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    • 4. 发明申请
    • PROCESS FOR THE PRODUCTION BY PLASMA OF NANOMETRIC THICKNESS COATINGS ALLOWING CONTROLLED RELEASE OF SILVER IONS OF OTHER ELEMENTS, OR OF MOLECULES OF BIOMEDICAL INTEREST, FROM SOLID PRODUCTS, AND PRODUCTS THUS COATED
    • 纳米厚度涂层的等离子体生产工艺,允许从固体产品和涂层产品中控制释放其他元素或生物医学利益分子的银离子
    • WO2013021409A1
    • 2013-02-14
    • PCT/IT2012/000255
    • 2012-08-10
    • UNIVERSITA' DEGLI STUDI DI BARIMEDIPLASMA S.R.L. DIPARTIMENTO DI SCIENZE PER LA SALUTE DELL'UNIVERSITA' DEL MOLISE (UNIMOL)PLASMA SOLUTION S.R.L.D'AGOSTINO, RiccardoFAVIA, PietroFRACASSI, FrancescoSARDELLA, EloisaCOSTAGLIOLA, CiroMANGONE, Annarosa
    • D'AGOSTINO, RiccardoFAVIA, PietroMANGONE, Annarosa
    • A61L27/34A61L27/54A61L31/10A61L31/16
    • A61L31/16A61L27/34A61L27/54A61L29/085A61L29/16A61L31/10A61L2300/104A61L2300/404A61L2300/602A61L2300/624A61L2400/18A61L2420/04A61L2420/08C08L71/02
    • Process for the production by plasmochemical deposition of a film having a nanometric thickness, optionally multilayered, permitting carrying out in a controlled, uniform and long lasting way, release of substances of interest in a surrounding medium containing liquids, from a substrate including the substance to be released as micro/nano particles, or from a layer deposited on the substrate including the substance to be released as micro/nano particles, or from a layer of the substance to be released deposited on the substrate, or from a substrate that is the substance to be released optionally in the form of particles. The substances to be released can be metals, compounds having anti-bacterial properties, biologically active molecules such as drugs, hormones, vegetable extracts, peptides, lipids, protides and glucides. The layer with the substance to be released, be it organic or inorganic, is obtained by plasmochemical deposition optionally having a structure similar to polyethylene oxide (PEO) or polyethylene glycol (PEG), called PEO-like polymers, constituted, in a variable percentage da ethylene oxide units (-CH2CH2O-, EO); barrier film is obtained by depositing by plasma at least one organic or inorganic layer, optionally with a PEO-like structure, wherein chemical composition, degree of crosslinking and thickness are adjustable by the plasmo chemical deposition process parameters, and allow to adjust the release of the active substance according to specific needs. The structures on which the above said films can be deposited are: medical-surgical devices, common handworks, structures known as scaffolds, and the above defined substances to be released themselves. The invention also relates to medical-surgical devices, common handworks and scaffolds coated by a substrate and barrier layer, as well as to biologically active substances coated by at least one barrier layer.
    • 用于通过等离子体化学沉积制备具有纳米厚度的膜的方法,任选地多层,允许以受控的,均匀的和持久的方式进行感兴趣物质在含有液体的周围介质中的释放 从包含待释放的物质的基底作为微米/纳米颗粒,或者从沉积在包括待释放的物质的基底上的层作为微米/纳米颗粒,或者从沉积在基底上的要释放的物质的层 或者从作为待释放物质的底物任选地以颗粒形式释放。 待释放的物质可以是金属,具有抗菌性质的化合物,生物活性分子如药物,激素,植物提取物,肽,脂质,protides和糖类。 具有待释放物质的层(无论是有机的还是无机的)是通过任选具有类似于聚环氧乙烷(PEO)或聚乙二醇(PEG)的称为PEO-样聚合物的结构的质化化学沉积获得的,其以可变百分比 环氧乙烷单元(-CH 2 CH 2 O-,EO); 通过等离子体沉积至少一个有机或无机层,任选具有PEO-样结构,其中化学组成,交联度和厚度可通过等离子体化学沉积工艺参数进行调节,并允许调节 根据特定需要的活性物质。 上述所述薄膜可以沉积在其上的结构是:医疗手术装置,普通手工工艺,称为支架的结构,以及上面定义的待释放物质本身。 本发明还涉及由基底和阻挡层涂覆的医疗外科装置,普通手工制品和支架以及由至少一个阻挡层涂覆的生物活性物质。