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1. 发明公开

EP3300671A1 TITANIUM CLIP WITH DRUG-LOADING FEATURE, DRUG-LOADED TITANIUM CLIP, AND MANUFACTURING METHOD THEREOF 有权
标题翻译：具有药物载荷功能的钛夹，药物负载的钛夹及其制造方法
公开(公告)号：EP3300671A1
公开(公告)日：2018-04-04
申请号：EP16861081.4
申请日：2016-12-09
申请人： B. J. ZH. F. PANTHER MEDICAL EQUIPMENT CO. LTD.
发明人： LIU, Qing , PU, Cong
IPC分类号： A61B17/064 , A61L31/02 , A61L31/08 , A61L31/14 , A61L31/16
CPC分类号： A61L31/022 , A61K9/0024 , A61L31/088 , A61L31/146 , A61L31/16 , A61L2300/104 , A61L2300/414 , A61L2300/602 , A61L2300/606 , A61L2300/622 , A61L2400/08
摘要： The present invention discloses a preparation method of a titanium nail capable of loading a drug. The titanium nail capable of loading a drug includes a titanium nail body capable of loading a drug, and a microporous ceramic layer capable of loading a drug arranged on the surface of the titanium nail body. The steps of the method include: pretreating the surface of the titanium nail body, preparing a microporous mould for hyaluronic acid-alginic acid microspheres, preparing a titanium sol solution, coating film, pore-forming and roasting. The present invention also discloses a titanium nail capable of loading a drug obtained by the preparation method above, and a drug-loaded titanium nail prepared with the titanium nail capable of loading a drug and a preparation method thereof. With the microporous ceramic layer on the surface of the titanium nail body, it is hard for the metal ions on the surface of the titanium nail to penetrate the human body, due to the properties of corrosion resistance and wear resistance of the ceramics. Further, it fails to generate the exfoliations and the wear debris to prevent the human body from "wear debris disease" and reaction to a foreign body. Moreover, various drugs such as the antibacterial drugs, and the drugs for promoting the healing etc. can be loaded, targeted and slow-released, which is good for medical usage.
摘要翻译：本发明公开了一种能够装载药物的钛钉的制备方法。能够装载药物的钛钉包括能够装载药物的钛钉体和能够装载排列在钛钉体表面上的药物的微孔陶瓷层。该方法的步骤包括：预处理钛钉体表面，制备透明质酸 - 海藻酸微球微孔模具，制备钛溶胶溶液，涂膜，成孔和焙烧。本发明还公开了一种能够装载通过上述制备方法得到的药物的钛钉和一种能够装载药物的钛钉制备的载药钛钉及其制备方法。由于陶瓷的耐腐蚀性和耐磨性，钛钉体表面的微孔陶瓷层难以渗入钛钉表面的金属离子。此外，它不会产生剥落和磨损碎片，以防止人体“磨损病”和对异物的反应。此外，可以装载各种药物如抗菌药物和促进愈合的药物，作为目标和缓释，这对医疗用途是有益的。

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