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1. 发明专利

CA1270198A ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSOMES 未知
公开(公告)号：CA1270198A
公开(公告)日：1990-06-12
申请号：CA488005
申请日：1985-08-02
申请人： BALLY MARCEL B , CULLIS PIETER B , HOPE MICHAEL J , MADDEN THOMAS D , MAYER LAWRENCE D
发明人： BALLY MARCEL B , CULLIS PIETER B , HOPE MICHAEL J , MADDEN THOMAS D , MAYER LAWRENCE D
IPC分类号： A61K45/08 , A61K9/00 , A61K9/10 , A61K9/127 , A61K31/435 , A61K31/505 , A61K31/519 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K45/00 , A61K47/48 , A61P35/00 , C07D475/08 , C07D519/00 , C07H15/252 , C07H19/09 , A61K9/60 , A61K7/44 , A61K9/52
摘要： Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials are provided. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplastic agents in a clinical setting are also provided. In accordance with other aspects of the invention, transmembrane potentials are used to reduce the rate of release of ionizable drugs from liposomes.

2. 发明申请

WO0141738A3 LIPID CARRIER COMPOSITIONS WITH PROTECTED SURFACE REACTIVE FUNCTIONS 审中-公开
标题翻译：具有保护表面反应功能的脂质载体组合物
公开(公告)号：WO0141738A3
公开(公告)日：2001-11-29
申请号：PCT/CA0001494
申请日：2000-12-11
申请人： CELATOR TECHNOLOGIES INC , MAYER LAWRENCE D , CHIU GIGI , BALLY MARCEL B
发明人： MAYER LAWRENCE D , CHIU GIGI , BALLY MARCEL B
IPC分类号： A61K9/127
CPC分类号： A61K9/1271
摘要： The liposomes of the invention have a reactive surface that demonstrates reduced interaction with macromolecules and increased blood circulation time. The reactive surface may comprise phosphatidylserine. The liposomes are protected by the presence of high levels of a hydrophilic polymer conjugated to a lipid. The invention further provides means for adjusting the appropriate ratio of hydrophilic polymer to a reactive lipid by a) determining the reactivity of the lipid; b) determining the time required for the carrier to reach its desired target location; c) determining the affinity of desired interactions with the reactive surface; and d) incorporating in the liposome or lipid carrier the amount of polyethylene glycol required to protect the reactive surface.
摘要翻译：本发明的脂质体具有反应性表面，其表现出与大分子减少的相互作用和增加的血液循环时间。反应性表面可以包含磷脂酰丝氨酸。通过存在高水平的与脂质缀合的亲水性聚合物来保护脂质体。本发明还提供了通过以下方法来调节亲水性聚合物与活性脂质的适当比例：a）确定脂质的反应性; b）确定承运人达到其所需目标位置所需的时间; c）确定与反应性表面的所需相互作用的亲和力; 和d）在脂质体或脂质载体中掺入保护反应性表面所需的聚乙二醇的量。

3. 发明申请

WO2006014626A3 PARTUCULATE CONSTRUCTS FOR RELEASE OF ACTIVE AGENTS 审中-公开
标题翻译：制定有效药剂释放结构
公开(公告)号：WO2006014626A3
公开(公告)日：2006-10-05
申请号：PCT/US2005025549
申请日：2005-07-19
申请人： CELATOR PHARMACEUTICALS INC , UNIV PRINCETON , MAYER LAWRENCE D , PRUD HOMME ROBERT K , ALLEN CHRISTINE J , SAAD WALID S
发明人： MAYER LAWRENCE D , PRUD HOMME ROBERT K , ALLEN CHRISTINE J , SAAD WALID S
IPC分类号： A61K31/74 , A61K31/77
CPC分类号： A61K47/482 , A61K8/85 , A61K9/5153 , A61K45/06 , A61K47/22 , A61K47/48107 , A61K47/48192 , A61K47/551 , A61K47/552 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/6935 , A61K2800/57 , A61Q17/04 , B82Y5/00
摘要： Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo environments.
摘要翻译：通过两亲性共聚物稳定并且包含至少一个与疏水部分结合的活性物质的颗粒构建物在体外和体内环境中均提供活性物质的持续释放。

4. 发明申请

WO03041681A3 LIPID CARRIER COMPOSITIONS WITH ENHANCED BLOOD STABILITY 审中-公开
标题翻译：具有增强的血液稳定性的脂质载体组合物
公开(公告)号：WO03041681A3
公开(公告)日：2003-09-18
申请号：PCT/CA0201726
申请日：2002-11-13
申请人： CELATOR TECHNOLOGIES INC , WEBB MURRAY , TARDI PAUL , MAYER LAWRENCE D , ICKENSTEIN LUDGER M
发明人： WEBB MURRAY , TARDI PAUL , MAYER LAWRENCE D , ICKENSTEIN LUDGER M
IPC分类号： A61K9/127 , A61K9/19 , A61K31/704 , A61K31/7072 , A61K33/24 , A61K9/00
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1278
摘要： Liposomes that contain at least 10 mol % of a negatively charged lipid coupled to an non-zwitterionic moiety are stable in the blood. Liposomes containing at least 1 mol % of such lipids may be frozen safely.
摘要翻译：含有至少10mol％与非两性离子部分偶联的负电荷脂质的脂质体在血液中是稳定的。含有至少1摩尔％这种脂质的脂质体可以安全冷冻。

5. 发明专利

CA1314481C LIPOSOMAL PREPARATION AND ANTIBIOTIC 未知
公开(公告)号：CA1314481C
公开(公告)日：1993-03-16
申请号：CA527232
申请日：1987-01-13
申请人： BALLY MARCEL B
发明人： BALLY MARCEL B , BOLCSAK LOIS E , CULLIS PIETER R , JANOFF ANDREW S , MAYER LAWRENCE D , LENK ROBERT P , JEDRUSIAK JO A
IPC分类号： A61K9/00 , A61K9/10 , A61K9/127 , A61K9/133 , A61K9/52 , A61K31/70 , A61K38/22 , A61K45/00 , A61K47/24 , A61K47/44 , A61P9/00 , A61P9/12 , A61P13/02 , A61P15/00 , A61P31/04 , B01J13/02 , C07H20060101 , C07H15/226 , C07H15/238
摘要： LIPOSOME PREPARATION AND ANTIBIOTIC Aminoglycosides, analogs and derivatives thereof, in the form of phosphate salts are described as well as the process for making and utilizing same. Aminoglycoside liposomes and nonguanidino aminoglycoside liposomes, their preparation and use, are particularly described.

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