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1. 发明授权

US07435949B2 Mass spectrometric analysis method and system using the method 有权
标题翻译：质谱分析方法和系统采用该方法
公开(公告)号：US07435949B2
公开(公告)日：2008-10-14
申请号：US11439949
申请日：2006-05-25
申请人： Atsushi Ohtake , Kinya Kobayashi , Toshiyuki Yokosuka , Kiyomi Yoshinari
发明人： Atsushi Ohtake , Kinya Kobayashi , Toshiyuki Yokosuka , Kiyomi Yoshinari
IPC分类号： B01D59/44 , H01J49/26
CPC分类号： H01J49/02 , H01J49/004
摘要： A tandem analysis system is provided for ionizing a substance, performing mass spectrometric analysis of various ion types generated, selecting and dissociating an ion type, the ion type having a specific mass-to-charge ratio, and thereby, repeating mass spectrometric analysis measurement on the ion of the ion type over n-th stages. A processing judges control content for the analysis next to MSn (the n-th stage mass spectrometric analysis) within a predetermined time, based on ion intensity being represented by an ion peak with respect to the mass-to-charge ratio of each ion in the MSn result. An ion detection unit judges isotope-peak from the measured ionized data. Assuming that the MS1 count number of a parent-ion peptide measured during a certain constant time-interval is I, a data processing unit makes the MS2 integration number-of-times or analysis time of the peptide proportional to 1/I.
摘要翻译：提供用于电离物质的串联分析系统，对所生成的各种离子类型进行质谱分析，选择和离解离子类型，具有特定质荷比的离子类型，从而重复质谱分析测量在第n级的离子型离子。基于离子强度由离子峰相对于质量分数表示，A处理在预定时间内判断用于分析MS（次级质谱分析）旁边的分析的控制内容，在MS＆lt; n＆gt;结果中的每个离子的电荷比。离子检测单元根据测得的电离数据判断同位素峰。假设在一定的时间间隔期间测量的亲代离子肽的MS 1的计数值为I，则数据处理单元使MS <2> 时间或肽的分析时间与1 / I成比例。

2. 发明授权

US07180056B2 Mass spectrometry and mass spectrometry system 失效
标题翻译：质谱和质谱系统
公开(公告)号：US07180056B2
公开(公告)日：2007-02-20
申请号：US11143717
申请日：2005-06-03
申请人： Atsushi Ohtake , Kinya Kobayashi , Kiyomi Yoshinari , Toshiyuki Yokosuka , Atsumu Hirabayashi
发明人： Atsushi Ohtake , Kinya Kobayashi , Kiyomi Yoshinari , Toshiyuki Yokosuka , Atsumu Hirabayashi
IPC分类号： H01J49/00 , C12P19/34 , G01N33/53
CPC分类号： H01J49/004 , G01N33/6848 , H01J49/0031 , Y10T436/13 , Y10T436/25
摘要： In a method of measuring by a tandem mass spectrometer a sample labeled with an isotope, measuring throughput is improved. In a technique in which tandem mass spectrometer is used to analyze a sample labeled with an isotope, spectra obtained by a first-stage measurement (MS1) are analyzed during a measuring session in a realtime fashion to determine ions to be used in second-stage and subsequent dissociation• spectral measurement (MS2).
摘要翻译：在通过串联质谱仪测量标记有同位素的样品的测量方法中，测量通量提高。在使用串联质谱仪分析用同位素标记的样品的技术中，在测量会话期间以实时方式分析通过第一阶段测量（MS ^{1）获得的光谱，以确定用于第二阶段和随后解离的离子。光谱测量（MS2）。}

3. 发明申请

US20060289735A1 Mass spectrometric analysis method and system using the method 有权
标题翻译：质谱分析方法和系统采用该方法
公开(公告)号：US20060289735A1
公开(公告)日：2006-12-28
申请号：US11439949
申请日：2006-05-25
申请人： Atsushi Ohtake , Kinya Kobayashi , Toshiyuki Yokosuka , Kiyomi Yoshinari
发明人： Atsushi Ohtake , Kinya Kobayashi , Toshiyuki Yokosuka , Kiyomi Yoshinari
IPC分类号： B01D59/44
CPC分类号： H01J49/02 , H01J49/004
摘要： A tandem analysis system is provided for ionizing a substance, performing mass spectrometric analysis of various ion types generated, selecting and dissociating an ion type, the ion type having a specific mass-to-charge ratio, and thereby, repeating mass spectrometric analysis measurement on the ion of the ion type over n-th stages. A processing judges control content for the analysis next to MSn (the n-th stage mass spectrometric analysis) within a predetermined time, based on ion intensity being represented by an ion peak with respect to the mass-to-charge ratio of each ion in the MSn result. An ion detection unit judges isotope-peak from the measured ionized data. Assuming that the MS1 count number of a parent-ion peptide measured during a certain constant time-interval is I, a data processing unit makes the MS2 integration number-of-times or analysis time of the peptide proportional to 1/I.
摘要翻译：提供用于电离物质的串联分析系统，对所生成的各种离子类型进行质谱分析，选择和离解离子类型，具有特定质荷比的离子类型，从而重复质谱分析测量在第n级的离子型离子。基于离子强度由离子峰相对于质量分数表示，A处理在预定时间内判断用于分析MS（次级质谱分析）旁边的分析的控制内容，在MS＆lt; n＆gt;结果中的每个离子的电荷比。离子检测单元根据测得的电离数据判断同位素峰。假设在一定的时间间隔期间测量的亲代离子肽的MS 1的计数值为I，则数据处理单元使MS <2> 时间或肽的分析时间与1 / I成比例。

4. 发明授权

US06806098B2 Method and device for assessing surface uniformity of semiconductor device treated by CMP 失效
标题翻译：用于评估CMP处理的半导体器件的表面均匀性的方法和装置
公开(公告)号：US06806098B2
公开(公告)日：2004-10-19
申请号：US10321603
申请日：2002-12-18
申请人： Atsushi Ohtake , Kinya Kobayashi
发明人： Atsushi Ohtake , Kinya Kobayashi
IPC分类号： H01L2100
CPC分类号： B24B37/005 , B24B49/12
摘要： This invention provides an inspection method and device which can efficiently measure the surface uniformity of a semiconductor device which is chemically and mechanically polished based on measured data at several points on the surface of the chip.
摘要翻译：本发明提供了一种检查方法和装置，其可以基于芯片表面上的几个点处的测量数据有效地测量化学和机械抛光的半导体器件的表面均匀性。

5. 发明申请

US20050172034A1 Method and system for managing programs for web service system 审中-公开
标题翻译：用于管理Web服务系统的方法和系统
公开(公告)号：US20050172034A1
公开(公告)日：2005-08-04
申请号：US10969101
申请日：2004-10-19
申请人： Nobuyoshi Sakai , Atsushi Ohtake , Jun Sugihara
发明人： Nobuyoshi Sakai , Atsushi Ohtake , Jun Sugihara
IPC分类号： G06F11/00 , G06F9/445 , G06F15/16 , G06F17/30
CPC分类号： G06F16/95
摘要： When a message is transmitted to an information processing device from a communication unit, the method of this invention receives a response from the destination information processing device by the communication unit and checks whether an error has occurred which was caused by a change made to the interface definition information representing an interface with the information processing device. In the event of an error caused by a change made to the interface definition information, the method of this invention test-transmits to the information processing device from the communication unit a message to identify an input type at a location of that change. According to the location of change and a result of test transmission, the method of this invention changes a content of a program on a memory unit which transmits the messages to the information processing device.
摘要翻译：当从通信单元向信息处理设备发送消息时，本发明的方法从通信单元接收来自目的地信息处理设备的响应，并检查是否发生由接口发生的改变引起的错误表示与信息处理装置的接口的定义信息。在由于对接口定义信息的改变引起的错误的情况下，本发明的方法从通信单元向信息处理设备发送消息以在该变化的位置识别输入类型。根据变更的位置和测试传输的结果，本发明的方法将发送消息的存储单元中的节目内容改变到信息处理设备。

6. 发明授权

US5401768A 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2, derivative, manufacturing process thereof and its use 失效
标题翻译： 2,5,6,7-四去甲-4,8-间间亚苯基PGI 2，其衍生物及其制备方法及其用途
公开(公告)号：US5401768A
公开(公告)日：1995-03-28
申请号：US90995
申请日：1993-07-13
申请人： Kiyotaka Ohno , Toshiya Takahashi , Atsushi Ohtake , Hisanori Wakita , Shintaro Nishio
发明人： Kiyotaka Ohno , Toshiya Takahashi , Atsushi Ohtake , Hisanori Wakita , Shintaro Nishio
IPC分类号： C07D307/93 , C07D407/14 , C07D493/04 , A61K31/34
CPC分类号： C07D407/14 , C07D307/93 , C07D493/04
摘要： Disclosed are 2,5,6,7-tetranor-4,8-inter-m-phemylene PGI.sub.2 derivatives such as 16-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 and methyl ester thereof, 17-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 and methyl ester thereof, 15-phenyl-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI.sub.2, 16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2, 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2, 16-methyl-16-phenoxy-2,5,6,7,17,18,19,20-octanor-4,8-inter-m-phenylene PGI.sub.2, 16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2 and methyl ester thereof, and 3-decarboxy-3-hydroxymethyl-16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8-inter-m-phenylene PGI.sub.2, which are useful as pharmaceuticals.These compounds are useful as an antiulcer drug, antihypertensive drug, antithrombus drug or the like.
摘要翻译： PCT No.PCT / JP88 / 01048 Sec。 371日期1989年8月14日 102（e）日期1989年8月14日PCT提交1988年10月14日PCT公布。出版物WO89 / 03387 日期：1989年4月20日。公开的是2,5,6,7-四去甲-4,8-间m-亚氨基PGI 2衍生物，如16-甲基-2,5,6,7-四去甲-4,8- 间 - 亚苯基PGI 2及其甲酯，17-甲基-2,5,6,7-四酮-4,8-间 - 间 - 亚苯基PGI 2及其甲酯，15-苯基-2,5,6， 7,16,17,18,19,20-壬腈-4,8-间间 - 亚苯基PGI2,16-甲基-17-苯基-2,5,6,7,18,19,20-庚酮-4 ，8-间 - 间 - 亚苯基PGI2,16,16-二甲基-17-苯基-2,5,6,7,18,19,20-庚烷-4,8-间间苯撑PGI2,16-甲基 -16-苯氧基-2,5,6,7,17,18,19,20-辛腈-4,8-间间苯撑PGI2,16-甲基-16-苯氧基-2,5,6,7， 18,19,20-庚酮-4,8-间 - 间 - 亚苯基PGI 2及其甲酯和3-脱羧基-3-羟甲基-16-甲基-16-苯氧基-2,5,6,7,18， 19,20-庚酮-4,8-间间 - 亚苯基PGI2，其可用作药物。这些化合物可用作抗溃疡药，抗高血压药，抗血栓药物等。

7. 发明申请

US20140377539A1 Electrical Insulation Resin Composition, Cured Product Thereof, Methods of Preparing the Composition and the Product, and High Voltage Apparatuses and Power Transmission and Distribution Apparatuses Using the Composition and the Product 审中-公开
标题翻译：电绝缘树脂组合物，其固化产品，组合物和产品的制备方法以及使用组合物和产品的高压设备和输配电设备
公开(公告)号：US20140377539A1
公开(公告)日：2014-12-25
申请号：US14376349
申请日：2012-02-17
申请人： Hironori Matsumoto , Atsushi Ohtake , Akihiro Sano
发明人： Hironori Matsumoto , Atsushi Ohtake , Akihiro Sano
IPC分类号： H01B3/40 , H01B3/28 , H01B3/02 , C08L63/00
CPC分类号： H01B3/40 , C08K3/36 , C08L9/06 , C08L63/00 , C08L2203/206 , H01B3/02 , H01B3/28 , Y10T428/25 , Y10T428/254 , Y10T428/259
摘要： The present invention is aimed at enhancing dispersibility of filler, maintaining uniform low-thermal-expansion properties and mechanical strength, enhancing insulation characteristics, especially treeing resistivity, of a resin composition or a cured resin product, and enhancing the reliability of a high voltage apparatus, a power transmission and distribution apparatus or the like to which the resin composition or the cured resin product is applied.An insulating resin composition contains an insulating resin 1 as a matrix, a large particle diameter filler 2, and a small particle diameter filler 3 smaller in particle diameter than the large particle diameter filler 2, the large particle diameter filler 2 and the small particle diameter filler 3 being dispersed in the insulating resin 1, wherein the insulating resin 1 and the large particle diameter filler 2 has an affinity for each other, whereas the insulating resin 1 and the small particle diameter filler 3 have no affinity for each other.
摘要翻译：本发明的目的在于提高填料的分散性，保持树脂组合物或固化树脂制品的均匀的低热膨胀性能和机械强度，提高树脂电阻率的绝缘特性，特别是树枝电阻率，提高高压装置的可靠性，施加了树脂组合物或固化树脂制品的动力传动配送装置等。绝缘树脂组合物含有作为基质的绝缘树脂1，大粒径填料2和小粒径填料3，其粒径小于大粒径填料2，大粒径填料2和小粒径填料3分散在绝缘树脂1中，其中绝缘树脂1和大粒径填料2彼此具有亲和性，而绝缘树脂1和小粒径填料3彼此不具有亲和力。

8. 发明授权

US06323235B1 Benzene-condensed heterocyclic derivatives and their uses 失效
标题翻译：苯稠合杂环衍生物及其用途
公开(公告)号：US06323235B1
公开(公告)日：2001-11-27
申请号：US09482279
申请日：2000-01-13
申请人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno
发明人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno
IPC分类号： C07D20918
CPC分类号： C07D307/79 , C07D209/08 , C07D307/86 , C07D407/12 , C07D409/12 , C07D413/06
摘要： Novel compounds having strong TXA2 receptor antagonist activities and PGI2 receptor agonist activities, which are effective for therapy and prevention of diseases related to TXA2, are disclosed. The compound of the present invention is represented by the following formula (I). (wherein the meanings of the symbols in the formula are as described in the specification).
摘要翻译：公开了具有强的TXA2受体拮抗剂活性和PGI2受体激动剂活性的新型化合物，其有效治疗和预防与TXA2相关的疾病。本发明的化合物由下式（I）表示（式中的符号的含义如说明书所述）。

9. 发明授权

US06201015B1 Therapeutic method for thrombocytopathy treatment 失效
标题翻译：血小板病变治疗方法
公开(公告)号：US06201015B1
公开(公告)日：2001-03-13
申请号：US09068807
申请日：1998-05-27
申请人： Mitsuko Miyamoto , Naohiro Yamada , Atsushi Ohtake , Hisanori Wakita
发明人： Mitsuko Miyamoto , Naohiro Yamada , Atsushi Ohtake , Hisanori Wakita
IPC分类号： A61K3134
CPC分类号： A61K31/5585 , A61K31/34
摘要： A platelet function increment agent including a prostaglandin I2 derivative as an active ingredient, and a therapeutic method for thrombocytopathy using the same. The platelet function increment agent of the present invention does not induce platelet aggregation, has superior activating action on platelets and is greatly useful as a platelet function increment agent.
摘要翻译：包含前列腺素I2衍生物作为活性成分的血小板功能增量剂和使用其的血小板病变的治疗方法。本发明的血小板功能增量剂不诱导血小板聚集，对血小板具有优异的活化作用，非常有用作为血小板功能增量剂。

10. 发明授权

US08735469B2 Resin material and high voltage equipment using the resin material 有权
标题翻译：树脂材料和高压设备使用树脂材料
公开(公告)号：US08735469B2
公开(公告)日：2014-05-27
申请号：US13212336
申请日：2011-08-18
申请人： Akihiro Sano , Atsushi Ohtake
发明人： Akihiro Sano , Atsushi Ohtake
IPC分类号： C08L63/00 , H01B3/00 , C08G59/00
CPC分类号： C08K9/06 , C08L63/00
摘要： A resin material of high strength and high voltage equipment capable of improving the reliability by using the resin material, the resin material being a hardened product including fine particles and resin ingredients, in which the fine particles have hydrophobic groups on the surface and have a particle diameter of 200 nm or less, the resin ingredients have hydrophilic groups on the side chains, and the fine particles form a plurality of linear aggregates inside the resin, thereby forming a dendritic structure.
摘要翻译：一种高强度高压设备的树脂材料，其能够通过使用树脂材料提高可靠性，树脂材料是包括细颗粒和树脂成分的硬化产物，其中细颗粒在表面上具有疏水基团并具有颗粒直径为200nm以下，树脂成分在侧链上具有亲水性基团，微粒在树脂内部形成多个线性聚集体，从而形成树枝状结构。

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