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1. 发明专利

JP2014005206A Arylamino heterocyclic carboxamide compound 审中-公开
标题翻译： ARYLAMINO杂环碳酰胺化合物
公开(公告)号：JP2014005206A
公开(公告)日：2014-01-16
申请号：JP2010236958
申请日：2010-10-22
申请人： Astellas Pharma Inc , アステラス製薬株式会社 , Kotobuki Seiyaku Kk , 壽製薬株式会社
发明人： SHIMADA ITSURO , MATSUYA TAKAHIRO , KUROSAWA KAZUO , IIKUBO KAZUHIKO , KAMIKAWA AKIO , KUROMITSU SADAO , SHINTO NOBUAKI , FUTAMI TAKASHI , KAWASE TATSUYA , SANO YORIMASA , YAMANAKA AYA , NISHIMURA KOICHI , ASAUMI MAKOTO , TOMIYAMA YASUSHI , IWAI TATSUNORI
IPC分类号： C07D239/06 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P11/00 , A61P35/00 , A61P43/00 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D451/02 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/20 , C07D493/08
CPC分类号： C07D493/08 , C07D239/06 , C07D241/20 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D451/02 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/20
摘要： PROBLEM TO BE SOLVED: To provide a compound useful as an inhibitor of a kinase activity of EML4-ALK fusion protein.SOLUTION: The present inventors conducted intensive studies about a compound having an inhibitory activity of the kinase activity of EML4-ALK fusion protein and found that the arylamino heterocyclic carboxamide compound of the present invention has the inhibitory activity of the kinase activity of EML4-ALK fusion protein, and completed the present invention. The compound of the present invention may be used for a pharmaceutical composition for preventing and/or treating cancer, lung cancer, non-small cell lung cancer, small cell lung cancer and the like.
摘要翻译：要解决的问题：提供可用作EML4-ALK融合蛋白的激酶活性抑制剂的化合物。解决方案：本发明人对具有EML4-ALK融合蛋白激酶活性抑制活性的化合物进行了深入研究，发现本发明的芳基氨基杂环羧酰胺化合物具有EML4-ALK融合蛋白的激酶活性的抑制活性，完成了本发明。本发明的化合物可以用于预防和/或治疗癌症，肺癌，非小细胞肺癌，小细胞肺癌等的药物组合物。

2. 发明专利

JP2008001596A Sodium channel inhibitor 审中-公开
标题翻译：钠通道抑制剂
公开(公告)号：JP2008001596A
公开(公告)日：2008-01-10
申请号：JP2004257280
申请日：2004-09-03
申请人： Astellas Pharma Inc , Kotobuki Seiyaku Kk , アステラス製薬株式会社 , 壽製薬株式会社
发明人： KIKUCHI KAZUMI , FUJIYASU JIRO , WATANABE TOSHIHIRO , NAGAKURA TOUKI , TOMIYAMA YASUSHI , SONEGAWA MOTOHARU , TOKUZAKI KAZUO , IWAI TATSUNORI
IPC分类号： C07D211/10 , A61K31/4465 , A61K31/4535 , A61P25/04 , C07D211/18 , C07D211/22 , C07D409/04
CPC分类号： C07D211/10 , C07D211/18 , C07D211/22 , C07D409/04
摘要： PROBLEM TO BE SOLVED: To obtain a sodium channel inhibitor having a high analgesic effect on neuropathic pain and a reduced adverse effect, a new piperidine derivative useful as a sodium channel inhibitor or its physiologically acceptable salt and a pharmaceutical composition containing the same as an active ingredient.
SOLUTION: The sodium channel inhibitor contains as an active ingredient a piperidine derivative or a pharmaceutically acceptable salt thereof. The derivative or salt has a structure in which the piperidine ring is directly bonded to a benzene ring or hetero ring and the benzene ring or hetero ring is directly bonded to another benzene ring.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题为了获得对神经性疼痛具有高镇痛作用和减少的副作用的钠通道抑制剂，可用作钠通道抑制剂或其生理学上可接受的盐的新的哌啶衍生物和含有它们的药物组合物作为活性成分。解决方案：钠通道抑制剂含有哌啶衍生物或其药学上可接受的盐作为活性成分。该衍生物或盐具有其中哌啶环直接键合到苯环或杂环的结构，苯环或杂环与另一苯环直接结合。版权所有（C）2008，JPO＆INPIT

3. 发明专利

JP2008222557A PYRROLO[3,2-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AS EFFECTIVE COMPONENT 审中-公开
标题翻译：吡咯并[3,2-d]吡嗪衍生物和药物组合物，其组成为有效成分
公开(公告)号：JP2008222557A
公开(公告)日：2008-09-25
申请号：JP2007058632
申请日：2007-03-08
申请人： Kotobuki Seiyaku Kk , 壽製薬株式会社
发明人： TOMIYAMA YASUSHI , IWAI TATSUNORI
IPC分类号： C07D487/04 , A61K31/519 , A61K31/695 , A61P1/04 , A61P31/04 , C07F7/08
摘要： PROBLEM TO BE SOLVED: To provide a compound that suppresses gastric acid secretion and has an antimicrobial action on Helicobacter pylori. SOLUTION: A compound represented by formula (I) [wherein R 1 represents a hydrogen atom, an alkyl group, an arylmethyl group, a trimethylsylilethoxymethyl group or the like; R 2 , R 3 may be the same or different and each represents a hydrogen atom, an alkyl group, an alkoxycarbonyl group, a carboxyl group, a carbamoyl group, an alkanoyl group, a cyano group, a halogen atom or the like; R 4 represents a hydrogen atom, an alkyl group, an alkoxy group, an alkoxycarbonyl group, a halogen atom, a hydroxy group, a carboxy group, a cyano group, a nitro group or the like; and R 5 represents an arylmethyl group, a heteroarylmethyl group or the like], a pharmacologically acceptable salt thereof, and a medicine comprising the compound as an effective component, are disclosed. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供抑制胃酸分泌并对幽门螺杆菌具有抗微生物作用的化合物。解决方案：由式（I）表示的化合物[其中R 1表示氢原子，烷基，芳基甲基，三甲基甲硅烷氧基甲基等; R 2 SP 3可以相同或不同，表示氢原子，烷基，烷氧基羰基，羧基，氨基甲酰基，烷酰基基团，氰基，卤素原子等; R 4表示氢原子，烷基，烷氧基，烷氧基羰基，卤素原子，羟基，羧基，氰基，硝基等; R＆lt; SP＆gt; 5＆lt; SP＆gt;表示芳基甲基，杂芳基甲基等]，其药理学上可接受的盐，以及包含该化合物作为有效成分的药物。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2008214305A Substituted amine derivative and pharmaceutical composition containing the same as active ingredient 审中-公开
标题翻译：取代的胺衍生物和药物组合物作为活性成分
公开(公告)号：JP2008214305A
公开(公告)日：2008-09-18
申请号：JP2007056979
申请日：2007-03-07
申请人： Kotobuki Seiyaku Kk , 壽製薬株式会社
发明人： TOMIYAMA YASUSHI , TOKUZAKI KAZUO , IWAI TATSUNORI
IPC分类号： C07D235/30 , A61K31/4184 , A61K31/7056 , A61K31/7076 , A61K45/00 , A61P13/02 , A61P19/06 , A61P43/00 , C07D403/12 , C07H19/04 , C07H19/167
摘要： PROBLEM TO BE SOLVED: To provide a novel compound excellent in CNT2 inhibition activity and excellent in vivo stability and physicochemical stability, to provide a pharmaceutical composition containing the compound as an active ingredient, and to provide a drug for treating hyperuricemia containing the compound. SOLUTION: Disclosed is a compound represented by formula (I) [wherein --- denotes a single bond or a double bond; n and w are each 0-5; L is -NH-, an alkenylene group, or the like; and A and B are specified substituents], a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. A pharmaceutical composition containing it as an active ingredient is also disclosed. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供具有优异的CNT2抑制活性和优异的体内稳定性和物理化学稳定性的新型化合物，以提供含有该化合物作为活性成分的药物组合物，并且提供一种治疗高尿酸血症的药物，其含有复合。解决方案：公开了由式（I）表示的化合物[其中---表示单键或双键; n和w分别为0-5; L是-NH-，亚烯基等; 并且A和B是指定的取代基]，其药学上可接受的盐，其前药，其水合物或其溶剂化物。还公开了含有它作为活性成分的药物组合物。版权所有（C）2008，JPO＆INPIT

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