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1. 发明申请

WO2012025582A3 METHOD FOR PRODUCING HIGHLY CONCENTRATED SOLUTIONS OF SELF-ASSEMBLING PROTEINS 审中-公开
标题翻译：工艺生产高浓度溶液自组装的蛋白质
公开(公告)号：WO2012025582A3
公开(公告)日：2012-09-07
申请号：PCT/EP2011064603
申请日：2011-08-25
申请人： BASF SE , FREUDENBERG FORSCHUNGSDIENSTE KG , KLIMOV EVGUENI , LIEBMANN BURGHARD , SUBKOWSKI THOMAS , MOELLER MARTIN , KLEE DORIS , DAVIDENKO ARTEM , VOIGT WIEBKE , SCHARFENBERGER GUNTER
发明人： KLIMOV EVGUENI , LIEBMANN BURGHARD , SUBKOWSKI THOMAS , MOELLER MARTIN , KLEE DORIS , DAVIDENKO ARTEM , VOIGT WIEBKE , SCHARFENBERGER GUNTER
IPC分类号： C07K14/435 , D01D5/00
CPC分类号： C07K14/43518 , C07K14/765 , C08L89/00 , C09D189/00 , D01D5/0053 , D01F1/02 , D01F4/00 , D06M15/15
摘要： The invention relates to stable aqueous protein dispersions, comprising in an aqueous phase at least one self-assembling protein in dispersed form and at least one special dispersant for the self-assembling protein; to a method for producing such stable aqueous dispersions; to a method for electrospinning self-assembling proteins using such stable aqueous dispersions; to a method for producing fibrous surface structures or fibres from such aqueous dispersions; to the use of such aqueous dispersions for coating surfaces; to the use of materials produced by electrospinning for producing medical products, hygiene articles and textiles; and to fibrous structures or fibrous surface structures produced by an electrospinning method according to the invention.
摘要翻译：本发明涉及包含在水相中的分散形式的至少一个selbstassemblierendes蛋白和至少为所述自组装蛋白的特定分散剂稳定的水分散体蛋白; 方法制备这种稳定的含水分散体; 一种用于使用这种稳定的水分散体自组装蛋白的Elektroverspinnung过程; 一种用于制造纤维片材或由这种水分散体的纤维的方法; 使用用于涂覆表面，例如水分散体; 使用由医疗Elektroverspinnung产品，个人护理和织物的制造中所制备的材料; 以及纤维或纤维织物，按照根据本发明的Elektroverspinnungsverfahren制造。

2. 发明申请

WO9848852A3 POLYMER-COATED STENTS 审中-公开
标题翻译：聚合物涂层支架
公开(公告)号：WO9848852A3
公开(公告)日：1999-04-22
申请号：PCT/EP9802528
申请日：1998-04-29
申请人： SCHERING AG , KRAUSE WERNER , HOECKER HARTWIG , LAHANN JOERG , KLEE DORIS
发明人： KRAUSE WERNER , HOECKER HARTWIG , LAHANN JOERG , KLEE DORIS
IPC分类号： A61L29/00 , A61K51/12 , A61L31/00 , A61L31/10 , A61L31/16 , A61M36/12
CPC分类号： A61L31/16 , A61K51/1282 , A61L31/10 , A61L2300/22 , A61L2300/416 , A61L2300/43 , A61L2300/44 , A61L2300/606 , C08L75/04
摘要： Polymer-coated stents, processes for producing the same and their use for restenosis prevention are disclosed.
摘要翻译：本发明涉及它们的制备方法以及它们用于再狭窄的预防使用聚合物涂覆的支架，方法。

3. 发明申请

WO9932080A3 DEVICE FOR TARGETED IMMOBILIZATION OF THE THROMBOGENIC INHIBITOR HIRUDINE ON POLYMER SURFACES 审中-公开
标题翻译：方法对聚合物表面THROMBOGENESEINHIBITORS水蛭素有针对性的固定化
公开(公告)号：WO9932080A3
公开(公告)日：1999-10-14
申请号：PCT/DE9803727
申请日：1998-12-18
申请人： HOECKER HARTWIG , LAHANN JOERG , PLUESTER WILHELM , KLEE DORIS
发明人： HOECKER HARTWIG , LAHANN JOERG , PLUESTER WILHELM , KLEE DORIS
IPC分类号： A61K38/58 , A61L33/12 , A61L33/00
CPC分类号： A61L33/128 , A61K38/58
摘要： Disclosed is a method for immobilizing the thrombogenic inhibitor hirudine on polymer surfaces of extracorporeal and/or intracorporeal medical objects by direct interaction or via appropriate spacer systems between functional groups of the hirudine and the corresponding functional groups of the polymers. The chemical and/or spatial environment of the hirudine functional groups is modified as regards their immobilization selectivity in a treatment step prior to immobilization. After immobilization, the chemical and/or spatial environment is no longer modified. The proposed procedure enables the functional groups needed for thrombin activity not to be bound during immobilization and are thus available for interacting with thrombin after immobilization. This causes an increased antithrombogenic and/or thrombocyte-repelling effect of the hirudine bound on the surfaces.
摘要翻译：在用于固定Thrombogeneseinhibitors水蛭素上体外的聚合物的表面和/或intracorporally到医用制品由直接或通过合适的Spacersysteme对应的聚合物的官能团的水蛭素的官能团之间的相互作用可以使用，提出了一种方法，该方法在固定化上游处理步骤中的一个，所述化学和/或水蛭素的官能团的空间环境中的Immobilisierungsselektivität方面发生变化，并且在固定之后，在化学和/或物理环境的变化将再次高。所提出的方法可以确保必要的官能团不会在凝血酶活性的固定化结合，并因此可用于提供固定之后与凝血酶的相互作用。这会导致接合面水蛭素的增加的抗血栓形成和/或血小板排斥效果。

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