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1. 发明授权

US08575569B2 Fluorescence imaging apparatus and method for detecting fluorescent image 有权
标题翻译：荧光成像装置和荧光图像检测方法
公开(公告)号：US08575569B2
公开(公告)日：2013-11-05
申请号：US13119418
申请日：2008-09-18
申请人： Atsushi Yajima , Ichiro Oda , Kentaro Hizume , Yoshio Tsunazawa
发明人： Atsushi Yajima , Ichiro Oda , Kentaro Hizume , Yoshio Tsunazawa
IPC分类号： G01J1/58 , H01J40/14
CPC分类号： G01N21/6458 , A61B5/0059 , G01J3/4406 , G01J2003/1226 , G01N21/6428 , G01N2021/6471 , G01N2201/0612 , G01N2201/064 , G02B5/285 , G02B21/0032 , G02B21/0076
摘要： In order to reduce light leak influencing the detection capability of a fluorescence imaging apparatus, an interference filter and an absorption filter on an emission-side filter section are arranged serially in the traveling direction of the fluorescence. The interference filter and the absorption filter that are in use for such an arrangement block the waveband light equivalent to the excitation light irradiated onto a sample while fully transmitting the waveband light equivalent to the fluorescence.
摘要翻译：为了减少影响荧光成像装置的检测能力的光泄漏，发射侧滤波器部分上的干涉滤光器和吸收滤光器在荧光的行进方向上串联布置。用于这种布置的干涉滤光器和吸收滤光器在完全透射等效于荧光的波段光的同时，阻挡与照射到样品上的激发光相当的波段光。

2. 发明申请

US20110164124A1 BIOLOGICAL IMAGE ACQUISITION DEVICE 有权
标题翻译：生物图像获取装置
公开(公告)号：US20110164124A1
公开(公告)日：2011-07-07
申请号：US12809042
申请日：2008-12-25
申请人： Kentaro Hizume , Ichiro Oda , Atsushi Yajima , Yoshio Tsunazawa
发明人： Kentaro Hizume , Ichiro Oda , Atsushi Yajima , Yoshio Tsunazawa
IPC分类号： H04N7/18
CPC分类号： G01N21/6456
摘要： This object aims to disclose a biological multi-directional observation device with measures to avoid an illumination backlight problem taken. In a preferable embodiment of the multi-directional observation device, a two-dimensional detector (6) is arranged right above a transparent specimen support (2) and a main image forming lens (8) is arranged right under the two-dimensional detector (6). A fluorescence-side filter (10) which allows only a fluorescence component from a biological specimen (4) pass therethrough is arranged, if necessary, between the main image forming lens (8) and the biological specimen (4). Reflection mirrors (M1, M2) are arranged on the down side of the specimen support (2), wherein the reflection mirrors are optional systems for leading a light of an image of the rear side of the biological specimen (4) to the main image forming lens (8). A light source device is provided to irradiate light to biological specimen (4). A light source in the light source device is set at a position that is not in direct and indirect viewing fields (16, 18) of the two-dimensional detector, so that the backlight problem is avoided and a vivid biological multi-directional observation image by the two-dimensional observation image by the two-dimensional detector can be acquired.
摘要翻译：该目的旨在公开具有避免照明背光问题的措施的生物多方位观察装置。在多方向观察装置的优选实施方式中，在透明试样支架（2）的正上方配置二维检测器（6），在二维检测器的正下方配置有主图像形成透镜（8） 6）。如果需要，在主成像透镜（8）和生物样本（4）之间设置仅允许来自生物样本（4）的荧光成分通过的荧光侧滤光片（10）。反射镜（M1，M2）布置在样本支架（2）的下侧，其中反射镜是用于将生物样本（4）的后侧的图像的光引导到主图像的可选系统（8）。提供光源装置以将光照射到生物样本（4）上。光源装置中的光源被设置在不在二维检测器的直接和间接观察区域（16,18）的位置，从而避免了背光问题，并且生动地生物多方向观察图像通过二维检测器可以获得二维观察图像。

3. 发明授权

US08842173B2 Biological image acquisition device 有权
标题翻译：生物图像采集装置
公开(公告)号：US08842173B2
公开(公告)日：2014-09-23
申请号：US12809042
申请日：2008-12-25
申请人： Kentaro Hizume , Ichiro Oda , Atsushi Yajima , Yoshio Tsunazawa
发明人： Kentaro Hizume , Ichiro Oda , Atsushi Yajima , Yoshio Tsunazawa
IPC分类号： H04N7/18 , G01N21/64 , G06T15/50
CPC分类号： G01N21/6456
摘要： This object aims to disclose a biological multi-directional observation device with measures to avoid an illumination backlight problem taken. In a preferable embodiment of the multi-directional observation device, a two-dimensional detector (6) is arranged right above a transparent specimen support (2) and a main image forming lens (8) is arranged right under the two-dimensional detector (6). A fluorescence-side filter (10) which allows only a fluorescence component from a biological specimen (4) pass therethrough is arranged, if necessary, between the main image forming lens (8) and the biological specimen (4). Reflection mirrors (M1, M2) are arranged on the down side of the specimen support (2), wherein the reflection mirrors are optional systems for leading a light of an image of the rear side of the biological specimen (4) to the main image forming lens (8). A light source device is provided to irradiate light to biological specimen (4). A light source in the light source device is set at a position that is not in direct and indirect viewing fields (16, 18) of the two-dimensional detector, so that the backlight problem is avoided and a vivid biological multi-directional observation image by the two-dimensional observation image by the two-dimensional detector can be acquired.
摘要翻译：该目的旨在公开具有避免照明背光问题的措施的生物多方位观察装置。在多方向观察装置的优选实施方式中，在透明试样支架（2）的正上方配置二维检测器（6），在二维检测器的正下方配置有主图像形成透镜（8） 6）。如果需要，在主成像透镜（8）和生物样本（4）之间设置仅允许来自生物样本（4）的荧光成分通过的荧光侧滤光片（10）。反射镜（M1，M2）布置在样本支撑件（2）的下侧，其中反射镜是用于将生物样本（4）的后侧的图像的光引导到主图像的可选系统（8）。提供光源装置以将光照射到生物样本（4）上。光源装置中的光源被设置在不在二维检测器的直接和间接观察区域（16,18）的位置，从而避免了背光问题，并且生动地生物多方向观察图像通过二维检测器可以获得二维观察图像。

4. 发明申请

US20110168915A1 Fluorescence Imaging Apparatus and Method for Detecting Fluorescent Image 有权
标题翻译：荧光成像设备和荧光图像检测方法
公开(公告)号：US20110168915A1
公开(公告)日：2011-07-14
申请号：US13119418
申请日：2008-09-18
申请人： Atsushi Yajima , Ichiro Oda , Kentaro Hizume , Yoshio Tsunazawa
发明人： Atsushi Yajima , Ichiro Oda , Kentaro Hizume , Yoshio Tsunazawa
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , A61B5/0059 , G01J3/4406 , G01J2003/1226 , G01N21/6428 , G01N2021/6471 , G01N2201/0612 , G01N2201/064 , G02B5/285 , G02B21/0032 , G02B21/0076
摘要： In order to reduce light leak influencing the detection capability of a fluorescence imaging apparatus, an interference filter and an absorption filter on an emission-side filter section are arranged serially in the traveling direction of the fluorescence. The interference filter and the absorption filter that are in use for such an arrangement block the waveband light equivalent to the excitation light irradiated onto a sample while fully transmitting the waveband light equivalent to the fluorescence.
摘要翻译：为了减少影响荧光成像装置的检测能力的光泄漏，发射侧滤波器部分上的干涉滤光器和吸收滤光器在荧光的行进方向上串联布置。用于这种布置的干涉滤光器和吸收滤光器在完全透射等效于荧光的波段光的同时，阻挡与照射到样品上的激发光相当的波段光。

5. 发明授权

US08304746B2 Fluorescent measurement device for living body and exciting light-irradiating device for fluorescent measurement 有权
标题翻译：用于生物体的荧光测量装置和用于荧光测量的激发光照射装置
公开(公告)号：US08304746B2
公开(公告)日：2012-11-06
申请号：US12531903
申请日：2007-03-19
申请人： Ichiro Oda , Shinji Nagamachi , Kentaro Hizume , Yoshio Tsunazawa
发明人： Ichiro Oda , Shinji Nagamachi , Kentaro Hizume , Yoshio Tsunazawa
IPC分类号： G01J1/58
CPC分类号： G01N21/6456 , G01N2021/6419 , G01N2021/6421 , G01N2021/6471
摘要： Disclosed herein is a fluorescence measurement device for a living body configured to be able to reduce wavelength components that will become leak light and to easily switch a wavelength and an irradiation direction. The fluorescence measurement device for a living body comprises: a sample holder on which a living body sample is to be placed; an exciting light-irradiating device having a plurality of exciting light sources arranged at mutually different positions, each of which is composed of a laser diode or a light-emitting diode and is provided with a filter having an optical property to eliminate, from a spectrum of the exciting light source, disturbing wavelength components overlapping with wavelength components of fluorescence to be detected; an electrical switch for switching lighting of the exciting light sources; a detector for picking up an image produced by fluorescence emitted from the sample placed on the sample holder; and an image display device for displaying the image picked up by the detector.
摘要翻译：本发明公开了一种用于生物体的荧光测量装置，其被配置为能够减少将成为泄漏光的波长成分并容易地切换波长和照射方向。用于生物体的荧光测量装置包括：待放置活体样品的样品架; 一激励光照射装置，其具有布置在相互不同位置的多个激发光源，每个激光光源由激光二极管或发光二极管组成，并且具有滤光器，该滤光器具有从光谱中消除的光学特性的激发光源，与待检测的荧光的波长成分重叠的干扰波长成分; 用于切换激发光源的照明的电开关; 用于拾取由放置在样品架上的样品发出的荧光产生的图像的检测器; 以及用于显示由检测器拾取的图像的图像显示装置。

6. 发明申请

US20100294947A1 FLUORESCENT MEASUREMENT DEVICE FOR LIVING BODY AND EXCITING LIGHT-IRRADIATING DEVICE FOR FLUORESCENT MEASUREMENT 有权
标题翻译：用于生活体内的荧光测量装置和用于荧光测量的激光照射装置
公开(公告)号：US20100294947A1
公开(公告)日：2010-11-25
申请号：US12531903
申请日：2007-03-19
申请人： Ichiro Oda , Shinji Nagamachi , Kentaro Hizume , Yoshio Tsunazawa
发明人： Ichiro Oda , Shinji Nagamachi , Kentaro Hizume , Yoshio Tsunazawa
IPC分类号： G01N21/64
CPC分类号： G01N21/6456 , G01N2021/6419 , G01N2021/6421 , G01N2021/6471
摘要： Disclosed herein is a fluorescence measurement device for a living body configured to be able to reduce wavelength components that will become leak light and to easily switch a wavelength and an irradiation direction. The fluorescence measurement device for a living body comprises: a sample holder on which a living body sample is to be placed; an exciting light-irradiating device having a plurality of exciting light sources arranged at mutually different positions, each of which is composed of a laser diode or a light-emitting diode and is provided with a filter having an optical property to eliminate, from a spectrum of the exciting light source, disturbing wavelength components overlapping with wavelength components of fluorescence to be detected; an electrical switch for switching lighting of the exciting light sources; a detector for picking up an image produced by fluorescence emitted from the sample placed on the sample holder; and an image display device for displaying the image picked up by the detector.
摘要翻译：本发明公开了一种用于生物体的荧光测量装置，其被配置为能够减少将成为泄漏光的波长成分并容易地切换波长和照射方向。用于生物体的荧光测量装置包括：待放置活体样品的样品架; 一激励光照射装置，其具有布置在相互不同位置的多个激发光源，每个激光光源由激光二极管或发光二极管组成，并且具有滤光器，该滤光器具有从光谱中消除的光学特性的激发光源，与待检测的荧光的波长成分重叠的干扰波长成分; 用于切换激发光源的照明的电开关; 用于拾取由放置在样品架上的样品发出的荧光产生的图像的检测器; 以及用于显示由检测器拾取的图像的图像显示装置。

7. 发明授权

US08345941B2 Biological imaging device 有权
标题翻译：生物成像装置
公开(公告)号：US08345941B2
公开(公告)日：2013-01-01
申请号：US12992560
申请日：2008-05-15
申请人： Ichiro Oda , Atsushi Yajima , Kentaro Hizumi , Akimasa Mega , Tadafumi Kamikake , Yutaka Kuratani , Takeshi Fujita , Yoshio Tsunazawa
发明人： Ichiro Oda , Atsushi Yajima , Kentaro Hizumi , Akimasa Mega , Tadafumi Kamikake , Yutaka Kuratani , Takeshi Fujita , Yoshio Tsunazawa
IPC分类号： G06K9/00
CPC分类号： G01N21/6456 , G01N21/6486 , G01N21/763 , H04N5/2254 , H04N13/218
摘要： Optical waveguide paths to observe a sample on a sample holder from a plurality of directions while guiding an image of light in each direction which is emitted out of the sample toward a direction of a two dimensional detector via a main imaging lens include an optical waveguide path which never receives the light directly from the sample. The optical waveguide path which never receives the light directly from the sample forms an image of the sample within a substantial focus range of the main imaging lens, and includes optical elements arranged such that a light beam after formation of the image proceeds toward a direction of the main imaging lens. Optical elements on at least one optical waveguide path are those for forming real images. Therefore, the main imaging lens images the sample and those real images in block on the two dimensional detector.
摘要翻译：从多个方向观察样品架上的样品的光波导路径，同时经由主成像透镜沿着从样品朝向二维检测器的方向引出的每个方向上的光的图像被引导，包括光波导路径从来没有从样品中直接收到光。直接从样品接收光的光波导路径在主成像透镜的实质焦距范围内形成样品的图像，并且包括光学元件，其被布置成使得在形成图像之后的光束朝向主要成像镜头。至少一个光波导路径上的光学元件是用于形成真实图像的光学元件。因此，主要成像透镜在二维检测器上对样本和块中的实像进行成像。

8. 发明申请

US20110096967A1 Biological Imaging Device 有权
标题翻译：生物成像装置
公开(公告)号：US20110096967A1
公开(公告)日：2011-04-28
申请号：US12992560
申请日：2008-05-15
申请人： Ichiro Oda , Atsushi Yajima , Kentaro Hizumi , Akimasa Mega , Tadafumi Kamikake , Yutaka Kuratani , Takeshi Fujita , Yoshio Tsunazawa
发明人： Ichiro Oda , Atsushi Yajima , Kentaro Hizumi , Akimasa Mega , Tadafumi Kamikake , Yutaka Kuratani , Takeshi Fujita , Yoshio Tsunazawa
IPC分类号： G01N21/64 , G01J1/58 , G06K9/00
CPC分类号： G01N21/6456 , G01N21/6486 , G01N21/763 , H04N5/2254 , H04N13/218
摘要： Optical waveguide paths to observe a sample on a sample holder from a plurality of directions while guiding an image of light in each direction which is emitted out of the sample toward a direction of a two dimensional detector via a main imaging lens include an optical waveguide path which never receives the light directly from the sample. The optical waveguide path which never receives the light directly from the sample forms an image of the sample within a substantial focus range of the main imaging lens, and includes optical elements arranged such that a light beam after formation of the image proceeds toward a direction of the main imaging lens. Optical elements on at least one optical waveguide path are those for forming real images. Therefore, the main imaging lens images the sample and those real images in block on the two dimensional detector.
摘要翻译：从多个方向观察样品架上的样品的光波导路径，同时经由主成像透镜沿着从样品朝向二维检测器的方向引出的每个方向上的光的图像被引导，包括光波导路径从来没有从样品中直接收到光。直接从样品接收光的光波导路径在主成像透镜的实质焦距范围内形成样品的图像，并且包括光学元件，其被布置成使得在形成图像之后的光束朝向主要成像镜头。至少一个光波导路径上的光学元件是用于形成真实图像的光学元件。因此，主要成像透镜在二维检测器上对样本和块中的实像进行成像。

9. 发明申请

US20110013008A1 DEVICE FOR ACQUIRING IMAGE OF LIVING BODY 审中-公开
标题翻译：用于获取生活体形象的设备
公开(公告)号：US20110013008A1
公开(公告)日：2011-01-20
申请号：US12515010
申请日：2006-11-16
申请人： Shinji Nagamachi , Yoshio Tsunazawa , Ichiro Oda
发明人： Shinji Nagamachi , Yoshio Tsunazawa , Ichiro Oda
IPC分类号： H04N7/18
CPC分类号： A61B5/0059
摘要： Observation of a living body sample from multiple directions can be measured in a short time and with a convenient structure. One two-dimensional detector is arranged in order to pick up the image of light emitted from a sample on a sample holder, and connected with a display for displaying the image picked up by means of the two-dimensional detector. In order to observe the sample on the sample holder from a plurality of directions and to introduce the image of light emitted from the sample in each direction to the two-dimensional detector, a light guide optical system including a multi-reflector assembly consisting of reflectors is provided. A main image formation lens for forming on the two-dimensional detector a plurality of images introduced by the light guide optical system is arranged between the two-dimensional detector and the light guide optical system. Auxiliary image formation lenses for correcting according to a light path length difference an image formed on the two-dimensional detector a main image formation lens is arranged between the main image formation lens and the light guide optical system.
摘要翻译：从多个方向观察活体样本可以在短时间内以及方便的结构进行测量。布置一个二维检测器以便拾取样品架上的样品发出的光的图像，并与用于显示通过二维检测器拾取的图像的显示器连接。为了从多个方向观察样品保持器上的样品，并将从各个方向发射的光的图像引入到二维检测器，导光光学系统包括由反射器组成的多反射器组件被提供。用于在二维检测器上形成由导光光学系统引入的多个图像的主图像形成透镜布置在二维检测器和导光光学系统之间。辅助图像形成透镜，用于根据光路长度差校正形成在主图像形成透镜和导光光学系统上的主图像形成透镜的二维检测器上的图像。

10. 发明授权

US08406846B2 Mammographic apparatus 有权
标题翻译：乳房造影仪
公开(公告)号：US08406846B2
公开(公告)日：2013-03-26
申请号：US12295265
申请日：2007-03-20
申请人： Mayuka Yoshizawa , Masami Maekawa , Keishi Kitamura , Ichiro Oda , Koji Shimizu
发明人： Mayuka Yoshizawa , Masami Maekawa , Keishi Kitamura , Ichiro Oda , Koji Shimizu
IPC分类号： A61B5/05
CPC分类号： G01T1/1642 , A61B5/0091 , A61B5/4312 , A61B6/037 , A61B6/04 , A61B6/0478 , A61B6/4258 , A61B6/502
摘要： The mammographic apparatus of this invention maintains peripheral portions of the breast area Ma of the sternal plate of a patient M in contact with a sternal plate contact box 3 during radiography for RI distribution images of the breast area Ma of the patient M. Since the body motion accompanying respiration of the patient M shifts from the breast side to the back side, the motion of the breast area Ma of the patient M accompanying respiration of the patient M is suppressed easily. In addition, since radiography for RI distribution images is carried out with the patient M in a seated position seated on a seating unit 2, the apparatus is compact and can installed in a limited area, compared with an apparatus that carries out radiography for RI distribution images with a patient in a sleeping position lying on her back or on a side on a top board.
摘要翻译：本发明的乳房X线摄影装置在患者M的乳房区域Ma的RI分布图像的放射线照相期间保持患者M的胸骨板的胸部区域Ma的周边部分与胸骨板接触盒3接触。由于身体伴随着患者M的呼吸的运动从乳房侧向背侧移动，患者M的乳房区域Ma的运动伴随着患者M的呼吸被容易地抑制。此外，由于RI分布图像的放射线照相是在患者M位于座位单元2上的就座位置中进行的，所以与进行RI分布放射线照相术的装置相比，该装置是紧凑的并且可以安装在有限的区域中患者躺在躺在她背后或顶板上的一侧的患者的图像。

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