61K9/0051 , A61F9/0017 , A61F2250/0068
摘要： A drug delivery device for placement in the eye includes a drug core comprising a pharmaceutically active agent, and a holder that holds the drug core. The holder is made of a material impermeable to passage of the active agent and includes an opening for passage of the pharmaceutically agent therethrough to eye tissue. The holder has a suture tab having a suture ring at an end thereof. The suture ring is used to secure the device at an implant site.
摘要翻译：用于放置在眼睛中的药物递送装置包括含有药物活性剂的药物核心和保持药物核心的支架。保持器由不透过活性剂通过的材料制成，并且包括用于药剂通过其到达眼组织的开口。保持器具有在其端部具有缝合环的缝合突片。缝合环用于将装置固定在植入部位。

7. 发明专利

CA2550697A1 DRUG DELIVERY DEVICE WITH MECHANICAL LOCKING MECHANISM 未知
公开(公告)号：CA2550697A1
公开(公告)日：2005-07-21
申请号：CA2550697
申请日：2004-12-16
申请人： BAUSCH & LOMB
发明人： PURTELL GEORGE , RUSCIO DOMINIC V , LEVY BRIAN , KUNZLER JAY F , SCHMIDT MICHAEL M , JONASSE MATTHEW S , SALAMONE JOSEPH C , WATSON DAVID
IPC分类号： A61F9/00 , A61F2/00 , A61K9/00
摘要： A drug delivery device (1) for placement in the eye includes a drug core (2) comprising a pharmaceutically active agent (3), and a holder (6) that holds the drug core. The holder is made of a material impermeable to passage of th e active agent and includes at least one opening (7) for passage of the pharmaceutically agent therethrough to eye tissue. The holder is mechanicall y secured to a suture tab (10).

8. 发明专利

MX2007013877A METODO NO QUIRURGICO PARA PREVENIR O REDUCIR EL INDICE DE PROGRESION DE RETINOPATIA DIABETICA NO PROLIFERATIVA Y TRATAMIENTO DE OTRAS CONDICIONES OCULARES. 未知
公开(公告)号：MX2007013877A
公开(公告)日：2008-01-24
申请号：MX2007013877
申请日：2006-05-10
申请人： BAUSCH & LOMB
发明人： MCINTIRE GREGORY L , BARTELS STEPHEN P , COMSTOCK TIMOTHY L , LEVY BRIAN
IPC分类号： A61K38/48 , A61K9/00 , A61K47/00 , A61P27/02 , C12N9/68
摘要： Un metodo no quirurgico para prevenir o reducir el indice de la progresion de retinopatia diabetica no proliferativa a la forma proliferativa de retinopatia diabetica que comprende administrar a un paciente que sufre de una retinopatia diabetica no proliferativa una cantidad efectiva de enzima de proteinasa de serina suficiente para producir sin cirugia, un desprendimiento vitreo posterior para prevenir o reducir el indice de progresion de retinopatia diabetica proliferativa en el paciente. Tambien describe un metodo no quirurigico para tratar condiciones oculares tales como isquemia retiniana, inflamacion retiniana, edema retiniano, desprendimiento de retina traccional, orificio macular, retinopatia traccional, hemorragia vitrea o maculopatia fraccional por administracion en forma vitrea a un paciente que sufre de una o mas de estas condiciones oculares una cantidad efectiva de enzima de proteinasa de serina para reducir o tratar esta condicion ocular particular. Se prefieren plasmina, microplasmina y miniplasmina, enzimas de proteinasa de serina y plasmina es las mas preferida.

9. 发明专利

BRPI0614072A2 未知
公开(公告)号：BRPI0614072A2
公开(公告)日：2012-12-25
申请号：BRPI0614072
申请日：2006-05-10
申请人： BAUSCH & LOMB
发明人： BARTELS STEPHEN P , MCINTIRE GREGORY L , COMSTOCK TIMOTHY L , LEVY BRIAN
IPC分类号： A61K38/48 , A61K9/00 , A61K47/00 , A61P27/02 , C12N9/68
摘要： A non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy to the proliferative form of diabetic retinopathy comprising intravitreally administering to a patient suffering from non-proliferative diabetic retinopathy an effective amount of serine proteinase enzyme sufficient to create, without surgery, a posterior vitreal detachment to prevent or reduce the progression of proliferative diabetic retinopathy is said patient. Also disclosed is a non-surgical method of treating ocular conditions such as retinal ischemia, retinal inflammation, retinal edema tractional retinal detachment, tractional retinopathy, vitreous hemorrhage and tractional maculopathy by intravitreally administering to a patient suffering from one or more of these conditions with an effective amount of a serine proteinase enzyme to reduce or treat that particular ocular condition. Plasmin, microplasmin and miniplasmin are preferred serine proteinase enzymes and plasmin is the most preferred.

10. 发明专利

AU2006243986A1 Use of plasmin for preventing of reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions 未知
公开(公告)号：AU2006243986A1
公开(公告)日：2006-11-16
申请号：AU2006243986
申请日：2006-05-10
申请人： BAUSCH & LOMB
发明人： COMSTOCK TIMOTHY L , LEVY BRIAN , MCINTIRE GREGORY L , BARTELS STEPHEN P
IPC分类号： A61K38/48 , A61K9/00 , A61K47/00 , A61P27/02 , C12N9/68
摘要： A non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy to the proliferative form of diabetic retinopathy comprising intravitreally administering to a patient suffering from non-proliferative diabetic retinopathy an effective amount of serine proteinase enzyme sufficient to create, without surgery, a posterior vitreal detachment to prevent or reduce the progression of proliferative diabetic retinopathy is said patient. Also disclosed is a non-surgical method of treating ocular conditions such as retinal ischemia, retinal inflammation, retinal edema tractional retinal detachment, tractional retinopathy, vitreous hemorrhage and tractional maculopathy by intravitreally administering to a patient suffering from one or more of these conditions with an effective amount of a serine proteinase enzyme to reduce or treat that particular ocular condition. Plasmin, microplasmin and miniplasmin are preferred serine proteinase enzymes and plasmin is the most preferred.

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