专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5723481A Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents 失效
标题翻译：咪唑并吡唑衍生物作为止痛剂和抗炎剂使用
公开(公告)号：US5723481A
公开(公告)日：1998-03-03
申请号：US260896
申请日：1994-06-16
申请人： Atsusuke Terada , Kazuyuki Wachi , Hachio Miyazawa , Yoshio Iizuka , Kazuo Hasegawa , Keiichi Tabata
发明人： Atsusuke Terada , Kazuyuki Wachi , Hachio Miyazawa , Yoshio Iizuka , Kazuo Hasegawa , Keiichi Tabata
IPC分类号： A61K31/415 , A61K31/4188 , A61K31/422 , A61K31/4439 , A61K31/4725 , C07D487/04 , C07D235/00
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4188 , A61K31/422 , A61K31/4439 , A61K31/4725
摘要： Described herein are of formula (I): ##STR1## and pharmaceutically acceptable salts thereof are analgesics and anti-inflammatory agents as well having anti-ulcer and 5-lipoxygenase inhibitory activities.
摘要翻译：本文所述的具有式（I）：其中（I）及其药学上可接受的盐是具有抗溃疡和5-脂氧合酶抑制活性的止痛剂和抗炎剂。

2. 发明授权

US5665752A Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents 失效
标题翻译：咪唑并吡唑衍生物作为止痛剂和抗炎剂使用
公开(公告)号：US5665752A
公开(公告)日：1997-09-09
申请号：US418825
申请日：1995-04-07
申请人： Atsusuke Terada , Kazuyuki Wachi , Hachio Miyazawa , Yoshio Iizuka , Kazuo Hasegawa , Keiichi Tabata
发明人： Atsusuke Terada , Kazuyuki Wachi , Hachio Miyazawa , Yoshio Iizuka , Kazuo Hasegawa , Keiichi Tabata
IPC分类号： A61K31/415 , A61K31/4188 , A61K31/422 , A61K31/4439 , A61K31/4725 , C07D487/04 , C07D235/00
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4188 , A61K31/422 , A61K31/4439 , A61K31/4725
摘要： Described herein are compounds of formula (I): ##STR1## and pharmaceutically acceptable salts thereof are analgesics and anti-inflammatory agents as well having anti-ulcer and 5-lipoxygenase inhibitory activities.
摘要翻译：本文描述的是式（I）的化合物：其中药学上可接受的盐是止痛剂和抗炎剂，并具有抗溃疡和5-脂氧合酶抑制活性。

3. 发明授权

US5698576A Use of imidazopyrazole derivatives as analgesics anti-inflammatory agents 失效
标题翻译：使用咪唑并吡唑衍生物作止痛剂抗炎剂
公开(公告)号：US5698576A
公开(公告)日：1997-12-16
申请号：US755290
申请日：1996-11-22
申请人： Atsusuke Terada , Kazuyuki Wachi , Hachio Miyazawa , Yoshio Iizuka , Kazuo Hasegawa , Keiichi Tabata
发明人： Atsusuke Terada , Kazuyuki Wachi , Hachio Miyazawa , Yoshio Iizuka , Kazuo Hasegawa , Keiichi Tabata
IPC分类号： A61K31/415 , A61K31/4188 , A61K31/422 , A61K31/4439 , A61K31/4725 , C07D487/04 , C07D235/00
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4188 , A61K31/422 , A61K31/4439 , A61K31/4725
摘要： Described herein are compounds of formula (I): ##STR1## �in which: R.sup.1 and R.sup.2 are hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, aralkyl, arylalkenyl, aryl, aromatic heterocyclic, cyano or halogen; R.sup.3 is hydrogen, optionally substituted alkyl, aralkyl or acyl; R.sup.4 and R.sup.5 are hydrogen, optionally substituted alkyl, cycloalkyl, alkenyl, aralkyl, arylalkenyl, aryl or aromatic heterocyclic!; and pharmaceutically acceptable salts thereof are analgesics and anti-inflammatory agents as well having anti-ulcer and 5-lipoxygenase inhibitory activities.
摘要翻译：本文描述的是式（I）的化合物：其中：R 1和R 2是氢，任选取代的烷基，环烷基，烯基，芳烷基，芳基烯基，芳基，芳族杂环，氰基或卤素; R3是氢，任选取代的烷基，芳烷基或酰基; R 4和R 5是氢，任选取代的烷基，环烷基，烯基，芳烷基，芳基烯基，芳基或芳族杂环]; 及其药学上可接受的盐是具有抗溃疡和5-脂氧合酶抑制活性的止痛剂和抗炎剂。

4. 发明授权

US5232939A Use of imidazopyrazole derivatives as analgesics and anti-inflammatory agents 失效
标题翻译：咪唑并吡唑衍生物作为止痛剂和抗炎剂使用
公开(公告)号：US5232939A
公开(公告)日：1993-08-03
申请号：US798256
申请日：1991-11-18
申请人： Atsusuke Terada , Kazuyuki Wachi , Hachio Miyazawa , Yoshio Iizuka , Kazuo Hasegawa , Keiichi Tabata
发明人： Atsusuke Terada , Kazuyuki Wachi , Hachio Miyazawa , Yoshio Iizuka , Kazuo Hasegawa , Keiichi Tabata
IPC分类号： A61K31/415 , A61K31/4188 , A61K31/422 , A61K31/4439 , A61K31/4725 , C07D487/04
CPC分类号： C07D487/04 , A61K31/415 , A61K31/4188 , A61K31/422 , A61K31/4439 , A61K31/4725
摘要： Compounds of formula (I): ##STR1## and pharmaceutically acceptable salts thereof are analgesics and anti-inflammatory agents as well having anti-ulcer and 5-lipoxygenase inhibitory activities.
摘要翻译：式（I）的化合物：其中（I）及其药学上可接受的盐是止痛剂和抗炎剂，并具有抗溃疡和5-脂氧合酶抑制活性。

5. 发明授权

US4247548A 7.alpha.-Methoxycephalosporin derivatives and their pharmaceutical compositions having antibacterial activity 失效
标题翻译： 7α-甲氧基头孢菌素衍生物及其具有抗菌活性的药物组合物
公开(公告)号：US4247548A
公开(公告)日：1981-01-27
申请号：US28707
申请日：1979-04-10
申请人： Masafumi Yoshimoto , Hachio Miyazawa , Takuzo Nishimura , Akiko Ando , Norio Nakamura , Hideo Nakao
发明人： Masafumi Yoshimoto , Hachio Miyazawa , Takuzo Nishimura , Akiko Ando , Norio Nakamura , Hideo Nakao
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D261/12 , C07D501/57
CPC分类号： C07D261/12 , Y02P20/55
摘要： 7.alpha.-Methoxycephalosporin derivatives of general formula (I): ##STR1## wherein: R.sup.1 represents a hydroxy group; a C.sub.1 -C.sub.4 alkoxy group; a C.sub.2 -C.sub.5 aliphatic acyloxy group; a benzoyloxy group which is unsubstituted or has one or more C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, nitro or halogen substituents; a benzenesulphonyloxy group which is unsubstituted or has one or more C.sub.1 -C.sub.4 alkyl substituents; or a C.sub.1 -C.sub.3 alkanesulphonyloxy group which is unsubstituted or has one or more C.sub.1 -C.sub.3 alkoxy, cyano, nitro, halogen or C.sub.2 -C.sub.4 alkoxycarbonyl substituents;R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl group, a halogen atom, a carboxyl group, a C.sub.2 -C.sub.5 alkoxycarbonyl group, a carbamoyl group, an alkylcarbamoyl group in which the alkyl moiety has from 1 to 3 carbon atoms, a di(C.sub.1 -C.sub.3 alkyl)carbamoyl group or a cyano group;R.sup.3 represents a hydrogen atom; an acetoxy group; a carbamoyloxy group; or a tetrazolylthio, thiadiazolylthio or oxadiazolylthio group which is unsubstituted or has one or more C.sub.1 -C.sub.3 alkyl, sulphomethyl or di(C.sub.1 or C.sub.2 alkyl)amino(C.sub.1 -C.sub.3 alkyl) substituents;m is 0 or 1; andn is 0 or 2exhibit potent antibacterial activity and are thus useful as medicines. The derivatives can be prepared by reacting the corresponding 7.alpha.-methoxycephalosporin derivative having an amino group at the 7.beta.-position with an acid halide corresponding to the substituted acetyl group which it is desired to attach to the amino group at the 7.beta.-position or by reacting Cephamycin C with the same acid halide.
摘要翻译： 7，通式（I）的α-甲氧基头孢菌素衍生物：其中：R1表示羟基; C1-C4烷氧基; C2-C5脂族酰氧基; 未取代或具有一个或多个C 1 -C 4烷基，C 1 -C 4烷氧基，硝基或卤素取代基的苯甲酰氧基; 未取代或具有一个或多个C 1 -C 4烷基取代基的苯磺酰氧基; 或未取代或具有一个或多个C 1 -C 3烷氧基，氰基，硝基，卤素或C 2 -C 4烷氧羰基取代基的C 1 -C 3烷磺酰氧基; R2表示氢原子，C1-C4烷基，卤素原子，羧基，C2-C5烷氧基羰基，氨基甲酰基，烷基部分具有1至3个碳原子的烷基氨基甲酰基，二（C 1 -C 3烷基）氨基甲酰基或氰基; R3表示氢原子; 乙酰氧基; 氨基甲酰氧基; 或未取代的或具有一个或多个C 1 -C 3烷基，磺基甲基或二（C 1或C 2烷基）氨基（C 1 -C 3烷基）取代基的四唑基硫代噻二唑基硫代或恶二唑基硫基; m为0或1; n为0或2表示有效的抗菌活性，因此可用作药物。衍生物可以通过使7β位具有氨基的相应的7α-甲氧基头孢菌素衍生物与对应于取代的乙酰基的酰基卤反应而制备，希望在7β位上附着氨基或通过使Cephamycin C与相同的酰卤反应。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式