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1. 发明申请

US20110257180A1 Novel Polymorphic Forms of 6-(1-methyl-1H-pyrazol-4-yl)-2--2H-pyridazin-3-one Dihydrogenphosphate and Processes of Manufacturing thereof 有权
标题翻译： 6-（1-甲基-1H-吡唑-4-基）-2-哒嗪-3-酮磷酸二氢盐的新型多晶型及其制造方法
公开(公告)号：US20110257180A1
公开(公告)日：2011-10-20
申请号：US13141142
申请日：2009-11-24
申请人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Eva Kriegbaum , Frank Stieber , Cristina Donini
发明人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Eva Kriegbaum , Frank Stieber , Cristina Donini
IPC分类号： A61K31/5377 , A61P35/00 , C07D413/14
CPC分类号： C07D403/14
摘要： The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
摘要翻译：本发明涉及6-（1-甲基-1H-吡唑-4-基）-2- {3- [5-（2-吗啉-4-基 - 乙氧基） - 嘧啶-2-基] - 苄基} -2H-哒嗪-3-酮磷酸二氢盐，其溶剂合物及其结晶修饰物。本发明进一步涉及制造这些结晶修饰的方法及其在治疗和/或预防生理和/或病理生理条件中的用途，其通过抑制，调节和/或调节引起，介导和/或传播的激酶的信号转导，特别是通过抑制酪氨酸激酶，例如病理生理条件如癌症。

2. 发明授权

US08586599B2 Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof 有权
标题翻译： 6-（1-甲基-1H-吡唑-4-基）-2- {3- [5-（2-吗啉-4-基 - 乙氧基） - 嘧啶-2-基] - 苄基} -2H的多晶型哒嗪-3-酮磷酸二氢盐及其制备方法
公开(公告)号：US08586599B2
公开(公告)日：2013-11-19
申请号：US13141142
申请日：2009-11-24
申请人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Eva Kriegbaum , Frank Stieber , Cristina Donini
发明人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Eva Kriegbaum , Frank Stieber , Cristina Donini
IPC分类号： A61K31/501 , A61K31/5377 , C07D413/14 , C07D403/14
CPC分类号： C07D403/14
摘要： The present invention relates to 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate, its solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
摘要翻译：本发明涉及6-（1-甲基-1H-吡唑-4-基）-2- {3- [5-（2-吗啉-4-基 - 乙氧基） - 嘧啶-2-基] - 苄基} -2H-哒嗪-3-酮磷酸二氢盐，其溶剂合物及其结晶修饰物。本发明进一步涉及制造这些结晶修饰的方法及其在治疗和/或预防生理和/或病理生理条件中的用途，其通过抑制，调节和/或调节引起，介导和/或传播的激酶的信号转导，特别是通过抑制酪氨酸激酶，例如病理生理条件如癌症。

3. 发明授权

US08710058B2 Polymorphic forms of 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride salt and processes of manufacturing thereof 有权
标题翻译： 3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 哒嗪-3-基的多晶型形式吡啶-3-基） - 苄腈盐酸盐及其制备方法
公开(公告)号：US08710058B2
公开(公告)日：2014-04-29
申请号：US13143831
申请日：2009-12-04
申请人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
发明人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
IPC分类号： C07D401/14 , A61K31/501 , A61P35/00
CPC分类号： A61K31/506 , A61K31/517 , A61K45/06 , C07D401/14 , C07D403/10
摘要： Compounds of the present invention concern 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The compound, 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile, has the following structural formula: The hydrochloride solvates and crystalline modifications thereof according to the invention are useful for treatment of physiological and/or pathophysiological conditions, such as cancer, that are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, especially Met-kinase. The present invention further relates to processes of manufacturing these crystalline modifications.
摘要翻译：本发明的化合物涉及3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 哒嗪 -3-基） - 苄腈盐酸盐溶剂合物及其结晶修饰物。化合物3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 哒嗪-3-基] 基） - 苄腈具有以下结构式：根据本发明的盐酸盐溶剂合物及其结晶修饰物可用于治疗通过抑制引起，介导和/或增殖的生理和/或病理生理条件如癌症，调节和/或调节激酶的信号转导，特别是抑制酪氨酸激酶，特别是Met激酶。本发明还涉及制造这些晶体改性的方法。

4. 发明申请

US20110269767A1 Novel Polymorphic Forms of 3-(1--6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile Hydrochloride Salt and Processes of Manufacturing Thereof 有权
标题翻译： 3-（1-6-氧代-1,6-二氢 - 哒嗪-3-基） - 苄腈盐酸盐的新型多晶型及其制备方法
公开(公告)号：US20110269767A1
公开(公告)日：2011-11-03
申请号：US13143831
申请日：2009-12-04
申请人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
发明人： Axel Becker , Clemens Kuehn , Christoph Saal , Oliver Schadt , Dieter Dorsch , Heinz Hermann Bokel , Frank Stieber , Cristina Donini
IPC分类号： A61K31/506 , A61P35/00 , A61P35/02 , C07D401/14
CPC分类号： A61K31/506 , A61K31/517 , A61K45/06 , C07D401/14 , C07D403/10
摘要： The present invention relates to 3-(1-{3-[5-(1-methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride solvates and crystalline modifications thereof. The present invention further relates to processes of manufacturing these crystalline modifications as well as their use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by the inhibition, regulation and/or modulation of signal transduction of kinases, in particular by the inhibition of tyrosine kinases, e.g. pathophysiological conditions such as cancer.
摘要翻译：本发明涉及3-（1- {3- [5-（1-甲基 - 哌啶-4-基甲氧基） - 嘧啶-2-基] - 苄基} -6-氧代-1,6-二氢 - 吡啶-3-基） - 苄腈盐酸盐溶剂合物及其结晶修饰物。本发明进一步涉及制造这些结晶修饰的方法及其在治疗和/或预防生理和/或病理生理条件中的用途，其通过抑制，调节和/或调节引起，介导和/或传播的激酶的信号转导，特别是通过抑制酪氨酸激酶，例如病理生理条件如癌症。

5. 发明申请

US20080158664A1 ARRANGEMENT AND METHOD FOR IMAGE ACQUISITION ON A PROBER 审中-公开
标题翻译：一个探测器的图像采集装置和方法
公开(公告)号：US20080158664A1
公开(公告)日：2008-07-03
申请号：US11964747
申请日：2007-12-27
申请人： Michael Teich , Axel Becker
发明人： Michael Teich , Axel Becker
IPC分类号： G02B21/36
CPC分类号： G02B21/241 , G02B21/006
摘要： A focused multi-planar image acquisition in real time, even while a test object is moving is achieved with a system and a method for a focused multi-planar image acquisition in a prober. When a surface of a test object is positioned laterally in relation to tips of separated probe needles, a microscope is focused on the surface of the test object at a first time and on a plane of the probe needles at a second time. The objective lens is provided with a microscope objective lens focusing system, which can focus the objective lens, independently of a vertical adjustment drive of the microscope, on the surface of the test object in a first focal plane and in a second focal plane, which is on a level with the probe needle tips.
摘要翻译：即使在测试对象正在移动的同时，也可以通过用于探测器中的聚焦多平面图像采集的系统和方法来实时地实现多焦点多平面图像采集。当测试对象的表面相对于分离的探针的尖端横向定位时，显微镜在第一时间和第二次在探针的平面上聚焦在测试对象的表面上。物镜上设有显微镜物镜聚焦系统，该系统可独立于显微镜的垂直调节驱动物体将物镜聚焦在第一焦平面和第二焦平面上的测试物体的表面上，在探针针尖的水平上。

6. 发明申请

US20070064992A1 PROCESS FOR THE INSPECTION OF A VARIETY OF REPETITIVE STRUCTURES 审中-公开
标题翻译：检查多种重复结构的过程
公开(公告)号：US20070064992A1
公开(公告)日：2007-03-22
申请号：US11470884
申请日：2006-09-07
申请人： Michael Teich , Juliane Busch , Axel Becker , Ralf Keller , Jorg Kiesewetter , Ulf Hackius
发明人： Michael Teich , Juliane Busch , Axel Becker , Ralf Keller , Jorg Kiesewetter , Ulf Hackius
IPC分类号： G06K9/00
CPC分类号： G06T7/001
摘要： A process is provided for inspection of a variety of structures on the basis of a golden template, that was attained by recording and statistical analysis of greyscale pictures and is compared to the greyscale picture of the structure to be evaluated based on position. The underlying task is to report any such inspection process, with which a positioning of the test structure relative to the golden template and a structure detection with sub-pixel accuracy is carried out. In positioning of each further structure to be recorded, which follows a first recorded structure, the further structure is fundamentally positioned in accordance with the first positioned structure, applicable characteristic values of the greyscale picture recorded in this position are determined and hence a degree of similarity is determined. On this basis, the position of further structures relative to the primary position are determined and corrected with sub-pixel accuracy, before a new greyscale picture is recorded, which forms the basis for further analysis.
摘要翻译：提供了一种基于黄色模板来检查各种结构的过程，这是通过记录和统计分析灰度图像而获得的，并且与基于位置的待评估结构的灰度图像进行比较。基本任务是报告任何这样的检查过程，通过该过程，测试结构相对于黄金模板的定位和进行子像素精度的结构检测。在按照第一记录结构进行记录的每个另外的结构的定位中，根据第一定位结构基本上定位另外的结构，确定记录在该位置的灰度图像的适用特征值，并因此确定相似度决心，决意，决定。在此基础上，在记录新的灰度图像之前，以子像素精度确定和校正进一步结构相对于主位置的位置，这是进一步分析的基础。

7. 发明申请

US20050049328A1 Surface film with depositing function, the production and use thereof 审中-公开
标题翻译：具有沉积功能的表面膜，其生产和使用
公开(公告)号：US20050049328A1
公开(公告)日：2005-03-03
申请号：US10487288
申请日：2002-08-13
申请人： Peter Schmiedel , Axel Becker , Annett Lossack , Andreas Ferencz , Elke Scholl
发明人： Peter Schmiedel , Axel Becker , Annett Lossack , Andreas Ferencz , Elke Scholl
IPC分类号： C08L101/00 , C03C17/00 , C03C17/32 , C09D5/00 , C09D5/02 , C09D201/00 , C09D11/26 , C08H1/00
CPC分类号： C03C17/32 , C03C17/007 , C03C2217/425 , C09D5/008
摘要： The invention relates to a composition, comprising at least water, a porous particulate polymer, or a mixture of two or more such polymers and at least one water-soluble or water-dispersible hydrophilic compound with a molecular weight of less than 1000, or a mixture of two or more thereof.
摘要翻译：本发明涉及至少包含水，多孔颗粒聚合物或两种或更多种这样的聚合物的混合物和至少一种分子量小于1000的水溶性或水分散性亲水性化合物的组合物，或两种或更多种的混合物。

8. 发明申请

US20120064312A1 USE OF RADIATION-CURABLE COATING MATERIAL FOR COATING WOOD-BASE MATERIALS 审中-公开
标题翻译：用于涂覆木基材料的可辐射涂层材料的使用
公开(公告)号：US20120064312A1
公开(公告)日：2012-03-15
申请号：US13321263
申请日：2010-06-01
申请人： Matthias Lokai , Oscar Lafuente Cerda , Axel Becker
发明人： Matthias Lokai , Oscar Lafuente Cerda , Axel Becker
IPC分类号： B32B21/08 , C08F2/46 , B32B3/18 , C08F2/48
CPC分类号： C09D167/06 , C08K5/0025 , C08K5/103 , Y10T428/24851 , Y10T428/31906 , C08L67/06
摘要： The present invention relates to the use of radiation-curable coating material for coating wood-base materials, a method for coating wood-base materials and the coated wood-base materials thus obtained.
摘要翻译：本发明涉及可辐射固化的涂料用于涂覆木质基材的方法，一种用于涂覆木质基材的方法和由此获得的涂覆的木质基材。

9. 发明申请

US20110224249A1 Novel Hydrate Form 审中-公开
标题翻译：新型水合物形式
公开(公告)号：US20110224249A1
公开(公告)日：2011-09-15
申请号：US13111799
申请日：2011-05-19
申请人： Axel Becker
发明人： Axel Becker
IPC分类号： A61K31/4709 , C07D471/04 , A61P31/00 , A61P31/04
CPC分类号： C07D471/04
摘要： The present invention relates to a novel hydrate form of moxifloxacin monohydrochloride, processes for preparing the form, pharmaceutical compositions comprising the form and uses of the form and compositions.
摘要翻译：本发明涉及一种新的水合物形式的莫西沙星单盐酸盐，制备方法，药物组合物，其包含形式和组合物的形式和用途。

10. 发明申请

US20110181710A1 ARRANGEMENT AND METHOD FOR IMAGE ACQUISITION ON A PROBER 审中-公开
标题翻译：一个探测器的图像采集装置和方法
公开(公告)号：US20110181710A1
公开(公告)日：2011-07-28
申请号：US12847308
申请日：2010-07-30
申请人： Michael Teich , Axel Becker
发明人： Michael Teich , Axel Becker
IPC分类号： H04N7/18
CPC分类号： G02B21/241 , G02B21/006
摘要： In a system and a method for capturing images in a prober, the surface of a test object is illuminated in succession with light of a first, second and third color; an image capturing device records a gray scale image of the surface; and a composite image is produced from the three gray scale images by an image evaluating device. The object is to qualitatively improve the image capturing, in order to raise the positioning accuracy by an improved display, as a result of which, finely structured test objects can be used. This object is achieved in that the lighting device is designed as a unit, controlled by the image evaluating unit, produces at least three colors and includes at least one light emitting diode (LED) as the lighting source.
摘要翻译：在用于在探测器中捕获图像的系统和方法中，测试对象的表面被第一，第二和第三颜色的光相继照射; 图像捕获装置记录表面的灰度图像; 并且通过图像评估装置从三个灰度图像产生合成图像。本发明的目的是定性改进图像捕获，以通过改进的显示来提高定位精度，从而可以使用精细结构的测试对象。该目的的实现是，照明装置被设计为由图像评估单元控制的单元，产生至少三种颜色，并且包括至少一个作为照明源的发光二极管（LED）。

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