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1. 发明申请

WO0240019A8 BENZIMIDAZOLE DERIVATIVES 审中-公开
标题翻译：苯并咪唑衍生物
公开(公告)号：WO0240019A8
公开(公告)日：2002-06-20
申请号：PCT/JP0109956
申请日：2001-11-14
申请人： BANYU PHARMA CO LTD , OKAMOTO OSAMU , KAWAMOTO HIROSHI , KOBAYASHI KENSUKE , ITOH SATORU , KATO TETSUYA , YAMAMOTO IZUMI , IWASAWA YOSHIKAZU
发明人： OKAMOTO OSAMU , KAWAMOTO HIROSHI , KOBAYASHI KENSUKE , ITOH SATORU , KATO TETSUYA , YAMAMOTO IZUMI , IWASAWA YOSHIKAZU
IPC分类号： A61P3/04 , A61P9/02 , A61P13/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D235/28 , A61K31/4184 , A61K31/454 , A61K31/496 , A61K31/529 , A61K31/5377 , A61K31/551 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D493/08
CPC分类号： C07D235/28
摘要： Compounds represented by the general formula [|]: [wherein A and A are each optionally fluorinated methine or the like; B is halogeno, cyano, lower alkyl, or the like; D is an optionally substituted heterocyclic group or the like; and G is a C3-20 aliphatic group such as an alicyclic group]. The compounds inhibit nociceptin by virtue of their high affinity for nociceptin receptor, and are therefore useful as analgesic, antiobestic, cerebral function improver, drugs for treatment of Alzheimer disease and dementia, remedies for schizophrenia and neurodegerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, and hypotension, and so on.
摘要翻译：由通式[|]表示的化合物：其中A 1和A 2均为任意氟化的次甲基等; B是卤代，氰基，低级烷基等; D是任选取代的杂环基等; G为碳数3〜20的脂肪族基，例如脂环基]。这些化合物由于其对伤害感受肽受体的高亲和力而抑制伤害感受肽，因此可用作止痛，抗胆碱，脑功能改善剂，用于治疗阿尔茨海默病和痴呆的药物，用于精神分裂症和神经变性疾病的药物，抗抑郁药，尿崩症药物，多尿和低血压等。

2. 发明公开

EP0882703A4 CYCLIC AMIC ACID DERIVATIVES 失效
标题翻译： CYCLISCHESÄUREDERIVATE-朋友
公开(公告)号：EP0882703A4
公开(公告)日：2000-08-02
申请号：EP97902605
申请日：1997-02-07
申请人： BANYU PHARMA CO LTD
发明人： IWASAWA YOSHIKAZU , AOYAMA TETSUYA , KAWAKAMI KUMIKO , ARAI SACHIE , SATOH TOSHIHIKO , MONDEN YOSHIAKI
IPC分类号： C07C233/51 , C07D317/32 , C07C233/01 , A61K31/27 , A61K31/33 , A61K31/335 , A61K31/34 , C07C237/42 , C07D307/68
CPC分类号： C07C233/51 , C07D317/32
摘要： Compounds represented by general formula (I), pharmacologically acceptable salts or esters thereof, antitumor agents comprising these as the active ingredients, and intermediates therefor wherein Ar1 represents aryl or heteroaryl; Ar represents a group represented by (A) or (B), Ar?2 and Ar3¿ each represents aryl or heteroaryl; Cy represents aryl, heteroaryl, or an alicyclic group optionally having one or two oxygen atoms; A1 represents C¿1-4? hydrocarbyl; m is an integer of 1 to 6; n and p each is an integer of 0 to 3; Q?1¿ represents a single bond, a group represented by -CH¿2?O-, -OCH2-, -CH2S-, or -SCH2-, or C1-6 hydrocarbyl; Q?2¿ represents a single bond or a group represented by -(CH¿2?)m- or -(CH2)n-W-(CH2)p-; Q?3¿ represents a single bond, oxygen, sulfur, methylene, vinylene, or a group represented by -CO-, -NH-, -COO-, -OCO-, -CH¿2?CH2-, -OCH2-, -SCH2-, -CH2O-, -CH2S-, -NHCO-, or -CONH-; R?1¿ represents lower alkyl; R?2 and R3¿ each represents hydrogen, hydroxy, or lower alkyl; W represents oxygen, sulfur, vinylene, or ethynylene; x is an interger of 0 to 2; and y is 0 or 1.

3. 发明公开

EP1754706A4 SELECTIVE INHIBITORS AGAINST Cdk4 AND Cdk6 HAVING AMINOTHIAZOLE SKELETON 审中-公开
标题翻译：选择性抑制剂反对CDK4和CDK6与AMINOTHIAZOLSKELETT
公开(公告)号：EP1754706A4
公开(公告)日：2010-08-18
申请号：EP05743671
申请日：2005-05-19
申请人： BANYU PHARMA CO LTD
发明人： IWASAWA YOSHIKAZU , SHIBATA JUN , SHIMAMURA TADASHI , KURIHARA HIDEKI , MITA TAKASHI , KAWANISHI NOBUHIKO , HASHIHAYATA TAKASHI , KAWAMURA MIKAKO , SAGARA TAKESHI , ARAI SACHIE , HIRAI HIROSHI
IPC分类号： C07D417/12 , A61K31/506 , A61K31/513 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D417/14 , C07D491/08
CPC分类号： C07D417/14 , C07D417/12 , C07D491/08

4. 发明公开

EP2062887A4 NOVEL AMINOPYRIDINE DERIVATIVE HAVING AURORA A-SELECTIVE INHIBITORY ACTIVITY 有权转让
标题翻译： WITH AURORA选择性抑制效果NEW氨基吡啶衍生物
公开(公告)号：EP2062887A4
公开(公告)日：2010-03-31
申请号：EP07806706
申请日：2007-08-29
申请人： BANYU PHARMA CO LTD
发明人： IWASAWA YOSHIKAZU , KATO TETSUYA , KAWANISHI NOBUHIKO , MASUTANI KOUTA , MITA TAKASHI , NONOSHITA KATSUMASA , OHKUBO MITSURU
IPC分类号： C07D401/12 , A61K31/4439 , A61K31/497 , A61K45/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07D403/12 , C07D417/12
CPC分类号： C07D413/14 , A61K45/06 , C07D401/12 , C07D403/12 , C07D417/12

5. 发明公开

EP2061782A4 NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION 审中-公开
标题翻译：与选择性AURORA-A-抗炎作用NEW氨基吡啶衍生物
公开(公告)号：EP2061782A4
公开(公告)日：2010-03-31
申请号：EP07806705
申请日：2007-08-29
申请人： BANYU PHARMA CO LTD
发明人： IWASAWA YOSHIKAZU , KATO TETSUYA , KAWANISHI NOBUHIKO , MASUTANI KOUTA , MITA TAKASHI , NONOSHITA KATSUMASA , OHKUBO MITSURU
IPC分类号： C07D401/12 , A61K31/4439 , A61K31/497 , A61K45/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07D403/12 , C07D417/12
CPC分类号： C07D413/14 , A61K45/06 , C07D401/12 , C07D403/12 , C07D417/12

6. 发明公开

EP1914232A4 N-DIHYDROXYALKYL-SUBSTITUTED 2-OXOIMIDAZOLE DERIVATIVE 有权转让
标题翻译： N-二羟基烷基取代基2-氧代氨基甲酸酯
公开(公告)号：EP1914232A4
公开(公告)日：2009-10-28
申请号：EP06781147
申请日：2006-07-11
申请人： BANYU PHARMA CO LTD
发明人： HASHIMOTO MASAYA , IWASAWA YOSHIKAZU , KAWAMOTO HIROSHI , OHTA HISASHI , OZAKI SATOSHI , SAGARA TAKESHI , SAKOH HIROKI , SATOH ATSUSHI
IPC分类号： C07D401/04 , A61K31/454 , A61P3/04 , A61P9/00 , A61P9/02 , A61P9/10 , A61P13/02 , A61P19/02 , A61P19/06 , A61P25/06 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P43/00
CPC分类号： C07D401/04

7. 发明公开

EP1342717A4 BENZIMIDAZOLE DERIVATIVES 审中-公开
标题翻译：苯并咪唑衍生物
公开(公告)号：EP1342717A4
公开(公告)日：2005-02-16
申请号：EP01996381
申请日：2001-11-14
申请人： BANYU PHARMA CO LTD
发明人： OKAMOTO OSAMU , KAWAMOTO HIROSHI , KOBAYASHI KENSUKE , ITOH SATORU , KATO TETSUYA , YAMAMOTO IZUMI , IWASAWA YOSHIKAZU
IPC分类号： A61P3/04 , A61P9/02 , A61P13/00 , A61P25/04 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D235/28 , A61K31/4184 , A61K31/437 , A61K31/454 , A61K31/46 , A61K31/496 , A61K31/4995 , A61K31/5377 , A61K31/551 , A61P25/00 , A61P29/00 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D487/04 , C07D487/08
CPC分类号： C07D235/28
摘要： Compounds represented by the general formula [|]: [wherein A?1 and A2¿ are each optionally fluorinated methine or the like; B is halogeno, cyano, lower alkyl, or the like; D is an optionally substituted heterocyclic group or the like; and G is a C¿3-20? aliphatic group such as an alicyclic group]. The compounds inhibit nociceptin by virtue of their high affinity for nociceptin receptor, and are therefore useful as analgesic, antiobestic, cerebral function improver, drugs for treatment of Alzheimer disease and dementia, remedies for schizophrenia and neurodegerative diseases, antidepressant, remedies for diabetes insipidus, polyuria, and hypotension, and so on.

8. 发明公开

EP0916668A4 CHEMOKINE RECEPTOR ANTAGONISTS 失效
标题翻译：趋化因子受体拮抗剂
公开(公告)号：EP0916668A4
公开(公告)日：2000-08-16
申请号：EP97932992
申请日：1997-07-23
申请人： BANYU PHARMA CO LTD
发明人： NAYA AKIRA , OWADA YUFU , SAEKI TOSHIHIKO , OHWAKI KENJI , IWASAWA YOSHIKAZU
IPC分类号： C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/14 , A61K31/445 , A61K31/535 , A61K31/54
CPC分类号： C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/14
摘要： Compounds represented by general formula (I), pharmaceutically acceptable anion-exchange products thereof, or hydrates of both, wherein R?1 and R2¿ are the same or different and each represents hydrogen, halogeno, lower alkyl, etc.; X represents oxygen, sulfur or CH; Y represents CH or nitrogen; and A represents 1-substituted-4-piperidinyl, etc. Because of having chemokine receptor antagonism, these compounds are useful as remedies for various diseases related to chemokine, such as acute inflammatory diseases, chronic inflammatory diseases, human acquired immunological deficiency syndrome, cancer, ischemic reflow disorders and/or arteriosclerosis.

9. 发明公开

EP0776884A4 SUBSTITUTED AMIDE DERIVATIVE 失效
标题翻译：取代衍生物AMID
公开(公告)号：EP0776884A4
公开(公告)日：1998-01-07
申请号：EP95928001
申请日：1995-08-10
申请人： BANYU PHARMA CO LTD
发明人： IWASAWA YOSHIKAZU , AOYAMA TETSUYA , KAWAKAMI KUMIKO , ARAI SACHIE , SATOH TOSHIHIKO , MONDEN YOSHIAKI
IPC分类号： C07C233/05 , C07C233/13 , C07C233/18 , C07C233/25 , C07C233/36 , C07D213/40 , C07D215/12 , C07D235/14 , C07D263/56 , C07D277/64 , C07D307/81 , C07D317/58 , C07D333/58 , C07D413/06 , C07D413/12 , C07D413/14 , A61K31/19 , A61K31/34 , A61K31/42 , C07D261/08 , C07D307/68 , C07D405/12
CPC分类号： C07D213/40 , C07C233/05 , C07C233/13 , C07C233/18 , C07C233/25 , C07C233/36 , C07D215/12 , C07D235/14 , C07D263/56 , C07D277/64 , C07D307/81 , C07D317/58 , C07D333/58 , C07D413/06 , C07D413/12 , C07D413/14
摘要： A compound represented by general formula (I), a medicinally acceptable salt or ester thereof, and an antineoplastic containing the same as the active ingredient, wherein Ar?1, Ar2 and Ar3¿ represent each aryl or heteroaryl; A represents an optionally substituted hydrocarbon group; Q represents -(CH¿2?)m- (m being an integer of 1 to 6) or -(CH2)n-W-(CH2)p- (W being oxygen, sulfur, vinylene or ethynylene; and n and p being each an integer of 0 to 3); R?1¿ represents hydrogen, halogeno, hydroxy, lower alkyl, lower alkoxy, or optionally substituted aryl or heteroaryl; R?2, R7 and R8¿ represent each hydrogen, halogeno, hydroxy, lower alkyl or lower alkoxy; R?3 and R4¿ represent each hydrogen, halogeno, hydroxy, amino, nitro cyano, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, lower alkyl, lower hydroxyalkyl, lower fluoroalkyl or lower alkoxy; R5 represents lower alkyl; and R6 represents hydrogen or lower alkyl.

10. 发明公开

EP0990653A4 2-OXOIMIDAZOLE DERIVATIVES 失效
标题翻译： 2- OXOIMIDAZOL衍
公开(公告)号：EP0990653A4
公开(公告)日：2001-04-11
申请号：EP98921842
申请日：1998-05-27
申请人： BANYU PHARMA CO LTD
发明人： OZAKI SATOSHI , KAWAMOTO HIROSHI , ITO YOSHIKI , HIRANO KAORI , HAYASHI KYOKO , IWASAWA YOSHIKAZU
IPC分类号： C07D401/04 , C07D403/04 , C07D451/06 , A61K31/415 , A61K31/435 , A61K31/445 , C07D401/14 , C07D453/06
CPC分类号： C07D401/04 , C07D403/04 , C07D451/06
摘要： Compounds represented by general formula (I), their salts or esters; processes for producing the same; and analgesics, antagonists against tolerance to narcotic analgesics typified by morphine, antagonists against dependence on narcotic analgesics typified by morphine, analgesic enhancers, antiobestics, drugs for ameliorating brain function, remedies for schizophrenia, remedies for Parkinson's disease, remedies for chorea, antidepressive drugs, remedies for diabetes insipidus, remedies for polyuria, or remedies for hypotension, each drug containing the above compounds as the active ingredient. In said formula, (a) represents an optionally substituted aromatic carbon ring or heterocycle; Cy represents an optionally substituted, mono-, di- or tricyclic C3-20 aliphatic carbon ring; (b) represents an optionally substituted, mono- or di-cyclic C3-14 aliphatic heterocycle containing nitrogen; R1 represents hydrogen, lower alkenyl, lower alkynyl, lower cycloalkyl, amino, lower alkylamino, di(lower alkyl)amino, hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, carbamoyl, lower alkylcarbamoyl, di(lower alkyl)carbamoyl or optionally substituted lower alkyl; and R2 represents hydrogen or lower alkyl.
摘要翻译：通式（I）代表的化合物，它们的盐或酯; 生产该工艺的过程; 和止痛药，针对耐受吗啡为代表的麻醉性镇痛药拮抗剂，对以吗啡为代表的麻醉性镇痛药，镇痛增强剂，antiobestics，药物改善脑功能，补救措施，精神分裂症，帕金森氏病的补救措施，补救措施舞蹈病，抗抑郁药物依赖性拮抗剂，用于尿崩症的治疗方法，多尿症的治疗方法或低血压的治疗方法，每种药物都含有上述化合物作为活性成分。在所述式中，（a）表示任选取代的芳族碳环或杂环; Cy代表任选取代的单 - ，二 - 或三环C3-20脂族碳环; （b）表示任选取代的含氮单环或双环C3-14脂族杂环; 低级链烯基，低级炔基，低级环烷基，氨基，低级烷基氨基，二（低级烷基）氨基，羟基，低级烷氧基，羧基，低级烷氧基羰基，氨基甲酰基，低级烷基氨基甲酰基或低级烷基氨基甲酰基烷基; 和R2代表氢或低级烷基。

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