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1. 发明申请

US20110120213A1 SAMPLE INJECTOR, SAMPLE INJECTING METHOD, AND LIQUID CHROMATOGRAPH 有权
标题翻译：样品注射器，样品注射方法和液相色谱
公开(公告)号：US20110120213A1
公开(公告)日：2011-05-26
申请号：US13055720
申请日：2009-07-28
申请人： Aya Hirayama , Osamu Shirota , Masashi Mita , Kazuhiko Mibayashi
发明人： Aya Hirayama , Osamu Shirota , Masashi Mita , Kazuhiko Mibayashi
IPC分类号： G01N30/20 , G01N35/10
CPC分类号： G01N30/20 , G01N30/16 , G01N30/24 , G01N35/1004 , G01N35/1097
摘要： A sample injection part connected to a column to inject a sample into the column; a sample injection needle attachable to the sample injection part; a sample suction part connectable to the sample injection needle and configured to cause a predetermined amount of the sample to be drawn by suction into the sample injection needle upon connecting to the sample connection needle; a mobile phase supply part configured to supply the column with a mobile phase; a first switching valve for selectively connecting the sample injection needle to one of the sample suction part and the mobile phase supply part; and a second switching valve, including the sample injection part, for supplying the sample and the mobile phase to the column via the sample injection needle in the case of having the sample injection needle attached to the sample injection part and for supplying the mobile phase to the column via the first switching valve in the case of having the sample injection needle removed from the sample injection part are included.
摘要翻译：连接到柱上以将样品注入柱中的样品注入部分; 可注入样品的样品注射针; 样品抽吸部分，其可连接到样品注射针，并且构造成在连接到样品连接针时使预定量的样品通过抽吸被抽吸到样品注射针中; 流动相供应部分，配置成向柱提供流动相; 第一切换阀，用于选择性地将样品注射针连接到样品吸入部分和流动相供应部分中的一个; 以及第二切换阀，包括样本注入部，用于在将样品注射针附接到样品注射部分并将流动相供给到样品注射部分的情况下经由样品注射针将样品和流动相供给到柱中包括在从样品注射部分取出样品注射针的情况下经由第一切换阀的柱。

2. 发明授权

US08574918B2 Sample injector, sample injecting method, and liquid chromatograph 有权
标题翻译：样品注射器，样品注射法和液相色谱仪
公开(公告)号：US08574918B2
公开(公告)日：2013-11-05
申请号：US13055720
申请日：2009-07-28
申请人： Aya Hirayama , Osamu Shirota , Masashi Mita , Kazuhiko Mibayashi
发明人： Aya Hirayama , Osamu Shirota , Masashi Mita , Kazuhiko Mibayashi
IPC分类号： G01N30/16 , G01N30/18
CPC分类号： G01N30/20 , G01N30/16 , G01N30/24 , G01N35/1004 , G01N35/1097
摘要： A sample injection part connected to a column to inject a sample into the column; a sample injection needle attachable to the sample injection part; a sample suction part connectable to the sample injection needle and configured to cause a predetermined amount of the sample to be drawn by suction into the sample injection needle upon connecting to the sample connection needle; a mobile phase supply part configured to supply the column with a mobile phase; a first switching valve for selectively connecting the sample injection needle to one of the sample suction part and the mobile phase supply part; and a second switching valve, including the sample injection part, for supplying the sample and the mobile phase to the column via the sample injection needle in the case of having the sample injection needle attached to the sample injection part and for supplying the mobile phase to the column via the first switching valve in the case of having the sample injection needle removed from the sample injection part are included.
摘要翻译：连接到柱上以将样品注入柱中的样品注入部分; 可注入样品的样品注射针; 样品抽吸部分，其可连接到样品注射针，并且构造成在连接到样品连接针时使预定量的样品通过抽吸被抽吸到样品注射针中; 流动相供应部分，配置成向柱提供流动相; 第一切换阀，用于选择性地将样品注射针连接到样品吸入部分和流动相供应部分中的一个; 以及第二切换阀，包括样本注入部，用于在将样品注射针附接到样品注射部分并将流动相供给到样品注射部分的情况下经由样品注射针将样品和流动相供给到柱中包括在从样品注射部分移除样品注射针的情况下经由第一切换阀的柱。

3. 发明申请

US20060107771A1 Sampling needle and sample injection apparatus 有权
标题翻译：取样针和样品注射装置
公开(公告)号：US20060107771A1
公开(公告)日：2006-05-25
申请号：US11272074
申请日：2005-11-14
申请人： Masashi Mita , Kazuhiko Mibayashi , Osamu Shirota
发明人： Masashi Mita , Kazuhiko Mibayashi , Osamu Shirota
IPC分类号： G01N1/04
CPC分类号： G01N35/1095
摘要： A sampling needle is disclosed that includes a sampling part that is inserted into a sample, and a sample holding part that holds the sample that is introduced through the sampling part. The sampling part and the sample holding part are arranged into a seamless structure,,and the inner diameter of the sampling part and the inner diameter of the sample holding part are equal.
摘要翻译：公开了一种采样针，其包括插入到样本中的采样部分和保持通过采样部分引入的样本的样本保持部分。取样部和样品保持部配置成无缝结构，采样部的内径和样品保持部的内径相等。

4. 发明授权

US07469607B2 Sampling needle and sample injection apparatus 有权
标题翻译：取样针和样品注射装置
公开(公告)号：US07469607B2
公开(公告)日：2008-12-30
申请号：US11272074
申请日：2005-11-14
申请人： Masashi Mita , Kazuhiko Mibayashi , Osamu Shirota
发明人： Masashi Mita , Kazuhiko Mibayashi , Osamu Shirota
IPC分类号： G01N1/10
CPC分类号： G01N35/1095
摘要： A sampling needle is disclosed that includes a sampling part that is inserted into a sample, and a sample holding part that holds the sample that is introduced through the sampling part. The sampling part and the sample holding part are arranged into a seamless structure, and the inner diameter of the sampling part and the inner diameter of the sample holding part are equal.
摘要翻译：公开了一种采样针，其包括插入到样本中的采样部分和保持通过采样部分引入的样本的样本保持部分。取样部和样品保持部配置成无缝结构，取样部的内径和样品保持部的内径相等。

5. 发明申请

US20120148509A1 COMPOSITION FOR ALLEVIATING ULTRAVIOLET IRRADIATION-INDUCED DAMAGE 审中-公开
标题翻译：用于治疗超紫外线辐射诱导的损伤的组合物
公开(公告)号：US20120148509A1
公开(公告)日：2012-06-14
申请号：US13261182
申请日：2010-09-14
申请人： Yutaka Ashida , Yosuke Tojo , Chieko Mizumoto , Masashi Mita
发明人： Yutaka Ashida , Yosuke Tojo , Chieko Mizumoto , Masashi Mita
IPC分类号： A61K31/198 , A61K31/42 , A61P17/00 , A61K8/49 , A61Q19/00 , A61Q17/04 , A61P27/12 , A61K8/44 , A61P35/00
CPC分类号： A61Q17/04 , A23L33/175 , A23V2002/00 , A61K8/0208 , A61K8/44 , A61K9/0014 , A61K9/107 , A61K9/12 , A61K9/2018 , A61K9/4858 , A61K9/7007 , A61K31/198 , A61Q19/004 , A61Q19/08 , A23V2200/318 , A23V2250/0632 , A23V2250/0642
摘要： Disclosed are a composition for alleviating ultraviolet irradiation-induced damage, which is stable and safe and can be used on a daily basis, and a pharmaceutical composition, an external skin preparation, a food composition and a medicine for cataract, each comprising aforesaid composition for alleviating ultraviolet irradiation-induced damage. Specifically disclosed is a composition for alleviating ultraviolet irradiation-induced damage which contains one or more kinds of compounds selected from the group consisting of methionine, D-serine and derivatives and/or salts of the same. The aforesaid composition may be an external preparation for the skin, an anti-wrinkle agent, a sunscreen agent, a medicinal composition for treating and/or preventing skin diseases, a food composition or a pharmaceutical product for cataract. In the aforesaid composition for alleviating ultraviolet irradiation-induced damage, the aforesaid methionine may be D-methionine, and the aforesaid D-serine derivative may be D-cycloserine.
摘要翻译：公开了一种缓和紫外线照射诱发的损伤的组合物，其是稳定和安全的并且可以每天使用，以及药物组合物，外用皮肤制剂，食品组合物和白内障药物，其各自包含上述组合物缓解紫外线照射引起的损伤。具体公开了含有选自甲硫氨酸，D-丝氨酸及其衍生物和/或其盐的一种或多种化合物的减轻紫外线照射诱发的损伤的组合物。上述组合物可以是用于皮肤的外用制剂，抗皱剂，防晒剂，用于治疗和/或预防皮肤病的药物组合物，食品组合物或白内障药物。在上述减轻紫外线照射诱发损伤的组合物中，上述甲硫氨酸可以是D-甲硫氨酸，上述D-丝氨酸衍生物可以是D-环丝氨酸。

6. 发明申请

US20120184619A1 COMPOSITION FOR PROMOTING COLLAGEN PRODUCTION 有权
标题翻译：促进胶原生产的组合物
公开(公告)号：US20120184619A1
公开(公告)日：2012-07-19
申请号：US13261238
申请日：2010-09-27
申请人： Yutaka Ashida , Yosuke Tojo , Shoichiro Shimada , Chieko Mizumoto , Masashi Mita
发明人： Yutaka Ashida , Yosuke Tojo , Shoichiro Shimada , Chieko Mizumoto , Masashi Mita
IPC分类号： A61K31/198 , A61P17/00
CPC分类号： A23C9/1322 , A21D2/245 , A23L2/52 , A23L11/05 , A23L11/09 , A23L23/00 , A23L27/14 , A23L27/50 , A23L27/60 , A23L33/17 , A23L33/175 , A23P10/28 , A23P10/30 , A23V2002/00 , A61K8/44 , A61K31/198 , A61K2800/592 , A61Q19/08 , C12J1/00 , A23V2200/318 , A23V2250/0604 , A23V2250/061
摘要： Disclosed is a novel composition which has an effect on promoting production of collagen. The composition has high photostability and is free from side effects such as those of retinoids. Specifically disclosed is a composition for promoting collagen production which contains one or more compounds selected from the group consisting of D-aspartic acid, D-alanine, derivatives and/or salts thereof. The composition may be used for the purpose of suppressing and/or improving skin a condition. The skin condition may include but is not limited to photoaging and/or wrinkles. The composition may be used for an external preparation for the skin or food. The composition may be a composition for promoting type I collagen production.
摘要翻译：公开了一种对促进胶原产生有影响的新型组合物。该组合物具有高的光稳定性，并且不含类视黄醇的副作用。具体公开了用于促进胶原产生的组合物，其含有选自D-天冬氨酸，D-丙氨酸，其衍生物和/或盐的一种或多种化合物。该组合物可以用于抑制和/或改善皮肤状况。皮肤状况可以包括但不限于光老化和/或皱纹。组合物可用于皮肤或食物的外用制剂。组合物可以是用于促进I型胶原产生的组合物。

7. 发明申请

US20060148025A1 Method of analyzing coenzyme q-10 and two-electron reduction product thereof and analysis system 失效
标题翻译：辅酶q-10及其双电子还原产物分析方法及分析系统
公开(公告)号：US20060148025A1
公开(公告)日：2006-07-06
申请号：US10537338
申请日：2003-12-03
申请人： Yorihiro Yamamoto , Masashi Mita
发明人： Yorihiro Yamamoto , Masashi Mita
IPC分类号： C12Q1/26
CPC分类号： G01N30/461 , C12Q1/008 , G01N30/78 , G01N2030/8804 , G01N2030/8813 , G01N2030/8822
摘要： The present invention relates to an analysis method and analysis system that can accurately analyze the contents of coenzyme Q-10 and a 2-electron reduced form thereof in a specimen, in which human blood plasma as the specimen is mixed with isopropyl alcohol as a pretreatment and the coenzyme Q-10 and the 2-electron reduced form thereof are extracted to the isopropyl alcohol. Extracted liquid is stored at a temperature of 4° C. until the analysis is performed. The extracted liquid as an analytical sample is analyzed by an analysis system provided with a liquid-sending mechanism, a switching mechanism, a concentration column, a separation column, a reduction column, an ultraviolet absorption detector, and an electrochemical detector.
摘要翻译：本发明涉及一种分析方法和分析系统，其能够准确地分析试样中的辅酶Q-10的含量和2电子还原体，其中作为样品的人血浆与异丙醇作为预处理并将辅酶Q-10及其2-电子还原体提取到异丙醇中。萃取的液体在4℃的温度下储存，直至进行分析。通过具有送液机构，开关机构，浓缩塔，分离塔，还原塔，紫外吸收检测器和电化学检测器的分析系统分析作为分析样品的提取液。

8. 发明申请

US20120189563A1 ORAL COMPOSITION FOR ALLEVIATING ULTRAVIOLET IRRADIATION-INDUCED DAMAGE 审中-公开
标题翻译：用于治疗超紫外线辐射诱导性损伤的口腔组合物
公开(公告)号：US20120189563A1
公开(公告)日：2012-07-26
申请号：US13261161
申请日：2010-03-31
申请人： Yutaka Ashida , Yosuke Tojo , Chieko Mizumoto , Masashi Mita , Shoichiro Shimada
发明人： Yutaka Ashida , Yosuke Tojo , Chieko Mizumoto , Masashi Mita , Shoichiro Shimada
IPC分类号： A61K31/197 , A61P17/12 , A61Q19/02 , A61Q19/08 , A61P27/12 , A61K8/44 , A61P17/00 , A61P35/00
CPC分类号： A61K31/198 , A21D2/245 , A23L33/175 , A23V2002/00 , A61K8/447 , A61K2800/92 , A61Q17/04 , A61Q19/08 , A23V2200/318 , A23V2250/06
摘要： Disclosed are: an oral composition for alleviating ultraviolet irradiation-induced damage, which can be used on a daily basis and is stable and safe; and a medicinal agent; and anti-wrinkle agent and a food composition, each of which comprises the oral composition. Specifically disclosed is an oral composition for alleviating ultraviolet irradiation-induced damage, which comprises at least one compound selected from the group consisting of methionine and derivatives and/or salts thereof. The composition may be an anti-wrinkle agent, a pharmaceutical composition for treating and/or preventing skin diseases, a food composition, or a pharmaceutical composition for preventing or treating cataract. In the oral composition for alleviating ultraviolet irradiation-induced damage, methionine may be in the D-form.
摘要翻译：公开了一种用于减轻紫外线照射引起的损伤的口服组合物，其可以每天使用并且是稳定和安全的; 和药剂; 和抗皱剂和食品组合物，其各自包含口腔组合物。具体公开了一种用于减轻紫外线照射诱发的损伤的口服组合物，其包含至少一种选自甲硫氨酸及其衍生物和/或盐的化合物。组合物可以是抗皱剂，用于治疗和/或预防皮肤病的药物组合物，食品组合物或用于预防或治疗白内障的药物组合物。在用于减轻紫外线照射诱发的损伤的口服组合物中，甲硫氨酸可以是D-型。

9. 发明申请

US20120142941A1 COMPOSITION FOR ALLEVIATING ULTRAVIOLET RADIATION-INDUCED DAMAGE 有权
标题翻译：用于治疗超紫外线辐射诱导的损伤的组合物
公开(公告)号：US20120142941A1
公开(公告)日：2012-06-07
申请号：US13138786
申请日：2010-03-30
申请人： Yutaka Ashida , Yosuke Tojo , Masashi Mita , Chieko Mizumoto , Shoichiro Shimada , Kayo Matsumoto
发明人： Yutaka Ashida , Yosuke Tojo , Masashi Mita , Chieko Mizumoto , Shoichiro Shimada , Kayo Matsumoto
IPC分类号： C07D207/16 , C07C323/58 , A61P27/12 , A61Q17/04 , A61P17/00 , A61P35/00 , C07C229/24 , A61Q19/00
CPC分类号： A61K31/401 , A23L33/175 , A23V2002/00 , A61K8/44 , A61K8/447 , A61K8/4913 , A61K9/0048 , A61K9/107 , A61K9/1617 , A61K9/2013 , A61K9/4858 , A61K31/198 , A61K47/183 , A61Q17/04 , A61Q19/08 , A61K2300/00 , A23V2200/318 , A23V2250/0618 , A23V2250/064 , A23V2250/0616
摘要： Disclosed are: a composition for alleviating ultraviolet irradiation-induced damage, which can be used on a daily based and is stable and safe; and a pharmaceutical preparation, a cosmetic and a food composition, each of which comprises the composition. The composition for alleviating ultraviolet irradiation-induced damage contains one or more compounds selected from the group consisting of D-glutamic acid, L-glutamic acid, D-proline, D-cystine, L-cystine, and derivatives and/or salts of the aforementioned compounds. The composition can be used as an external formulation for the skin, a cosmetic composition, an anti-wrinkle agent, a sunscreen agent, a pharmaceutical composition for treating and/or preventing skin diseases, a food composition, or a pharmaceutical composition for preventing or treating cataract.
摘要翻译：本发明公开了一种用于减轻紫外线照射诱发的损伤的组合物，其可以基于日常使用并且是稳定和安全的; 和药物制剂，化妆品和食品组合物，其中每一种都包含该组合物。用于缓解紫外线照射诱发的损伤的组合物含有选自D-谷氨酸，L-谷氨酸，D-脯氨酸，D-胱氨酸，L-胱氨酸的一种或多种化合物，以及上述化合物。该组合物可以用作皮肤的外用制剂，化妆品组合物，抗皱剂，防晒剂，用于治疗和/或预防皮肤病的药物组合物，食品组合物或用于预防或/ 治疗白内障。

10. 发明申请

US20110217707A1 EVALUATION/SCREENING METHOD FOR DISEASES ASSOCIATED WITH D-AMINO ACID UTILIZING DA01-/-MOUSE 有权
标题翻译：与D-氨基酸相关的疾病的评估/筛选方法利用DA01 - / - 小鼠
公开(公告)号：US20110217707A1
公开(公告)日：2011-09-08
申请号：US13060824
申请日：2009-07-31
申请人： Kenji Hamase , Kiyoshi Zaitsu , Masashi Mita , Yutaka Ashida , Yousuke Toujo
发明人： Kenji Hamase , Kiyoshi Zaitsu , Masashi Mita , Yutaka Ashida , Yousuke Toujo
IPC分类号： C12Q1/02 , C12Q1/68 , G01N33/577
CPC分类号： G01N33/5088 , A01K67/0276 , A01K2217/03 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/0331 , A01K2267/0356 , C07K14/4702 , C12N9/0024 , C12N15/8509 , C12Q1/26 , G01N2333/90644 , G01N2500/10
摘要： Disclosed is an evaluation method which can rapidly discriminate a Dao−/− homozygote from a large number of animals produced in a mating experiment between a DAO enzyme deficient mouse and other disease model mice, to rapidly perform a quantitative measurement of the D-amino acids contained in a large number of samples. The invention provides a method for evaluating the effect of a test condition on a mouse tissue, or cultured tissue cells derived from the tissue. The method comprises the steps of: providing a Dao1−/− mouse or the like; exposing the tissue from the Dao1−/− mouse or the like, to the test condition; and analyzing the effect of exposing the tissue from the Dao1−/− mouse or the like, to the test condition.
摘要翻译：公开了一种评估方法，其可以快速区分DAO- / - 纯合子与DAO酶缺陷小鼠和其他疾病模型小鼠之间的交配实验中产生的大量动物，以快速进行D-氨基酸的定量测量包含在大量样品中。本发明提供了一种用于评估测试条件对小鼠组织或来自组织的培养的组织细胞的影响的方法。该方法包括以下步骤：提供Dao1 - / - 鼠标等; 将来自Dao1 / / - 小鼠等的组织暴露于测试条件; 并分析将来自Dao1 - / - 小鼠等的组织暴露于测试条件的效果。

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