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1. 发明授权

US6043264A Benzene-condensed heterocyclic derivatives and their uses 失效
标题翻译：苯稠合杂环衍生物及其用途
公开(公告)号：US6043264A
公开(公告)日：2000-03-28
申请号：US700477
申请日：1997-06-26
申请人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno, deceased
发明人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno, deceased
IPC分类号： C07D209/08 , C07D307/79 , C07D307/86 , C07D407/12 , C07D409/12 , C07D413/06 , A61K31/34 , C07D307/80 , C07D307/81
CPC分类号： C07D307/79 , C07D209/08 , C07D307/86 , C07D407/12 , C07D409/12 , C07D413/06
摘要： Novel compounds having strong TXA.sub.2 receptor antagonist activities and PGI.sub.2 receptor agonist activities, which are effective for therapy and prevention of diseases related to TXA.sub.2, are disclosed. The compound of the present invention is represented by the following formula (I). ##STR1## (wherein the meanings of the symbols in the formula are as described in the specification).
摘要翻译： PCT No.PCT / JP96 / 00011 Sec。 371日期：1997年6月26日 102（e）日期1996年6月26日PCT提交1996年1月8日PCT公布。出版物WO96 / 20925 日期1996年7月11日公开了具有强的TXA2受体拮抗剂活性和PGI2受体激动剂活性的新型化合物，其有效治疗和预防与TXA2相关的疾病。本发明的化合物由下式（I）表示。（其中式中符号的含义如说明书中所述）。

2. 发明授权

US06323235B1 Benzene-condensed heterocyclic derivatives and their uses 失效
标题翻译：苯稠合杂环衍生物及其用途
公开(公告)号：US06323235B1
公开(公告)日：2001-11-27
申请号：US09482279
申请日：2000-01-13
申请人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno
发明人： Atsushi Ohtake , Kazuhiro Hoshi , Shunji Tsukamoto , Takahiro Takeda , Naohiro Yamada , Kazuhisa Matsumoto , Michihiro Ohno , Kiyotaka Ohno
IPC分类号： C07D20918
CPC分类号： C07D307/79 , C07D209/08 , C07D307/86 , C07D407/12 , C07D409/12 , C07D413/06
摘要： Novel compounds having strong TXA2 receptor antagonist activities and PGI2 receptor agonist activities, which are effective for therapy and prevention of diseases related to TXA2, are disclosed. The compound of the present invention is represented by the following formula (I). (wherein the meanings of the symbols in the formula are as described in the specification).
摘要翻译：公开了具有强的TXA2受体拮抗剂活性和PGI2受体激动剂活性的新型化合物，其有效治疗和预防与TXA2相关的疾病。本发明的化合物由下式（I）表示（式中的符号的含义如说明书所述）。

3. 发明授权

US5496849A Sulfonic acid derivative and its pharmaceutical application 失效
标题翻译：磺酸衍生物及其制药应用
公开(公告)号：US5496849A
公开(公告)日：1996-03-05
申请号：US244141
申请日：1994-05-17
申请人： Kiyotaka Ohno , Atsushi Ohtake , Shintaro Nishio , Kazuhiro Hoshi , Shunji Tsukamoto
发明人： Kiyotaka Ohno , Atsushi Ohtake , Shintaro Nishio , Kazuhiro Hoshi , Shunji Tsukamoto
IPC分类号： C07D307/93 , A61K31/34 , C07D307/78 , C07D307/80
CPC分类号： C07D307/93
摘要： The present invention discloses sulfonamide derivative represented by the following general formula: ##STR1## [wherein, R.sub.1 is(i) --COOR.sub.2 (where, R.sub.2 is (1) hydrogen, (2) a pharmacologically acceptable cation, or (3) an alkyl having 1 to 14 carbon atoms) or,(ii) --C(.dbd.O)--R.sub.3 (wherein, R.sub.3 represents an alkyl having 1 to 4 carbon atoms); A is(i) --(CH.sub.2)n-- (wherein, n represents an integer of 0 to 3),(ii) --CH.dbd.CH--, or the group:(iii) --O--C(R.sub.4) (R.sub.5)-- (wherein, R.sub.4 and R.sub.5 represent (1) hydrogen or (2) an alkyl having 1 to 4 carbon atoms, and R.sub.4 and R.sub.5 may be identical or different); and,w is NH or --O--], as well as a thromboxane A2 receptor antagonistic drug having said derivative for its active ingredient.Since the compound of the present invention has excellent thromboxane A2 receptor antagonistic action, it can be used as a thromboxane A2 receptor antagonist of high activity and long duration.
摘要翻译： PCT No.PCT / JP93 / 01339 Sec。 371日期：1994年5月17日 102（e）日期1994年5月17日PCT提交1993年9月17日PCT公布。出版物WO94 / 06785 日本3月3日公开本发明公开了由以下通式表示的磺酰胺衍生物：其中，R 1为（ⅰ）-COOR 2（其中，R 2为（1）氢），（2）药理学上可接受的阳离子，或（3）具有1至14个碳原子的烷基）或（ii）-C（= O）-R 3（其中，R 3表示具有1至4个碳原子的烷基）; A是（i） - （CH 2）n - （其中，n表示0至3的整数），（ii）-CH = CH-或基团：（iii）-OC（R4）（R5） - （其中，R4和R5表示（1）氢或（2）具有1至4个碳原子的烷基，R4和R5可以相同或不同）; 和w是NH或-O-]，以及具有所述衍生物作为其活性成分的血栓素A2受体拮抗药。由于本发明化合物具有优异的血栓素A2受体拮抗作用，因此可用作活性高且持续时间长的血栓烷A2受体拮抗剂。

4. 发明授权

US4735288A Detachably attaching mechanism for cup of lubricator or filter used with air-actuated device 失效
标题翻译：用于空气驱动装置的杯子的可分离的安装机构
公开(公告)号：US4735288A
公开(公告)日：1988-04-05
申请号：US3773
申请日：1987-01-16
申请人： Eiji Uematsu , Shunji Tsukamoto , Fumika Hayashi , Kouichi Miyake , Toshiyuki Watanabe
发明人： Eiji Uematsu , Shunji Tsukamoto , Fumika Hayashi , Kouichi Miyake , Toshiyuki Watanabe
IPC分类号： F16N7/34 , F16B2/00 , F16D1/00
CPC分类号： F16N7/34 , B01D2201/4015 , Y10T403/60 , Y10T403/7005
摘要： A detably attaching mechanism for a cup of a lubricator or a filter used with an air-actuated device comprising such cup containing therein a quantity of lubrication oil or filter elements, means to supply a quantity of lubrication oil from the cup into an air stream flowing from an inlet to an outlet or to introduce the air stream through the filter elements contained within the cup, a cover mounted on the cup and a protective cylinder mounted around the cup, characterized by that the protective cylinder is provided on its outer periphery with a locking piece adapted to have its front or top end being outwardly tilted away from the outer periphery of the protective cylinder by depressing its rear or lower end and this locking piece is mounted with interposition of an elastically flexible leg on the outer periphery of the protective cylinder and that the cover is provided in its outer periphery with receiving means adapted to receive the front or top end of the locking piece upon completion of attachment of the cup and the protective cylinder to the cover and thereby to prevent rotation of the cup and the protective cylinder relative to the cover.
摘要翻译：一种用于杯子的润滑器或与空气致动装置一起使用的过滤器的可选择地附接机构，其包括含有一定数量的润滑油或过滤元件的杯，用于将一定数量的来自杯的润滑油供应到流动的气流中从入口到出口，或者将空气流引入容纳在杯内的过滤器元件，安装在杯上的盖和围绕杯安装的保护筒，其特征在于，保护筒在其外周上设置有锁定件适于使其前端或顶端通过按压其后端或下端而远离保护筒的外周向外倾斜，并且该锁定件安装成在保护筒的外周上插入弹性柔性腿并且所述盖在其外周设置有接收装置，所述接收装置适于在完成时接收所述锁定件的前端或顶端将杯和保护筒连接到盖上，从而防止杯和保护筒相对于盖旋转。

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