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1. 发明授权

US08131349B2 Lesion extracting device and lesion extracting method 有权
标题翻译：病变提取装置及病变提取方法
公开(公告)号：US08131349B2
公开(公告)日：2012-03-06
申请号：US11805228
申请日：2007-05-22
申请人： Atsushi Okawa , Tianyu Xie , Toshiaki Watanabe , Yasushige Ishihara
发明人： Atsushi Okawa , Tianyu Xie , Toshiaki Watanabe , Yasushige Ishihara
IPC分类号： A61B8/00
CPC分类号： A61B5/0071 , A61B1/00096 , A61B1/00188 , A61B1/043 , A61B1/0638 , A61B1/07 , A61B5/0084
摘要： A lesion extracting device having a control unit for changing an amount of the excitation light emitted toward a subject body, a measuring unit for measuring a change in the intensity of fluorescence generated from the subject body with respect to a change in the amount of the excitation light, and an extracting unit for calculating a ratio of the change in the intensity of fluorescence on the basis of a ratio of the change in the amount of the excitation light to the change in the intensity of fluorescence and for extracting a lesion part of the subject body on the basis of the ratio of the changes in the amount of the excitation light to the ratio of the changes in the intensity of fluorescence.
摘要翻译：一种病变提取装置，具有用于改变朝向被检体发射的激发光的量的控制单元，测量单元，用于测量从被检体发出的荧光的强度相对于激发量的变化的变化光和提取单元，用于基于激发光的量的变化与荧光强度的变化的比率和用于提取荧光强度的变化的比例来计算荧光强度的变化的比率基于激发光量的变化与荧光强度的变化率的比率的对象体。

2. 发明申请

US20080058594A1 Endoscope apparatus 有权
标题翻译：内窥镜装置
公开(公告)号：US20080058594A1
公开(公告)日：2008-03-06
申请号：US11897848
申请日：2007-08-31
申请人： Tianyu Xie , Atsushi Okawa , Yasushige Ishihara , Toshiaki Watanabe
发明人： Tianyu Xie , Atsushi Okawa , Yasushige Ishihara , Toshiaki Watanabe
IPC分类号： A61B1/07
CPC分类号： A61B1/042 , A61B1/00154 , A61B1/00163 , A61B1/00165 , A61B1/00177 , A61B1/0615 , A61B1/07 , A61B5/064
摘要： The invention includes an insertion portion, one end of which is inserted inside a lumen of a subject; an image-acquisition unit for acquiring an image of an interior wall in the lumen as a substantially circular or substantially ring-shaped interior wall image; a transformation processing unit for transforming, in the interior wall image, at least substantially ring-shaped images concerning the interior wall, whose distance from the one end is uniform, to substantially straight-line-shaped or substantially band-shaped images; a distance-measuring unit for measuring a distance moved by the insertion portion relative to the subject; and an image synthesizing unit for joining the transformed images on the basis of the distance moved measured by the distance-measuring unit.
摘要翻译：本发明包括一个插入部分，其一端插入被检体内腔内; 图像获取单元，用于获取内腔中的内壁的图像为大致圆形或大致环形的内壁图像; 变换处理单元，用于在内壁图像中转换至少基本上呈直线状或基本上带状的图像的关于内壁的距离为一体的内壁的环形图像; 距离测量单元，用于测量由插入部分相对于被摄体移动的距离; 以及图像合成单元，用于基于由距离测量单元测量的移动距离来连接变换图像。

3. 发明授权

US08521261B2 Lesion extracting device and lesion extracting method 有权
标题翻译：病变提取装置及病变提取方法
公开(公告)号：US08521261B2
公开(公告)日：2013-08-27
申请号：US13359671
申请日：2012-01-27
申请人： Atsushi Okawa , Tianyu Xie , Toshiaki Watanabe , Yasushige Ishihara
发明人： Atsushi Okawa , Tianyu Xie , Toshiaki Watanabe , Yasushige Ishihara
IPC分类号： A61B5/05
CPC分类号： A61B5/0071 , A61B1/00096 , A61B1/00188 , A61B1/043 , A61B1/0638 , A61B1/07 , A61B5/0084
摘要： A lesion extracting device includes a light source for emitting an excitation light toward a subject body, a control unit for changing an amount of the excitation light, a light irradiating and receiving portion for irradiating the excitation light to the subject body and receiving fluorescence generated from the subject body, a distance holding member for holding a distance between the subject body and the light irradiating and receiving portion at a predetermined value, a measuring unit for measuring the intensity of the fluorescence received by the light irradiating and receiving portion, and an extracting unit for extracting a lesion part of the subject body based on relationships between measured values of changes in the fluorescence intensity with respect to changes in the amount of the excitation light and information regarding the changes in the amount of the excitation light, the information being obtained from the control unit.
摘要翻译：病变提取装置包括用于向受检者体发射激发光的光源，用于改变激发光量的控制单元，用于将激发光照射到被摄体的光照射和接收部分，并接收从被检体，用于将被检体与受光部之间的距离保持在预定值的距离保持构件，用于测量由光照射和接收部接收的荧光强度的测量单元，基于与激发光量的变化相关的荧光强度的变化的测量值与激发光量的变化的信息之间的关系来提取被检体的病变部的单元，获得的信息从控制单元。

4. 发明申请

US20120197134A1 Lesion Extracting Device and Lesion Extracting Method 有权
标题翻译：病变提取装置及病变提取方法
公开(公告)号：US20120197134A1
公开(公告)日：2012-08-02
申请号：US13359671
申请日：2012-01-27
申请人： Atsushi Okawa , Tianyu Xie , Toshiaki Watanabe , Yasushige Ishihara
发明人： Atsushi Okawa , Tianyu Xie , Toshiaki Watanabe , Yasushige Ishihara
IPC分类号： A61B5/107 , A61B6/00
CPC分类号： A61B5/0071 , A61B1/00096 , A61B1/00188 , A61B1/043 , A61B1/0638 , A61B1/07 , A61B5/0084
摘要： A lesion extracting device includes a light source for emitting an excitation light toward a subject body, a control unit for changing an amount of the excitation light, a light irradiating and receiving portion for irradiating the excitation light to the subject body and receiving fluorescence generated from the subject body, a distance holding member for holding a distance between the subject body and the light irradiating and receiving portion at a predetermined value, a measuring unit for measuring the intensity of the fluorescence received by the light irradiating and receiving portion, and an extracting unit for extracting a lesion part of the subject body based on relationships between measured values of changes in the fluorescence intensity with respect to changes in the amount of the excitation light and information regarding the changes in the amount of the excitation light, the information being obtained from the control unit.
摘要翻译：病变提取装置包括用于向受检者体发射激发光的光源，用于改变激发光量的控制单元，用于将激发光照射到被摄体的光照射和接收部分，并接收从被检体，用于将被检体与受光部之间的距离保持在预定值的距离保持构件，用于测量由光照射和接收部接收的荧光强度的测量单元，基于与激发光量的变化相关的荧光强度的变化的测量值与激发光量的变化的信息之间的关系来提取被检体的病变部的单元，获得的信息从控制单元。

5. 发明授权

US08123679B2 Endoscope apparatus 有权
标题翻译：内窥镜装置
公开(公告)号：US08123679B2
公开(公告)日：2012-02-28
申请号：US11897848
申请日：2007-08-31
申请人： Tianyu Xie , Atsushi Okawa , Yasushige Ishihara , Toshiaki Watanabe
发明人： Tianyu Xie , Atsushi Okawa , Yasushige Ishihara , Toshiaki Watanabe
IPC分类号： A61B1/06
CPC分类号： A61B1/042 , A61B1/00154 , A61B1/00163 , A61B1/00165 , A61B1/00177 , A61B1/0615 , A61B1/07 , A61B5/064
摘要： The invention includes an insertion portion, one end of which is inserted inside a lumen of a subject; an image-acquisition unit for acquiring an image of an interior wall in the lumen as a substantially circular or substantially ring-shaped interior wall image; a transformation processing unit for transforming, in the interior wall image, at least substantially ring-shaped images concerning the interior wall, whose distance from the one end is uniform, to substantially straight-line-shaped or substantially band-shaped images; a distance-measuring unit for measuring a distance moved by the insertion portion relative to the subject; and an image synthesizing unit for joining the transformed images on the basis of the distance moved measured by the distance-measuring unit.
摘要翻译：本发明包括一个插入部分，其一端插入被检体内腔内; 图像获取单元，用于获取内腔中的内壁的图像为大致圆形或大致环形的内壁图像; 变换处理单元，用于在内壁图像中转换至少基本上呈直线状或基本上带状的图像的关于内壁的距离为一体的内壁的环形图像; 距离测量单元，用于测量由插入部分相对于被摄体移动的距离; 以及图像合成单元，用于基于由距离测量单元测量的移动距离来连接变换图像。

6. 发明申请

US20070276259A1 Lesion extracting device and lesion extracting method 有权
标题翻译：病变提取装置及病变提取方法
公开(公告)号：US20070276259A1
公开(公告)日：2007-11-29
申请号：US11805228
申请日：2007-05-22
申请人： Atsushi Okawa , Tianyu Xie , Toshiaki Watanabe , Yasushige Ishihara
发明人： Atsushi Okawa , Tianyu Xie , Toshiaki Watanabe , Yasushige Ishihara
IPC分类号： A61B6/00
CPC分类号： A61B5/0071 , A61B1/00096 , A61B1/00188 , A61B1/043 , A61B1/0638 , A61B1/07 , A61B5/0084
摘要： A lesion extracting device comprises a light source for emitting an excitation light toward a subject body to be examined, a control unit for changing an amount of the excitation light, a light irradiating and receiving portion for irradiating the excitation light to the subject body and receiving fluorescence generated from the subject body, a distance holding member for holding a distance between the subject body and the light irradiating and receiving portion at a predetermined value, a measuring unit for measuring the intensity of the fluorescence received by the light irradiating and receiving portion, and an extracting unit for extracting a lesion part of the subject body based on relationships between measured values of changes in the fluorescence intensity with respect to changes in the amount of the excitation light and information regarding the changes in the amount of the excitation light, the information being obtained from the control unit.
摘要翻译：病变提取装置包括：朝向被检体的发射激发光的光源，用于改变激发光量的控制单元，用于将激发光照射到被检体并接收的光照射和接收部从被摄体体产生的荧光，用于将被检体与受光部之间的距离保持在规定值的距离保持部件，测定由光照射接收部接收的荧光强度的测定部，以及提取单元，其基于与激发光量的变化相关的荧光强度的变化的测量值与激发光量的变化的信息之间的关系来提取被检体的病变部，从控制单元获得的信息。

7. 发明申请

US20100020163A1 FLUORESCENCE ENDOSCOPE 审中-公开
标题翻译：荧光内窥镜
公开(公告)号：US20100020163A1
公开(公告)日：2010-01-28
申请号：US12518377
申请日：2007-12-07
申请人： Toshiaki Watanabe , Atsushi Okawa , Yasushige Ishihara , Ryo Karasawa
发明人： Toshiaki Watanabe , Atsushi Okawa , Yasushige Ishihara , Ryo Karasawa
IPC分类号： H04N7/18
CPC分类号： A61B5/0071 , A61B1/00165 , A61B1/043 , A61B5/0084 , A61B2560/0223
摘要： A fluorescence endoscope is provided that can easily judge whether body-cavity tissue is benign or malignant when fluorescence generated at the entire inner circumferential face of the body cavity serving as a subject is observed. The fluorescence endoscope includes: an insertion portion (5) be inserted into a body cavity (3); a balloon (15) brought into contact with an inner wall of the body cavity (3) located in radial directions of the insertion portion (5), thereby positioning the insertion portion (5) with respect to the body cavity (3) in the radial directions of the insertion portion (5); a light emitting and introducing unit (17, 19) emits excitation light for irradiating the inner wall, outward in the radial directions of the insertion portion (5), and introduces fluorescence generated at the inner wall to the inside of the insertion portion (5) from a plurality of different radial directions of the insertion portion (5); an image-acquisition unit (21) acquires an image with the fluorescence introduced by the light emitting and introducing unit (17, 19); a correction-signal calculating unit (57) calculates a correction signal for correcting an image-acquisition signal output from the image-acquisition unit (21), based on a distance between the insertion portion (5) and a contact surface of the balloon (15) that is brought into contact with the inner wall; and a signal processing unit (57) corrects the intensity of the image-acquisition signal based on the correction signal and generates an image signal from the corrected image-acquisition signal.
摘要翻译：提供了一种荧光内窥镜，其可以容易地判断当观察到在用作对象的体腔的整个内周面处产生的荧光时，体腔组织是良性还是恶性。荧光内窥镜包括：插入部（5）插入体腔（3）中; 与所述体腔（3）的位于所述插入部（5）的径向方向的内壁接触的气囊（15），从而将所述插入部（5）相对于所述体腔（3）定位在所述插入部插入部分（5）的径向方向; 发光引入单元（17,19）发射用于照射插入部（5）的径向外侧的内壁的激发光，并且将在内壁产生的荧光引入到插入部（5）的内部）从所述插入部（5）的多个不同的径向方向移动; 图像获取单元（21）获取由发光和导入单元（17,19）引入的荧光的图像。校正信号计算单元（57）基于插入部分（5）和气球的接触表面之间的距离来计算用于校正从图像获取单元（21）输出的图像采集信号的校正信号 15）与内壁接触; 并且信号处理单元（57）基于校正信号校正图像采集信号的强度，并从校正后的图像采集信号生成图像信号。

8. 发明申请

US20060089554A1 Image generating device for generating a fluorescence image 有权
标题翻译：用于产生荧光图像的图像产生装置
公开(公告)号：US20060089554A1
公开(公告)日：2006-04-27
申请号：US11258964
申请日：2005-10-26
申请人： Yasushige Ishihara , Toshiaki Watanabe
发明人： Yasushige Ishihara , Toshiaki Watanabe
IPC分类号： A61B6/00 , A61B1/06
CPC分类号： A61B1/043 , A61B1/0646 , A61B5/0068 , A61B5/0071 , A61B5/0084
摘要： Excitation light λex is two-dimensionally scanned onto the living body tissue in the form of condensed light using an x-axis scanning mirror, a y-axis scanning mirror, and a condenser lens, whereby the excitation light λex is cast onto the living body tissue. This allows fluorescence observation with a relatively low output intensity of a laser light source. Furthermore, a white light image is generated by scanning the white light in the same way, thereby enabling fluorescence observation in the same observation region and at the same timing as with normal observation. This enables fluorescence observation of a sufficient area which allows the user to distinguish living body tissues in an endoscope observation image while suppressing deterioration in the laser light source.
摘要翻译：激发光λex使用x轴扫描镜，y轴扫描镜和聚光透镜以聚光的形式二维扫描到生物体组织上，由此将激发光λex投射到生物体上组织。这允许以相对低的激光光源的输出强度进行荧光观察。此外，通过以相同的方式扫描白光来产生白光图像，从而能够在与正常观察相同的观察区域和相同的定时进行荧光观察。这使得能够荧光观察足够的面积，其允许用户在抑制激光源的劣化的同时，在内窥镜观察图像中区分活体组织。

9. 发明授权

US08345090B2 Fluoroscopy apparatus having an image correction section 有权
标题翻译：具有图像校正部的荧光透视装置
公开(公告)号：US08345090B2
公开(公告)日：2013-01-01
申请号：US12726549
申请日：2010-03-18
申请人： Toshiaki Watanabe , Yasushige Ishihara
发明人： Toshiaki Watanabe , Yasushige Ishihara
IPC分类号： A62B1/04
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/043 , A61B1/051 , A61B5/0084 , G06T5/50 , G06T2207/10064 , G06T2207/10068 , G06T2207/20192 , G06T2207/20224 , G06T2207/30101 , H04N5/325
摘要： A fluoroscopy apparatus includes an illumination portion irradiating an observation target with illumination light; a fluorescence image acquisition device acquires fluorescence emitted from an observation target to acquire a fluorescence image; a fluorescence image-acquisition optical system forms an image of the observation target using the fluorescence; a reference-light image acquisition device acquires returning light from the observation region to acquire a reference image; a reference-light image-acquisition optical system forms an image using the returning light; and an image correction section corrects the fluorescence image by the reference image, wherein the product of an pixel density of the reference-light image acquisition device and the image-forming magnification of the reference-light image-acquisition optical system is less than the product of the pixel density of the fluorescence image acquisition device and the image-forming magnification of the fluorescence image-acquisition optical system.
摘要翻译：荧光透视设备包括：用照明光照射观察目标的照明部分; 荧光图像获取装置获取从观察对象发出的荧光以获取荧光图像; 荧光图像采集光学系统使用荧光形成观察目标的图像; 参考光图像获取装置获取来自观察区域的返回光以获取参考图像; 参考光图像采集光学系统使用返回光形成图像; 并且图像校正部分通过参考图像来校正荧光图像，其中参考光图像获取装置的像素密度与参考光图像采集光学系统的图像形成倍率的乘积小于产品的荧光图像获取装置的像素密度和荧光图像采集光学系统的图像形成倍率。

10. 发明授权

US07798955B2 Image generating device for generating a fluorescence image 有权
标题翻译：用于产生荧光图像的图像产生装置
公开(公告)号：US07798955B2
公开(公告)日：2010-09-21
申请号：US11258964
申请日：2005-10-26
申请人： Yasushige Ishihara , Toshiaki Watanabe
发明人： Yasushige Ishihara , Toshiaki Watanabe
IPC分类号： A61B1/00
CPC分类号： A61B1/043 , A61B1/0646 , A61B5/0068 , A61B5/0071 , A61B5/0084
摘要： Excitation light λex is two-dimensionally scanned onto the living body tissue in the form of condensed light using an x-axis scanning mirror, a y-axis scanning mirror, and a condenser lens, whereby the excitation light λex is cast onto the living body tissue. This allows fluorescence observation with a relatively low output intensity of a laser light source. Furthermore, a white light image is generated by scanning the white light in the same way, thereby enabling fluorescence observation in the same observation region and at the same timing as with normal observation. This enables fluorescence observation of a sufficient area which allows the user to distinguish living body tissues in an endoscope observation image while suppressing deterioration in the laser light source.
摘要翻译：激发光λex使用x轴扫描镜，y轴扫描镜和聚光透镜以聚光的形式二维扫描到生物体组织上，由此将激发光λex投射到生物体组织。这允许以相对低的激光光源的输出强度进行荧光观察。此外，通过以相同的方式扫描白光来产生白光图像，从而能够在与正常观察相同的观察区域和相同的定时进行荧光观察。这使得能够荧光观察足够的面积，其允许用户在抑制激光源的劣化的同时，在内窥镜观察图像中区分活体组织。

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