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1. 发明申请

WO2002069968A1 NEW USE 审中-公开
标题翻译：新用途
公开(公告)号：WO2002069968A1
公开(公告)日：2002-09-12
申请号：PCT/SE2002/000375
申请日：2002-03-05
申请人： ASTRAZENECA AB , EEK, Arne
发明人： EEK, Arne
IPC分类号： A61K31/437
CPC分类号： A61K45/06 , A61K31/437 , A61K31/4375 , A61K31/5025 , A61K31/506 , A61K2300/00
摘要： The present invention relates to a new use of certain pharmaceutically active compounds in the treatment and/or prevention of medicament induced gastric ulcer. More particularly the invention is directed to the use of said compounds, and pharmaceutically acceptable salts thereof, for the treatment and/or prevention of NSAID (non-steroidal antiinflammatory drugs) induced gastric ulcer as well as a pharmaceutical composition in the unit dosage form for the prevention of NSAID induced gastric ulcer in a mammal comprising an NSAID together with a 6-carboxamido-imidazo[1,2-a]pyridine compounds. Other pharmaceutically active compounds used in the present invention comprises COX-2 inhibitors, NO-NSAIDs and bisphosphonates.
摘要翻译：本发明涉及某些药物活性化合物在治疗和/或预防药物诱导的胃溃疡中的新用途。更具体地，本发明涉及所述化合物及其药学上可接受的盐在治疗和/或预防NSAID（非甾体抗炎药）诱导的胃溃疡中的用途以及单位剂型中的药物组合物预防包含NSAID的哺乳动物中的NSAID诱导的胃溃疡以及6-甲酰氨基 - 咪唑并[1,2-a]吡啶化合物。本发明中使用的其它药物活性化合物包括COX-2抑制剂，NO-NSAID和双膦酸盐。

2. 发明申请

WO2004056840A1 NOVEL COMPOUNDS USEFUL IN BORON NEUTRON CAPTURE THERAPY 审中-公开
标题翻译：新的化合物可用于硼中毒治疗
公开(公告)号：WO2004056840A1
公开(公告)日：2004-07-08
申请号：PCT/SE2003/002007
申请日：2003-12-18
申请人： ASTRAZENECA AB , EEK, Arne , MALMQUIST, Jonas , OLSSON, Lars-Inge
发明人： EEK, Arne , MALMQUIST, Jonas , OLSSON, Lars-Inge
IPC分类号： C07F15/06
CPC分类号： C07F15/065
摘要： The present invention relates to novel compounds useful in boron neutron capture therapy. A further aspect of the invention is the use of the compounds in tumour therapy and in the manufacture of a medicament for use in tumour therapy. Yet another aspect of the invention is a method for preparing the novel compounds. A further aspect of the invention is a pharmaceutical preparation comprising said compounds.
摘要翻译：本发明涉及可用于硼中子俘获治疗的新化合物。本发明的另一方面是这些化合物在肿瘤治疗中的用途以及制造用于肿瘤治疗的药物。本发明的另一方面是制备新化合物的方法。本发明的另一方面是包含所述化合物的药物制剂。

3. 发明公开

EP1039861A1 MEDICAL DEVICE FOR INTERNAL HEAT TREATMENT AND DRUG DELIVERY 有权
标题翻译：医疗设备内部的热量治疗和药物管理局
公开(公告)号：EP1039861A1
公开(公告)日：2000-10-04
申请号：EP98963729.3
申请日：1998-12-16
申请人： AstraZeneca AB , LUND INSTRUMENTS AB
发明人： BOLMSJÖ, Magnus , EEK, Arne
IPC分类号： A61F7/12 , A61M31/00 , A61B17/36
CPC分类号： A61F7/12 , A61B2017/4216 , A61M2025/0057
摘要： Medical device (1) for effecting heat treatment and local delivery of a fluid medicament on body tissue presenting a predetermined section of a boundary wall of a passageway in a human or animal body comprising a catheter-like member (12) for insertion into the passageway to a predetermined insertion position, the catheter-like member being provided with an inflatable balloon structure (11) having a boundary wall which is inflatable against the body tissue when the catheter-like member (12) is in the predetermined insertion position and delivery means (2, 11, 25) for local delivery of the fluid medicament on the body tissue when the catheter-like member (12) is in the predetermined insertion position, and a heating arrangement (10, 15) which is adapted to heat the body tissue when the catheter-like member (12) is in the predetermined insertion position. The delivery means (2, 11, 25) comprises a supply channel (25) for supply of the fluid medicament to the balloon structure (11) and a construction for the boundary wall (2) of the balloon structure (11) which is permeable to the fluid medicament. Supply of the fluid medicament to the balloon structure along the supply channel (25) when the catheter-like member (12) is in the predetermined insertion position thereby causes the balloon structure (11) to inflate and fluid medicament to be delivered locally on the body tissue through the boundary wall (2) of the balloon structure (11).

4. 发明公开

EP1196155A1 NEW USE OF COMPOUNDS AS ANTIBACTERIAL AGENTS 有权
标题翻译：作为抗菌剂化合物的新用途
公开(公告)号：EP1196155A1
公开(公告)日：2002-04-17
申请号：EP00937451.3
申请日：2000-05-25
申请人： AstraZeneca AB
发明人： EEK, Arne , RAUD, Johan
IPC分类号： A61K31/04 , A61K31/196 , A61K31/33 , A61P1/04 , A61P31/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/21 , A61K31/216 , A61K31/381 , A61K31/403 , A61K31/4035 , A61K31/405 , A61K31/407 , Y10S514/926 , Y10S514/927
摘要： The present invention discloses a new use of NO-releasing NSAIDs, especially NO-releasing NSAIDs of formula (I), or a pharmaceutically acceptable salt or enantiomer thereof, for the manufacture of a medicament for the treatment of bacterial infections, especially caused or mediated by Helicobacter pylori. Disclosed is also the new use of a NO-releasing NSAID in combination with an acid susceptible proton pump inhibitor for the treatment of bacterial infections.

5. 发明公开

EP1039945A1 DEVICE FOR DELIVERING LIQUID CONTAINING MEDICAMENT 审中-公开
标题翻译： DEVICE有关供应的含药FLÜSSGKEIT的
公开(公告)号：EP1039945A1
公开(公告)日：2000-10-04
申请号：EP98964601.3
申请日：1998-12-15
申请人： AstraZeneca AB
发明人： EEK, Arne , NILSON, Billy
IPC分类号： A61M31/00 , A61M11/06 , A61M3/00
CPC分类号： B05B11/04 , A61M15/0065 , A61M31/00 , A61M2210/0618 , B05B1/14 , B05B11/02 , B05B11/025 , B05B11/3032
摘要： A delivery means for delivering liquid containing medicament to a posterior region of the nasal cavity, comprising an elongate tubular member (35; 151) and a nozzle (37; 153) at the free end thereof, which nozzle (37; 153) includes at least one opening (39; 155) through which liquid is in use delivered.

6. 发明公开

EP1370551A2 NEW COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：新的连接IN USE作为抗菌剂
公开(公告)号：EP1370551A2
公开(公告)日：2003-12-17
申请号：EP01944038.7
申请日：2001-06-20
申请人： AstraZeneca AB
发明人： BERGMAN, Rolf , EEK, Arne , LINDBERG, Per , OLSSON, Lars-Inge
IPC分类号： C07D401/12 , A61K31/4439
CPC分类号： C07D401/12
摘要： The present invention relates to novel compounds of Formula I, and pharmaceutically acceptable salts thereof, as antibacterial agents. The compounds of the present invention are nitric oxide releasing derivatives of proton pump inhibitors (NO-releasing PPIs). In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaceutically acceptable salt thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above. The invention also relates to new intermediates for use in the preparation of the novel compounds. Additionally the present invention relates to co-administration of NO-releasing PPIs with other known medicaments.

7. 发明公开

EP1047412A1 NEW USE OF LOCAL ANAESTHETICS AGAINST VASCULAR HEADACHES 审中-公开
标题翻译：新的用于治疗局部麻醉剂的血管性头痛
公开(公告)号：EP1047412A1
公开(公告)日：2000-11-02
申请号：EP98963712.9
申请日：1998-12-14
申请人： AstraZeneca AB
发明人： DALSGAARD, Carl-Johan , EEK, Arne , WALDENLIND, Lennart
IPC分类号： A61K31/135
CPC分类号： A61K31/138
摘要： The present invention discloses a new use of a compound of formula (I) wherein R1 represents C¿3-5? alkyl; and R?2 and R3¿ independently represent C¿1-3? alkyl; or a pharmaceutically acceptable salt thereof; for the manufacture of a medicament for the treatment of a vascular headache condition, particularly migraine.

8. 发明授权

EP1196155B1 NEW USE OF COMPOUNDS AS ANTIBACTERIAL AGENTS 有权
标题翻译：作为抗菌剂化合物的新用途
公开(公告)号：EP1196155B1
公开(公告)日：2004-08-04
申请号：EP00937451.3
申请日：2000-05-25
申请人： AstraZeneca AB
发明人： EEK, Arne , RAUD, Johan
IPC分类号： A61K31/04 , A61K31/196 , A61K31/33 , A61P1/04 , A61P31/00
CPC分类号： A61K45/06 , A61K31/00 , A61K31/21 , A61K31/216 , A61K31/381 , A61K31/403 , A61K31/4035 , A61K31/405 , A61K31/407 , Y10S514/926 , Y10S514/927
摘要： The present invention discloses a new use of NO-releasing NSAIDs, especially NO-releasing NSAIDs of formula (I), or a pharmaceutically acceptable salt or enantiomer thereof, for the manufacture of a medicament for the treatment of bacterial infections, especially caused or mediated by Helicobacter pylori. Disclosed is also the new use of a NO-releasing NSAID in combination with an acid susceptible proton pump inhibitor for the treatment of bacterial infections.

9. 发明授权

EP0862462B1 COMBINATION OF A BETA-RECEPTOR BLOCKER AND AN OPIOID 失效
标题翻译：组合的β受体阻断剂和阿片
公开(公告)号：EP0862462B1
公开(公告)日：2004-02-18
申请号：EP96933709.6
申请日：1996-10-03
申请人： AstraZeneca AB
发明人： EEK, Arne
IPC分类号： A61K45/06 , A61K31/485 , A61K31/445 , A61P25/04
CPC分类号： A61K31/435 , A61K31/485 , A61K45/06 , A61K31/135 , A61K2300/00
摘要： PCT No. PCT/SE96/01248 Sec. 371 Date Jan. 2, 1997 Sec. 102(e) Date Jan. 2, 1997 PCT Filed Oct. 3, 1996 PCT Pub. No. WO97/12634 PCT Pub. Date Apr. 10, 1997New combination of a beta -receptor blocker or a pharmaceutically acceptable salt thereof, and an opioid or a pharmaceutically acceptable salt thereof, optionally in the presence of a pharmaceutically acceptable carrier or any additional agents which may be active or inactive. The new combination confers a synergistic effect, and provides unexpected efficacy in the treatment of pain.

10. 发明公开

EP1370261A2 NEW USE 审中-公开
标题翻译：新用途
公开(公告)号：EP1370261A2
公开(公告)日：2003-12-17
申请号：EP02701851.4
申请日：2002-03-05
申请人： AstraZeneca AB
发明人： EEK, Arne
IPC分类号： A61K31/437 , A61K31/4375 , A61K45/00 , A61K31/405 , A61P1/04 , A61P29/00
CPC分类号： A61K45/06 , A61K31/437 , A61K31/4375 , A61K31/5025 , A61K31/506 , A61K2300/00
摘要： The present invention relates to a new use of certain pharmaceutically active compounds in the treatment and/or prevention of medicament induced gastric ulcer. More particularly the invention is directed to the use of said compounds, and pharmaceutically acceptable salts thereof, for the treatment and/or prevention of NSAID (non-steroidal antiinflammatory drugs) induced gastric ulcer as well as a pharmaceutical composition in the unit dosage form for the prevention of NSAID induced gastric ulcer in a mammal comprising an NSAID together with a 6-carboxamido-imidazo[1,2-a]pyridine compounds. Other pharmaceutically active compounds used in the present invention comprises COX-2 inhibitors, NO-NSAIDs and bisphosphonates.
摘要翻译：本发明涉及某些药物活性化合物在治疗和/或预防药物诱导的胃溃疡中的新用途。更具体地说，本发明涉及所述化合物及其药学上可接受的盐用于治疗和/或预防NSAID（非甾体抗炎药）诱发的胃溃疡的用途以及单位剂型中的药物组合物，用于在包含NSAID以及6-甲酰氨基 - 咪唑并[1,2-a]吡啶化合物的哺乳动物中预防NSAID诱导的胃溃疡。用于本发明的其它药物活性化合物包含COX-2抑制剂，NO-NSAID和双膦酸盐。

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