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    • 2. 发明授权
    • Catalyst for asymmetric induction
    • 非对称诱导催化剂
    • US5288682A
    • 1994-02-22
    • US851285
    • 1992-03-12
    • Atsunori MoriShohei Inoue
    • Atsunori MoriShohei Inoue
    • B01J31/02C07C253/08C07C255/36B01J31/00
    • C07C253/00B01J31/0212B01J31/0241B01J31/0247B01J2231/343C07B2200/07
    • Optically active cyanohydrins are prepared by addition of hydrogen cyanide to aldehydes in the presence of catalysts which comprise the dipeptide derivative represented by the formula ##STR1## wherein R.sup.1 represents an isopropyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a methyl group, a benzyl group or a phenyl group, R.sup.2 represents a benzyl group, an indol-3-ylmethyl group, an isopropyl group, an isobutyl group or a phenyl group, R.sup.3 represents a lower alkoxy group, a hydroxy group or a mono- or di-lower alkylamino group, R.sup.4 represents a hydrogen atom, or R.sup.2 and R.sup.4 are bonded together at their terminals to form a CH.sub.2 CH.sub.2 CH.sub.2 group, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are the same or different, and each represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group or R.sup.5 and R.sup.6, R.sup.6 and R.sup.7, or R.sup.7 and R.sup.8 are bonded together at their terminals to form CH.dbd.CH--CH.dbd.CH or OCH.sub.2 O, and * denotes an absolute configuration of S or R, and a titanium (IV) alkoxide.
    • 通过在催化剂存在下,将氰化氢加入到醛中来制备光活性氰醇,该催化剂包含由式(* CHEMICAL STRUCTURE *)(I)表示的二肽衍生物,其中R 1表示异丙基,异丁基,仲丁基 基团,叔丁基,甲基,苄基或苯基,R 2表示苄基,吲哚-3-基甲基,异丙基,异丁基或苯基,R 3表示低级 烷氧基,羟基或单 - 或二 - 低级烷基氨基,R 4表示氢原子,或者R 2和R 4在其末端键合在一起形成CH 2 CH 2 CH 2基,R 5,R 6,R 7和R 8相同, 各自表示氢原子,卤素原子,低级烷基或低级烷氧基或R5和R6,R6和R7,或R7和R8在其末端键合在一起形成CH = CH-CH = CH 或OCH 2 O,*表示S或R的绝对构型,钛(IV) 醇盐