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1. 发明申请

WO0194561A3 THE NON-MEVALONATE ISOPRENOID PATHWAY 审中-公开
标题翻译：非诺贝特伊斯兰布尔途径
公开(公告)号：WO0194561A3
公开(公告)日：2002-05-30
申请号：PCT/EP0106255
申请日：2001-06-01
申请人： BACHER ADELBERT , ZENK MEINHART H , ADAM PETRA , EISENREICH WOLFGANG , FELLERMEIER MONIKA , HECHT STEFAN , ROHDICH FELIX , SCHUHR CHRISTOPH A , WUNGSINTAWEEKUL JURAITHIP
发明人： BACHER ADELBERT , ZENK MEINHART H , ADAM PETRA , EISENREICH WOLFGANG , FELLERMEIER MONIKA , HECHT STEFAN , ROHDICH FELIX , SCHUHR CHRISTOPH A , WUNGSINTAWEEKUL JURAITHIP
IPC分类号： C12N9/00 , C12N15/52 , C12N15/82 , C12P9/00 , A01H5/10
CPC分类号： C12N9/00 , C12N15/52 , C12N15/8274 , C12P9/00
摘要： The present invention is directed to enzymes and intermediates of the non-mevalonate isoprenoid pathway downstream of 2C-methyl-D-erythritol 2,4-cyclopyrophosphate and upstream of isopentenyl pyrophosphate or dimethylallyl pyrophosphate. These are used as a basis for a screening method for inhibitors of these enzymes, and a method for identifying inhibitor-resistant variants thereof. Further disclosures refer to DNA coding for said enzymes and for inhibitor-resistant variants thereof, vectors containing said DNA, cells containing said vector, and plant seeds comprising cells containing said vector. This invention is useful for the inhibition of the biosynthesis of isoprenoids in plants, bacteria and protozoa, for confering herbicide-resistance to plants, as well as for weed control in agriculture using a crop containing a herbicide-resistant gene and an effective amount of a suitable herbicide.
摘要翻译：本发明涉及2-甲基-D-赤藓糖醇2,4-环丙基磷酸酯和异戊烯基焦磷酸或二甲基烯丙基焦磷酸的上游的非甲羟戊酸异戊二烯通路的酶和中间体。这些用作这些酶的抑制剂的筛选方法的基础，以及用于鉴定其抑制剂抗性变体的方法。还涉及编码所述酶和其抑制剂抗性变体的DNA，含有所述DNA的载体，含有所述载体的细胞，以及含有所述载体的细胞的植物种子。本发明可用于抑制植物，细菌和原生动物中的类异戊二烯的生物合成，以赋予对植物的除草剂抗性，以及在使用含有除草剂抗性基因的作物和有效量的合适的除草剂。

2. 发明专利

AU7408401A The non-mevalonate isoprenoid pathway 未知
公开(公告)号：AU7408401A
公开(公告)日：2001-12-17
申请号：AU7408401
申请日：2001-06-01
申请人： BACHER ADELBERT , ZENK MEINHART H
发明人： BACHER ADELBERT , ZENK MEINHART H , ADAM PETRA , EISENREICH WOLFGANG , FELLERMEIER MONIKA , HECHT STEFAN , ROHDICH FELIX , SCHUHR CHRISTOPH A , WUNGSINTAWEEKUL JURAITHIP
IPC分类号： C12N9/00 , C12N15/52 , C12N15/82 , C12P9/00
摘要： Intermediate (A), optionally isotopically labeled, in the mevalonate-independent pathway of isoprenoid biosynthesis, is new. Independent claims are also included for the following: (a) aqueous cell fluid containing (I) and (A), with at least one present at higher concentration than in fluids from normal cells or organisms; (b) preparing (A); (c) enzymes (B) that convert (I) to (A); (d) isolated, purified nucleic acid (C) encoding (B); (e) DNA vectors containing (C); (f) recombinant cells containing the vector of (e); (g) screening chemical libraries for inhibitors of isoprenoid biosynthesis based on blocking conversion of (I); (h) identifying inhibitor-resistant variants of (B); (i) (B) variants identified by method (h); (j) nucleic acid (C') encoding the variants of (f); (k) (l) vectors containing (C'); (l) cells containing the vectors of (l); (m) imparting herbicide resistance to plants by incorporation of (C'); (n) weed control that involves growing crop plants of (n); (o) inhibitors (D) identified by method (g); (p) composition for inhibiting biosynthesis of isoprenoids containing (D); and (q) inhibiting biosynthesis of isoprenoids by treatment with (D) or the compositions of (q).

3. 发明专利

AT415479T 未知
公开(公告)号：AT415479T
公开(公告)日：2008-12-15
申请号：AT01940547
申请日：2001-06-01
申请人： BACHER ADELBERT , ZENK MEINHART H
发明人： BACHER ADELBERT , ZENK MEINHART , ADAM PETRA , EISENREICH WOLFGANG , FELLERMEIER MONIKA , HECHT STEFAN , ROHDICH FELIX , SCHUHR CHRISTOPH , WUNGSINTAWEEKUL JURAITHIP
IPC分类号： C12N15/52 , A01H5/10 , C12N9/00 , C12N15/82 , C12P9/00
摘要： Intermediate (A), optionally isotopically labeled, in the mevalonate-independent pathway of isoprenoid biosynthesis, is new. Independent claims are also included for the following: (a) aqueous cell fluid containing (I) and (A), with at least one present at higher concentration than in fluids from normal cells or organisms; (b) preparing (A); (c) enzymes (B) that convert (I) to (A); (d) isolated, purified nucleic acid (C) encoding (B); (e) DNA vectors containing (C); (f) recombinant cells containing the vector of (e); (g) screening chemical libraries for inhibitors of isoprenoid biosynthesis based on blocking conversion of (I); (h) identifying inhibitor-resistant variants of (B); (i) (B) variants identified by method (h); (j) nucleic acid (C') encoding the variants of (f); (k) (l) vectors containing (C'); (l) cells containing the vectors of (l); (m) imparting herbicide resistance to plants by incorporation of (C'); (n) weed control that involves growing crop plants of (n); (o) inhibitors (D) identified by method (g); (p) composition for inhibiting biosynthesis of isoprenoids containing (D); and (q) inhibiting biosynthesis of isoprenoids by treatment with (D) or the compositions of (q).

4. 发明专利

DE60036477T2 未知
公开(公告)号：DE60036477T2
公开(公告)日：2008-06-12
申请号：DE60036477
申请日：2000-08-03
申请人： BACHER ADELBERT , ZENK MEINHART H
发明人： BACHER ADELBERT , ZENK MEINHART H , EISENREICH WOLFGANG , FELLERMEIER MONIKA , FISCHER MARKUS , HECHT STEFAN , HERZ STEFAN , KIS KLAUS , LUETTGEN HOLGER , ROHDICH FELIX , SAGNER SILVIA , SCHUHR CHRISTOPH A , WUNGSINTAWEEKUL JURAITHIP
IPC分类号： C12N15/54 , A01N61/00 , C12N9/12 , C12N9/88 , C12N15/60 , C12P23/00 , G01N33/68

5. 发明专利

AT373715T 未知
公开(公告)号：AT373715T
公开(公告)日：2007-10-15
申请号：AT00949452
申请日：2000-08-03
申请人： BACHER ADELBERT , ZENK MEINHART H
发明人： BACHER ADELBERT , ZENK MEINHART H , EISENREICH WOLFGANG , FELLERMEIER MONIKA , FISCHER MARKUS , HECHT STEFAN , HERZ STEFAN , KIS KLAUS , LUETTGEN HOLGER , ROHDICH FELIX , SAGNER SILVIA , SCHUHR CHRISTOPH , WUNGSINTAWEEKUL JURAITHIP
IPC分类号： C12N15/54 , A01N61/00 , C12N9/12 , C12N9/88 , C12N15/60 , C12P23/00 , G01N33/68

6. 发明专利

AU1978200A Screening for inhibitors of terpenoids biosynthesis 未知
公开(公告)号：AU1978200A
公开(公告)日：2000-07-03
申请号：AU1978200
申请日：1999-12-13
申请人： BACHER ADELBERT , ZENK MEINHART H
发明人： BACHER ADELBERT , ZENK MEINHART H , KIS KLAUS , FELLERMEIER MONIKA
IPC分类号： A01G7/00 , A01N43/58 , A01N57/12 , C07F9/09 , C07H3/02 , C07H13/00 , C12N5/04 , C12N9/00 , C12N9/99 , C12Q1/02 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/92 , A01N61/00

7. 发明专利

DE60036477D1 ISOPRENOID BIOSYNTHESE 未知
公开(公告)号：DE60036477D1
公开(公告)日：2007-10-31
申请号：DE60036477
申请日：2000-08-03
申请人： BACHER ADELBERT , ZENK MEINHART H
发明人： BACHER ADELBERT , ZENK MEINHART H , EISENREICH WOLFGANG , FELLERMEIER MONIKA , FISCHER MARKUS , HECHT STEFAN , HERZ STEFAN , KIS KLAUS , LUETTGEN HOLGER , ROHDICH FELIX , SAGNER SILVIA , SCHUHR CHRISTOPH A , WUNGSINTAWEEKUL JURAITHIP
IPC分类号： C12N15/54 , A01N61/00 , C12N9/12 , C12N9/88 , C12N15/60 , C12P23/00 , G01N33/68

8. 发明专利

DE19948615A1 Screening for inhibitors of the terpenoid biosynthetic pathway that may be used as herbicides 未知
公开(公告)号：DE19948615A1
公开(公告)日：2001-04-12
申请号：DE19948615
申请日：1999-10-08
申请人： BACHER ADELBERT , ZENK MEINHART H
发明人： BACHER ADELBERT , ZENK MEINHART , FELLERMEIER MONIKA , KIS KLAUS
IPC分类号： C07H3/02 , C07H13/00 , C12Q1/02 , G01N33/50 , G01N33/92 , C07H11/04 , A01H3/04 , C12N5/04 , C12N9/99 , C12Q1/25
摘要： A method (I) of screening for inhibitors of enzymes in the biosynthetic pathway that produces terpenoids via 1-deoxy-D-xylulose 5-phosphate in plants, comprises incubating plastids in the presence of a labeled precursor, ATP, CTP (or a source of CTP) and a candidate inhibitor and detecting the formation of labeled products, is new. Independent claims are included for the following: (1) a method (I) for screening for the presence of inhibition of at least one enzyme in the biosynthetic pathway to terpenoids via 1-deoxy-D-xylulose 5-phosphate in plants, comprising: (a) preparing a suspension of cells or plastids of a plastid-bearing organism in a culture medium for supporting the metabolism of the cells or plastids at least to the extent of the biosynthetic pathway; (b) adding to the suspension a predetermined amount of a carbon-13-, carbon-14-, deuterium-, or tritium-labeled biochemical precursor for generating terpenoids via the pathway; (c) incubating the mixture obtained in step (b) for a predetermined period of time at a predetermined temperature; (d) separating from the incubated mixture obtained in step (c), a fraction comprising a product or intermediate downstream from 1-deoxy-D-xylulose-5-phosphate in the pathway; (e) detecting the concentration of labeled product(s) in the fraction obtained in step (d); (f) repeating step (b) with the addition of a predetermined amount of a chemical test sample under otherwise identical conditions; (g) repeating steps (c) to (e) with the mixture obtained in step (f) under the same conditions as in steps (c) to (e); and (h) determining the presence of inhibition of at least one enzyme in the pathway by observation of whether the concentration of labeled product(s) detected in step (e) is higher than that detected when step (e) is repeated in step (g); (2) a method (II) for inhibiting the growth of a plant by treatment with a herbicide selected from a class of compounds exhibiting inhibition of the biosynthetic pathway to terpenoids via 1-deoxy-D-xylulose 5 phosphate in the test (I); (3) a method (III) of inhibiting, in the chloroplasts of plants, an enzyme in the biosynthetic pathway to terpenoids via 1-deoxy-D-xylulose 5 phosphate by treatment with a compound that inhibits that biosynthetic pathway identified in the test (I); (4) an inhibitor (IV) exhibiting inhibition in (I); (5) a method (V) for increasing the titer of an intermediate in the biosynthetic pathway via 1-deoxy-D-xylulose 5 phosphate upstream from IPP (undefined) in plants, plant cells or plastids by treatment with a synthetic inhibitor exhibiting inhibition in (I); (6) plant cells or plasmids containing a synthetic inhibitor and exhibiting a titer of an intermediate in the biosynthetic terpenoid pathway via 1-deoxy-D-xylulose 5 phosphate upstream from IPP which is increased over the titer absent in the inhibitor; (7) 14-carbon-, 13-carbon-, deuterium- or tritium-labelled 1-deoxy-D-xylulose 5 phosphate or 2C-methyl-D-erythritol 4-phosphate; (8) tritiated 2C-methyl-D-erythritol 4-phosphate or tritiated 1-deoxy-xylulose 5-phosphate; (9) 2C--methyl-D-erythritol 4-phosphate tritiated at positions 1 and/or 3 or in the methyl group; and (10) 1-deoxy-D-xylulose 5-phosphate, tritiated in positions 1, 3 and/or 4.

9. 发明申请

WO2005094783A3 SERUM-STABLE AMPHOTERIC LIPOSOMES 审中-公开
标题翻译：血清中稳定脂质体两性
公开(公告)号：WO2005094783A3
公开(公告)日：2006-03-02
申请号：PCT/DE2005000589
申请日：2005-03-29
申请人： NOVOSOM AG , ENDERT GEROLD , KERWITZ YVONNE , FELLERMEIER MONIKA
发明人： ENDERT GEROLD , KERWITZ YVONNE , FELLERMEIER MONIKA
IPC分类号： A61K9/00 , A61K9/127
CPC分类号： A61K9/1272 , A61K9/127 , Y10S977/907 , Y10T428/2984
摘要： The invention relates to amphoteric liposomal formulations which are provided with great serum stability and are suitable for the intracellular delivery of oligonucleotides.
摘要翻译：本发明涉及表现出特定的血清稳定性和适合于寡核苷酸的细胞内递送两性脂质体制剂。

10. 发明专利

DE10018368A1 Screening for kinase able to phosphorylate 1-deoxy-D-xylulose, useful for producing the 5-phosphate, an intermediate for vitamins and terpenoids 未知
公开(公告)号：DE10018368A1
公开(公告)日：2001-10-25
申请号：DE10018368
申请日：2000-04-13
申请人： BACHER ADELBERT , ZENK MEINHART
发明人： BACHER ADELBERT , EISENREICH WOLFGANG , FELLERMEIER MONIKA , HECHT STEFAN , HERZ STEFAN , ROHDICH FELIX , WUNGSINTAWEEKUL JURAITHIP , ZENK MEINHART H
IPC分类号： C12N9/12 , C12N15/54 , C12P19/02 , C12Q1/48 , C12N5/10
摘要： Screening for a class of kinases, (I), able to phosphorylate 1-deoxy-D-xylulose (II) at the 5-position, comprising a reaction mixture of suspected kinase, (II) and a compound (III) able to transfer a phosphorylation group is incubated for a predetermined time at predetermined temperature, then the conversion of (II) to its 5-phosphate (IIa) measured, is new. An Independent claim is included for a method, (M1), of preparing (IIa) by reacting (II) and (III) in presence of (I) identified by M1.

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