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    • 2. 发明申请
    • DIMERIC BENZYLIDENE MALONATES
    • 二甲苯胆碱
    • WO2009112403A3
    • 2009-11-12
    • PCT/EP2009052531
    • 2009-03-04
    • BASF SEHANSCH MARKUSEHLIS THOMASWAGNER BARBARA
    • HANSCH MARKUSEHLIS THOMASWAGNER BARBARA
    • A61K8/37A61Q17/04C07C67/347C07C69/618
    • A61Q17/04A61K8/37A61K8/585C07C67/03C07C67/31C07C67/343C07C69/734C07C2601/14C07F7/0889C07C69/732
    • Disclosed is the use of benzylidene malonates of formula (1), wherein R1 and R2, independently from each other are hydrogen; OH; C1-C12alkyl; C1-C12alkoxy; C1-C12alkylamino; C1-C12dialkylamino; water-solubilizing groups, selected from carboxylate, sulfonates or ammonium radicals; R3 is COOR5; COR5; CONR5R6; CN; or SO2R7, R4 is COOR8; COR9; CONR8R9; CN; or SO2R10; R5, R6, R7, R8, R9 and R10 independently from each other are C1-C18alkyl; unsubstituted or by one or more than one C1-C4alkyl substituted C3-C12-cycloalkyl; unsubstituted or C1-C6alkyl-substituted C6-C20aryl; organosilanyl, or organosiloxanyl; A is -C1-C20alkylene-, -CH2CH(OH)CH2-, -C5-C20cycloalkylene, --C2-C20alkenylene-, -C5- C10arylene-, or -C5-C10arylene-(C1-C10alkylene)- which are unsubstituted or substituted, straight-chain or branched, optionally interrupted by one or more than one heteroatoms selected from -O, -S- or -NH-; for the protection of human and animal hair and skin against UV radiation.
    • 公开了式(1)的亚苄基丙二酸酯的用途,其中R 1和R 2彼此独立地为氢; 哦; C1-C12烷基; C1-C12烷氧基; C1-C12alkylamino; C1-C12dialkylamino; 选自羧酸盐,磺酸盐或铵基的水溶性基团; R3为COOR5; COR5; CONR5R6; CN; 或SO 2 R 7,R 4为COOR 8; COR 9; CONR8R9; CN; 或SO2R10; R 5,R 6,R 7,R 8,R 9和R 10彼此独立地为C 1 -C 18烷基; 未取代或被一个或多个C 1 -C 4烷基取代的C 3 -C 12 - 环烷基取代; 未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; 有机硅烷基或有机硅氧烷基; A是未取代的-C 1 -C 20亚烷基 - , - CH 2 CH(OH)CH 2 - , - C 5 -C 20亚环烷基,-C 2 -C 20亚烯基,-C 5 -C 10亚芳基或-C 5 -C 10亚芳基 - (C 1 -C 10亚烷基) 任选被一个或多于一个选自-O,-S-或-NH-的杂原子间隔的取代的,直链或支链的; 用于保护人和动物的头发和皮肤免受紫外线辐射。
    • 3. 发明申请
    • UV FILTER COMBINATIONS COMPRISING BENZYLIDENE MALONATES
    • 包含苯甲酸二甲酯的UV过滤器组合
    • WO2011003774A3
    • 2011-04-21
    • PCT/EP2010059181
    • 2010-06-29
    • BASF SEGRUMELARD JULIEEHLIS THOMASHANSCH MARKUSSOHN MYRIAM
    • GRUMELARD JULIEEHLIS THOMASHANSCH MARKUSSOHN MYRIAM
    • A61K8/29A61K8/35A61K8/37A61K8/40A61K8/41A61K8/49A61K8/58A61Q17/04
    • A61Q17/04A61K8/37
    • Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone; (b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.
    • 公开了UV过滤剂组合的用途,其包含(a)选自式(1)的亚甲基丙二酸酯的第一UV过滤剂,其中R 1甲基; 乙基; 丙基; 或正丁基; 如果R1是甲基,则R是叔。 丁基; 公式(II); 公式(III); 式(1a)的基团; 或式(1b)的基团; 其中R 2和R 3彼此独立地为氢; 或甲基; R4是甲基; 乙基; 或正丙基​​; R5和R6彼此独立地为氢; 或C 1 -C 3烷基; 如果R1是乙基; 丙基; 或正丁基,则R是异丙基; 和(b)选自(b1)双 - 乙基己氧基苯酚甲氧基苯基三嗪的第二UV过滤剂; (b2)丁基甲氧基二苯甲酰基甲烷; (b3)二乙基己基丁酰氨基三嗪酮; (b4)乙基己基三嗪酮; (b5)二乙氨基羟苯甲酰基苯甲酸己酯; (b6)甲氧基肉桂酸乙基己酯; (b7)水杨酸乙基己酯; (b8)胡莫柳油; (b9)奥克立林; (b10)微粉化的亚甲基双 - 苯并三唑基四甲基丁基苯酚; (b11)苯基苯并咪唑磺酸; (b12)二氧化钛; (b13)微粉化的三联苯三嗪; 和(b14)微粉化(2- {4- [2-(4-二乙基氨基-2-羟基 - 苯甲酰基) - 苯甲酰基] - 哌嗪-1-羰基} - 苯基) - (4-二乙基氨基-2-羟基 - 苯基) - 甲酮; (b15)苯甲酸,4,4 - [[3- [1,3,3,3-四甲基-1- [三甲基甲硅烷基]氧基] -1-二硅氧烷基]丙基]氨基] -1,3,5-三嗪-2 (b1) - (b14)的至少2个紫外线过滤剂;其中所述紫外线过滤剂组合物包含至少2种组分(b1) - (b14)的紫外线过滤剂; 用于保护人类和动物毛发和皮肤免受紫外线辐射。