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1. 发明授权

US09314650B2 Method and apparatus for treatment of adipose tissue 有权
标题翻译：用于治疗脂肪组织的方法和装置
公开(公告)号：US09314650B2
公开(公告)日：2016-04-19
申请号：US13369583
申请日：2012-02-09
申请人： Avner Rosenberg , Shimon Eckhouse , Michael Kreindel
发明人： Avner Rosenberg , Shimon Eckhouse , Michael Kreindel
IPC分类号： A61N7/00 , A61N1/04 , A61N1/32 , A61B17/00 , A61B19/00 , A61B18/12 , A61B18/00
CPC分类号： A61N7/00 , A61B18/12 , A61B2017/00026 , A61B2017/00061 , A61B2017/00106 , A61B2018/0047 , A61B2090/378 , A61N1/0408 , A61N1/0472 , A61N1/328 , A61N2007/0008 , A61N2007/0039 , A61N2007/0078
摘要： The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.
摘要翻译：本发明提供了用于治疗脂肪组织的方法和装置。所述方法包括将超声能量应用于脂肪组织的区域，并且所述装置包括至少一个超声能量源，其被配置为将超声能量通过皮肤表面引导到皮下脂肪组织中。在一个实施例中，在产生具有不同密度的脂肪细胞组分之间产生相对运动的区域中产生压力梯度。在另一个实施方案中，形成皮肤的突起和包含的下面的脂肪组织，并且将超声能量辐射到突起中的脂肪组织中。在另一个实施例中，在脂肪组织的区域内与超声波能量一起产生RF电场。

2. 发明申请

US20090221938A1 Method and Apparatus for Treatment of Adipose Tissue 审中-公开
标题翻译：用于治疗脂肪组织的方法和装置
公开(公告)号：US20090221938A1
公开(公告)日：2009-09-03
申请号：US12223964
申请日：2007-02-15
申请人： Avner Rosenberg , Shimon Eckhouse , Michael Kreindel
发明人： Avner Rosenberg , Shimon Eckhouse , Michael Kreindel
IPC分类号： A61N7/00 , A61B18/18
CPC分类号： A61N7/00 , A61B18/12 , A61B2017/00026 , A61B2017/00061 , A61B2017/00106 , A61B2018/0047 , A61B2090/378 , A61N1/0408 , A61N1/0472 , A61N1/328 , A61N2007/0008 , A61N2007/0039 , A61N2007/0078
摘要： The invention provides methods and apparatuses (4) for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy (42a, 42b) configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.
摘要翻译：本发明提供了用于治疗脂肪组织的方法和装置（4）。所述方法包括将超声能量施加到脂肪组织的区域，并且所述装置包括至少一个超声能量源（42a，42b），其被配置为将超声能量通过皮肤表面引导到皮下脂肪组织中。在一个实施例中，在产生具有不同密度的脂肪细胞组分之间产生相对运动的区域中产生压力梯度。在另一个实施方案中，形成皮肤的突起和包含的下面的脂肪组织，并且将超声能量辐射到突起中的脂肪组织中。在另一个实施例中，在脂肪组织的区域内与超声波能量一起产生RF电场。

3. 发明授权

US08133191B2 Method and apparatus for treatment of adipose tissue 有权
标题翻译：用于治疗脂肪组织的方法和装置
公开(公告)号：US08133191B2
公开(公告)日：2012-03-13
申请号：US11355181
申请日：2006-02-16
申请人： Avner Rosenberg , Shimon Eckhouse , Michael Kreindel
发明人： Avner Rosenberg , Shimon Eckhouse , Michael Kreindel
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B18/12 , A61B2017/00026 , A61B2017/00061 , A61B2017/00106 , A61B2018/0047 , A61B2090/378 , A61N1/0408 , A61N1/0472 , A61N1/328 , A61N2007/0008 , A61N2007/0039 , A61N2007/0078
摘要： The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.
摘要翻译：本发明提供了用于治疗脂肪组织的方法和装置。所述方法包括将超声能量应用于脂肪组织的区域，并且所述装置包括至少一个超声能量源，其被配置为将超声能量通过皮肤表面引导到皮下脂肪组织中。在一个实施例中，在产生具有不同密度的脂肪细胞组分之间产生相对运动的区域中产生压力梯度。在另一个实施方案中，形成皮肤的突起和包含的下面的脂肪组织，并且将超声能量辐射到突起中的脂肪组织中。在另一个实施例中，在脂肪组织的区域内与超声波能量一起产生RF电场。

4. 发明申请

US20070239075A1 Method and apparatus for treatment of adipose tissue 有权
标题翻译：用于治疗脂肪组织的方法和装置
公开(公告)号：US20070239075A1
公开(公告)日：2007-10-11
申请号：US11355181
申请日：2006-02-16
申请人： Avner Rosenberg , Shimon Eckhouse , Michael Kreindel
发明人： Avner Rosenberg , Shimon Eckhouse , Michael Kreindel
IPC分类号： A61H1/00 , A61H1/02
CPC分类号： A61N7/00 , A61B18/12 , A61B2017/00026 , A61B2017/00061 , A61B2017/00106 , A61B2018/0047 , A61B2090/378 , A61N1/0408 , A61N1/0472 , A61N1/328 , A61N2007/0008 , A61N2007/0039 , A61N2007/0078
摘要： The invention provides methods and apparatuses for the treatment of adipose tissue. The methods comprise application of ultrasound energy to a region of adipose tissue, and the apparatuses comprise at least one source of ultrasound energy configured to direct ultrasound energy through a skin surface into the subcutaneous adipose tissue. In one embodiment, a pressure gradient is created in the region generating relative movement between fat cell constituents having different densities. In another embodiment, a protrusion of skin and underlying adipose tissue containing is formed and ultrasound energy is radiated into the adipose tissue in the protrusion. In another embodiment, an RF electric field is generated inside a region of adipose tissue together with the ultrasound energy.
摘要翻译：本发明提供了用于治疗脂肪组织的方法和装置。所述方法包括将超声能量应用于脂肪组织的区域，并且所述装置包括至少一个超声能量源，其被配置为将超声能量通过皮肤表面引导到皮下脂肪组织中。在一个实施例中，在产生具有不同密度的脂肪细胞组分之间产生相对运动的区域中产生压力梯度。在另一个实施方案中，形成皮肤的突起和包含的下面的脂肪组织，并且将超声能量辐射到突起中的脂肪组织中。在另一个实施例中，在脂肪组织的区域内与超声波能量一起产生RF电场。

5. 发明授权

US6162212A Optimal procedure for performing a hair removal 失效
标题翻译：执行脱毛的最佳步骤
公开(公告)号：US6162212A
公开(公告)日：2000-12-19
申请号：US294753
申请日：1999-04-19
申请人： Michael Kreindel , Shimon Eckhouse
发明人： Michael Kreindel , Shimon Eckhouse
IPC分类号： A61B18/20 , A61B18/18
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/00476
摘要： A method for determining an optimal plan of sessions for hair removal treatment. The method includes the steps of receiving information about a hair growth cycle duration of a person to be treated, a duration of the Anagen stage of the person and at least one parameter of a device to be used for performing the treatment, and processing the received information thereby determining at least one of the group including the optimal number of hair removal tretament sessions and the optimal delay between sessions of the treatment.
摘要翻译：一种用于确定脱毛治疗的最佳疗程计划的方法。该方法包括以下步骤：接收关于待治疗的人的毛发生长周期持续时间的信息，人的Anagen阶段的持续时间和用于执行治疗的装置的至少一个参数，以及处理所接收的信息，从而确定组中的至少一个，包括最佳毛发去除时间段的次数以及治疗期间之间的最佳延迟。

6. 发明授权

US5833612A Method and apparatus for diagnosis skin lesions 失效
标题翻译：用于诊断皮肤损伤的方法和装置
公开(公告)号：US5833612A
公开(公告)日：1998-11-10
申请号：US594891
申请日：1996-02-09
申请人： Shimon Eckhouse , Michael Kreindel
发明人： Shimon Eckhouse , Michael Kreindel
IPC分类号： A61B5/00 , A61B5/103 , A61B10/00
CPC分类号： A61B5/441 , A61B5/0059 , A61B2562/0242 , A61B5/0062
摘要： A method and apparatus for determining skin lesion parameters comprise directing light to the skin in which the lesion is located and monitoring the reflection of that light. Then, the spatial and spectral distribution of the reflected light is analyzed. The depth is determined by finding a location where the difference between a spectral intensity of reflected light and an average reflected intensity is greater than a maximal difference between the intensity of each point and an average intensity for normal skin. The wavelength of the light reflected from the location is determined, and from the wavelength the penetration depth is determined. The penetration depth is also the depth of the lesion below the skin surface. The size is determined by determining a plurality of locations where the deviation between the spectral intensity and the average intensity is greater than the maximal deviation for normal skin. Based on the spatial distribution of the locations the size of the lesion is determined.
摘要翻译：用于确定皮肤损伤参数的方法和装置包括将光引导到病变位于其中的皮肤并监测该光的反射。然后，分析反射光的空间和光谱分布。通过找到反射光的光谱强度和平均反射强度之间的差异大于每个点的强度与正常皮肤的平均强度之间的最大差异的位置来确定深度。确定从该位置反射的光的波长，并从波长确定穿透深度。穿透深度也是皮肤表面下方病变的深度。通过确定光谱强度和平均强度之间的偏差大于正常皮肤的最大偏差的多个位置来确定尺寸。基于位置的空间分布，确定病变的大小。

7. 发明授权

US5776175A Method and apparatus for treatment of cancer using pulsed electromagnetic radiation 失效
标题翻译：使用脉冲电磁辐射治疗癌症的方法和装置
公开(公告)号：US5776175A
公开(公告)日：1998-07-07
申请号：US536985
申请日：1995-09-29
申请人： Shimon Eckhouse , Michael Kreindel
发明人： Shimon Eckhouse , Michael Kreindel
IPC分类号： A61B18/00 , A61N5/06 , A61F2/00
CPC分类号： A61N5/06 , A61N5/0616 , A61N2005/0644 , A61N2005/0659
摘要： The invention includes a method for the hyperthermic treatment of tumors including the steps of providing a pulsed radiation output from a radiation source; and directing said pulsed radiation output toward a tumor. The invention further includes an apparatus for the treatment of tumors having a radiation source adapted to produce broad-band pulsed radiation output at least in the visible and near-infrared range of wavelengths, a delivery system proximal to the radiation source and adapted to focus and direct the pulsed radiation output to a dermal treatment site, and a filtering system adapted to restrict the pulsed radiation output to bands in the visible and near-infrared range of wavelengths.
摘要翻译：本发明包括用于高热治疗肿瘤的方法，包括从辐射源提供脉冲辐射输出的步骤; 并将所述脉冲辐射输出引向肿瘤。本发明还包括一种用于治疗肿瘤的装置，其具有适于产生至少在可见光和近红外波长范围内的宽带脉冲辐射输出的辐射源，靠近辐射源的输送系统，并适于聚焦和将脉冲辐射输出引导到皮肤处理部位，以及适于将脉冲辐射输出限制在可见光和近红外波长范围内的滤光系统。

8. 发明授权

US5964749A Method and apparatus for skin rejuvenation and wrinkle smoothing 失效
标题翻译：皮肤恢复和皱纹平滑的方法和装置
公开(公告)号：US5964749A
公开(公告)日：1999-10-12
申请号：US529044
申请日：1995-09-15
申请人： Shimon Eckhouse , Michael Kreindel
发明人： Shimon Eckhouse , Michael Kreindel
IPC分类号： A45D44/22 , A61B17/00 , A61B18/00 , A61B18/18 , A61B18/20 , A61N5/06
CPC分类号： A61B18/203 , A61B2017/00172 , A61B2017/00761 , A61B2018/00023 , A61B2018/00452 , A61B2018/0047 , A61B2018/1807 , A61N2005/0659
摘要： A method and apparatus for treating skin includes applying pulsed light to the skin to heat and shrinking collagen within the skin, thereby reviving the elasticity of the collagen and of the skin. The epidermis and outer layers of the skin may be protected by cooling with a transparent substance, such as ice or gel, to the skin. The temperature distribution within the skin is controlled by controlling the delay between the time the coolant is applied, and the time the light is applied, by controlling the pulse duration and applying multiple pulses, and by filtering the light and controlling the radiation spectrum, preferably, the spectrum includes light having a wavelength in the range of 600-1200 nm. The pulsed light may be incoherent, such as that produced by a flashlamp, or coherent, such as that produced by a Nd(Yag) laser or a ruby laser, and may be directed to the skin using a flexible or rigid light guide. Also, a method and apparatus for cutaneous resurfacing including directing Er:YAG laser light to the skin. The light may be pulsed, preferably with a delay of about 0.5-10 msec between pulses. In one embodiment the pulses have energy fluences of preferably about 100 J/cm.sup.2.
摘要翻译：用于治疗皮肤的方法和装置包括向皮肤施加脉冲光以加热和收缩皮肤内的胶原，从而恢复胶原和皮肤的弹性。皮肤的表皮和外层可以通过用透明物质（例如冰或凝胶）冷却至皮肤来保护。皮肤中的温度分布通过控制施加冷却剂的时间和施加光的时间之间的延迟来控制，通过控制脉冲持续时间并施加多个脉冲，并且通过过滤光并控制辐射光谱，优选地该光谱包括波长在600-1200nm范围内的光。脉冲光可能是不相干的，例如由闪光灯产生的光，或相干的，例如由Nd（Yag）激光或红宝石激光产生的光，并且可以使用柔性或刚性的光导导向皮肤。另外，一种用于皮肤表面置换的方法和装置，包括将Er：YAG激光导向皮肤。光可以是脉冲的，优选在脉冲之间延迟大约0.5-10毫秒。在一个实施例中，脉冲具有优选约100J / cm 2的能量密度。

9. 发明授权

US5643334A Method and apparatus for the diagnostic and composite pulsed heating and photodynamic therapy treatment 失效
标题翻译：用于诊断和复合脉冲加热和光动力治疗治疗的方法和装置
公开(公告)号：US5643334A
公开(公告)日：1997-07-01
申请号：US385190
申请日：1995-02-07
申请人： Shimon Eckhouse , Michael Kreindel
发明人： Shimon Eckhouse , Michael Kreindel
IPC分类号： G02B6/04 , A61N5/06 , A61N5/067 , A61N5/00
CPC分类号： A61N5/062 , A61N2005/0644 , A61N2005/067
摘要： The present invention is directed toward an apparatus and method for diagnostic and composite treatment of a wide range of solid tumors. More particularly, the invention relates to an efficient apparatus and method for diagnosing and simultaneously treating certain types of cancer with photodynamic therapy and pulse heating.
摘要翻译：本发明涉及用于广泛实体瘤的诊断和复合治疗的装置和方法。更具体地说，本发明涉及一种利用光动力疗法和脉冲加热来诊断和同时治疗某些癌症的有效装置和方法。

10. 发明授权

US5836999A Method and apparatus for treating psoriasis using pulsed electromagnetic radiation 失效
标题翻译：使用脉冲电磁辐射治疗牛皮癣的方法和设备
公开(公告)号：US5836999A
公开(公告)日：1998-11-17
申请号：US535705
申请日：1995-09-28
申请人： Shimon Eckhouse , Michael Kreindel
发明人： Shimon Eckhouse , Michael Kreindel
IPC分类号： A61B18/00 , A61N5/00 , A61N5/06
CPC分类号： A61N5/0616 , A61B2018/00029 , A61N2005/007 , A61N2005/0644
摘要： A method and apparatus for treating psoriasis includes a source of incoherent electromagnetic energy. The energy is directed to a region of tissue to be treated. The pulse duration and the number of pulses may be selected to control treatment parameters such as the heating of healthy tissue and the penetration depth of the energy to optimize the treatment. Also, the radiation may be filtered to control the radiation spectrum and penetration depth. The filtering may include attenuating an UV portion of the radiation spectrum and portions of the spectrum below a desired treatment bandwidth. A light guide for large or small spot sizes may be used to direct the light to the skin. A cooling gel is applied to the skin to be treated in another embodiment. The gel may be cooled either before or after it is applied to the skin.
摘要翻译：用于治疗牛皮癣的方法和装置包括非相干电磁能源。能量被引导到要治疗的组织的区域。可以选择脉冲持续时间和脉冲数来控制治疗参数，例如加热健康组织和能量的穿透深度以优化治疗。此外，辐射可以被过滤以控制辐射光谱和穿透深度。滤波可以包括将辐射光谱的UV部分衰减，并将光谱的部分衰减到期望的处理带宽以下。可以使用大尺寸或小尺寸的光导来将光引导至皮肤。在另一个实施方案中，将待冷却的凝胶施用于待治疗的皮肤。凝胶可以在施用于皮肤之前或之后冷却。

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