专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2006219481A Method for producing acylaminothiazole derivative 有权
标题翻译：制备酰氨基噻唑衍生物的方法
公开(公告)号：JP2006219481A
公开(公告)日：2006-08-24
申请号：JP2006003657
申请日：2006-01-11
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： SUGASAWA KEIZOU , KOGA YUJI , KOHITSU KAZUYOSHI , OKUDA TAKAO , HARADA KOICHIRO , KUBOTA HIDEKI , HIRAYAMA FUKUSHI , ABE MASAKI , SUZUKI KENICHI
IPC分类号： C07D417/04 , A61K31/427 , A61K31/4439 , A61K31/4545 , A61P7/04 , C07D417/14
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a 2-acylaminothiazole derivative or its pharmaceutically allowable salt which has thrombocytosis activity based on excellent human c-mpl-Ba/F3 cell proliferation action and megakaryocyte colony formation acceleration action and is useful for curing thrombocytopenia. SOLUTION: The method produces a 2-acylaminothiazole derivative represented by formula (I) or its pharmaceutically allowable salt. In formula (I), -R 1 is a lower alkyl group or a cycloalkyl group; -A= is -N= or -CH=; -X is a halogen; (a) when -A= is -N=, then -Y- is -NR 3 - and (b) when -A= is -CH=, then -Y- is -O-; -R 2 is a substituted lower alkyl group; and -R 3 is -H or a lower alkyl group; and optionally, R 2 and R 3 may be united with an adjacent nitrogen atom to form a substituted piperidin-1-yl group or a piperazin-1-yl group substituted by an oxo group. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：提供一种基于优异的人c-mpl-Ba / F3细胞增殖作用和巨核细胞集落形成加速作用产生具有血小板增多活性的2-酰基氨基噻唑衍生物或其药学上允许的盐的方法，并且是可用于治疗血小板减少症。方法：该方法产生由式（I）表示的2-酰基氨基噻唑衍生物或其药学上可允许的盐。在式（I）中，-R SP 1是低级烷基或环烷基; -A = = -N =或-CH =; -X是卤素; （a）当-A =为-N =时，-Y-为-NR 3，和（b）当-A =为-CH =时，-Y-为-O-; -R 2 是取代的低级烷基; 且R 3 = H或低级烷基; 并且任选地，R“SP”2和R“3”可以与相邻的氮原子一起形成取代的哌啶-1-基或被哌嗪-1-基取代的哌嗪-1-基，氧代基团。版权所有（C）2006，JPO＆NCIPI

2. 发明专利

JP2006219480A Pharmaceutical composition containing acylaminothiazole derivative as active ingredient 有权
标题翻译：含有乙酰胺唑衍生物作为活性成分的药物组合物
公开(公告)号：JP2006219480A
公开(公告)日：2006-08-24
申请号：JP2006003655
申请日：2006-01-11
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： SUGASAWA KEIZOU , KOGA YUJI , KOHITSU KAZUYOSHI , OKUDA TAKAO , HARADA KOICHIRO , KUBOTA HIDEKI , HIRAYAMA FUKUSHI , ABE MASAKI , SUZUKI KENICHI
IPC分类号： A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K31/695 , A61P7/04 , A61P7/06 , C07D417/04 , C07D417/14 , C07D513/14
摘要： PROBLEM TO BE SOLVED: To provide a pharmaceutical composition containing a compound, which has excellent thrombocyte increasing activity based on human c-mpl-Ba/F3 cell growth action and megakaryocyte colony formation accelerating action and is useful for treating thrombocytopenia, as an active ingredient. SOLUTION: This pharmaceutical composition contains a new 2-acylaminothiazole derivative expressed by formula (1) (B is a lower alkylene; R 4 is an amino or a cyclic amino of which the each may be substituted; R 5 is thienyl or phenyl of which the each may be substituted; and R 6 is an aromatic heterocyclic, an aryl or a cyclic amino of which the each may be substituted, provided that R 6 does not include phenyl which is not substituted nor indole which may be substituted) or a pharmacologically acceptable salt thereof and a pharmacologically acceptable carrier. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供一种含有化合物的药物组合物，其基于人c-mpl-Ba / F3细胞生长作用和巨核细胞集落形成促进作用具有优异的血小板增加活性，并且可用于治疗血小板减少症，如活性成分。解决方案：该药物组合物含有由式（1）表示的新的2-酰基氨基噻唑衍生物（B为低级亚烷基; R 4为每个氨基或环状氨基的氨基或环状氨基） R 6是其中每个可以被取代的噻吩基或苯基;并且R 6是芳族杂环，芳基或环氨基，其各自可以是取代的，条件是R 6不包括未被取代的苯基或可被取代的吲哚）或其药学上可接受的盐和药理学上可接受的载体。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2008111001A 2-acylaminothiazole derivative or salt thereof 有权
标题翻译： 2-氨基苯并噻唑衍生物或其盐
公开(公告)号：JP2008111001A
公开(公告)日：2008-05-15
申请号：JP2008023950
申请日：2008-02-04
申请人： Astellas Pharma Inc , アステラス製薬株式会社
发明人： SUGASAWA KEIZOU , WATANUKI SUSUMU , KOGA YUJI , OSADA HIROSHI , KOHITSU KAZUYOSHI , WAKAYAMA RYUTARO , HIRAYAMA FUKUSHI , SUZUKI KENICHI
IPC分类号： C07D417/12 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P7/04 , A61P43/00 , C07D417/14
摘要： PROBLEM TO BE SOLVED: To provide a 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies, and to provide a compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia. SOLUTION: The invention relates to the platelet-increasing agent comprising 2-acylaminothiazole derivative, which is represented by formula (I), or a pharmaceutically acceptable salt thereof as an active ingredient. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供具有优异的人c-mpl-Ba / F3细胞增殖效果的2-酰基氨基噻唑衍生物或其药学上可接受的盐，并且基于促进形成巨核细胞集落，并提供可用于治疗血小板减少症的化合物或其药学上可接受的盐。解决方案：本发明涉及包含由式（I）表示的2-酰基氨基噻唑衍生物或其药学上可接受的盐作为活性成分的血小板增加剂。版权所有（C）2008，JPO＆INPIT

4. 发明专利

DE69837675T2 未知
公开(公告)号：DE69837675T2
公开(公告)日：2008-01-10
申请号：DE69837675
申请日：1998-10-12
申请人： ASTELLAS PHARMA INC
发明人： KUBOTA HIROKAZU , YONETOKU YASUHIRO , SUGASAWA KEIZOU , FUNATSU MASASHI , KAWAZOE SOUICHIROU , TOYOSHIMA AKIRA , OKAMOTO YOSHINORI , ISHIKAWA JUN , TAKEUCHI MAKOTO
IPC分类号： C07D231/12 , A61K31/4155 , A61K31/416 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/538 , C07D231/14 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/04 , C07D413/12 , C07D417/02 , C07D417/04 , C07D417/12 , C07D417/14 , C07D521/00
摘要： Drugs, in particular, pyrazole derivatives represented by the following general formula (I) which have a calcium release-dependent calcium channel inhibitory effect and medicinal compositions, in particular, calcium release-dependent calcium channel inhibitors containing the above compounds as the active ingredient, (in the formula, each symbol has the following meaning: D: pyrazolyl which may have 1 to 3 substituents selected from the group consisting of -Alk, -lower alkenyl, -lower alkynyl, -halogeno-lower alkyl, -Alk-cycloalkyl, -Alk-O-Alk, -cycloalkyl, -O-Alk, -COOH, -COO-Alk and -Hal, n: 0 or 1, B: phenylene, a nitrogen-containing, divalent, saturated ring group, or a monocyclic, divalent heteroaromatic ring group which may be substituted with Alk, X: -NR -CR R -, -CR R -NR -, -NR -SO2-, -SO2-NR - or -CR =CR -, and A: benzene ring which may have one or more substituents; mono-, di- or tricyclic fused heteroaryl which may have one or more substituents; cycloalkyl which may have one or more substituents; a nitrogen-containing, saturated ring group which may have one or more substituents; lower alkenyl which may have one or more substituents; lower alkynyl which may have one or more substituents; or Alk which may have one or more substituents).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式