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1. 发明授权

US08012500B2 Implantable device 有权
标题翻译：植入式装置
公开(公告)号：US08012500B2
公开(公告)日：2011-09-06
申请号：US11001556
申请日：2004-11-30
申请人： Avi Rotem , Yoav Evron , Pnina Vardi , Konstantin Bloch
发明人： Avi Rotem , Yoav Evron , Pnina Vardi , Konstantin Bloch
IPC分类号： A61F2/00
CPC分类号： A61F2/022
摘要： Apparatus is provided including a chamber, which is adapted to be implanted in a body of an individual, the chamber including functional cells and chlorophyll-containing elements comprising chlorophyll of an obligate photoautotroph.
摘要翻译：提供了包括适于植入个人体内的腔室，所述腔室包括功能性细胞和包含专性光自养基的叶绿素的含叶绿素的元件。

2. 发明授权

US08444630B2 Oxygen supply for cell transplant and vascularization 有权
标题翻译：氧气供应用于细胞移植和血管化
公开(公告)号：US08444630B2
公开(公告)日：2013-05-21
申请号：US12064946
申请日：2007-11-28
申请人： Avi Rotem , Chanan Schneider , Uriel Barkai , Yoav Evron , Pnina Vardi , Konstantin Bloch
发明人： Avi Rotem , Chanan Schneider , Uriel Barkai , Yoav Evron , Pnina Vardi , Konstantin Bloch
IPC分类号： A61K9/22
CPC分类号： A61F2/022 , A61K35/12
摘要： Apparatus is provided, including a housing (22), configured for insertion into a body of a patient; a photosynthetic oxygen supply (24) configured to supply oxygen; and functional cells (30), coupled to the housing (22). The functional cells (30) are adapted to receive the oxygen and to secrete at least one factor that induces vascularization in a vicinity of the housing (22) when the housing (22) is in the body of the patient. Other embodiments are also described.
摘要翻译：提供了一种设备，包括构造成用于插入患者体内的壳体（22）配置为供应氧气的光合氧供应源（24）; 以及耦合到所述壳体（22）的功能单元（30）。当壳体（22）在患者体内时，功能细胞（30）适于接收氧气并分泌至少一个在壳体（22）附近引起血管形成的因素。还描述了其它实施例。

3. 发明申请

US20050136092A1 Implantable device 有权
标题翻译：植入式装置
公开(公告)号：US20050136092A1
公开(公告)日：2005-06-23
申请号：US11001556
申请日：2004-11-30
申请人： Avi Rotem , Yoav Evron , Pnina Vardi , Konstantin Bloch
发明人： Avi Rotem , Yoav Evron , Pnina Vardi , Konstantin Bloch
IPC分类号： A61F2/02 , A61K35/80
CPC分类号： A61F2/022
摘要： Apparatus is provided including a chamber, which is adapted to be implanted in a body of an individual, the chamber including functional cells and chlorophyll-containing elements comprising chlorophyll of an obligate photoautotroph.
摘要翻译：提供了包括适于植入个人体内的腔室，所述腔室包括功能性细胞和包含专性光自养基的叶绿素的含叶绿素的元件。

4. 发明申请

US20100047311A1 PROTECTING ALGAE FROM BODY FLUIDS 审中-公开
标题翻译：保护身体液体
公开(公告)号：US20100047311A1
公开(公告)日：2010-02-25
申请号：US12515818
申请日：2007-11-22
申请人： Avi Rotem , Chanan Schneider , Tova Neufeld , Yoav Evron
发明人： Avi Rotem , Chanan Schneider , Tova Neufeld , Yoav Evron
IPC分类号： A61F2/00 , A61K36/02
CPC分类号： A61F2/022 , A61K35/39 , A61L27/38
摘要： Apparatus (20) is provided for implantation into a body of a subject, including isolated functional cells (28). At least one first barrier (22) having a first molecular weight cutoff is disposed with respect to the functional cells so as to protect the functional cells from components disposed within body fluid of the subject having molecular weights higher than the first cutoff. Photosynthetic elements (26) are disposed with respect to the functional cells so as to provide oxygen thereto. At least one second barrier (24) has a second molecular weight cutoff that is lower than the first cutoff. The second barrier is disposed with respect to the photosynthetic elements so as to protect the photosynthetic elements from components disposed within the body fluid of the subject having molecular weights higher than the second cutoff. Other embodiments are also described.
摘要翻译：提供装置（20）用于植入受试者的身体，包括分离的功能细胞（28）。相对于功能性细胞设置具有第一分子量截留值的至少一个第一屏障（22），以便保护功能细胞免受配对在具有高于第一截止值的分子量的受检者体液内的组分。相对于功能单元设置光合元件（26），以向其提供氧气。至少一个第二屏障（24）具有低于第一截止值的第二分子量截止值。第二屏障相对于光合元件设置，以便保护光合元件免受被配置在受试者体液中的分子量高于第二截止值的组分。还描述了其它实施例。

5. 发明申请

US20090012502A1 Oxygen Supply for Cell Transplant and Vascularization 有权
标题翻译：细胞移植和血管化供氧
公开(公告)号：US20090012502A1
公开(公告)日：2009-01-08
申请号：US12064946
申请日：2007-11-28
申请人： Avi Rotem , Chanan Schneider , Uriel Barkai , Yoav Evron
发明人： Avi Rotem , Chanan Schneider , Uriel Barkai , Yoav Evron
IPC分类号： A61K35/12 , A61K9/22
CPC分类号： A61F2/022 , A61K35/12
摘要： Apparatus is provided, including a housing (22), configured for insertion into a body of a patient; a photosynthetic oxygen supply (24) configured to supply oxygen; and functional cells (30), coupled to the housing (22). The functional cells (30) are adapted to receive the oxygen and to secrete at least one factor that induces vascularization in a vicinity of the housing (22) when the housing (22) is in the body of the patient. Other embodiments are also described.
摘要翻译：提供了一种设备，包括构造成用于插入患者体内的壳体（22）配置为供应氧气的光合氧供应源（24）; 以及耦合到所述壳体（22）的功能单元（30）。当壳体（22）在患者体内时，功能细胞（30）适于接收氧气并分泌至少一个在壳体（22）附近引起血管形成的因素。还描述了其它实施例。

6. 发明申请

US20100130916A1 Apparatus for transportation of oxygen to implanted cells 有权
标题翻译：用于将氧气输送到植入细胞的装置
公开(公告)号：US20100130916A1
公开(公告)日：2010-05-27
申请号：US12315102
申请日：2008-11-26
申请人： Yaki Stern , Uriel Barkai , Avi Rotem , Meir Reingewirtz
发明人： Yaki Stern , Uriel Barkai , Avi Rotem , Meir Reingewirtz
IPC分类号： A61M37/00
CPC分类号： A61M13/003 , A61F2/022 , A61M2202/0208
摘要： Apparatus is provided which includes a housing, configured for insertion into a body of a subject. The apparatus includes functional cells coupled to the housing and a source of oxygen configured to supply oxygen to the functional cells. The apparatus further includes an oxygen delivery interface configured to receive oxygen from the source of oxygen, and to facilitate passage of the oxygen to the functional cells, while the housing is disposed within the body of the subject. Other embodiments are also described.
摘要翻译：提供了一种装置，其包括构造成用于插入到受试者的身体中的壳体。该装置包括耦合到壳体的功能单元和被配置为向功能单元供应氧气的氧源。该装置还包括氧气输送界面，其构造成从氧源接收氧气，并且有助于氧气通向功能单元，同时壳体设置在受试者的身体内。还描述了其它实施例。

7. 发明授权

US09446168B2 Multiple-layer immune barrier for donor cells 有权
标题翻译：供体细胞的多层免疫屏障
公开(公告)号：US09446168B2
公开(公告)日：2016-09-20
申请号：US13153721
申请日：2011-06-06
申请人： Uriel Barkai , Avi Rotem , Yehezkel Bremer , Tova Neufeld
发明人： Uriel Barkai , Avi Rotem , Yehezkel Bremer , Tova Neufeld
IPC分类号： A61K9/00 , A61J3/06 , A61P1/18 , A61K35/12 , A61K35/39 , A61L27/20 , A01N1/02 , A61L27/36 , A61L27/34 , A61K9/50 , C12N5/00 , C12N5/071 , A61K9/16
CPC分类号： A61L27/00 , A01N1/0231 , A61K9/0024 , A61K9/1652 , A61K9/5073 , A61K35/39 , A61L27/20 , A61L27/34 , A61L27/36 , A61L27/505 , A61L27/56 , A61L2400/18 , A61L2420/02 , A61L2420/08 , A61L2430/40 , C12N5/0012 , C12N5/0676 , Y10S623/915
摘要： A system is provided, including a plurality of donor cells and a first alginate structure that encapsulates the plurality of donor cells. The first alginate structure has a guluronic acid concentration of between 64% and 74%. The system additionally includes a second alginate structure that surrounds the first alginate structure, the second alginate structure having a mannuronic acid concentration of between 52% and 60%. A selectively-permeable membrane is coupled at least in part to the second alginate structure. Other embodiments are also described.
摘要翻译：提供了一种系统，包括多个供体细胞和封装多个供体细胞的第一藻酸盐结构。第一藻酸盐结构的古洛糖醛酸浓度为64％至74％。该系统还包括围绕第一藻酸盐结构的第二藻酸盐结构，第二藻酸盐结构具有52％至60％之间的甘露糖醛酸浓度。至少部分地将选择性渗透膜耦合到第二藻酸盐结构。还描述了其它实施例。

8. 发明授权

US08784389B2 Oxygen supply for implantable medical device 有权
标题翻译：可植入医疗器械的氧气供应
公开(公告)号：US08784389B2
公开(公告)日：2014-07-22
申请号：US12551151
申请日：2009-08-31
申请人： Jacob Stern , Avi Rotem , Yoav Hevron , Yehezkel Bermer
发明人： Jacob Stern , Avi Rotem , Yoav Hevron , Yehezkel Bermer
IPC分类号： A61M37/00
CPC分类号： A61M39/0208 , A61M5/1582 , A61M2005/006 , A61M2039/0211 , A61M2039/0217 , A61M2202/0208 , A61M2209/045
摘要： A method for replenishing gas in a subcutaneously implanted medical device containing functional cells comprising: inserting at least one needle, adopted to penetrate the skin and connecting a subcutaneously implanted medical device; connecting the inserted at least one needle to a gas replenishing apparatus; extracting gas from a gas reservoir in the implanted device into the gas replenishing apparatus; sensing oxygen level in the extracted gas; calculating the amount of gas needed for replenishing oxygen in the reservoir based on the sensed oxygen level in the extracted gas; and supplying gas from a gas tank in the gas replenishing apparatus to the gas reservoir in the implanted device.
摘要翻译：一种在含有功能细胞的皮下植入的医疗装置中补充气体的方法，包括：插入至少一个针，用于穿透皮肤并连接皮下植入的医疗装置; 将插入的至少一个针连接到气体补充装置; 将所述植入装置中的气体储存器中的气体提取到所述气体补充装置中; 检测提取气中的氧含量; 基于所提取的气体中检测到的氧水平计算储存器中补充氧气所需的气体量; 并将气体从气体补充装置中的气罐供给到植入装置中的气体储存器。

9. 发明授权

US08043271B2 Apparatus for transportation of oxygen to implanted cells 有权
标题翻译：用于将氧气输送到植入细胞的装置
公开(公告)号：US08043271B2
公开(公告)日：2011-10-25
申请号：US12315102
申请日：2008-11-26
申请人： Yaki Stern , Uriel Barkai , Avi Rotem , Meir Reingewirtz
发明人： Yaki Stern , Uriel Barkai , Avi Rotem , Meir Reingewirtz
IPC分类号： A61M37/00
CPC分类号： A61M13/003 , A61F2/022 , A61M2202/0208
摘要： Apparatus is provided which includes a housing, configured for insertion into a body of a subject. The apparatus includes functional cells coupled to the housing and a source of oxygen configured to supply oxygen to the functional cells. The apparatus further includes an oxygen delivery interface configured to receive oxygen from the source of oxygen, and to facilitate passage of the oxygen to the functional cells, while the housing is disposed within the body of the subject. Other embodiments are also described.
摘要翻译：提供了一种装置，其包括构造成用于插入到受试者的身体中的壳体。该装置包括耦合到壳体的功能单元和被配置为向功能单元供应氧气的氧源。该装置还包括氧气输送界面，其构造成从氧源接收氧气，并且有助于氧气通向功能单元，同时壳体设置在受试者的身体内。还描述了其它实施例。

10. 发明申请

US20110165219A1 OPTIMIZATION OF ALGINATE ENCAPSULATION OF ISLETS FOR TRANSPLANTATION 有权
标题翻译：用于运输的离心机的铝酸盐包封的优化
公开(公告)号：US20110165219A1
公开(公告)日：2011-07-07
申请号：US12996592
申请日：2009-09-16
申请人： Uriel Barkai , Avi Rotem , Dimitry Azarov , Tova Neufeld , Zohar Gendler
发明人： Uriel Barkai , Avi Rotem , Dimitry Azarov , Tova Neufeld , Zohar Gendler
IPC分类号： A61K9/00 , A61K35/12 , A61P13/12
CPC分类号： A61L27/52 , A61L27/20 , A61L27/26 , A61L27/3604 , A61L27/3633 , A61L27/3641 , A61L27/3834 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N5/0677 , C12N11/04 , C12N11/10
摘要： Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space (21) of a kidney (22) of a subject and is shaped to define a planar configuration. Other applications are also described.
摘要翻译：提供了包括多个胰岛的设备，以及被配置为将所述多个胰岛大包封的水凝胶。水凝胶可植入在受试者的肾脏（22）的囊下空间（21）中并且被成形为限定平面构型。还描述了其它应用。

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