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1. 发明专利

AU2016249005A1 Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells 未知
公开(公告)号：AU2016249005A1
公开(公告)日：2017-11-02
申请号：AU2016249005
申请日：2016-04-15
申请人： BARRETT DAVID , BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL , LEVINE BRUCE , MELENHORST JAN , MILONE MICHAEL , POWELL DANIEL , SINGH NATHAN , ZHENG ZOE
发明人： BARRETT DAVID MAXWELL , BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL H , LEVINE BRUCE L , MELENHORST JAN J , MILONE MICHAEL C , POWELL DANIEL J , SINGH NATHAN AMAR , ZHENG ZOE
IPC分类号： C12N5/0783 , A61K35/17 , C07K14/47 , C07K14/705 , C12N5/00
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

2. 发明专利

SG11201708516YA METHODS FOR IMPROVING THE EFFICACY AND EXPANSION OF CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS 未知
公开(公告)号：SG11201708516YA
公开(公告)日：2017-11-29
申请号：SG11201708516Y
申请日：2016-04-15
申请人： BARRETT DAVID MAXWELL , BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL H , LEVINE BRUCE L , MELENHORST JAN J , MILONE MICHAEL C , POWELL DANIEL J , SINGH NATHAN AMAR , ZHENG ZOE
发明人： BARRETT DAVID MAXWELL , BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL H , LEVINE BRUCE L , MELENHORST JAN J , MILONE MICHAEL C , POWELL DANIEL J , SINGH NATHAN AMAR , ZHENG ZOE
IPC分类号： C12N5/0783 , A61K35/17 , C07K14/47 , C07K14/705 , C12N5/00
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

3. 发明专利

CA2982996A1 METHODS FOR IMPROVING THE EFFICACY AND EXPANSION OF CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS 未知
公开(公告)号：CA2982996A1
公开(公告)日：2016-10-20
申请号：CA2982996
申请日：2016-04-15
申请人： BARRETT DAVID MAXWELL , BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL H , LEVINE BRUCE L , MELENHORST JAN J , MILONE MICHAEL C , POWELL DANIEL J , SINGH NATHAN AMAR , ZHENG ZOE
发明人： BARRETT DAVID MAXWELL , BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL H , LEVINE BRUCE L , MELENHORST JAN J , MILONE MICHAEL C , POWELL DANIEL J , SINGH NATHAN AMAR , ZHENG ZOE
IPC分类号： C12N5/10 , A61K35/17 , C07K14/705 , C07K19/00 , C12N5/078 , C12N5/0783 , C12N15/62
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

4. 发明申请

WO2017015427A8 METHODS FOR IMPROVING THE EFFICACY AND EXPANSION OF IMMUNE CELLS 审中-公开
标题翻译：提高免疫细胞的效力和扩增的方法
公开(公告)号：WO2017015427A8
公开(公告)日：2017-07-13
申请号：PCT/US2016043255
申请日：2016-07-21
申请人： NOVARTIS AG , UNIV PENNSYLVANIA , BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL H , KAWALEKAR OMKAR U , LEVINE BRUCE L , MELENHORST JAN J , MILONE MICHAEL C , POWELL DANIEL JR J , ZHENG ZOE
发明人： BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL H , KAWALEKAR OMKAR U , LEVINE BRUCE L , MELENHORST JAN J , MILONE MICHAEL C , POWELL DANIEL JR J , ZHENG ZOE
IPC分类号： C07K14/725 , A61K48/00 , C07K16/30
CPC分类号： C12N5/0636 , A61K35/17 , A61K48/00 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/30 , C07K2317/622 , C07K2319/03 , C07K2319/33 , C07K2319/74 , C12N5/0087 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/50 , C12N2510/00
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.
摘要翻译：本发明提供了制备可被工程化以表达嵌合抗原受体（CAR）的免疫效应细胞（例如T细胞，NK细胞）的方法，包含其的组合物和反应混合物，以及使用其的治疗方法。

5. 发明申请

WO2016109410A3 METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS 审中-公开
标题翻译：制备抗逆转录病毒载体表达细胞的方法
公开(公告)号：WO2016109410A3
公开(公告)日：2016-08-25
申请号：PCT/US2015067635
申请日：2015-12-28
申请人： NOVARTIS AG , UNIV PENNSYLVANIA , BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL H , LEVINE BRUCE L , MELENHORST JAN J , MILONE MICHAEL C , POWELL DANIEL J JR , ZHENG ZOE
发明人： BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL H , LEVINE BRUCE L , MELENHORST JAN J , MILONE MICHAEL C , POWELL DANIEL J JR , ZHENG ZOE
IPC分类号： C07K14/725 , A61K39/00 , C12N5/00 , C12N5/0783
CPC分类号： C07K16/2803 , A61K35/17 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K14/70517 , C07K14/70578 , C07K16/28 , C07K2317/14 , C07K2317/622 , C07K2319/03 , C07K2319/74 , C12N5/0087 , C12N5/0636 , C12N5/0638 , C12N9/1276 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/51 , C12N2501/515 , C12N2510/00 , C12Y207/07049
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), and compositions and reaction mixtures comprising the same.
摘要翻译：本发明提供了可以进行工程化以表达嵌合抗原受体（CAR）的免疫效应细胞（例如，T细胞，NK细胞）的制备方法，以及包含其的组合物和反应混合物。

6. 发明申请

WO2006110591A2 POP2 NFkB-INHIBITING POLYPEPTIDES, NUCLEIC ACIDS AND METHODS OF USE 审中-公开
标题翻译： POP2 NFkB抑制多肽，核酸和使用方法
公开(公告)号：WO2006110591A2
公开(公告)日：2006-10-19
申请号：PCT/US2006013170
申请日：2006-04-07
申请人： UNIV SOUTH FLORIDA , HARTON JONATHAN A , BEDOYA FELIPE , SANDLER LAUREL L
发明人： HARTON JONATHAN A , BEDOYA FELIPE , SANDLER LAUREL L
IPC分类号： C07K14/705 , A61K38/17
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K16/18 , C12N15/113 , C12Q1/6888 , C12Q1/6897 , G01N33/5041 , G01N33/6872 , G01N2500/00
摘要： This invention provides a novel pyrin-only protein (POP2), polypeptides, nucleic acids encoding them and methods for making and using them. The polypeptides of this invention have nuclear factor -?B (NF-?B) modulating activity. NF-?B is pivotal for transactivation of cell-cycle regulatory, cytokine and adhesion molecule genes and is dysregulated in many cancers, neurodegenerative disorders, and inflammatory diseases. Proteins with Pyrin and/or caspase recruitment (CARD) domains have roles in apoptosis, innate immunity, and inflammation. Many pyrin domain proteins modulate NF-?B activity as well as participate in assembling both the perinuclear "apoptotic speck" and the pro- IL1ß/IL-18 converting inflammasome complex. 'Pyrin-only' proteins are attractive as negative regulators of pyrin domain-mediated functions and one such protein, POP1 , has been reported. We teach a second Pyrin-only protein (POP2). POP2 is a 294 nt single exon gene located on human chromosome (3) encoding a (97) amino acid protein with sequence and predicted structural similarity to other pyrin domains. Highly similar to pyrin domains in CATERPILLER (CLR, NLR, NALP) family proteins, POP2 is less like the prototypic Pyrin and ASC pyrin domains. POP2 is expressed principally in peripheral blood leukocytes and displays both cytoplasmic and nuclear expression patterns in transfected cells. TNFa-stimulated and p65 (ReIA) induced NF-?B-dependent gene transcription is inhibited by POP2 in vitro by a mechanism involving changes in NF-?B nuclear import or distribution. While colocalizing with ASC in perinuclear specks, POP2 also inhibits the formation of specks by the CLR protein CIAS1/NALP3. Together these observations indicate that POP2 is a negative regulator of NF-?B activity that may influence the assembly of pyrin-domain dependent complexes.
摘要翻译：本发明提供了一种新型的仅蛋白质蛋白（POP2），多肽，编码它们的核酸及其制备和使用方法。本发明的多肽具有核因子-βB（NF-κB）调节活性。 NF-κB是细胞周期调控，细胞因子和粘附分子基因的反式激活的关键，并且在许多癌症，神经变性疾病和炎性疾病中失调。具有蛋白质和/或胱天蛋白酶募集（CARD）结构域的蛋白质在凋亡，先天免疫和炎症中具有作用。许多pyrin结构域蛋白调节NF-κB活性，并参与组装核周的“凋亡斑点”和proIL1β/ IL-18转换炎症复合体。 “Pyrin-only”蛋白质是有吸引力的，因为已经报道了pyrin结构域介导的功能的负调节因子和一种这样的蛋白质POP1。我们教一个第二个仅含蛋白质的蛋白质（POP2）。 POP2是位于人染色体（3）上的294nt单个外显子基因，编码（97）氨基酸蛋白，其序列和预测与其他pyrin结构域的结构相似性。与CATERPILLER（CLR，NLR，NALP）家族蛋白中的pyrin结构域非常相似，POP2较不像原型的Pyrin和ASC pyrin结构域。 POP2主要表达于外周血白细胞，并在转染细胞中显示细胞质和核表达模式。 TNFα刺激和p65（ReIA）诱导的NF-κB依赖性基因转录被POP2在体外受到涉及NF-κB核进入或分布变化的机制的抑制。当与ASC在核周斑中共定位时，POP2还抑制CLR蛋白CIAS1 / NALP3形成斑点。这些观察结果一起表明，POP2是NF-κB活性的负调节因子，其可能影响pyrin结构域依赖性复合物的组装。

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