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1. 发明申请

WO2013121382A3 MEANS AND METHODS FOR ASSESSING BONE DISORDERS 审中-公开
标题翻译：用于评估骨质疏松症的手段和方法
公开(公告)号：WO2013121382A3
公开(公告)日：2016-09-01
申请号：PCT/IB2013051228
申请日：2013-02-15
申请人： BASF SE , BASF (CHINA) COMPANY LTD
发明人： WALK TILMANN B , RAVENZWAAY BENNARD VAN , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE
IPC分类号： C07F9/117 , C07C53/126 , C07C69/30 , C07F9/10
CPC分类号： G01N33/6893 , G01N33/5044 , G01N33/6806 , G01N33/84 , G01N33/92 , G01N2570/00 , G01N2800/108
摘要： The present invention pertains to the field of diagnostics for bone disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing a bone disorder, it also relates to a method for determining whether a compound is capable of inducing such a bone disorder in a subject and to a method of identifying a drug for treating a bone disorder. Furthermore, the present invention relates to a device and a kit for diagnosing a bone disorder.
摘要翻译：本发明涉及骨骼疾病的诊断领域和化学化合物的风险分层的毒理学评估。具体地，本发明涉及诊断骨骼疾病的方法，还涉及确定化合物是否能够诱导受试者中的这种骨病的方法以及鉴定用于治疗骨病的药物的方法。此外，本发明涉及用于诊断骨骼疾病的装置和试剂盒。

2. 发明申请

WO2013132467A3 MEANS AND METHODS FOR ASSESSING LIVER DISORDERS 审中-公开
标题翻译：评估肝脏疾病的手段和方法
公开(公告)号：WO2013132467A3
公开(公告)日：2013-10-31
申请号：PCT/IB2013051862
申请日：2013-03-08
申请人： BASF SE , BASF CHINA CO LTD
发明人： WALK TILMANN B , RAVENZWAAY BENNARD VAN , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE
IPC分类号： A61B5/00 , A61B19/00
CPC分类号： G01N33/6893 , G01N2500/20 , G01N2800/085
摘要： The present invention pertains to the field of diagnostics for liver disorders and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver disorders. It also relates to a method for determining whether a compound is capable of inducing such liver disorders in a subject and to a method of identifying a drug for treating liver disorders. Furthermore, the present invention relates to a device and a kit for diagnosing liver disorders.
摘要翻译：本发明涉及用于化学化合物风险分层的肝脏失调和毒理学评估的诊断领域。具体而言，涉及诊断肝脏疾病的方法。本发明还涉及确定化合物是否能够在受试者中诱导这种肝病的方法以及鉴定用于治疗肝病的药物的方法。此外，本发明涉及用于诊断肝脏疾病的装置和试剂盒。

3. 发明申请

WO2009153139A3 MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION 审中-公开
标题翻译：评估增加的过度增殖的手段和方法
公开(公告)号：WO2009153139A3
公开(公告)日：2010-02-18
申请号：PCT/EP2009056386
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , WALK TILMANN B , LOOSER RALF , LEIBOLD EDGAR , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE
发明人： VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , WALK TILMANN B , LOOSER RALF , LEIBOLD EDGAR , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE
IPC分类号： G01N33/92 , G01N33/68 , G01N33/82 , G01N33/84
CPC分类号： G01N33/487 , G01N33/50 , G01N33/68 , G01N33/6812 , G01N33/82 , G01N33/92 , G01N2405/00 , G01N2500/00 , G01N2800/046 , G01N2800/10 , G01N2800/24 , G01N2800/60 , H01J49/0036 , Y10T436/200833 , Y10T436/24
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions. The metabolite markers of the metabolome are selected from: Coenzyme Q10, 16-Methylheptadecanoic acid, 17-Methyloctadecanoic acid, Eicosatrienoic acid (C20:3), Threonine, Proline, Tyrosine, trans-4-Hydroxyprolme, Pantothenic acid, Coenzyme Q9, Glycerol, Palmitic acid (C16:0), Lmoleic acid (C18 :cis (9, 12) 2), 14-Methylhexadecanoic acid, gamma-Linoleic acid (C18 : cis (6, 9, 12) 3), Threonic acid, Cytosine, Phosphatidylcholine (C18 : 0/C22 : 6). Different multimarker sets are proposed for male and female subjects.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体而言，涉及用于（i）诊断，（ii）确定化合物是否能够诱导，（iii）鉴定用于治疗增加的过氧化物酶体增殖的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断的系统和装置。最后，本发明涉及一组代谢物或装置用于制造诊断装置或组合物的用途。代谢组胺的代谢物标记选自：辅酶Q10,16-甲基十七烷酸，17-甲基十八烷酸，二十碳三烯酸（C20：3），苏氨酸，脯氨酸，酪氨酸，反式-4-羟基丙酸，泛酸，辅酶Q9，甘油，棕榈酸（C16：0），Lmoleic acid（C18：顺式（9,12）2），14-甲基十六烷酸，γ-亚油酸（C18：顺式（6,9,12）3），苏氨酸，，磷脂酰胆碱（C18：0 / C22：6）。男性和女性受试者提出了不同的多标记组合。

4. 发明申请

WO2013132460A3 MEANS AND METHODS FOR ASSESSING DISORDERS RELATED TO IMPAIRED IRON ADSORPTION OR ENERGY METABOLISM 审中-公开
标题翻译：用于评估与受限制的铁吸收或能量代谢有关的疾病的手段和方法
公开(公告)号：WO2013132460A3
公开(公告)日：2016-09-01
申请号：PCT/IB2013051819
申请日：2013-03-07
申请人： BASF SE , BASF (CHINA) COMPANY LTD
发明人： WALK TILMANN B , VAN RAVENZWAAY BENNARD , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE
IPC分类号： A61B5/00
CPC分类号： G01N33/492 , G01N33/90 , G01N2500/04
摘要： The present invention pertains to the field of diagnostics for iron adsorption disorder or impaired energy metabolism and toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing iron adsorption disorder or impaired energy metabolism. It also relates to a method for determining whether a compound is capable of inducing such iron adsorption disorder or impaired energy metabolism in a subject and to a method of identifying a drug for treating iron adsorption disorder or impaired energy metabolism. Furthermore, the present invention relates to a device and a kit for diagnosing iron adsorption disorder or impaired energy metabolism.
摘要翻译：本发明涉及铁吸附障碍或能量代谢受损的诊断领域和化学化合物危险分层的毒理学评估。具体地说，涉及一种诊断铁吸收障碍或能量代谢受损的方法。它还涉及一种用于确定化合物是否能够诱导受试者的铁吸附障碍或能量代谢受损的方法以及鉴定用于治疗铁吸收障碍或能量代谢受损的药物的方法。此外，本发明涉及用于诊断铁吸收障碍或能量代谢受损的装置和试剂盒。

5. 发明申请

WO2009153136A3 MEANS AND METHODS FOR ASSESSING LIVER TOXICITY 审中-公开
标题翻译：用于评估肝脏毒性的方法和方法
公开(公告)号：WO2009153136A3
公开(公告)日：2010-03-18
申请号：PCT/EP2009056367
申请日：2009-05-26
申请人： BASF SE , VAN RAVENZWAAY BENNARD , MELLERT WERNER , COELHO PALERMO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
发明人： VAN RAVENZWAAY BENNARD , MELLERT WERNER , COELHO PALERMO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
IPC分类号： G01N33/66 , G01N33/82 , G01N33/84 , G01N33/92
CPC分类号： G01N33/92 , G01N2500/00 , G01N2560/00 , G01N2800/085 , G01N2800/60 , Y02A90/26
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention- pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed. The liver toxicity markers are mainly selected from free fatty acids, but also include various phosphatidylcholines, Hydroxyphenylpyruvic acid, alpha-Tocopherol, Cholesterol,myo-Inositol-2-monophosphate, 4-Hydroxysphinganine, Ceramide (dl8:1, C24:1), Ceramide (dl8:2, C24:0), Sphingomyelin (dl8:1, C16:0), 1, 2-Dioleoyl-sn-glycero-3-phosphatidyl-L-serine, 18:1 Lyso Phosphatidylcholine, CoenzymeQ9, Glucose, Glycerol, Glycerophosphates, Phosphate, 5-Methoxysphingosine, erythrosphingosine, Threonine, Diacylglycerides and Triacylglycerides.
摘要翻译：本发明涉及化学化合物危险分层的毒理学评估领域。具体地说，涉及一种诊断肝毒性的方法。它还涉及确定化合物是否能够在受试者中诱导这种肝毒性的方法以及鉴定用于治疗肝毒性的药物的方法。此外，本发明涉及包含至少五种代谢物的特征值的数据收集，包括所述数据收集的数据存储介质，以及用于诊断肝脏毒性的系统和装置。最后，本发明涉及一组代谢物或方法用于制备用于诊断受试者的肝脏毒性的诊断装置或组合物的用途。对于每个性别，公开了不同的代谢组织模式，即不同的分析物组。肝毒性标志物主要选自游离脂肪酸，还包括各种磷脂酰胆碱，羟基苯基丙酮酸，α-生育酚，胆固醇，肌醇-2-单磷酸，4-羟基鞘氨醇，神经酰胺（dl8：1，C24：1）神经酰胺（dl8：2，C24：0），鞘磷脂（dl8：1，C16：0），1,2-二油酰-sn-甘油-3-磷脂酰-L-丝氨酸，18:1溶血磷脂酰胆碱，辅酶Q9，葡萄糖，甘油，磷酸甘油酯，磷酸酯，5-甲氧基肌氨酸，红细胞素，苏氨酸，二酰基甘油酯和三酰基甘油酯。

6. 发明专利

AU2009259540B2 Means and methods for assessing liver toxicity 未知
公开(公告)号：AU2009259540B2
公开(公告)日：2015-11-05
申请号：AU2009259540
申请日：2009-05-26
申请人： BASF SE
发明人： COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , MELLERT WERNER , LOOSER RALF , PROKOUDINE ALEXANDRE , KAMP HENNICKE , WALK TILMANN B , LEIBOLD EDGAR , STRAUSS VOLKER , WIEMER JAN C , FABIAN ERIC , VAN RAVENZWAAY BENNARD
IPC分类号： G01N33/66 , G01N33/68 , G01N33/82 , G01N33/84 , G01N33/92
摘要： The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject.

8. 发明专利

AU2012310147A1 Means and methods for assessing hematopoietic toxicity 未知
公开(公告)号：AU2012310147A1
公开(公告)日：2014-03-13
申请号：AU2012310147
申请日：2012-09-12
申请人： BASF SE
发明人： WALK TILMANN B , RAVENZWAAY BENNARD VAN , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WIEMER JAN C , LOOSER RALF , HEROLD MICHAEL MANFRED , PROKOUDINE ALEXANDRE
IPC分类号： G01N33/50
摘要： A method for diagnosing hematopoietic toxicity comprises: a) determining the amount of at least one biomarker in a test sample of a subject suspected to suffer from hematopoietic toxicity, and b) comparing the amounts determined in step a) to a reference, whereby hematopoietic toxicity is to be diagnosed. A method for determining whether a compound is capable of inducing such hematopoietic toxicity in a subject, a method of identifying a drug for treating hematopoietic toxicity, a device and a kit for diagnosing hematopoietic toxicity are also disclosed.

9. 发明专利

DE112009001301T5 Mittel und Verfahren zur Beurteilung einer erhöhten Peroxisomenproliferation 未知
公开(公告)号：DE112009001301T5
公开(公告)日：2011-06-09
申请号：DE112009001301
申请日：2009-05-26
申请人： BASF SE
发明人： RAVENZWAAY BENNARD VAN , MELLERT WERNER , FABIAN ERIC , STRAUSS VOLKER , WALK TILMANN B , LOOSER RALF , LEIBOLD EDGAR , KAMP HENNICKE , COELHO PALERMO CUNHA GEORGIA , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE
IPC分类号： G01N33/50 , C40B30/04

10. 发明专利

DE112009001234T5 Mittel und Verfahren zur Abschätzung von Lebertoxizität 未知
公开(公告)号：DE112009001234T5
公开(公告)日：2011-04-28
申请号：DE112009001234
申请日：2009-05-26
申请人： BASF SE
发明人： RAVENZWAAY BENNARD , MELLERT WERNER , COELO PALERNO CUNHA GEORGIA , FABIAN ERIC , STRAUSS VOLKER , KAMP HENNICKE , WALK TILMANN B , LOOSER RALF , HEROLD MICHAEL MANFRED , WIEMER JAN C , PROKOUDINE ALEXANDRE , LEIBOLD EDGAR
IPC分类号： G01N33/66 , G01N33/68 , G01N33/82 , G01N33/84 , G01N33/92

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