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1. 发明授权

US09624477B2 Method for producing unsaturated omega-3-fatty acids in transgenic organisms 有权
公开(公告)号：US09624477B2
公开(公告)日：2017-04-18
申请号：US13737513
申请日：2013-01-09
申请人： BASF Plant Science GmbH
发明人： Petra Cirpus , Jörg Bauer , Thorsten Zank , Ernst Heinz
IPC分类号： C12N15/82 , C12N9/02
CPC分类号： C12N9/0071 , C12N9/0004 , C12N15/8247
摘要： The present invention relates to nucleic acid sequences coding for polypeptides with ω-3-desaturase activity. The invention furthermore relates to nucleic acid constructs, vectors and organisms comprising at least one nucleic acid sequence according to the invention, at least one vector comprising the nucleic acid sequence and/or the nucleic acid constructs, and transgenic organisms comprise the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors.

2. 发明授权

US11952581B2 Process for the production of polyunsaturated fatty acids in transgenic organisms 有权
公开(公告)号：US11952581B2
公开(公告)日：2024-04-09
申请号：US17532634
申请日：2021-11-22
申请人： BASF PLANT SCIENCE GMBH
发明人： Thorsten Zank , Jörg Bauer , Petra Cirpus , Amine Abbadi , Ernst Heinz , Xiao Qiu , Patricia Vrinten , Petra Sperling , Frederic Domergue , Astrid Schmidt , Helene Kirsch
IPC分类号： A01H1/00 , A23D9/00 , A23D9/02 , A23L33/115 , C11B1/00 , C12N9/02 , C12N9/10 , C12N15/82 , C12P7/64 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472
CPC分类号： C12N15/8247 , A01H1/00 , A23D9/00 , A23D9/02 , A23L33/115 , C11B1/00 , C12N9/0071 , C12N9/0083 , C12N9/0093 , C12N9/1029 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12Y114/19 , C12Y114/19003 , C12Y203/01199 , A23V2002/00 , Y02P20/52
摘要： The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with Δ5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode Δ6-desaturases, Δ5-desaturases, Δ4-desaturases and/or Δ6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained. The invention also relates to the nucleic acids, and constructs, vectors and transgenic organisms comprising the same, as well as oils, lipids and/or fatty acids produced by the process according to the invention and to their use.

3. 发明申请

US20170016015A1 METHOD FOR THE PRODUCTION OF MULTIPLE-UNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS 审中-公开
标题翻译：在转基因生物中生产多余不饱和脂肪酸的方法
公开(公告)号：US20170016015A1
公开(公告)日：2017-01-19
申请号：US15237901
申请日：2016-08-16
申请人： BASF Plant Science GmbH
发明人： Thorsten Zank , Jörg Bauer , Petra Cirpus , Amine Abbadi , Ernst Heinz , Xiao Qiu , Patricia Vrinten , Petra Sperling , Frederic Domergue , Astrid Meyer , Jelena Kirsch
IPC分类号： C12N15/82 , A23L33/115 , C12N9/10 , A23D9/02 , C11B1/00 , C12N9/02
CPC分类号： C12N15/8247 , A23D9/00 , A23D9/02 , A23L33/115 , A23V2002/00 , C11B1/00 , C12N9/0071 , C12N9/0083 , C12N9/0093 , C12N9/1029 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , C12Y114/19 , C12Y114/19003 , C12Y203/01199 , Y02P20/52
摘要： The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with Δ5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode Δ6-desaturases, Δ5-desaturases, Δ4-desaturases and/or Δ6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained. The invention also relates to the nucleic acids, and constructs, vectors and transgenic organisms comprising the same, as well as oils, lipids and/or fatty acids produced by the process according to the invention and to their use.
摘要翻译：本发明涉及通过向生物体中引入编码具有Δ5延伸酶活性的多肽的核酸来生产生物体中多不饱和脂肪酸的方法。有利地，这些核酸可以与编码脂肪酸或脂质代谢生物合成多肽的另外的核酸一起在生物体中表达。特别有利的是编码Δ6去饱和酶，Δ5去饱和酶，Δ4去饱和酶和/或Δ6-延长酶的核酸。这些去饱和酶和延伸酶有利地衍生自海水藻，欧洲淋巴球菌或油球菌。本发明还涉及生产具有升高的多链多不饱和脂肪酸含量的油和/或三酰基甘油酯的方法，以及由此获得的油和/或三酰基甘油酯。本发明还涉及包含其的核酸，构建体，载体和转基因生物，以及通过根据本发明的方法产生的油，脂质和/或脂肪酸及其用途。

4. 发明申请

US20140026259A1 Method for the Production of Polyunsaturated Fatty Acids 审中-公开
标题翻译：多不饱和脂肪酸生产方法
公开(公告)号：US20140026259A1
公开(公告)日：2014-01-23
申请号：US13912731
申请日：2013-06-07
申请人： BASF Plant Science GmbH
发明人： Andreas Renz , Ernst Heinz , Amine Abbadi , Frederic Domergue , Thorsten Zank
IPC分类号： C12N15/82
CPC分类号： C12N15/8247 , C12N9/1029 , C12P7/6427 , C12P7/6472
摘要： The present invention relates to a process for producing polyunsaturated fatty acids in an organism by introducing nucleic acids into the organism which code for polypeptides having acyl-CoA:lysophospholipid a cyltransferase activity. Advantageously, these nucleic acid sequences may, if appropriate together with further nucleic acid sequences coding for biosynthesis polypeptides of the fatty acid or lipid metabolism, be expressed in the transgenic organism. The invention furthermore relates to the nucleic acid sequences, to nucleic acid constructs comprising the nucleic acid sequences of the invention, to vectors comprising the nucleic acid sequences and/or the nucleic acid constructs and to transgenic organisms comprising the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors. A further part of the invention relates to oils, lipids and/or fatty acids produced by the process of the invention and to their use.
摘要翻译：本发明涉及通过将核酸引入生物体中来生产多不饱和脂肪酸的方法，该生物体编码具有酰基-CoA：溶血磷脂一羧酰基转移酶活性的多肽。有利地，如果合适的话，这些核酸序列可以与编码脂肪酸或脂质代谢的生物合成多肽的其它核酸序列一起在转基因生物中表达。本发明还涉及核酸序列，包含本发明的核酸序列的核酸构建体，包含核酸序列和/或核酸构建体的载体以及包含上述核酸序列的转基因生物，核酸构建体和/或载体。本发明的另一部分涉及通过本发明的方法生产的油，脂和/或脂肪酸及其用途。

5. 发明申请

US20220162629A1 Process for the Production of Polyunsaturated Fatty Acids in Transgenic Organisms 有权
公开(公告)号：US20220162629A1
公开(公告)日：2022-05-26
申请号：US17532634
申请日：2021-11-22
申请人： BASF PLANT SCIENCE GMBH
发明人： Thorsten Zank , Jörg Bauer , Petra Cirpus , Amine Abbadi , Ernst Heinz , Xiao Qiu , Patricia Vrinten , Petra Sperling , Frederic Domergue , Astrid Schmidt , Helene Kirsch
IPC分类号： C12N15/82 , C12N9/02 , C12N9/10 , C12P7/6409 , C12P7/6427 , C12P7/6463 , C12P7/6472 , A23D9/00 , A23L33/115 , A23D9/02 , C11B1/00
摘要： The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with Δ5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode Δ6-desaturases, Δ5-desaturases, Δ4-desaturases and/or Δ6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained. The invention also relates to the nucleic acids, and constructs, vectors and transgenic organisms comprising the same, as well as oils, lipids and/or fatty acids produced by the process according to the invention and to their use.

6. 发明授权

US11180769B2 Method for the production of multiple-unsaturated fatty acids in transgenic organisms 有权
公开(公告)号：US11180769B2
公开(公告)日：2021-11-23
申请号：US16509247
申请日：2019-07-11
申请人： BASF Plant Science GmbH
发明人： Thorsten Zank , Jörg Bauer , Petra Cirpus , Amine Abbadi , Ernst Heinz , Xiao Qiu , Patricia Vrinten , Petra Sperling , Frederic Domergue , Astrid Schmidt , Helene Kirsch
IPC分类号： C12N15/82 , C12N9/02 , C12N9/10 , C12P7/64 , A23D9/00 , A23L33/115 , A23D9/02 , C11B1/00
摘要： The present invention relates to a process for the production of polyunsaturated fatty acids in an organism by introducing, into the organism, nucleic acids which encode polypeptides with Δ5-elongase activity. Advantageously, these nucleic acids can be expressed in the organism together with further nucleic acids which encode polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Especially advantageous are nucleic acids which encode Δ6-desaturases, Δ5-desaturases, Δ4-desaturases and/or Δ6-elongases. These desaturases and elongases are advantageously derived from Thalassiosira, Euglena or Ostreococcus. The invention furthermore relates to a process for the production of oils and/or triacylglycerides with an elevated content of long-chain polyunsaturated fatty acids, and oils and/or triacylglycerides thus obtained. The invention also relates to the nucleic acids, and constructs, vectors and transgenic organisms comprising the same, as well as oils, lipids and/or fatty acids produced by the process according to the invention and to their use.

7. 发明申请

US20130116421A1 Method for Producing Unsaturated Omega-3-Fatty Acids in Transgenic Organisms 有权
标题翻译：在转基因生物中生产不饱和ω-3-脂肪酸的方法
公开(公告)号：US20130116421A1
公开(公告)日：2013-05-09
申请号：US13737513
申请日：2013-01-09
申请人： BASF Plant Science GmbH
发明人： Petra Cirpus , Jörg Bauer , Thorsten Zank , Ernst Heinz
IPC分类号： C12N9/00
CPC分类号： C12N9/0071 , C12N9/0004 , C12N15/8247
摘要： The present invention relates to nucleic acid sequences coding for polypeptides with ω-3-desaturase activity. The invention furthermore relates to nucleic acid constructs, vectors and organisms comprising at least one nucleic acid sequence according to the invention, at least one vector comprising the nucleic acid sequence and/or the nucleic acid constructs, and transgenic organisms comprise the abovementioned nucleic acid sequences, nucleic acid constructs and/or vectors.
摘要翻译：本发明涉及编码具有ω-3-去饱和酶活性的多肽的核酸序列。本发明还涉及包含至少一个本发明核酸序列的至少一种核酸构建体，载体和生物体，至少一种包含核酸序列和/或核酸构建体的载体，转基因生物体包含上述核酸序列，核酸构建体和/或载体。

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