专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1180099A1 NEW COMPOUNDS 审中-公开
公开(公告)号：EP1180099A1
公开(公告)日：2002-02-20
申请号：EP00925844.3
申请日：2000-05-03
申请人： AstraZeneca AB
发明人： LINSCHOTEN, Marcel , POLLA, Magnus
IPC分类号： C07D213/54
CPC分类号： A61K38/57 , A61K2300/00
摘要： The present invention relates to compounds of Formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases associated with carboxypeptidase U. In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt or solvate thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above.

2. 发明公开

EP1180098A1 NEW COMPOUNDS 审中-公开
标题翻译：新化合物
公开(公告)号：EP1180098A1
公开(公告)日：2002-02-20
申请号：EP00930001.3
申请日：2000-05-03
申请人： AstraZeneca AB
发明人： LINSCHOTEN, Marcel , POLLA, Magnus , SVENSSON, Peder
IPC分类号： C07D211/34 , C07D213/54 , C07D213/73 , A61K31/44 , A61K31/445
CPC分类号： A61K38/57 , A61K2300/00
摘要： The present invention relates to compounds of Formula (I), and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases associated with carboxypeptidase U. In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt or solvate thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐或溶剂合物或此类盐的溶剂化物，所述化合物抑制羧肽酶U并因此可用于预防和治疗与羧肽酶U相关的疾病。进一步地方面，本发明涉及用于治疗的本发明化合物; 涉及制备这种新化合物的方法; 涉及含有至少一种本发明化合物或其药学上可接受的盐或溶剂化物作为活性成分的药物组合物; 并涉及活性化合物在制造用于上述医疗用途的药物中的用途。

3. 发明公开

EP1012140A1 NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS 失效
标题翻译：脒衍生物及其作为凝血酶抑制剂的用途
公开(公告)号：EP1012140A1
公开(公告)日：2000-06-28
申请号：EP98929969.8
申请日：1998-06-09
申请人： AstraZeneca AB
发明人： KARLSSON, Olle , LINSCHOTEN, Marcel , NYSTRÖM, Jan-Erik
IPC分类号： C07D207/16 , A61K31/40
CPC分类号： C07D405/06 , C07D205/04
摘要： There is provided compounds of formula (I), wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

4. 发明授权

EP1140820B1 NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS 有权
标题翻译：脒衍生物及其作为凝血酶抑制剂的使用
公开(公告)号：EP1140820B1
公开(公告)日：2004-03-17
申请号：EP99963821.6
申请日：1999-12-10
申请人： AstraZeneca AB
发明人： INGHARDT, Tord , KARLSSON, Olle , LINSCHOTEN, Marcel , NYSTRÖM, Jan-Erik
IPC分类号： C07D207/16 , C07D405/06 , A61K31/40
CPC分类号： C07D205/04 , C07D207/16 , C07D405/06

5. 发明授权

EP1036061B1 NEW COMPOUNDS 有权
标题翻译：新化合物
公开(公告)号：EP1036061B1
公开(公告)日：2003-09-24
申请号：EP98962750.0
申请日：1998-12-01
申请人： AstraZeneca AB
发明人： KARLSSON, Olle , LINSCHOTEN, Marcel , NYSTRÖM, Jan-Erik
IPC分类号： C07D207/16 , C07K5/06 , A61K38/05
CPC分类号： C07D207/16 , A61K38/00

6. 发明公开

EP1036061A1 NEW COMPOUNDS 有权
标题翻译：新化合物
公开(公告)号：EP1036061A1
公开(公告)日：2000-09-20
申请号：EP98962750.0
申请日：1998-12-01
申请人： AstraZeneca AB
发明人： KARLSSON, Olle , LINSCHOTEN, Marcel , NYSTRÖM, Jan-Erik
IPC分类号： C07D207/16 , C07K5/06 , A61K38/05
CPC分类号： C07D207/16 , A61K38/00
摘要： There are provided compounds of formula (I), wherein R?1, R2, R3, R¿x, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
摘要翻译：提供了式（I）的化合物，其中R 1，R 2，R 3，R 1，X，Y，n和B具有在说明书中给出的含义，其可用作胰蛋白酶样蛋白酶的竞争性抑制剂，例如凝血酶，特别是用于治疗需要抑制凝血酶（例如血栓形成）或作为抗凝血剂的病症。

7. 发明授权

EP1012140B1 NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS 失效
标题翻译：脒衍生物及其作为凝血酶抑制剂的用途
公开(公告)号：EP1012140B1
公开(公告)日：2004-09-29
申请号：EP98929969.8
申请日：1998-06-09
申请人： AstraZeneca AB
发明人： KARLSSON, Olle , LINSCHOTEN, Marcel , NYSTRÖM, Jan-Erik
IPC分类号： C07D207/16 , A61K31/40
CPC分类号： C07D405/06 , C07D205/04

8. 发明公开

EP1140820A1 NEW AMIDINO DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS 有权
标题翻译：脒衍生物及其作为凝血酶抑制剂的使用
公开(公告)号：EP1140820A1
公开(公告)日：2001-10-10
申请号：EP99963821.6
申请日：1999-12-10
申请人： AstraZeneca AB
发明人： INGHARDT, Tord , KARLSSON, Olle , LINSCHOTEN, Marcel , NYSTRÖM, Jan-Erik
IPC分类号： C07D207/16 , C07D405/06 , A61K31/40
CPC分类号： C07D205/04 , C07D207/16 , C07D405/06
摘要： There is provided compounds of formula (I), wherein R1, Rx, Y, Ry, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式