专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1996008246A2 INDUCERS OF GAMMA GLOBIN GENE EXPRESSION AND SCREENING ASSAYS THEREFOR 审中-公开
标题翻译： GAMMA GLOBIN基因表达和筛选测定的诱导剂
公开(公告)号：WO1996008246A2
公开(公告)日：1996-03-21
申请号：PCT/US1995011823
申请日：1995-09-15
申请人： BASF AKTIENGESELLSCHAFT , VOSS, Jeffrey, W. , CARON, Connie
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , C12Q1/6897 , Y02A50/411
摘要： Methods for stimulating gamma globin gene expression in a mammalian cell comprising contacting the cell with a compound selected from valeric acid and certain isomers, derivatives or salts thereof, including isovaleric acid, 4-pentynoic acid and methylthioacetic acid, or an inhibitor of a short chain fatty acyl CoA dehydrogenase, or an activator of protein kinase C are disclosed. The methods of the invention are particularly useful for ameliorating beta -globin disorders, such as sickle cell anemia or beta -thalassemia. The method of the invention can also be used to prevent or ameliorate malaria in a mammal. The compounds of the invention can also be used to stimulate differentiation of a cell. Pharmaceutical compositions of the acive compounds of the invention are also disclosed. Screening assays for identifying agents that stimulate gamma globin gene expression in an erythroid cell, stimulate cell differentiation or stimulate transport of a short chain fatty acid, or derivative or salt thereof, into cells are also disclosed.
摘要翻译：用于刺激哺乳动物细胞中的γ珠蛋白基因表达的方法，包括使细胞与选自戊酸和某些异构体，其衍生物或其盐的化合物，包括异戊酸，4-戊炔酸和甲基硫代乙酸或短链的抑制剂接触脂肪酰辅酶A脱氢酶或蛋白激酶C的活化剂。本发明的方法特别可用于改善β-球蛋白病症，例如镰状细胞性贫血或β-地贫。本发明的方法也可用于预防或改善哺乳动物的疟疾。本发明的化合物也可用于刺激细胞的分化。还公开了本发明的酸性化合物的药物组合物。还公开了用于鉴定刺激红细胞中的γ珠蛋白基因表达，刺激细胞分化或刺激短链脂肪酸或其衍生物或其盐转运到细胞中的药剂的筛选试验。

2. 发明申请

WO1994029442A2 TIGHT CONTROL OF GENE EXPRESSION IN EUCARYOTIC CELLS BY TETRACYCLINE-RESPONSIVE PROMOTERS 审中-公开
标题翻译：通过四环素反应促进剂对真核细胞中基因表达的严格控制
公开(公告)号：WO1994029442A2
公开(公告)日：1994-12-22
申请号：PCT/US1994006734
申请日：1994-06-14
申请人： BASF AKTIENGESELLSCHAFT , BUJARD, Hermann , GOSSEN, Manfred , SALFELD, Jochen, G. , VOSS, Jeffrey, W.
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C12N15/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/075 , C07K2319/09 , C07K2319/61 , C07K2319/71 , C07K2319/80 , C12N15/62 , C12N15/635 , C12N15/85 , C12N2830/006
摘要： Transgenic animals carrying two transgenes, the first coding for a transactivator fusion protein comprising a tet repressor and a polypeptide which directly or indirectly activates in eucaryotic cells, and the second comprising a gene operably linked to a minimal promotor operably linked to at least one tet operator sequence, are disclosed. Isolated DNA molecules (e.g., targeting vectors) for integrating a polynucleotide sequence encoding a transactivator of the invention at a predetermined location within a second target DNA molecule by homologous recombination are also disclosed. Transgenic animals having the DNA molecules of the invention integrated at a predetermined location in a chromosome by homologous recombination are also encompassed by the invention. Methods to regulate the expression of a tet operator linked gene of interest by administering tetracycline or a tetracycline analogue to an animal of the invention are also disclosed. The regulatory system of the invention allows for conditional inactivation or modulation of expression of a gene of interest in a host cell or animal.
摘要翻译：携带两个转基因的转基因动物，首先编码包含tet阻遏物和在真核细胞中直接或间接激活的多肽的反式激活因子融合蛋白，第二编码包含与可操作地连接至少一个tet操纵子的最小启动子可操作地连接的基因序列。还公开了通过同源重组将编码本发明的反式激活物的多核苷酸序列整合到第二靶DNA分子内的预定位置的分离的DNA分子（例如靶向载体）。通过同源重组将具有整合在染色体中预定位置的本发明的DNA分子的转基因动物也包括在本发明中。还公开了通过向本发明的动物施用四环素或四环素类似物来调节所述目的基因的表达的方法。本发明的调节系统允许在宿主细胞或动物中有条件地失活或调控感兴趣的基因的表达。

3. 发明申请

WO2001051440A1 A PROCESS FOR THE PREPARATION OF SUBSTITUTED BENZOPHENONES 审中-公开
标题翻译：一种制备取代苯并噻吩的方法
公开(公告)号：WO2001051440A1
公开(公告)日：2001-07-19
申请号：PCT/EP2001000047
申请日：2001-01-04
申请人： BASF AKTIENGESELLSCHAFT
发明人： BASF AKTIENGESELLSCHAFT , KAMESWARAN, Venkataraman
IPC分类号： C07C45/46
CPC分类号： C07D295/185 , C07C45/008 , C07C45/46 , C07C201/12 , C07C49/84 , C07C205/45
摘要： There is provided a process for the preparation of a compound of formula (I) via the acylation of the appropriate substituted benzene substrate in the presence of graphite and FeC13. Compounds of formula (I) are useful as intermediates in the manufacture of agrichemical agents.
摘要翻译：提供了通过在石墨和FeC 13存在下酰化合适的取代苯底物制备式（I）化合物的方法。式（I）化合物可用作制造农药的中间体。

4. 发明申请

WO2001038432A1 FLAMEPROOFED THERMOPLASTIC POLYESTER MOLDING MATERIALS 审中-公开
标题翻译：阻燃热塑性聚酯模塑化合物
公开(公告)号：WO2001038432A1
公开(公告)日：2001-05-31
申请号：PCT/EP2000011192
申请日：2000-11-13
申请人： BASF AKTIENGESELLSCHAFT , FISCHER, Michael , KLATT, Martin
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C08K13/02
CPC分类号： C08K3/2279 , C08K5/02 , C08L63/00 , C08L67/02 , C08L2666/14
摘要： The invention relates to thermoplastic molding materials containing the following: A) 10 to 98 wt. % of at least one polyester a¿1) which is different from polyethylene terephthalate (PET), containing 1 to 50 wt. % PET a¿2) in relation to 100 wt. % A); B) 1 to 30 wt. % of a flameproofing combination consisting of b¿2) 20 to 99 wt. % of a flameproofing agent containing halogen and b¿2 1 to 80 wt. % of an antimonoxyde, in relation to 100 wt. % B); C) 0.1 to 5 wt. % of a stabilizer, which is different from component b¿2) or component E); D) 0.01 to 10 wt. % of an epoxyde resin; E) 0 to 70 % other additives, the sum of the weight percentages of components A) to E) being 100 % equal.
摘要翻译：含有A Thermoplatische模塑组合物）10至98重量％的至少一种聚酯的％），不同的（聚对苯二甲酸乙酯PET），其中包含1〜50重量％的A1，基于100重量％A）PET A2）; B）1至30重量份从由阻燃组合的，基于100重量％B），B1）20〜99重量的含卤素的阻燃剂b2的％）1到80重量的氧化锑的％; C）0.1〜5重量从部件B2不同的稳定剂）或e）的％; D）为0.01〜10重量的环氧树脂E％）0至70重量％的其它添加剂，其中百分数以重量计的组分A）到E）的总和为100％。

5. 发明申请

WO2001016212A2 METHOD FOR PRODUCING CARBON MONOXIDE COPOLYMERS IN SUPERCRITICAL SOLVENTS OR SUSPENDING AGENTS 审中-公开
标题翻译：用于生产一氧化碳在超临界溶液或混悬液基金
公开(公告)号：WO2001016212A2
公开(公告)日：2001-03-08
申请号：PCT/EP2000008219
申请日：2000-08-23
申请人： BASF AKTIENGESELLSCHAFT , QUEISSER, Joachim , HILDEBRANDT, Volker , LINDNER, Ekkehard , SCHMID, Markus , WALD, Joachim , WEGNER, Peter
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C08G67/00
CPC分类号： C08G67/02 , Y02P20/544
摘要： The invention relates to a method for producing, in the presence of a polymerization catalyst, copolymers comprised of carbon monoxide and of at least one olefinically unsaturated compound having 2 to 20 carbon atoms. The inventive method is characterized in that the polymerization is carried out in a supercritical solvent or suspending agent.
摘要翻译：一种用于一氧化碳和从在聚合催化剂的存在2至20个碳原子的具有至少一个烯属不饱和化合物的共聚物的制备方法，其特征在于所述聚合反应是在超临界溶剂或悬浮介质中进行。

6. 发明申请

WO2001000723A1 POLYISOCYANATE-POLYADDITION PRODUCTS 审中-公开
标题翻译：聚异氰酸酯加聚
公开(公告)号：WO2001000723A1
公开(公告)日：2001-01-04
申请号：PCT/EP2000005493
申请日：2000-06-15
申请人： BASF AKTIENGESELLSCHAFT , ARLT, Andreas , RODEWALD, Dieter , KREYENSCHMIDT, Martin , TESCH, Helmut
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C08K5/15
CPC分类号： C08K5/15 , C08G18/2027 , C08G18/4804 , C08G2101/0008 , C08G2101/0083 , C08K5/3412 , C08L75/04
摘要： The invention relates to polyurethane flexible foams which have a density ranging from 15 to 300 kg/m3¿ and which contain lactones, lactams and/or cyclic esters.
摘要翻译：本发明涉及一种具有15至300千克/立方米<3>含有内酯，内酰胺和/或环状酯的密度的柔性聚氨酯泡沫。

7. 发明申请

WO1999067326A1 FLAMEPROOF POLYESTER-BASED MOULDING MATERIALS 审中-公开
标题翻译：隔爆聚酯模塑化合物
公开(公告)号：WO1999067326A1
公开(公告)日：1999-12-29
申请号：PCT/EP1999004024
申请日：1999-06-11
申请人： BASF AKTIENGESELLSCHAFT , KLATT, Martin , NAM, Michael , FISCH, Herbert
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C08K13/02
CPC分类号： C08K5/5313 , C08K5/103 , C08K5/3492 , C08K5/5397 , C08L67/02 , C08L85/00
摘要： The invention relates to thermoplastic moulding materials containing (A) from 5 to 96 % by weight of a polyester, (B) from 1 to 30 % by weight of a nitrogen compound, (C) from 1 to 30 % by weight of an inorganic phosphorus compound, (D) from 1 to 30 % by weight of an organic phosphorus compound, (E) from 0 to 5 % by weight of at least one ester or amide of saturated or unsaturated aliphatic carboxylic acids having 10 to 40 carbon atoms with aliphatic saturated alcohols or amines having 2 to 40 carbon atoms and (F) from 0 to 60 % by weight of other additives, wherein the sum of weight percentages of components (A) to (F) is equal to 100 %.
摘要翻译：含有A）5〜96重量的聚酯的％热塑性模塑化合物; B）1至30重量的氮化合物的％; C）1〜30重量的无机磷化合物的％; D）1〜30重量的有机磷化合物的％; E）0至5重量％的至少一种酯或具有饱和脂肪族醇或具有2至40个碳原子的胺10至40个碳原子的饱和或不饱和脂族羧酸酰胺的％; F）0至60重量％的其它添加剂，其中百分数以重量计的组分A的总和）到F）为100％。

8. 发明申请

WO1999064515A1 THERMOPLASTIC POLYESTER MOLDING MATERIALS WITH ENHANCED STABILITY 审中-公开
标题翻译：稳定性改进热塑性聚酯模塑材料
公开(公告)号：WO1999064515A1
公开(公告)日：1999-12-16
申请号：PCT/EP1999003543
申请日：1999-05-22
申请人： BASF AKTIENGESELLSCHAFT , HEITZ, Thomas , KLATT, Martin
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C08L67/02
CPC分类号： C08L67/02 , C08G63/85 , C08L2666/02
摘要： The invention relates to thermoplastic polyester molding materials, containing: A) 30 to 100 % by weight polyesters consisting of a1) 50 to 100 % by weight of polybutylene terephthalate with a Lewis acid inorganic or organic metal compound content in the range of from 65 to 100 ppm (in relation to the metal) and a2) 0 to 50 % by weight of polyesters different from polybutylene terephthalate; B) 0 to 40 % by weight of impact resistance modifiers; C) 0 to 30 % by weight of flameproofing agents; D) 0 to 50 % by weight of filling materials and E) 0 to 20 % by weight of further additives, whereby the sum of the weight percentages of constituents A) to E) always equals 100.
摘要翻译：含有A）30〜100重量a1的构成聚酯）50〜100重量具有路易斯酸的无机或有机金属化合物的范围为65至100ppm的含量对苯二甲酸丁二醇酯的％的％的热塑性聚酯模塑组合物（基于金属的），和a2）0至50重量比聚对苯二甲酸丁酯，B）0至40重量的抗冲改性剂％，C）0至30重量阻燃剂％其它聚酯的％，D） 0至50重量的填料和e）0至20重量的其它添加剂的％的％，组分a）至e）的重量百分比的总和始终是第100次

9. 发明申请

WO1999064514A1 POLYESTER OR POLYCARBONATE BASED POLYMER MIXTURES AND RUBBER MODIFIED MOULDING MATERIALS 审中-公开
标题翻译：聚合物共混物基于聚酯或聚碳酸酯和橡胶改性模塑料
公开(公告)号：WO1999064514A1
公开(公告)日：1999-12-16
申请号：PCT/EP1999003649
申请日：1999-05-26
申请人： BASF AKTIENGESELLSCHAFT , MC KEE, Graham, Edmund , JÜNGLING, Stephan , WARZELHAN, Volker , GAUSEPOHL, Hermann
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C08L67/00
CPC分类号： C08L67/02 , C08L69/00 , C08L51/00
摘要： Polymer mixtures, containing the following essential ingredients: A) 1-99 wt.% polycarbonates or polyester; B) 1-99 wt.% acrylate rubber modified moulding material, produced by b1) anionic polymerisation of monomers selected from the group consisting of i) (meth)acrylic acid esters of general formula (I) CH2=C(R )-CO2R , and ii) (meth)acrylic acid esters of general formula (II) CH2=C(R )-C(O)O-CR R R in a solvent containing vinyl aromatic compounds of general formula (III) and b2) by adding to the reaction mixture obtained according to b1) b21) acrylonitrile, methacrylonitrile, C1-C8 methacrylates or mixtures thereof and optionally, other radically polymerisable monomers selected from the group consisting of b22) vinyl aromatic compounds according to general formula (III), (C1-C8 alkyl) (meth)acrylic acid esters or the mixtures thereof, b23) other olefinically unsaturated compounds that are different from acrylonitrile or methacrylonitrile or vinyl aromatic compound (III), b3) radical polymerisation of the mixture obtained according to b2), in addition b4 to isolating the rubber modified moulding material obtained according to b3); C) 0-50 wt.% acrylate rubber modified moulding material, whereby at least the rubber phase is produced by means of emulsion polymerisation; D) 0-50 wt.% inorganic filler and E) 0-50 wt.% additives and auxiliary agents.
摘要翻译：含有作为主要组分的聚合物混合物：A）1〜99级重量％的聚碳酸酯或聚酯; B）1〜99重量％与丙烯酸橡胶改性的模制材料，由B1制备）选自下组的单体的阴离子聚合：通式（I）的ⅰ）（甲基）丙烯酸酯：CH 2 = C（R < 一>） - CO 2的，和ii）（甲基）通式（II）的丙烯酸酯：CH 2 = C（R ） - C（O）O-CR - [R - [R 在含有通式的乙烯基芳族化合物的溶剂（III）和b2）添加到由B1）中获得的反应B21的丙烯腈的混合物），甲基丙烯腈，C1-C8的甲基丙烯酸酯或它们的并任选地进一步可自由基聚合的单体的混合物; 选自B22的）通式（III），（C1-C8烷基）（甲基）丙烯酸酯或它们的混合物，B23）还烯属不饱和化合物中，乙烯基芳族不丙烯腈或甲基丙烯腈或乙烯基 - 芳族化合物的组中选出化合物（III）分离在B2中获得的混合物的，b3）的自由基聚合）和b4）的根据b3）的橡胶改性的模制材料而获得; C）0至50重量与模塑组合物改性的丙烯酸酯橡胶的％，其中至少橡胶相是由乳液聚合制备; D）的无机填料0〜50重量％，E）0至50重量的添加剂和助剂的百分比。

10. 发明申请

WO1999038825A1 METHOD FOR PRODUCING ALKYLENE GLYCOL 审中-公开
标题翻译：用于生产亚
公开(公告)号：WO1999038825A1
公开(公告)日：1999-08-05
申请号：PCT/EP1999000476
申请日：1999-01-26
申请人： BASF AKTIENGESELLSCHAFT , DOCKNER, Toni , MOHR, Jürgen , FREDE, Markus
发明人： BASF AKTIENGESELLSCHAFT
IPC分类号： C07C29/76
CPC分类号： C07C29/106 , B01D61/44 , B01D61/445 , C07C31/202
摘要： The invention relates to a method for producing alkylene glycol, according to which a reaction mixture containing an alkylene oxide or a mixture of two or more alkylene oxides as well as water and a catalyst triggering dissociation in water is reacted. In this way a product mixture containing alkylene glycol is obtained which is then purified by means of electrodialysis.
摘要翻译：本发明涉及一种用于生产亚烷基二醇，其中的反应混合物被带含有氧化烯烃或两种或多种氧化烯的混合物，以及水和水催化剂的反应的解离，得到alkylenglykolhaltiges产物混合物的形式的方法，以及亚烷基二醇产物混合物通过电渗析进行纯化。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式