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1. 发明授权

EP2069490B2 AMYLASES AND GLUCOAMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 有权转让
标题翻译： AMYLASES和GLUCOAMYLASES，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：EP2069490B2
公开(公告)日：2018-02-21
申请号：EP07869797.6
申请日：2007-12-21
申请人： BASF Enzymes LLC , Syngenta Participations AG
发明人： SLUPSKA, Malgorzata , HAZLEWOOD, Geoff , CHANG, Cathy , LUGINBUHL, Peter , BURKE, Ellen , CAYOUETTE, Michelle , GUNAVARDENA, Uvini , GHASSEMIAN, Majid , SILVERSTONE, Aron , ZHANG, Yan
IPC分类号： C12N9/32 , C12P21/06 , C12N15/00 , C12Q1/68 , C12N1/20 , C12N1/00 , C12N15/86 , C12P19/04 , C12P21/08 , C07H21/04 , A61K38/47 , C12C11/00 , A21D2/00 , A01K67/027 , A01H1/00
CPC分类号： C12N9/96 , C12N9/2408 , C12N9/2414 , C12N9/2425 , C12N9/2428 , Y02E50/16 , Y02E50/17
摘要： In one aspect, the invention is directed to polypeptides having an amylase and/or glucoamylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of polysaccharide, oligosaccharide or starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating. In alternative embodiments, enzymes are used to make biofuels, e.g., ethanol, butanol, propanol, or a gasoline-ethanol mix, including a bioethanol, biopropanol, biobutanol, or a biodiesel, or for any form of fuel or biomass processing.

2. 发明申请

WO2002090300A3 NUCLEIC ACIDS AND PROTEINS WITH THIOREDOXIN REDUCTASE ACTIVITY 审中-公开
公开(公告)号：WO2002090300A3
公开(公告)日：2002-11-14
申请号：PCT/US2002/014358
申请日：2002-05-06
申请人： XENCOR , SYNGENTA PARTICIPATIONS AG
发明人： BRIGGS, Steven, P. , DALMIA, Bipin, K. , DEL VAL, Gregory , DESJARLAIS, John, R. , HEIFETZ, Peter , LUGINBUHL, Peter , MUCHHAL, Umesh
IPC分类号： C12N9/00
摘要： The present invention relates to the use of a variety of methods for generating functional thioredoxin reductase variants in which at least one physical, chemical or biological property of the variant is altered in a specific and desired manner when compared to the wild-type protein.

3. 发明申请

WO2002090300A2 NUCLEIC ACIDS AND PROTEINS WITH THIOREDOXIN REDUCTASE ACTIVITY 审中-公开
标题翻译：具有三羟甲基纤维素还原酶活性的核酸和蛋白质
公开(公告)号：WO2002090300A2
公开(公告)日：2002-11-14
申请号：PCT/US2002/014358
申请日：2002-05-06
申请人： XENCOR , SYNGENTA PARTICIPATIONS AG
发明人： BRIGGS, Steven, P. , DALMIA, Bipin, K. , DEL VAL, Gregory , DESJARLAIS, John, R. , HEIFETZ, Peter , LUGINBUHL, Peter , MUCHHAL, Umesh
IPC分类号： C07C
CPC分类号： C12N9/0036 , C07K2319/00 , C12N15/8242 , C12N15/8257 , C12Y108/01009 , Y02A90/26
摘要： The present invention relates to the use of a variety of methods for generating functional thioredoxin reductase variants in which at least one physical, chemical or biological property of the variant is altered in a specific and desired manner when compared to the wild-type protein.
摘要翻译：本发明涉及用于产生功能性硫氧还蛋白还原酶变体的各种方法的用途，其中与野生型蛋白质相比，变体的至少一种物理，化学或生物学特性以特异性和所需方式改变。

4. 发明申请

WO2004043981A2 NUCLEIC ACIDS AND PROTEINS WITH THIOREDOXIN REDUCTASE ACTIVITY 审中-公开
标题翻译：具有硫氧还蛋白还原酶活性的核酸和蛋白质
公开(公告)号：WO2004043981A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035867
申请日：2003-11-06
申请人： XENCOR , SYNGENTA PARTICIPATIONS AG , BRIGGS, Steven, P. , DALMIA, Bipin, K. , DEL VAL, Greg , DESJARLAIS, John, R. , LUGINBUHL, Peter , MUCHHAL, Umesh
发明人： BRIGGS, Steven, P. , DALMIA, Bipin, K. , DEL VAL, Greg , DESJARLAIS, John, R. , LUGINBUHL, Peter , MUCHHAL, Umesh
IPC分类号： C07H
CPC分类号： C12N9/0036 , C07K19/00 , C07K2319/00 , C12N15/8242 , C12N15/8257 , C12Y108/01009
摘要： The present invention relates to the use of a variety of methods for generating functional thioredoxin reductase variants in which at least one physical, chemical or biological property of the variant is altered in a specific and desired manner when compared to the wild-type protein.
摘要翻译：本发明涉及用于产生功能性硫氧还蛋白还原酶变体的多种方法的用途，其中所述变体的至少一种物理，化学或生物学特性在被比较时以特定和期望的方式改变到野生型蛋白质。

5. 发明申请

WO2008095033A2 ENZYMES FOR THE TREATMENT OF LIGNOCELLULOSICS, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于处理木质纤维体的酶，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：WO2008095033A2
公开(公告)日：2008-08-07
申请号：PCT/US2008/052517
申请日：2008-01-30
申请人： VERENIUM CORPORATION , SYNGENTA PARTICIPATIONS AG , CHANG, Cathy , STEGE, Justin, T. , ABOUSHADI, Nahla , DJORDJEVIC, Gordana , BURKE, Ellen , LUGINBUHL, Peter , DYCAICO, Mark , RICHARDSON, Toby , POLAND, John , HEFNER, Ying , MILES, Stacy, Marie
发明人： STEGE, Justin, T. , ABOUSHADI, Nahla , DJORDJEVIC, Gordana , BURKE, Ellen , LUGINBUHL, Peter , DYCAICO, Mark , RICHARDSON, Toby , POLAND, John , HEFNER, Ying , MILES, Stacy, Marie
CPC分类号： C12P19/14 , C12N9/2437 , C12N9/2445 , C12P7/04 , C12P19/02 , C12Y302/01021 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The invention provides polypeptides having a lignocellulolytic activity, e.g., a glycosyl hydrolase, a cellulase, an endoglucanase, a cellobiohydrolase, a beta- glucosidase, a xylanase, a mannanse, a xylosidase (e.g., a β- xylosidase), an arabinofuranosidase, and/or a glucose oxidase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In one aspect, the invention provides polypeptides that can enzymatically process (hydrolyze) sugarcane bagasse, i.e., for sugarcane bagasse degradation, or for biomass processing, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. In one embodiment, the invention provides thermostable and thermotolerant forms of polypeptides of the invention. The polypeptides of the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts; for example, the invention provides a multi-enzyme system that can hydrolyze polysaccharides in a bagasse component of sugarcane processed in sugar mills. The invention provides enzymes for the bioconversion of lignocellulosic residues into fermentable sugars; and these sugars can be used as a chemical feedstock for the production of ethanol and fuels, including biofuels such as bioethanol, biopropanol, biobutanol and biodiesels.
摘要翻译：
本发明提供了一种具有木质纤维素酶活性，例如，糖基水解酶，纤维素酶，内切葡聚糖酶，纤维二糖水解，β-葡糖苷酶，木聚糖酶，甘露聚糖酶，木糖苷酶的多肽（例如，β - 木糖苷酶），阿拉伯呋喃糖苷酶和/或葡萄糖氧化酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，本发明提供了能够酶处理（水解）甘蔗渣，即用于甘蔗渣降解或用于生物质处理的多肽，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。在一个实施方案中，本发明提供了本发明的热稳定和耐热形式的多肽。本发明的多肽可以用于各种制药，农业和工业领域; 例如，本发明提供了一种多酶体系，其能够水解在糖厂中加工的甘蔗的甘蔗渣组分中的多糖。本发明提供了用于将木质纤维素残基生物转化成可发酵糖的酶; 这些糖可以用作生产乙醇和燃料的化学原料，包括生物燃料，如生物乙醇，生物丙醇，生物丁醇和生物柴油。

6. 发明申请

WO2008080093A2 AMYLASES AND GLUCOAMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： AMYLASES和GLUCOAMYLASES，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：WO2008080093A2
公开(公告)日：2008-07-03
申请号：PCT/US2007/088631
申请日：2007-12-21
申请人： VERENIUM CORPORATION , SYNGENTA PARTICIPATIONS AG , SLUPSKA, Malgorzata , HAZLEWOOD, Geoff , CHANG, Cathy , LUGINBUHL, Peter , BURKE, Ellen , CAYOUETTE, Michelle , GUNAVARDENA, Uvini , GHASSEMIAN, Majid , SILVERSTONE, Aron , ZHANG, Yan
发明人： SLUPSKA, Malgorzata , HAZLEWOOD, Geoff , CHANG, Cathy , LUGINBUHL, Peter , BURKE, Ellen , CAYOUETTE, Michelle , GUNAVARDENA, Uvini , GHASSEMIAN, Majid , SILVERSTONE, Aron , ZHANG, Yan
IPC分类号： C12N9/28
CPC分类号： C12N9/96 , C12N9/2408 , C12N9/2414 , C12N9/2425 , C12N9/2428 , Y02E50/16 , Y02E50/17
摘要： In one aspect, the invention is directed to polypeptides having an amylase and/or glucoamylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and polypeptides. In one aspect, the polypeptides of the invention can be used as amylases, for example, alpha amylases, to catalyze the hydrolysis of polysaccharide, oligosaccharide or starch into sugars. In one aspect, the invention provides delayed release compositions comprising an desired ingredient coated by a latex polymer coating. In alternative embodiments, enzymes are used to make biofuels, e.g., ethanol, butanol, propanol, or a gasoline-ethanol mix, including a bioethanol, biopropanol, biobutanol, or a biodiesel, or for any form of fuel or biomass processing.
摘要翻译：一方面，本发明涉及具有淀粉酶和/或葡糖淀粉酶活性的多肽，编码所述多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一个方面，本发明的多肽可以用作淀粉酶，例如α-淀粉酶，以催化多糖，寡糖或淀粉水解成糖。在一个方面，本发明提供了包含通过胶乳聚合物涂层涂覆的期望成分的延迟释放组合物。在替代实施方案中，使用酶来制造生物燃料，例如乙醇，丁醇，丙醇或汽油 - 乙醇混合物，包括生物乙醇，生物丙醇，生物丁醇或生物柴油，或用于任何形式的燃料或生物质处理。

7. 发明公开

EP2865750A2 Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them 审中-公开
标题翻译：转移酶，和氧化还原酶，编码它们的核酸，以及制备方法及其用途
公开(公告)号：EP2865750A2
公开(公告)日：2015-04-29
申请号：EP14194469.4
申请日：2008-12-31
申请人： BASF Enzymes LLC
发明人： WEINER, David , LUGINBUHL, Peter , BUENO, Analia , CUENCA, Joslin , MARASCO, Erin
IPC分类号： C12N9/10 , C12N9/02 , C12Q1/48 , C12Q1/26 , C07K14/38 , C07K16/40 , C07K9/00 , A61K38/44 , A61K38/45
CPC分类号： C12N9/1096 , A21D8/042 , A61K38/00 , C12N9/0004 , C12N9/0006 , C12N9/0014 , C12N9/10 , C12N15/1137 , C12N15/63 , C12N15/86 , C12P7/10 , C12Q1/6876 , C12Y206/01021 , D06L4/40 , D06M16/003 , G01N33/573 , Y02E50/16 , Y02P20/52 , Y02T50/678
摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity, e.g., transaminase activity, e.g., d-amino-acid transferase activity, and/or oxidoreductase activity, e.g., dehydrogenase activity, e.g., damino-acid dehydrogenase activity, and/or catalyze the transfer of a chemical group, catalyze transamination, catalyze the reaction: D-alanine + 2-oxoglutarate pyruvate + D-glutamate, and/or catalyze an oxidation-reduction reaction, catalyze the removal of hydrogen atoms, and/or catalyze the reaction: D-amino acid + H 2 O + acceptor a 2-oxo acid + NH 3 + reduced acceptor. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.
摘要翻译：本发明涉及基因的反弹到酶，多核苷酸更具体编码酶，使用搜索多核苷酸和多肽的，并具有转移酶活性，例如转氨酶活性，例如d-氨基酸酸转移酶活性，和/或氧化还原酶活性，例如酶脱氢酶活性，例如，Damino酸脱氢酶活性，和/或催化化学基团的转移，催化转氨基，催化反应：D-丙氨酸+ 2-酮戊二酸丙酮酸<=> + D-谷氨酸，和/或催化到氧化还原反应，催化除去氢原子的，和/或催化下列反应：D-氨基酸+ H 2 O +受体<=> 2-含氧酸+ NH 3 +还原的受体。因此，本发明提供的酶，组合物，方法用于制备药物组合物，医药中间体，抗生素，甜味剂，肽酶，肽类激素，燃料，燃料添加剂组合物，食品和食品添加剂，饮料和饮料添加剂，饲料和饲料添加剂，药物和药物添加剂，膳食补充剂，纺织品，木材，纸，纸浆，和洗涤剂包括以本发明在雅舞蹈的多肽或多核苷酸。

8. 发明公开

EP1507852A2 NUCLEIC ACIDS AND PROTEINS WITH THIOREDOXIN REDUCTASE ACTIVITY 审中-公开
标题翻译：核酸和蛋白质与THIOREDOXINREDUKTASEWIRKUNG
公开(公告)号：EP1507852A2
公开(公告)日：2005-02-23
申请号：EP02739225.7
申请日：2002-05-06
申请人： Xencor , Syngenta Participations AG
发明人： BRIGGS, Steven, P. , DALMIA, Bipin, K. , DEL VAL, Gregory , DESJARLAIS, John, R. , HEIFETZ, P, , LUGINBUHL, Peter , MUCHHAL, Umesh
IPC分类号： C12N9/00 , C12N15/00 , C12P21/04 , C07H21/04 , C07H21/02 , C07K1/00
CPC分类号： C12N9/0036 , C07K2319/00 , C12N15/8242 , C12N15/8257 , C12Y108/01009 , Y02A90/26
摘要： The present invention relates to the use of a variety of methods for generating functional thioredoxin reductase variants in which at least one physical, chemical or biological property of the variant is altered in a specific and desired manner when compared to the wild-type protein.

9. 发明公开

EP3153580A3 ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：醛缩酶于编码，以及它们的方法进行生产及其用途
公开(公告)号：EP3153580A3
公开(公告)日：2017-04-19
申请号：EP16199751.5
申请日：2007-03-07
申请人： BASF Enzymes LLC
发明人： BURKE, Ellen , HICKS, Paula M. , LUGINBUHL, Peter , RICHARDSON, Toby , ZHAO, Lishan , WEINER, David P.
IPC分类号： C12N9/10 , C12N9/88 , C12N15/82
CPC分类号： C12N9/88 , A01K2217/05 , A61K38/00 , C07K2317/92 , C12N9/1022 , C12N15/8243 , C12P17/10 , C12Y401/03016 , C12Y401/03017 , Y02E50/16 , Y02E50/17
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及所述多肽具有醛缩酶活性，包括丙酮酸活性：如但不限于，HMG和/或KHG醛缩酶活性，多核苷酸编码所述多肽的合成，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性，以多肽，包括丙酮酸活性：如但不限于，HMG和/或KHG醛缩酶活性，包括热电表和耐热活性，多核苷酸编码合成的酶，以及制备和使用这些多核苷酸和多肽。在与本发明雅舞蹈的多肽可以在多种药物，农业和工业环境中使用。在一些实施方案中，本发明提供的多肽和生物合成途径也都在生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体的有用：如R ，R和S，R莫纳甜，以及它们的盐，以及莫纳甜衍生物，：如R，R和S，R构型，和它们的盐的某些立体异构体。

10. 发明公开

EP3153580A2 ALDOLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译： ALDOLASES，编码它们的核酸以及制备和使用它们的方法
公开(公告)号：EP3153580A2
公开(公告)日：2017-04-12
申请号：EP16199751.5
申请日：2007-03-07
申请人： BASF Enzymes LLC
发明人： BURKE, Ellen , HICKS, Paula M. , LUGINBUHL, Peter , RICHARDSON, Toby , ZHAO, Lishan , WEINER, David P.
IPC分类号： C12N9/10 , C12N9/88 , C12N15/82
CPC分类号： C12N9/88 , A01K2217/05 , A61K38/00 , C07K2317/92 , C12N9/1022 , C12N15/8243 , C12P17/10 , C12Y401/03016 , C12Y401/03017 , Y02E50/16 , Y02E50/17
摘要： This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.
摘要翻译：本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。在一些实施方案中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如但不限于HMG和/或KHG醛缩酶活性（包括热稳定性和耐热活性），以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽。根据本发明的多肽可以用于各种制药，农业和工业环境中。在一些实施方案中，本发明提供了用于生产R-2-羟基2-（吲哚-3-基甲基）-4-酮戊二酸（R-MP）和莫纳甜的某些立体异构体诸如R的多肽和生物合成途径，R和S，R莫纳甜及其盐，以及莫纳甜衍生物的某些立体异构体，如R，R和S，R构型及其盐。

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