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1. 发明申请

WO2010060811A2 SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：表面活性蛋白作为固体药物制剂的优点
公开(公告)号：WO2010060811A2
公开(公告)日：2010-06-03
申请号：PCT/EP2009/065100
申请日：2009-11-13
申请人： BASF SE , BUTHE, Andreas , HAFNER, Andreas , KAUFMANN, Franz , GABOR, Esther , MEURER, Guido , ECK, Jürgen , BRADLEY, Gordon
发明人： BUTHE, Andreas , HAFNER, Andreas , KAUFMANN, Franz , GABOR, Esther , MEURER, Guido , ECK, Jürgen , BRADLEY, Gordon
IPC分类号： A61K9/20 , A61K9/28 , C07K14/37 , A61K9/00
CPC分类号： A61K9/4891 , A61K9/0065 , A61K9/2063 , A61K9/2095 , A61K9/2873 , C07K14/37
摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e. g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.
摘要翻译：本发明涉及用于制药技术中的表面活性疏水蛋白的用途，特别是作为涂覆液使用的赋形剂。提供了将疏水蛋白与盖仑组合物混合或用含疏水蛋白的溶液处理药物形式的表面以改变盖仑膜形式的药物性质的方法。在本发明的优选实施方案中，疏水蛋白用于改善药物组合物的性质，例如， G。作为表面活性剂或增加耐受霜冻形式的崩解以实现延缓药物释放。通过使用表面活性蛋白质作为赋形剂来修饰的盖仑形式可以是胶囊，片剂，丸剂，微粒，囊泡和栓剂，尽管可以预见到更多的盖仑制剂形式。用于本发明目的的表面活性蛋白质可以从其各自的天然来源分离或通过重组技术制备并在合适的宿主中表达。

2. 发明申请

WO2010097344A1 COMPOSITIONS, USE AND METHOD FOR THE USE OF SURFACE ACTIVE PROTEINS IN TOPICAL DRUG DELIVERY ACROSS KERATIN 审中-公开
标题翻译：组合物，使用和方法使用表面活性蛋白质在主题药物递送过程中
公开(公告)号：WO2010097344A1
公开(公告)日：2010-09-02
申请号：PCT/EP2010/052125
申请日：2010-02-19
申请人： BASF SE , BUTHE, Andreas , HAFNER, Andreas , KAUFMANN, Franz , FIEDLER, Babette , MEURER, Guido , BRADLEY, Gordon
发明人： BUTHE, Andreas , HAFNER, Andreas , KAUFMANN, Franz , FIEDLER, Babette , MEURER, Guido , BRADLEY, Gordon
IPC分类号： A61K47/42 , A61K9/00 , A61K31/522 , A61K38/02 , A61K45/06 , A61P17/00
CPC分类号： A61K9/0014 , A61K31/522 , A61K38/02 , A61K45/06 , A61K47/42 , A61K2300/00
摘要： The present invention provides the use of surface active proteins, especially class I and class Il hydrophobins, in topically applied pharmaceutical formulations. The invention is particularly directed to topically applied pharmaceutical products for enhancing the penetration to achieve a transungual delivery of a prophylactically and/or therapeutically effective amount of an active ingredient (drug) to a patient (including animals and humans) into and/or through a nail, of the animal or human body, in order to treat one or more of a variety of diseases or disorders. Related embodiments of the invention are also disclosed.
摘要翻译：本发明提供在局部应用的药物制剂中使用表面活性蛋白质，特别是I类和II类疏水蛋白。本发明特别涉及用于增强渗透以实现预防和/或治疗有效量的活性成分（药物）向患者（包括动物和人）递送到和/或通过指甲，动物或人体，以治疗各种疾病或病症中的一种或多种。还公开了本发明的相关实施例。

3. 发明申请

WO2008110456A3 METHOD OF TREATING CELLULOSIC MATERIALS WITH HYDROPHOBINS 审中-公开
公开(公告)号：WO2008110456A3
公开(公告)日：2008-09-18
申请号：PCT/EP2008/052333
申请日：2008-02-27
申请人： CIBA HOLDING INC. , GABOR, Esther , BUTHE, Andreas , ECK, Jürgen , KAUFMANN, Franz , KOCH, Hans-Jörg , MEURER, Guido
发明人： GABOR, Esther , BUTHE, Andreas , ECK, Jürgen , KAUFMANN, Franz , KOCH, Hans-Jörg , MEURER, Guido
IPC分类号： D21C5/00 , D21H17/22 , D06M15/15 , B27K3/34
摘要： By treatment with hydrophobins, cellulosic materials such as paper, cardboard, cotton or, especially, wood-based materials, such as solid wood, glued wood products or particle board, can be effectively protected against absorption of and attack by water and/or moisture.

4. 发明申请

WO2011101457A1 CHIMERIC SURFACE ACTIVE PROTEINS 审中-公开
标题翻译： CHIMERIC表面活性蛋白
公开(公告)号：WO2011101457A1
公开(公告)日：2011-08-25
申请号：PCT/EP2011/052470
申请日：2011-02-18
申请人： B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG , MEURER, Guido , GABOR, Esther , BACHERT, Anke , ECK, Jürgen
发明人： MEURER, Guido , GABOR, Esther , BACHERT, Anke , ECK, Jürgen
IPC分类号： C07K14/37 , A61K47/42 , C09D189/00
CPC分类号： C07K14/37 , A61K9/286 , A61K9/2873 , C09D189/00 , C12N15/62
摘要： The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an N-terminal portion of a first surface active protein, wherein the N-terminal portion is devoid of between 0 and 10 of the most N-terminal amino acids of the mature first surface active protein; and, C-terminally thereof, (b) a C-terminal portion of a second surface active protein, wherein the C-terminal portion is devoid of between 0 and 10 of the most C-terminal amino acids of the mature second surface active protein. The present invention further relates to a vector, a non-human host and a method for the production of a chimeric protein having the biochemical activity of a surface active protein. In addition, the present invention relates to a chimeric protein encoded by the nucleic acid molecule of the invention and a composition comprising the chimeric protein. The chimeric protein may only consist of the above mentioned core of (a) and (b), but may also be flanked by additional components of the core, i.e. (a) or (b) or by (an) additional complete core(s) (a) and (b). The present invention furthermore relates to a method of coating and/or impregnating a material, comprising contacting the material with the chimeric protein or the composition of the invention.
摘要翻译：本发明涉及编码具有表面活性蛋白的生化活性的嵌合蛋白的核酸分子，其中所述嵌合蛋白包含：（a）第一表面活性蛋白的N末端部分，其中所述N末端部分没有成熟的第一表面活性蛋白的最多N末端氨基酸的0和10之间; 并且其C末端，（b）第二表面活性蛋白质的C末端部分，其中所述C末端部分缺少所述成熟第二表面活性蛋白质的最C末端氨基酸的0至10个。本发明还涉及载体，非人宿主和生产具有表面活性蛋白的生化活性的嵌合蛋白的方法。此外，本发明涉及由本发明的核酸分子编码的嵌合蛋白质和包含该嵌合蛋白质的组合物。嵌合蛋白质只能由上述（a）和（b）的核心组成，但也可以由核心的另外的组分，即（a）或（b）或另外一个完整的核心）（a）和（b）。本发明还涉及一种涂覆和/或浸渍材料的方法，包括使材料与本发明的嵌合蛋白或组合物接触。

5. 发明申请

WO2012172050A1 NEW MEANS AND METHODS FOR PRODUCING PROPANEDIOL 审中-公开
标题翻译：用于生产丙二醇的新手段和方法
公开(公告)号：WO2012172050A1
公开(公告)日：2012-12-20
申请号：PCT/EP2012/061449
申请日：2012-06-15
申请人： B.R.A.I.N. BIOTECHNOLOGY RESEARCH AND INFORMATION NETWORK AG , KOCH, Daniel , MEURER, Guido , ECK, Jürgen
发明人： KOCH, Daniel , MEURER, Guido , ECK, Jürgen
IPC分类号： C12P7/18 , C12P7/24 , C12N9/00 , C12N9/02 , C12N9/10 , C12N15/52 , C12N1/21
CPC分类号： C12P7/24 , C12N9/0006 , C12N9/0008 , C12N9/13 , C12P7/18 , C12Y101/01077 , C12Y102/01 , C12Y208/03001 , Y02P20/52
摘要： The present invention relates to a host cell having an elevated expression or activity of an enzyme as compared with the parent cell from which it has been derived, said enzyme having lactoyl-CoA reductase activity. Furthermore, provided is a method of producing lactaldehyde and/or 1,2-propanediol, said method comprising culturing said host cell and/or utilizing said enzyme to produce said compound.
摘要翻译：本发明涉及一种具有升高的酶表达或活性的宿主细胞，与其衍生的亲本细胞相比，所述酶具有乳酰基-CoA还原酶活性。此外，提供了生产乳醛和/或1,2-丙二醇的方法，所述方法包括培养所述宿主细胞和/或利用所述酶产生所述化合物。

6. 发明申请

WO2011078667A2 METHOD OF FINDING A BIOCATALYST HAVING AMMONIA LYASE ACTIVITY 审中-公开
标题翻译：发现具有氨基酸活性的生物质的方法
公开(公告)号：WO2011078667A2
公开(公告)日：2011-06-30
申请号：PCT/NL2010/050876
申请日：2010-12-22
申请人： DSM IP Assets B.V. , RAEMAKERS-FRANKEN, Petronella Catharina , MEURER, Guido , ECK, Jürgen Wolfgang , LIEBETON, Klaus Jürgen , TREFZER, Axel Christoph
发明人： RAEMAKERS-FRANKEN, Petronella Catharina , MEURER, Guido , ECK, Jürgen Wolfgang , LIEBETON, Klaus Jürgen , TREFZER, Axel Christoph
IPC分类号： C12Q1/527
CPC分类号： C12Q1/527 , C07C229/08 , C07C229/26 , C07C233/47 , C12N9/88 , C12P13/005
摘要： A method of finding a biocatalyst having ammonia lyase activity, in particular a lysine ammonia lyase, comprising - providing a library comprising a plurality of cells in one or more cell cultures, which cells are candidates for having an ammonia lyase activity, which one or more cultures comprise a culture medium containing at least one nitrogen source selected from the group of amines, including amino acids, and structural analogues thereof, as sole nitrogen source or sources for the cells; - selecting at least one candidate which grows in said culture medium; and - screening the selected candidate or candidates which grow in said culture for the ammonia lyase activity.
摘要翻译：一种发现具有氨裂解酶活性的生物催化剂，特别是赖氨酸氨裂解酶的方法，包括 - 提供包含多个细胞在一个或多个细胞培养物中的文库，该细胞是具有氨裂解酶活性的候选物，其中一个或多个培养物包含含有至少一种氮源的培养基，所述氮源选自胺，包括氨基酸及其结构类似物，作为细胞的唯一氮源或来源; - 选择至少一种在所述培养基中生长的候选物质; 以及 - 筛选在所述培养物中生长用于氨裂解酶活性的所选候选物。

7. 发明申请

WO2010012604A1 PRODUCTION METHOD 审中-公开
标题翻译：生产方法
公开(公告)号：WO2010012604A1
公开(公告)日：2010-02-04
申请号：PCT/EP2009/059132
申请日：2009-07-16
申请人： CLARIANT INTERNATIONAL LTD , MAMPEL, Jörg , MEURER, Guido , ECK, Jürgen
发明人： MAMPEL, Jörg , MEURER, Guido , ECK, Jürgen
IPC分类号： C12N1/20
CPC分类号： C12P7/18
摘要： The invention relates to the development of microorganisms that produce 1,2- propanediol (1,2-PD) from glycerol, whereas glycerol is simultaneously the substrate carbon source for 1,2-PD- and biomass production. The invention demonstrates that any type of glycerol serves as carbon substrate for 1,2-PD biosynthesis. The microorganism is a recombinant organism, preferentially an E. coli K12 strain or a derivative thereof, particularly a strain, which is inactivated in competing pathways that lower 1,2-PD production.
摘要翻译：本发明涉及从甘油生产1,2-丙二醇（1,2-PD）的微生物的开发，而甘油同时是用于1,2-PD和生物质生产的底物碳源。本发明证明任何类型的甘油都用作用于1,2-PD生物合成的碳底物。微生物是重组生物，优选大肠杆菌K12菌株或其衍生物，特别是在降低1,2-PD产生的竞争途径中灭活的菌株。

8. 发明公开

EP2370060A2 HYDROPHOBINS AS SURFACE ACTIVE PROTEINS AS EXCIPIENTS IN SOLID PHARMACEUTICAL FORMULATIONS 有权
标题翻译：疏水蛋白用作表面活性蛋白，如固体药物制剂剂
公开(公告)号：EP2370060A2
公开(公告)日：2011-10-05
申请号：EP09755883.7
申请日：2009-11-13
申请人： BASF SE
发明人： BUTHE, Andreas , HAFNER, Andreas , KAUFMANN, Franz , GABOR, Esther , MEURER, Guido , ECK, Jürgen , BRADLEY, Gordon
IPC分类号： A61K9/20 , A61K9/28 , C07K14/37 , A61K9/00
CPC分类号： A61K9/4891 , A61K9/0065 , A61K9/2063 , A61K9/2095 , A61K9/2873 , C07K14/37
摘要： The invention relates to a use of surface active hydrophobins for applications in pharmaceutical technology, in particular as excipients for galenic use. Provided is a method for either admixture of hydrophobins to galenic compositions or for treating the surface of pharmaceutical forms with a hydrophobin-containing solution to modify the pharmaceutical properties of the galenic form. In a preferred embodiment of the invention hydrophobins are used to improve the properties of a pharmaceutical composition, e. g. to act as a surfactant or to increase resistance to disintegration of the galenic forms to achieve a retarded drug release. The galenic form to be modified by the use of surface active proteins as excipients can be capsules, tablets, pills, microparticles, vesicles, and suppositories, although further galenic forms are envisioned. The surface active proteins used for the purpose of present invention can either be isolated from their respective natural source or prepared by recombinant techniques and expression in a suitable host.

9. 发明公开

EP2400988A1 COMPOSITIONS, USE AND METHOD FOR THE USE OF SURFACE ACTIVE PROTEINS IN TOPICAL DRUG DELIVERY ACROSS KERATIN 有权
标题翻译：组合物，用途和方法表面活性蛋白作者：外用药角蛋白的用途
公开(公告)号：EP2400988A1
公开(公告)日：2012-01-04
申请号：EP10704826.6
申请日：2010-02-19
申请人： BASF SE
发明人： BUTHE, Andreas , HAFNER, Andreas , KAUFMANN, Franz , FIEDLER, Babette , MEURER, Guido , BRADLEY, Gordon
IPC分类号： A61K47/42 , A61K9/00 , A61K31/522 , A61K38/02 , A61K45/06 , A61P17/00
CPC分类号： A61K9/0014 , A61K31/522 , A61K38/02 , A61K45/06 , A61K47/42 , A61K2300/00
摘要： The present invention provides the use of surface active proteins, especially class I and class Il hydrophobins, in topically applied pharmaceutical formulations. The invention is particularly directed to topically applied pharmaceutical products for enhancing the penetration to achieve a transungual delivery of a prophylactically and/or therapeutically effective amount of an active ingredient (drug) to a patient (including animals and humans) into and/or through a nail, of the animal or human body, in order to treat one or more of a variety of diseases or disorders. Related embodiments of the invention are also disclosed.

10. 发明公开

EP2134901A2 METHOD OF TREATING CELLULOSIC MATERIALS WITH HYDROPHOBINS 有权
标题翻译：方法处理材料纤维素与疏水
公开(公告)号：EP2134901A2
公开(公告)日：2009-12-23
申请号：EP08709224.3
申请日：2008-02-27
申请人： BASF SE
发明人： GABOR, Esther , BUTHE, Andreas , ECK, Jürgen , KAUFMANN, Franz , KOCH, Hans-Jörg , MEURER, Guido
IPC分类号： D21C5/00 , D21H17/22 , D06M15/15 , B27K3/34
CPC分类号： D21H17/22 , B27K3/002 , B27K3/15 , B27K2240/70 , C08L89/00 , C08L97/02 , D06M15/15 , D21C5/005 , D21H17/005 , D21H19/50 , Y10T428/31971 , Y10T428/31978 , Y10T428/31986 , Y10T428/31989 , Y10T428/31993
摘要： By treatment with hydrophobins, cellulosic materials such as paper, cardboard, cotton or, especially, wood-based materials, such as solid wood, glued wood products or particle board, can be effectively protected against absorption of and attack by water and/or moisture.

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